C119 EFFECT OF SURGICAL TREATMENT ON SURVIVAL WITHOUT RECURRENCE (RFS) IN PATIENTS WITH UROTHELIAL CARCINOMA OF UPPER URINARY TRACT (UCUUT)

2011 ◽  
Vol 10 (9) ◽  
pp. 642
Author(s):  
P.G. Yakovlev ◽  
V.S. Sakalo ◽  
V.V. Mrachkovskiy ◽  
Y.Y. Kuranov
Keyword(s):  
Urinary Tract ◽  
Surgical Treatment ◽  
Urothelial Carcinoma ◽  
Upper Urinary Tract

Therapeutic Strategies for Asymptomatic Upper Urinary Tract Urothelial Carcinoma

2021 ◽  
Author(s):  
Deng Lin ◽  
Yun Hong ◽  
Zesong Yang ◽  
Liefu Ye
Keyword(s):  
Urinary Tract ◽  
Surgical Treatment ◽  
Urothelial Carcinoma ◽  
Upper Urinary Tract ◽  
Clinicopathological Features ◽  
Clinical Staging ◽  
Sleeve Resection ◽  
Bladder Urothelial Carcinoma ◽  
Group A ◽  
Group B

Abstract A total of 136 patients with upper urinary tract epithelial carcinoma (UTUC) were recruited, of which 21 patients with asymptomatic UTUC were group A, and 115 UTUC patients with hematuria or low back pain were group B. The clinicopathological features, oncologic outcomes, and surgical methods of patients were evaluated. The full-length renal ureterectomy+bladder sleeve resection was the main surgical treatment which was included (group A 80.95%, group B 90.43%). Other patients were treated with kidney-retaining surgery. No statistically significant difference was observed in the grading between groups A and B, pathological stage (p >0.05). During a median follow-up period of 44.3 months, tumor-specific mortality of group A was 7.14%, and that of group B was 5.10%. At the same period, the clinical data of 106 patients with asymptomatic bladder tumor were collected: 31 patients of them had asymptomatic bladder urothelial carcinoma. The asymptomatic UTUC group had a higher stage and grade clinicopathological features (P = 0.00), more aggressive than the asymptomatic bladder urothelial carcinoma group. The principle of asymptomatic UTUC treatment is the same as that of symptomatic UTUC. Risk stratification should be carried out according to clinical staging and other parameters, and the corresponding surgical treatment should be selected.

scholarly journals Primary-multiple synchronous malignant neoplasms renal pelvis and both ureters

2021 ◽  
Vol 14 (2) ◽  
pp. 23-29
Author(s):  
S.V. Popov S.V. ◽  
◽  
R.G. Guseynov ◽  
O.N. Skryabin ◽  
A.S. Peremyshlenko ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Surgical Treatment ◽  
Urothelial Carcinoma ◽  
Bladder Wall ◽  
Upper Urinary Tract ◽  
Malignant Neoplasms ◽  
Low Grade ◽  
Left Ureter ◽  
Organ Sparing ◽  
The Right

Introduction. Urothelial carcinoma of the upper urinary tract in Western countries of Erope and USA occurs in 1-2 cases per 100,000 populations. Nephroretrectomy remains the main method of treatment of this pathology, however, the role of organ-sparing surgeries increases with the bilateral localization of the tumor process. Due to the rarity of bilateral upper urinary tract lesions with urothelial cancer and the lack of data evaluating the results of organ-sparing surgeries in such situations, each clinical case is of interest. Materials and methods. The article describes a case of surgical treatment of a patient with non-invasive papillary urothelial carcinomas of both ureters and the pelvis of the right kidney, which were manifested by macrohematuria. Results. The diagnosis was confirmed by computer tomography (CT) and ureteroscopy with tumor biopsy, which revealed a neoplasm of the right kidney pelvis, multiple tumors of the distal part of the right ureter and a solitary neoplasm of the middle part of left ureter. The patient underwent laparoscopic nephrureterectomy on the right with transurethral resection of the bladder wall in the area of the mouth of the right ureter and endoscopic removal of the neoplasm in the middle third of the left ureter using laser energy. At the control examination 1,5 months after the surgical treatment, according to the results of CT, cystoscopy with biopsy of the bladder and ureteroscopy, as well as histological examination of the biopsies, no data for tumor growth were found. At CT 6 months after the surgery, no data for the recurrence of cancer were obtained. Сonclusions. This clinical observation demonstrates the technical feasibility and oncological feasibility of using organ-preserving surgical treatment for bilateral localization of low-grade urothelial carcinoma.

Higher Cancer Mortality in Rural Upper Urinary Tract Urothelial Carcinoma Patients

2021 ◽  
pp. 1-7
Author(s):  
Claudia Collà Ruvolo ◽  
Lara F. Stolzenbach ◽  
Luigi Nocera ◽  
Marina Deuker ◽  
Mike Wenzel ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Surgical Treatment ◽  
Urothelial Carcinoma ◽  
Tumor Grade ◽  
Tumor Location ◽  
Upper Urinary Tract ◽  
Low Grade ◽  
Exact Matching ◽  
T Stage ◽  
Urinary Tract Urothelial Carcinoma

Objective: The aim of the study was to investigate differences in the stage at presentation and cancer-specific mortality (CSM) between rural area (RA) and urban area (UA) residence status in nonmetastatic upper urinary tract urothelial carcinoma (UTUC) patients. Methods: Newly diagnosed T1–3N0M0 UTUC patients with available residence status were abstracted from the Surveillance, Epidemiology, and End Results database (2004–2016). Propensity score (PS) matching (1 RA vs. 3 UA) accounted for age (interval ≤2 years), T stage (exact matching: T1, T2, and T3), and tumor grade (exact matching: high grade, low grade/unknown). Cumulative incidence plots and multivariable competing risk regression models focused on CSM, after adjustment for other-cause mortality. Results: Of 6,012 patients, 125 (2.1%) resided in RAs and 5,887 (97.9%) in UAs. RA patients were younger than UA patients (median age 72 vs. 75 years, p = 0.03). No differences were recorded in tumor location, T stage, tumor grade, or surgical treatment between RA and UA patients. After 1:3 PS matching, 125 RA patients and 375 UA patients were assessable. At 5 years of follow-up, CSM rates were 26.7 versus 15.7% according to RA versus UA, respectively. After additional multivariable adjustment for age, sex, tumor location, and surgical treatment, RA remained an independent predictor of higher CSM (hazard ratio 1.75, p = 0.02). Conclusions: Despite no differences in cancer characteristics, UTUC patients in RA are at higher risk of CSM than their UA counterparts. This suggests suboptimal care delivery and compliance as possible causes. Complex and/or rare disease should be centralized to expert centers, which are often in UAs.

403: Desmoplasia is an Independent Prognostic Indicator in Urothelial Carcinoma of the Upper Urinary Tract

2007 ◽  
Vol 177 (4S) ◽  
pp. 134-134
Author(s):  
Richard E. Zigeuner ◽  
Thomas Chromecki ◽  
Sebastian Leibl ◽  
Peter Rehak ◽  
Cord Langner
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Prognostic Indicator ◽  
Upper Urinary Tract

1093: Tumor Necrosis as Prognostic Indicator in Urothelial Carcinoma of the Upper Urinary Tract

2006 ◽  
Vol 175 (4S) ◽  
pp. 351-352
Author(s):  
Richard E. Zigeuner ◽  
Georg Hutterer ◽  
Thomas Chromecki ◽  
Sebastian Leibl ◽  
Peter Rehak ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Tumor Necrosis ◽  
Prognostic Indicator ◽  
Upper Urinary Tract

405: Alpha-Methylacyl-CoA Racemase (AMACR/P504S) Protein Expression in Urothelial Carcinoma of the Upper Urinary Tract Correlates with Tumour Progression

2006 ◽  
Vol 175 (4S) ◽  
pp. 132-132
Author(s):  
Richard E. Zigeuner ◽  
Sebastian Leibl ◽  
Georg Hutterer ◽  
Thomas Chromecki ◽  
Peter Rehak ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Protein Expression ◽  
Urothelial Carcinoma ◽  
Tumour Progression ◽  
Upper Urinary Tract

scholarly journals Ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation: a case report

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shangqing Ren ◽  
Hualin Feng ◽  
Yige Bao ◽  
Yi Wei ◽  
Yong Ou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Standard Treatment ◽  
Clinical Manifestations ◽  
Sarcomatoid Carcinoma ◽  
Upper Urinary Tract ◽  
Malignant Tumours

Abstract Background Upper urinary tract urothelial carcinoma (UTUC) with multiple pathological types is extremely rare in the clinic, but the recurrence rate and mortality these patients are high. At present, there is no standard treatment for such cases. Case presentation We reported a case of ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation and rapid ileal metastasis and reviewed the literature related to different pathological types of upper urinary tract tumours to explore the diagnosis, treatment and prognosis characteristics of the disease, enhance our understanding of its clinical manifestations and history of evolution and provide guidance for avoiding missed diagnosis and misdiagnosis. Conclusion There is no standard treatment for urinary malignant tumours with multiple pathological types; radical surgery is considered a suitable choice. Chemotherapy, targeted drug therapy and immunotherapy may be beneficial to the survival of patients. In short, these patients have a high risk of recurrence and metastasis and a poor prognosis.

scholarly journals Comparison of oncologic and functional outcomes between radical nephroureterectomy and segmental ureterectomy for upper urinary tract urothelial carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tae Heon Kim ◽  
Chung Un Lee ◽  
Minyong Kang ◽  
Hwang Gyun Jeon ◽  
Byong Chang Jeong ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Functional Outcomes ◽  
Upper Urinary Tract ◽  
Rank Test ◽  
Radical Nephroureterectomy ◽  
Free Survival ◽  
Significant Difference ◽  
Segmental Ureterectomy ◽  
Urinary Tract Urothelial Carcinoma

AbstractThis study aims to compare oncologic and functional outcomes after radical nephroureterectomy (RNU) and segmental ureterectomy (SU) in patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively collected data on patients who underwent either RNU or SU of UTUC. Propensity score matching was performed among 394 cases to yield a final cohort of 40 RNU and 40 SU cases. Kaplan–Meier analysis and the log-rank test were used to compare overall survival (OS), cancer-specific survival (CSS), progression-free survival (PFS), and intravesical recurrence-free survival (IVRFS) between the groups. We also compared the change in postoperative estimated glomerular filtration rate (eGFR). There was no significant difference in terms of CSS, PFS, and IVRFS between the RNU and SU groups, but the RNU group had a better OS than the SU group (p = 0.032). Postoperative eGFR was better preserved in the SU group than in the RNU group (p < 0.001). SU provides comparable CSS, PFS, and IVRFS for patients with UTUC compared to RNU, even in patients with advanced-stage and/or high-grade cancer. Further, SU achieves better preservation of renal function.

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