P.003 FUNCTIONAL AND STRUCTURAL VASCULAR BED PROPERTIES IN YOUNG WOMEN WITH POLYCYSTIC OVARY SYNDROME AND NORMAL LIPIDEMIC, GLYCEMIC AND BLOOD PRESSURE PROFILE

2007 ◽  
Vol 1 (S1) ◽  
pp. S28
Author(s):  
K. Alexandraki* ◽  
A. Protogerou ◽  
T. Papaioannou ◽  
C. Piperi ◽  
G. Mastorakos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Pressure Profile ◽  
Ovary Syndrome ◽  
Vascular Bed ◽  
Blood Pressure Profile

scholarly journals Relationship Between Androgen Levels and Blood Pressure in Young Women With Polycystic Ovary Syndrome

Hypertension ◽  
2007 ◽  
Vol 49 (6) ◽  
pp. 1442-1447 ◽  
Author(s):  
Mei-Jou Chen ◽  
Wei-Shiung Yang ◽  
Jehn-Hsiahn Yang ◽  
Chi-Ling Chen ◽  
Hong-Nerng Ho ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Androgen Levels

Obesity Is the Major Determinant of the Abnormalities in Blood Pressure Found in Young Women with the Polycystic Ovary Syndrome

2007 ◽  
Vol 92 (6) ◽  
pp. 2141-2148 ◽  
Author(s):  
Manuel Luque-Ramírez ◽  
Francisco Álvarez-Blasco ◽  
Covadonga Mendieta-Azcona ◽  
José I. Botella-Carretero ◽  
Héctor F. Escobar-Morreale
Keyword(s):  
Blood Pressure ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Major Determinant ◽  
Ovary Syndrome

scholarly journals Metformin Reduces Arterial Stiffness and Improves Endothelial Function in Young Women with Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled, Crossover Trial

2010 ◽  
Vol 95 (2) ◽  
pp. 722-730 ◽  
Author(s):  
Neera Agarwal ◽  
Sam P. L. Rice ◽  
Hemanth Bolusani ◽  
Stephen D. Luzio ◽  
Gareth Dunseath ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Polycystic Ovary Syndrome ◽  
Endothelial Function ◽  
Outcome Measures ◽  
Young Women ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
The Difference

Abstract Context: Patients with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance and display subclinical evidence of early cardiovascular disease. Metformin improves insulin sensitivity and circulating markers of cardiovascular risk in patients with PCOS, but it is unclear whether this translates into improvements in vascular function. Objective: Our objective was to evaluate the effects of metformin on arterial stiffness and endothelial function in women with PCOS. Design and Intervention: Thirty women with PCOS were assigned to consecutive 12-wk treatment periods of metformin or placebo in a randomized, double-blind, crossover design separated by an 8-wk washout. Main Outcome Measures: The primary outcome measures were assessments of arterial stiffness [augmentation index (AIx), central blood pressure, and brachial and aortic pulse wave velocity (PWV)] and endothelial function. Anthropometry, testosterone, and metabolic biochemistry (lipids, homeostasis model of assessment for insulin resistance, high-sensitivity C-reactive protein, adiponectin, and plasminogen activator inhibitor-1) were also assessed. Results: Metformin improved AIx [−6.1%; 95% confidence interval (CI) for the difference −8.5 to −3.5%; P < 0.001], aortic PWV (−0.76 m/sec; 95% CI for the difference −1.12 to −0.4 m/sec; P < 0.001), brachial PWV (−0.73 m/sec; 95% CI for the difference −1.09 to −0.38; P < 0.001), central blood pressure (P < 0.001), and endothelium-dependent (AIx after albuterol; P = 0.003) and endothelium-independent (AIx after nitroglycerin; P < 0.001) vascular responses. Metformin also reduced weight (P < 0.001), waist circumference (P < 0.001), and triglycerides (P = 0.004) and increased adiponectin (P = 0.001) but did not affect testosterone or other metabolic measures. Conclusions: Short-term metformin therapy improves arterial stiffness and endothelial function in young women with PCOS.

scholarly journals Association of polycystic ovary syndrome and a non-dipping blood pressure pattern in young women

Clinics ◽  
2010 ◽  
Vol 65 (5) ◽  
pp. 475-479 ◽  
Author(s):  
Ayse Kargili ◽  
Feridun Karakurt ◽  
Benan Kasapoglu ◽  
Aysel Derbent ◽  
Cemile Koca ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Pressure Pattern

scholarly journals Effect of Metformin Therapy on Clinical and Hormonal Indices of Patients with Polycystic Ovary Syndrome

2021 ◽  
Vol 15 (5) ◽  
pp. 1522-1525
Author(s):  
S. Inayat ◽  
H. F. Khattak ◽  
M. G. Muhammad ◽  
K. Robeen ◽  
A. Inayat ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Polycystic Ovary Syndrome ◽  
Blood Sugar ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Fasting Blood Sugar ◽  
Ovary Syndrome ◽  
Group Ii

Objective: The main objective of this study is to determine the efficacy of metformin therapy on clinical and hormonal indices of patients with polycystic ovary syndrome. Study Design: Randomized control trial Place and Duration: Study was conducted at Obstetrics & Gynaecology department of Northwest General Hospital and Research Center, Peshawar and Mian Rashid Hussain Shaheed Memorial Hospital, Pabbi for duration of nine months from March 2020 to November 2020. Methods: Total 100 patients of polycystic ovary syndrome were presented in this study. Patients were aged between 18 to 45years. Patients detailed demographics including age, body mass index and socio-economicstatus were recorded after taking informed written consent. Patients were divided into 2-groups, group I had 50 patients and received metformin (500 mg) three times a day and group II had 50 patients and received pioglitazone (30 mg) three times a day for 3months.Clinical (body weight, blood pressure (BP), and body mass index) and indices fasting blood sugar (FBS), serum triglyceride (TG), cholesterol, low-density lipoprotein, high-density lipoprotein, insulin, testosterone, and dehydroepiandrosterone (DHEA) were measured before and after therapy. Complete data was analyzed by SPSS 22.0 version. Results: Mean age of the patients in group I was 29.18 ± 2.25 years with mean BMI 26.14 ± 8.86 kg/m2 and in group II mean age was 29.8 ± 2.52 years with mean BMI 27.64 ± 7.68 kg/m2.Significantly decrease in blood pressure (systolic 105.41±8.57, diastolic 67.19±8.9), hair loss 20 (40%),oligomenorrhea 23 (46%), body weight 74.45±9.72, waist circumference and dehydroepiandrosterone (DHEA) 2.35±0.67 and as compared to group II. Only triglycerides gave results of reduction in group II 115.39±64.11. Among both groups serum insulin, acne, menstrual disturbance and fasting blood sugar were controlled after treatment. Conclusion: We concluded in this study that use of metformin in patients with polycystic ovary syndrome resulted in to decrease clinical body weight, blood pressure (BP), body mass index and hormonal indices with reduction of serum insulin, acne, menstrual disturbance and fasting blood sugar but pioglitazone was an alternative effective and reliable method in PCOS patients. Keywords: Polycystic ovary syndrome, Insulin resistance, Metformin, Pioglitazone

Impaired cardiopulmonary parameters in young women with polycystic ovary syndrome

2006 ◽  
Vol 0 (0) ◽  
pp. 061020035253002-??? ◽  
Author(s):  
Francesco Orio ◽  
Stefano Palomba ◽  
Francesco Giallauria ◽  
Annamaria Colao ◽  
Carlo Vigorito
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Heart Rate Variability in Young Women with Polycystic Ovary Syndrome

2006 ◽  
Vol 11 (4) ◽  
pp. 306-312 ◽  
Author(s):  
Aylin Yildirir ◽  
Funda Aybar ◽  
Giray Kabakci ◽  
Hakan Yarali ◽  
Ali Oto
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Ovary Syndrome
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