The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action

2021 ◽  
Vol 8 (9) ◽  
pp. 824-835 ◽  
Author(s):  
Susannah E Murphy ◽  
Liliana P Capitão ◽  
Sophie L C Giles ◽  
Philip J Cowen ◽  
Argyris Stringaris ◽  
...  
2017 ◽  
Vol 51 ◽  
pp. 30-47 ◽  
Author(s):  
Aliza Werner-Seidler ◽  
Yael Perry ◽  
Alison L. Calear ◽  
Jill M. Newby ◽  
Helen Christensen

10.2196/26584 ◽  
2021 ◽  
Vol 23 (12) ◽  
pp. e26584
Author(s):  
Lindsay H Dewa ◽  
Emma Lawrance ◽  
Lily Roberts ◽  
Ellie Brooks-Hall ◽  
Hutan Ashrafian ◽  
...  

Background Disrupted social connections may negatively affect youth mental health. In contrast, sustained quality social connections (QSCs) can improve mental health outcomes. However, few studies have examined how these quality connections affect depression and anxiety outcomes within digital interventions, and conceptualization is limited. Objective The aim of this study is to conceptualize, appraise, and synthesize evidence on QSC within digital interventions (D-QSC) and the impact on depression and anxiety outcomes for young people aged 14-24 years. Methods A systematic scoping review and meta-analysis was conducted using the Joanna Briggs Institute methodological frameworks and guided by experts with lived experience. Reporting was guided by the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The MEDLINE, Embase, PsycINFO, and CINAHL databases were searched against a comprehensive combination of key concepts on June 24, 2020. The search concepts included young people, digital intervention, depression, anxiety, and social connection. Google was also searched. A reviewer independently screened abstracts and titles and full text, and 9.99% (388/3882) of these were screened by a second reviewer. A narrative synthesis was used to structure the findings on indicators of D-QSC and mechanisms that facilitate the connection. Indicators of D-QSC from the included studies were synthesized to produce a conceptual framework. Results Of the 5715 publications identified, 42 (0.73%) were included. Among the included studies, there were 23,319 participants. Indicators that D-QSC was present varied and included relatedness, having a sense of belonging, and connecting to similar people. However, despite the variation, most of the indicators were associated with improved outcomes for depression and anxiety. Negative interactions, loneliness, and feeling ignored indicated that D-QSC was not present. In 24% (10/42) of the applicable studies, a meta-analysis showed a significant decrease in depression (–25.6%, 95% CI –0.352 to –0.160; P<.001) and anxiety (–15.1%, 95% CI –0.251 to –0.051; P=.003) after a D-QSC. Digital mechanisms that helped create a quality connection included anonymity, confidentiality, and peer support. In contrast, mechanisms that hindered the connection included disconnection from the real world and inability to see body language. Data synthesis also identified a 5-component conceptual framework of D-QSC that included rapport, identity and commonality, valued interpersonal dynamic, engagement, and responded to and accepted. Conclusions D-QSC is an important and underconsidered component for youth depression and anxiety outcomes. Researchers and developers should consider targeting improved QSC between clinicians and young people within digital interventions for depression. Future research should build on our framework to further examine relationships among individual attributes of QSC, various digital interventions, and different populations.


2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Tracey D. Wade ◽  
Sarah J. Egan ◽  
Maggie Wleklinski ◽  
Amy O’Brien ◽  
Grace Fitzallen ◽  
...  

Abstract Background Perfectionism is a risk factor for depression and anxiety and is increasing in young people. It is important to understand the information that youth are exposed to about perfectionism on the internet and what may be required to make this more helpful in terms of accessing empirically supported descriptions and advice. Methods This research used novel methodology to investigate content about perfectionism on websites by conducting a realist synthesis of the definitions of perfectionism, and the degree to which websites contain empirically supported strategies and recognise the advantages and disadvantages of perfectionism. The results were presented to people aged 18 to 24 (N = 18) with a lived experience of anxiety/depression for feedback. Results The search yielded 992 websites, 266 of which were included in the synthesis; only one met the criteria for excellent quality with most (56%) judged as moderate. The feelings, thoughts, and behaviours that accompany perfectionism were commonly described, and strategies included identifying cognitions and developing alternatives, moving from self-criticism to self-compassion, normalising mistakes, adjusting goals, receiving practical support, and strategies for procrastination. The young people wanted further emphasis on depression and anxiety as consequences of perfectionism that contributed to a vicious cycle. They identified interventions were difficult, with greater levels of support needed. Conclusions While most websites contained empirically supported information, the quality needs to improve, and further information needs to be provided on the links with anxiety and depression. Interventions for perfectionism need to have more focus on helping young people develop support networks.


2015 ◽  
Vol 13 (10) ◽  
pp. 1770-1786 ◽  
Author(s):  
Anastasiya Slyepchenko ◽  
Andre Carvalho ◽  
Danielle Cha ◽  
Siegfried Kasper ◽  
Roger McIntyre

2021 ◽  
Author(s):  
Daniel Michelson

Background: Problem solving is a key developmental capacity and a common focus of psychological interventions for young people. Despite widespread use of problem solving in practice, existing evidence syntheses of this therapeutic approach are relatively limited in their scope and conclusions. Method: We examined the role of problem solving as an active ingredient for the indicated prevention and treatment of depression and anxiety in 14-24-year-olds. Three information sources were integrated: (i) a systematic review of randomised controlled trials of problem solving; (ii) a meta-synthesis of qualitative evidence on the therapeutic experience of problem solving; and (iii) consultation with a youth advisory group. Results: Problem solving appeared to be effective as a sole intervention for depression but not anxiety. Multi-component interventions with a problem-solving element achieved moderate effect sizes for both conditions. There was no clear evidence that effectiveness varied by population characteristics, intervention formats or contextual factors. Evidence about why problem solving works was generally consistent with Lazarus &amp; Folkman’s “stress-coping” theory.Discussion: Problem solving is a widely applicable therapeutic approach that can help young people with emotional problems to resolve specific stressors and lead to a more hopeful mindset about managing future challenges. Implications for practice are discussed.


2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Omar Al Omari ◽  
Sulaiman Al Sabei ◽  
Omar Al Rawajfah ◽  
Loai Abu Sharour ◽  
Khalid Aljohani ◽  
...  

Depression and anxiety are prevalent mental illnesses among young people. Crisis like the Coronavirus Disease 2019 (COVID-19) pandemic may increase the current prevalence of these illnesses. A cross-sectional, descriptive design was used to (1) explore the prevalence of depression, anxiety, and stress among youth and (2) identify to what extent certain variables related to COVID-19 could predict depression, anxiety, and stress (DAS) among young people in six different countries. Participants were requested to complete an online survey including demographics and the DAS scale. A total of 1,057 participants from Oman (n=155), Saudi Arabia (n=121), Jordan (n=332), Iraq (n=117), United Arab Emirates (n=147), and Egypt (n=182) completed the study. The total prevalence of depression, anxiety, and stress was 57%, 40.5%, and 38.1%, respectively, with no significant differences between countries. Significant predictors of stress, anxiety, and depression were being female, being in contact with a friend and/or a family member with mental illness, being quarantined for 14 days, and using the internet. In conclusion, COVID-19 is an epidemiological crisis that is casting a shadow on youths’ DAS. The restrictions and prolonged lockdowns imposed by COVID-19 are negatively impacting their level of DAS. Healthcare organisations, in collaboration with various sectors, are recommended to apply psychological first aid and design appropriate educational programmes to improve the mental health of youth.


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