The Role of Bacteriophages in the Generation and Spread of Bacterial Pathogens

2009 ◽  
pp. 79-112 ◽  
Author(s):  
Roger W. Hendrix ◽  
Sherwood R. Casjens
Keyword(s):  
Bacterial Pathogens

Clinical and hemostatic responses to treatment in ventilator-associated pneumonia: Role of bacterial pathogens*

2007 ◽  
Vol 35 (2) ◽  
pp. 490-496 ◽  
Author(s):  
Ali A. El Solh ◽  
Goda Choi ◽  
Marcus J. Schultz ◽  
Lilibeth A. Pineda ◽  
Corey Mankowski
Keyword(s):  
Bacterial Pathogens ◽  
Ventilator Associated Pneumonia

scholarly journals The complex, bidirectional role of extracellular vesicles in infection

2021 ◽  
Author(s):  
Joni Renee White ◽  
Priscila Dauros-Singorenko ◽  
Jiwon Hong ◽  
Frédérique Vanholsbeeck ◽  
Anthony Phillips ◽  
...  
Keyword(s):  
Immune Response ◽  
Extracellular Vesicles ◽  
Bacterial Pathogens ◽  
Host Cells ◽  
Signalling Molecules ◽  
Host Pathogen ◽  
Domains Of Life

Cells from all domains of life release extracellular vesicles (EVs), packages that carry a cargo of molecules that participate in communication, co-ordination of population behaviours, virulence and immune response mechanisms. Mammalian EVs play an increasingly recognised role to fight infection, yet may also be commandeered to disseminate pathogens and enhance infection. EVs released by bacterial pathogens may deliver toxins to host cells, signalling molecules and new DNA to other bacteria, and act as decoys, protecting infecting bacteria from immune killing. In this review, we explore the role of EVs in infection from the perspective of both the pathogen and host, and highlight their importance in the host/pathogen relationship. We highlight proposed strategies for EVs in therapeutics, and call attention to areas where existing knowledge and evidence is lacking.

Role of phages in the control of bacterial pathogens in food.

2012 ◽  
pp. 240-255 ◽  
Author(s):  
Y. D. Niu ◽  
K. Stanford ◽  
T. A. McAllister ◽  
T. R. Callaway
Keyword(s):  
Bacterial Pathogens

scholarly journals Assessment of the Role of Wastewater Treatment Plant in Spread of Antibiotic Resistance and Bacterial Pathogens

2019 ◽  
Vol 59 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Yogesh S. Nimonkar ◽  
Bhoomika Yadav ◽  
Payal Talreja ◽  
Ashutosh Sharma ◽  
Shalaka Patil ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Wastewater Treatment ◽  
Wastewater Treatment Plant ◽  
Bacterial Pathogens ◽  
Treatment Plant

scholarly journals RTX Toxins of Animal Pathogens and Their Role as Antigens in Vaccines and Diagnostics

Toxins ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 719 ◽  
Author(s):  
Joachim Frey
Keyword(s):  
Bacterial Pathogens ◽  
Rtx Toxins ◽  
Animal Pathogens ◽  
Genes Encoding ◽  
Specific Receptors ◽  
Diagnostic Applications ◽  
Β2 Integrins ◽  
Important Marker

Exotoxins play a central role in the pathologies caused by most major bacterial animal pathogens. The large variety of vertebrate and invertebrate hosts in the animal kingdom is reflected by a large variety of bacterial pathogens and toxins. The group of repeats in the structural toxin (RTX) toxins is particularly abundant among bacterial pathogens of animals. Many of these toxins are described as hemolysins due to their capacity to lyse erythrocytes in vitro. Hemolysis by RTX toxins is due to the formation of cation-selective pores in the cell membrane and serves as an important marker for virulence in bacterial diagnostics. However, their physiologic relevant targets are leukocytes expressing β2 integrins, which act as specific receptors for RTX toxins. For various RTX toxins, the binding to the CD18 moiety of β2 integrins has been shown to be host specific, reflecting the molecular basis of the host range of RTX toxins expressed by bacterial pathogens. Due to the key role of RTX toxins in the pathogenesis of many bacteria, antibodies directed against specific RTX toxins protect against disease, hence, making RTX toxins valuable targets in vaccine research and development. Due to their specificity, several structural genes encoding for RTX toxins have proven to be essential in modern diagnostic applications in veterinary medicine.

scholarly journals The Role of Innate Immunity in the Host Defense Against Intestinal Bacterial Pathogens

2011 ◽  
Vol 14 (1) ◽  
pp. 15-23 ◽  
Author(s):  
John Sotolongo ◽  
Jose Ruiz ◽  
Masayuki Fukata
Keyword(s):  
Innate Immunity ◽  
Host Defense ◽  
Bacterial Pathogens

The Role of Dystroglycan and Its Ligands in Physiology and Disease

Physiology ◽  
2000 ◽  
Vol 15 (5) ◽  
pp. 255-259 ◽  
Author(s):  
Thomas Meier ◽  
Markus A. Ruegg
Keyword(s):  
Extracellular Matrix ◽  
Cell Membrane ◽  
Basement Membrane ◽  
Embryonic Development ◽  
Bacterial Pathogens ◽  
Membrane Integrity ◽  
Muscle Disease ◽  
Entry Point ◽  
Cell Membrane Integrity

Dystroglycan contributes to the formation of basement membrane during embryonic development and enforces cell membrane integrity by bridging cytoskeleton and components of the extracellular matrix. In several forms of muscle disease, dystroglycan is reduced in abundance. Moreover, human viral and bacterial pathogens use dystroglycan as their cellular entry point.

scholarly journals Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens

2019 ◽  
Vol 10 ◽  
Author(s):  
Elodie Ramond ◽  
Anne Jamet ◽  
Mathieu Coureuil ◽  
Alain Charbit
Keyword(s):  
Bacterial Pathogens ◽  
Pivotal Role ◽  
Macrophage Response
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