scholarly journals P.034 Eye movement assessment and diffusion tensor imaging in patients with post concussion syndrome

2016 ◽  
Vol 43 (S2) ◽  
pp. S29-S30
Author(s):  
F Taghdiri ◽  
SL Irwin ◽  
N Multani ◽  
M Eizenman ◽  
A Tarazi ◽  
...  
Keyword(s):  
Executive Function ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Eye Tracking ◽  
Diffusion Tensor ◽  
White Matter Integrity ◽  
Matching Task ◽  
Imaging Data ◽  
Post Concussion Syndrome ◽  
Number Of Visits

Background: Post concussion syndrome (PCS) can affect up to 30% of patients with concussion. Biomarkers of this condition would be beneficial for diagnosis and management. We hypothesized that eye tracking parameters would correlate with microstructural changes of white matter integrity, as measured by diffusion tensor imaging (DTI), in patients with PCS. Methods: Sixty patients with PCS and at least 2 concussions participated in our prospective study. Attention and executive function were tested using Visual Attention Scanning Technology (VAST). In a matching task, the normalized number of visits to master image before making the first selection is used as a surrogate of working memory. We related performance on VAST to white matter integrity using Tract-Based Spatial Statistics of diffusion tensor imaging data. Results: 60 participants (mean age 34.3 years, SD 13.8) had a mean of 4 concussions. There were negative correlations between fractional anisotropy (FA) of the genu, body, and splenium of the corpus callosum and normalized number of visits to master image before first selection (r=-0.432, p=0.001; r=-0.504, p<0.001; and r=-0.388, p=0.002; respectively). A negative correlation was also seen between right cingulum FA and the global processing index (r=-0.349, p=0.006). Conclusions: Impaired performance on eye tracking measures of attention and executive function may reflect alterations in white matter tracts.

Using CForest to Analyze Diffusion Tensor Imaging Data: A Study of White Matter Integrity in Healthy Aging

2016 ◽  
Vol 6 (10) ◽  
pp. 747-758 ◽  
Author(s):  
Sean R. McWhinney ◽  
Antoine Tremblay ◽  
Thérèse M. Chevalier ◽  
Vanessa K. Lim ◽  
Aaron J. Newman
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Healthy Aging ◽  
Diffusion Tensor ◽  
White Matter Integrity ◽  
Imaging Data ◽  
Diffusion Tensor Imaging Data

Diffusion tensor imaging analysis in scrub typhus meningoencephalitis to determine the alteration of microstructural subcortical white-matter integrity

2020 ◽  
pp. 197140092098031
Author(s):  
Pranjal Phukan ◽  
Kalyan Sarma ◽  
Aman Yusuf Khan ◽  
Bhupen Barman ◽  
Md Jamil ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Scrub Typhus ◽  
Diffusion Tensor ◽  
Neuronal Degeneration ◽  
Central Nervous System Involvement ◽  
Subcortical White Matter ◽  
White Matter Integrity ◽  
Conventional Mri ◽  
Significant Difference

Background and purpose Magnetic resonance imaging (MRI) of the brain in scrub typhus meningoencephalitis is non-specific, and in the majority of the cases, conventional MRI fails to detect any abnormality. However, autopsy reports depict central nervous system involvement in almost all patients. There is therefore a need for research on the quantitative assessment of brain parenchyma that can detect microstructural abnormalities. The study aimed to assess the microstructural integrity changes of scrub typhus meningoencephalitis by using different diffusion tensor imaging (DTI) parameters. Methods This was a retrospective analysis of scrub typhus meningoencephalitis. Seven patients and seven age- and sex-matched healthy controls were included. Different DTI parameters such as apparent diffusion coefficient (ADC), fractional anisotropy (FA), relative anisotropy (RA), trace, volume ratio (VR) and geodesic anisotropy (GA) were obtained from six different regions of subcortical white matter at the level of the centrum semiovale. Intergroup significant difference was determined by one-way analysis of variance followed by Tukey’s post hoc test. Receiver operating characteristic curves were constructed to determine the accuracy of the DTI matrices. Results There was a significant decrease in FA, RA and GA as well as an increase in ADC and VR in the subcortical white matter in patients with scrub typhus meningoencephalitis compared to controls ( p < 0.001). The maximum sensitivity of the DTI parameters was 85.7%, and the maximum specificity was 81%. Conclusion There was an alteration of subcortical white-matter integrity in scrub typhus meningoencephalitis that represents the axonal degeneration, myelin breakdown and neuronal degeneration. DTI may be a useful tool to detect white-matter abnormalities in scrub typhus meningoencephalitis in clinical practice, particularly in patients with negative conventional MRI.

Age-related changes in white matter integrity: A diffusion tensor imaging study

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. S128
Author(s):  
H Lemaitre ◽  
S Marenco ◽  
M Emery ◽  
T Alam ◽  
M Geramita ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
White Matter Integrity ◽  
Age Related ◽  
Diffusion Tensor Imaging Study ◽  
Age Related Changes

Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease

2021 ◽  
pp. 155005942110582
Author(s):  
Sophie A. Stewart ◽  
Laura Pimer ◽  
John D. Fisk ◽  
Benjamin Rusak ◽  
Ron A. Leslie ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Diffusion Tensor Imaging ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Neurodegenerative Disorder ◽  
Diffusion Tensor ◽  
Early Stage ◽  
White Matter Integrity

Parkinson's disease (PD) is a neurodegenerative disorder that is typified by motor signs and symptoms but can also lead to significant cognitive impairment and dementia Parkinson's Disease Dementia (PDD). While dementia is considered a nonmotor feature of PD that typically occurs later, individuals with PD may experience mild cognitive impairment (PD-MCI) earlier in the disease course. Olfactory deficit (OD) is considered another nonmotor symptom of PD and often presents even before the motor signs and diagnosis of PD. We examined potential links among cognitive impairment, olfactory functioning, and white matter integrity of olfactory brain regions in persons with early-stage PD. Cognitive tests were used to established groups with PD-MCI and with normal cognition (PD-NC). Olfactory functioning was examined using the University of Pennsylvania Smell Identification Test (UPSIT) while the white matter integrity of the anterior olfactory structures (AOS) was examined using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) analysis. Those with PD-MCI demonstrated poorer olfactory functioning and abnormalities based on all DTI parameters in the AOS, relative to PD-NC individuals. OD and microstructural changes in the AOS of individuals with PD may serve as additional biological markers of PD-MCI.

scholarly journals Abnormal asymmetry of white matter integrity in schizophrenia revealed by voxelwise diffusion tensor imaging

2011 ◽  
Vol 33 (7) ◽  
pp. 1741-1749 ◽  
Author(s):  
Jun Miyata ◽  
Akihiko Sasamoto ◽  
Katja Koelkebeck ◽  
Kazuyuki Hirao ◽  
Keita Ueda ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
White Matter Integrity
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