scholarly journals P.020 The North American AED Pregnancy Registry: A Canadian Subgroup Analysis (1997-2019)

2021 ◽  
Vol 48 (s3) ◽  
pp. S25-S25
Author(s):  
J Hébert ◽  
SN Conant ◽  
LB Holmes ◽  
E Bui
Keyword(s):  
North American ◽  
Prince Edward Island ◽  
Population Based ◽  
Enrollment Rate ◽  
The North ◽  
The Usa ◽  
Canadian Provinces ◽  
Northern Territories ◽  
Rate Ratios ◽  
Pregnancy Registry

Background: This study aims to provide data on the care of pregnant women with epilepsy (pWWE) that is directly applicable to the Canadian context. Methods: Between 1997 and 2019, pWWE from Canada and the USA who enrolled into the North American AED Pregnancy Registry (NAARP) completed a questionnaire on their AED (anti-epileptic drug) usage. Enrollment rates to NAARP were compared between the two countries, and between the different Canadian provinces using population-based enrollment rate ratios (PERR). The AED prescription pattern among Canadian pWWE was analysed and compared with the USA. Results: During the study period, 10,215 women enrolled into NAARP : 4.1% (n=419) were Canadian, below the expected population-based contribution (PERR=0.42; p<0.01). Within Canada, the three northern territories (PERR=0; p<0.01), Prince-Edward Island (PERR=0; p<0.01), and Quebec (PERR=0.41; p<0.01) had the lowest enrollment rate ratios. Lamotrigine was the most commonly prescribed AED among canadian pWWE; they were, however, more likely to be on polytherapy (25%; p=0.13), on Carbamazepine (24%; p<0.01) or valproic acid (21%; p<0.01) than their American counterparts. Conclusions: Greater enrollment of Canadian women to NAARP, through enhanced clinician referrals, in particular from underrepresented provinces/territories, could lead to more accurate population-specific data and help identify gaps in the care of this vulnerable patient population.

Incidence trends of conjunctival malignant melanoma in Canada

2019 ◽  
Vol 104 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Feras M Ghazawi ◽  
Rami Darwich ◽  
Michelle Le ◽  
Abdulhadi Jfri ◽  
Elham Rahme ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Uveal Melanoma ◽  
Population Based ◽  
Incidence Rates ◽  
Primary Malignancy ◽  
Incidence Trends ◽  
The North ◽  
Independent Population ◽  
The Usa ◽  
Canadian Provinces

BackgroundMelanoma is the most common primary malignancy of the eye in adults. While the epidemiology of uveal melanoma has recently been described in Canada, little is known about the epidemiology and geographic distribution of patients with conjunctival melanoma (CM) in Canada.MethodsWe conducted a population-based study of CM incidence across all Canadian provinces and territories during 1992–2010 using two independent population-based registries.Results190 patients were diagnosed with CM in Canada from 1992 to 2010. 55.3 % of these patients were men. The mean annual incidence rate of CM in Canada was 0.32 cases per million individuals (0.35 and 0.29 cases per million individuals for men and women, respectively). The incidence rates for Canadian provinces demonstrated that the eastern provinces of Nova Scotia and New Brunswick had higher age-adjusted incidence rates than the national average, with rates of 0.52 and 0.47 cases per million individuals per year, respectively.ConclusionsThis analysis demonstrates novel variations in CM incidence rates between different Canadian provinces. These results taken together with the data reported from the USA confirm the North-to-South geographic gradient of increasing CM incidence. This research highlights that the epidemiology of CM in North America is comparable to that of cutaneous malignant melanoma in contrast to the trends for uveal melanoma distribution.

scholarly journals The Epidemiology of Infantile Spasms

2001 ◽  
Vol 28 (4) ◽  
pp. 309-312 ◽  
Author(s):  
P.M. Brna ◽  
K.E. Gordon ◽  
J.M. Dooley ◽  
E.P. Wood
Keyword(s):  
Prince Edward Island ◽  
Disease Incidence ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Incidence Rates ◽  
Infantile Spasms ◽  
Clinical Impression ◽  
Birth Cohorts ◽  
Marked Variability ◽  
Canadian Provinces

Objective:The aim of this study was to estimate population based incidence rates for infantile spasms (IS) and to study our clinical impression that the incidence of IS has recently decreased in the Canadian Provinces of Nova Scotia and Prince Edward Island.Methods:Birth cohorts from 1978 to 1998, identified through the hospital health records, EEG records and physician computerized databases, were followed for two years for the development of IS. Disease incidence rates were calculated using denominators derived from Statistics Canada's reported annual live birth rates.Results:The inclusion criteria for IS were fulfilled by 75 patients. The overall incidence of IS was 30.7/100,000 live births (95% CI 24.3, 38.8). Etiologic classification was symptomatic for 51 cases (68%), cryptogenic for 18 (24%), and idiopathic in six children (8%). Although there were more males (N=44) than females (N=31), the incidence rates were similar. There was a marked variability in annual and five-year incidence rates.Conclusion:Although the clinical characteristics of our patients were similar to other reported IS populations, the instability in IS incidence rates indicates a need for caution in interpreting smaller IS epidemiologic studies.

Five years before multiple sclerosis onset: Phenotyping the prodrome

2018 ◽  
Vol 25 (8) ◽  
pp. 1092-1101 ◽  
Author(s):  
José MA Wijnands ◽  
Feng Zhu ◽  
Elaine Kingwell ◽  
Yinshan Zhao ◽  
Okechukwu Ekuma ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Symptom Onset ◽  
International Classification Of Diseases ◽  
Population Based ◽  
Drug Classes ◽  
Classification Of Diseases ◽  
Health Care Encounters ◽  
Canadian Provinces ◽  
Using Data ◽  
Rate Ratios

Background: The multiple sclerosis (MS) prodrome is poorly characterized. Objective: To phenotype the MS prodrome via health care encounters. Methods: Using data from a population-based cohort study linking administrative and clinical data in four Canadian provinces, we compared physician and hospital encounters and prescriptions filled (via International Classification of Diseases chapters, physician specialty or drug classes) for MS subjects in the 5 years before the first demyelinating claim in an administrative cohort or the clinical symptom onset in an MS clinic-derived cohort, to age-, sex- and geographically matched controls. Rate ratios (RRs), 95% confidence intervals (95% CIs) and proportions were estimated. Results: The administrative and clinical cohorts included 13,951/66,940 and 3202/16,006 people with and without MS (cases/controls). Compared to controls, in the 5 years before the first demyelinating claim or symptom onset, cases had more physician and hospital encounters for the nervous (RR (range) = 2.31; 95% CI: 1.05–5.10 to 4.75; 95% CI: 3.11–7.25), sensory (RR (range) = 1.40; 95% CI: 1.34–1.46 to 2.28; 95% CI: 1.72–3.02), musculoskeletal (RR (range) = 1.19; 95% CI: 1.07–1.33 to 1.70; 95% CI: 1.57–1.85) and genito-urinary systems (RR (range) = 1.17; 95% CI: 1.05–1.30 to 1.59; 95% CI: 1.48–1.70). Cases had more psychiatrist and urologist encounters (RR (range) = 1.48; 95% CI: 1.36–1.62 to 1.80; 95% CI: 1.61–2.01), and higher proportions of musculoskeletal, genito-urinary or hormonal-related prescriptions (1.1–1.5 times higher, all p < 0.02). However, cases had fewer pregnancy-related encounters than controls (RR = 0.78; 95% CI: 0.71–0.86 to 0.88; 95% CI: 0.84–0.92). Conclusion: Phenotyping the prodrome 5 years before clinical recognition of MS is feasible.

scholarly journals Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group

2017 ◽  
Vol 62 (8) ◽  
pp. 2133-2140 ◽  
Author(s):  
Darwin L. Conwell ◽  
Peter A. Banks ◽  
Bimaljit S. Sandhu ◽  
Stuart Sherman ◽  
Samer Al-Kaade ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Pancreatitis ◽  
North American ◽  
The North ◽  
The Usa

A dream deferred: interdisciplinary accounting in the US

2014 ◽  
Vol 27 (8) ◽  
pp. 1265-1270 ◽  
Author(s):  
Timothy J. Fogarty
Keyword(s):  
North American ◽  
Design Methodology ◽  
Content Type ◽  
Research Perspective ◽  
Accounting Research ◽  
Policy Practice ◽  
The North ◽  
Current State ◽  
The Us ◽  
The Usa

Purpose – The purpose of this paper is to set out to examine and critique the current state and future trajectory of interdisciplinary accounting research in the USA. Design/methodology/approach – The analysis is based on the author's involvement in and research into accounting research and publication contexts, drivers and patterns in the accounting discipline. Findings – In all likelihood, research will continue established traditions that prevent the explorations of economics and finance from material broadening. This paper identifies how that which everyone believes to be such a good idea cannot bear fruit. Research limitations/implications – Conventional economics-based accounting research has proliferated in volume but has largely exhausted its potential for significant contributions to knowledge. Failure to embrace broadened interdisciplinary perspectives risks a crisis of accounting research contribution to policy, practice, and society. Originality/value – This critique reveals the serious weaknesses and serious risks to international accounting scholarship of the continuance and global mimicking of the North American pursuit of an exclusively economic accounting research perspective.

scholarly journals International Trade and the Convergence in Youth Technological Awareness and Expectations within NAFTA: The Case of GMOs and Nuclear Power Technologies

2019 ◽  
Author(s):  
Ibrahim Niankara ◽  
Lee C. Adkins
Keyword(s):  
International Trade ◽  
Free Trade ◽  
North American ◽  
Nuclear Power ◽  
Genetically Modified Organisms ◽  
Situational Factors ◽  
Model Parameters ◽  
Probit Regression ◽  
The North ◽  
The Usa

Relying on the USA, Canada and Mexico extract from the cross-national data sample on the environmental affection and cognition of adolescent students (Niankara, 2019), along with seemingly unrelated bivariate weighted ordered probit regression modeling (Niankara and Zoungrana, 2018), this study reports on the convergence of technological awareness and expectations within the context of international trade. We achieve this by adopting a regional perspective in investigating the effects of affective, cognitive and situational factors on youth's awareness and expectations about genetically modified organisms (GMOs) and nuclear power technology (NPT) within the North American free trade block. Identification of model parameters is achieved using maximum simulated likelihood methods. The findings show that although it has been over 20 years as of 2015 that USA, Canada, and Mexico ratified the north American free trade agreement (NAFTA), the diffusion of technology and information within the trade block has not succeeded in homogenizing awareness and expectations about GMOs and Nuclear power technology, as observed in the youth population across the three countries. Indeed, with regards to technological awareness, compared to youth from the USA, those from Canada show 15% (GMOs) and 7.1% (NPT) more awareness respectively; while those in Mexico are respectively 34.4% and 19.5% less aware about GMOs and NPT. With respect to technological expectations, compared to youth from the USA, those from Canada and Mexico are respectively 34.4% and 39.9% more optimistic about GMOs, while 15% and 49.7% more optimistic about NPT. Overall, youth within NAFTA country members are respectively 2.5% and 6.7% more optimistic about GMOs and NPT for every level increase in their awareness about the two technologies.

scholarly journals Youth Awareness and Expectations about GMOs and Nuclear Power Technologies within the North American Free Trade Bloc: A Retrospective Cross-Country Comparative Analysis

2020 ◽  
Vol 6 (2) ◽  
pp. 34 ◽  
Author(s):  
Ibrahim Niankara ◽  
Lee C. Adkins
Keyword(s):  
Free Trade ◽  
North American ◽  
Nuclear Power ◽  
Genetically Modified Organisms ◽  
Free Trade Area ◽  
Probit Regression ◽  
The North ◽  
Trade Bloc ◽  
The Usa ◽  
Cross Country

This study reports on the cross-country heterogeneity in youth awareness and expectations about genetically modified organisms (GMOs) and nuclear power technology (NPT) within the North American free trade area (NAFTA). Models are estimated with data on youth respondents from the USA, Canada and Mexico, using seemingly unrelated bivariate weighted ordered probit regression, with maximum simulated likelihood estimation. Our findings show that the diffusion of technology and information within the trade bloc, for the 20 years prior to the 2015 data collection period, did not significantly contribute to cross-country convergence in youth awareness and expectations about GMOs and NPTs. Indeed, with regard to awareness, compared to youth from the USA, those from Canada show 15% (GMOs) and 7.1% (NPT) more awareness, respectively; while youth from Mexico show 34.4% and 19.5% less awareness about GMOs and NPT, respectively. With respect to expectations about future developments of the two technological artifacts, compared to youth from the USA, those from Canada and Mexico are 34.4% and 39.9% more optimistic about GMOs, respectively, while 15% and 49.7% are more optimistic about NPT. Overall, our findings show that the youth population within NAFTA is 2.5% and 6.7% more optimistic about GMOs and NPT for each level of increase in their awareness about the two technologies, respectively. Theoretically, our results seem to reject the hypothesis of NAFTA being a technology convergence country club in the Schumpeterian view, while seemingly supporting the existence of heterogeneous growth regimes within NAFTA.

NAFTA at 20

2015 ◽  
pp. 41-52
Author(s):  
E. Komkova
Keyword(s):  
Free Trade ◽  
North American ◽  
Free Trade Agreement ◽  
Trade Agreement ◽  
The United States ◽  
Economic Transformation ◽  
Export Market ◽  
The North ◽  
The Usa ◽  
Trade And Investment

2014 marked the 20th anniversary of the entry into force of the North American Free Trade Agreement (NAFTA), which created the world’s largest free trade area. Now it links 470 million people producing more than 19 trillion USD worth of goods and services. The article addresses five issues: the international importance of NAFTA; the economic transformation that has occurred in the USA, Canada and Mexico since the advent of the NAFTA; a “thought experiment” on what American, Canadian and Mexican performance might have been without the NAFTA; the detrimental effect of 9/11 on the North American economic integration; and what’s next? At the time of its signing, NAFTA in many ways was considered a “gold standard” in terms of international free trade agreements. For the first time ever a free trade agreement brought together both developed and developing countries. It also broadened the scope of traditional FTAs by embracing services, foreign investments and property rights, and recognized the importance of workers' and environmental rights and issues. In terms of trade and investment NAFTA has been an undisputed success. Canada ranks as the United States’ largest export market, while Mexico is its second-largest export market. Today – thanks to NAFTA – North Americans not only sell more goods to one another, they also make more things together. For every dollar of goods that Canada and Mexico export to the USA, there are 25 cents’ worth of US inputs into Canadian goods and 40 cents’ worth into Mexican ones. Regardless of the impressive economic record, NAFTA has its critics. The agreement has not underwent a major update since its inception in 1994, i.e. prior to the rise of electronic commerce and, digital services, advanced manufacturing and many other innovative features of the global economy. As far as there is no political appetite to update NAFTA directly, indirect route is a subject of wide speculation. Canada, the USA and Mexico are negotiating partners to the Trans-Pacific Partnership and any benefits conferred by the TPP that go further than NAFTA would take precedence. It is assumed that the TPP should help to modernize NAFTA commitments and upgrade the North American trade and investment.

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