Incidence trends of conjunctival malignant melanoma in Canada

2019 ◽  
Vol 104 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Feras M Ghazawi ◽  
Rami Darwich ◽  
Michelle Le ◽  
Abdulhadi Jfri ◽  
Elham Rahme ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Uveal Melanoma ◽  
Population Based ◽  
Incidence Rates ◽  
Primary Malignancy ◽  
Incidence Trends ◽  
The North ◽  
Independent Population ◽  
The Usa ◽  
Canadian Provinces

BackgroundMelanoma is the most common primary malignancy of the eye in adults. While the epidemiology of uveal melanoma has recently been described in Canada, little is known about the epidemiology and geographic distribution of patients with conjunctival melanoma (CM) in Canada.MethodsWe conducted a population-based study of CM incidence across all Canadian provinces and territories during 1992–2010 using two independent population-based registries.Results190 patients were diagnosed with CM in Canada from 1992 to 2010. 55.3 % of these patients were men. The mean annual incidence rate of CM in Canada was 0.32 cases per million individuals (0.35 and 0.29 cases per million individuals for men and women, respectively). The incidence rates for Canadian provinces demonstrated that the eastern provinces of Nova Scotia and New Brunswick had higher age-adjusted incidence rates than the national average, with rates of 0.52 and 0.47 cases per million individuals per year, respectively.ConclusionsThis analysis demonstrates novel variations in CM incidence rates between different Canadian provinces. These results taken together with the data reported from the USA confirm the North-to-South geographic gradient of increasing CM incidence. This research highlights that the epidemiology of CM in North America is comparable to that of cutaneous malignant melanoma in contrast to the trends for uveal melanoma distribution.

Epidemiology of invasive ocular surface squamous neoplasia in Canada during 1992–2010

2020 ◽  
Vol 104 (10) ◽  
pp. 1368-1372 ◽  
Author(s):  
Rami Darwich ◽  
Feras M Ghazawi ◽  
Michelle Le ◽  
Elham Rahme ◽  
Nebras Alghazawi ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Geographical Distribution ◽  
Ocular Surface ◽  
Cancer Registries ◽  
Population Based ◽  
Incidence Rates ◽  
Ocular Surface Squamous Neoplasia ◽  
Independent Population ◽  
The Usa ◽  
Canadian Provinces

BackgroundOcular surface squamous neoplasia (OSSN) is the most common non-pigmented ocular surface malignancy. It is classified as invasive OSNN (IOSSN) when the underlying stroma are infiltrated by dysplastic squamous epithelial cells through the basement membrane. Here, we present the descriptive epidemiology and geographical distribution of IOSSN in Canada.MethodsWe determined the incidence and geographical distribution of IOSSN cases diagnosed between 1992 and 2010 using two independent population-based cancer registries: the Canadian Cancer Registry and Le Registre Québécois du Cancer.ResultsThe mean annual age-standardised incidence rate (WHO 2000–2025) of IOSSN for 1992–2010 was 0.45 cases per million individuals per year with an average annual percent increase in incidence of 4.5%. IOSSN localisation to the conjunctiva was documented in at least 57% of the reported cases. IOSSN exhibited a male predilection ratio of 3.3:1.0 with a mean age at diagnosis of 69 years. Incidence rates of IOSSN across Canadian provinces and cities showed no significant differences from the crude national average.ConclusionsOur results, particularly concerning IOSSN patient age and male predilection, corroborate with data reported from the USA. Additional studies are needed to determine whether the observed increase in incidence rate over the study period (1992–2010) is significant.

Uveal melanoma incidence trends in Canada: a national comprehensive population-based study

2019 ◽  
pp. bjophthalmol-2018-312966 ◽  
Author(s):  
Feras M Ghazawi ◽  
Rami Darwich ◽  
Michelle Le ◽  
Elham Rahme ◽  
Andrei Zubarev ◽  
...  
Keyword(s):  
Geographical Distribution ◽  
Uveal Melanoma ◽  
Developed Countries ◽  
Population Based ◽  
National Study ◽  
Steady Increase ◽  
Incidence Trends ◽  
Melanoma Incidence ◽  
Independent Population ◽  
Canadian Provinces

BackgroundIn the developed countries, uveal melanoma is the most common primary intraocular malignancy in adults. Little is known about the epidemiological and geographical distribution of uveal melanoma in Canada.MethodsTo determine the incidence patterns and geographical distribution of uveal melanoma cases in Canada, we conducted the first comprehensive, population-based national study of this malignancy across all Canadian provinces and territories during 1992–2010 years. We examined two independent population-based registries: the Canadian Cancer Registry and Le Registre Québécois du Cancer using corresponding International Classification of Diseases for Oncology-3rd edition codes for all histological subtypes of uveal melanoma.ResultsWe report that 2215 patients were diagnosed with uveal melanoma, of which 52.1% were males. The average -annual incidence rate of uveal melanoma in Canada was 3.75 cases per million individuals per year (95% CI 3.60 to 3.91). Overall, we report a steady increase in uveal melanoma incidence with an annual increase of 0.074 cases per million individuals per year. Significant differences in the incidence rates of uveal melanoma between Canadian provinces and territories were noted, where the highest crude incidence was in British Columbia and Saskatchewan with rates of 6.38 and 5.47 cases per million individuals per year, respectively.ConclusionsThis work, for the first time, defines the disease burden of uveal melanoma in Canada and highlights important longitudinal, geographical and spatial differences in the distribution of uveal melanoma in Canada.

scholarly journals Is the epidemiology of rheumatoid arthritis changing? Results from a population-based incidence study, 1985–2014

2020 ◽  
Vol 79 (4) ◽  
pp. 440-444 ◽  
Author(s):  
Elena Myasoedova ◽  
John Davis ◽  
Eric L Matteson ◽  
Cynthia S Crowson
Keyword(s):  
Rheumatoid Arthritis ◽  
Population Based ◽  
Incidence Rates ◽  
Regression Methods ◽  
Incidence Trends ◽  
American College Of Rheumatology ◽  
Acr Criteria ◽  
Previous Decade ◽  
The Usa ◽  
Adjusted Incidence

ObjectivesTo examine trends in the incidence of rheumatoid arthritis (RA) from 2005 to 2014 overall and by serological status as compared with 1995–2004 and 1985–1994.MethodsWe evaluated RA incidence trends in a population-based inception cohort of individuals aged ≥18 years who first fulfilled the 1987 American College of Rheumatology (ACR) criteria for RA between 1 January 1985 and 31 December 2014. Incidence rates were estimated and were age-adjusted and sex-adjusted to the white population in the USA in 2010. Trends in incidence were examined using Poisson regression methods.ResultsThe 2005–2014 incidence cohort comprised 427 patients: mean age 55.4 years, 68% female, 51% rheumatoid factor (RF) positive and 50% anti-cyclic citrullinated peptide antibody positive. The overall age-adjusted and sex-adjusted annual RA incidence in 2005–2014 was 41/100 000 population (age-adjusted incidence: 53/100 000 in women and 29/100 000 in men). While these estimates were similar to the 1995–2004 decade, there was a decline in the incidence of RF-positive RA in 2005–2014 compared with the previous two decades (p=0.004), with a corresponding increase in RF-negative cases (p<0.001). Smoking rates declined and obesity rates increased from earlier decades to more recent years.ConclusionsSignificant increase in incidence of RF-negative RA and decrease in RF-positive RA in 2005–2014 compared with previous decades was found using 1987 ACR criteria. The incidence of RA overall during this period remained similar to the previous decade. The changing prevalence of environmental factors, such as smoking, obesity and others, may have contributed to these trends. Whether these trends represent a changing serological profile of RA requires further investigation.

scholarly journals P.020 The North American AED Pregnancy Registry: A Canadian Subgroup Analysis (1997-2019)

2021 ◽  
Vol 48 (s3) ◽  
pp. S25-S25
Author(s):  
J Hébert ◽  
SN Conant ◽  
LB Holmes ◽  
E Bui
Keyword(s):  
North American ◽  
Prince Edward Island ◽  
Population Based ◽  
Enrollment Rate ◽  
The North ◽  
The Usa ◽  
Canadian Provinces ◽  
Northern Territories ◽  
Rate Ratios ◽  
Pregnancy Registry

Background: This study aims to provide data on the care of pregnant women with epilepsy (pWWE) that is directly applicable to the Canadian context. Methods: Between 1997 and 2019, pWWE from Canada and the USA who enrolled into the North American AED Pregnancy Registry (NAARP) completed a questionnaire on their AED (anti-epileptic drug) usage. Enrollment rates to NAARP were compared between the two countries, and between the different Canadian provinces using population-based enrollment rate ratios (PERR). The AED prescription pattern among Canadian pWWE was analysed and compared with the USA. Results: During the study period, 10,215 women enrolled into NAARP : 4.1% (n=419) were Canadian, below the expected population-based contribution (PERR=0.42; p<0.01). Within Canada, the three northern territories (PERR=0; p<0.01), Prince-Edward Island (PERR=0; p<0.01), and Quebec (PERR=0.41; p<0.01) had the lowest enrollment rate ratios. Lamotrigine was the most commonly prescribed AED among canadian pWWE; they were, however, more likely to be on polytherapy (25%; p=0.13), on Carbamazepine (24%; p<0.01) or valproic acid (21%; p<0.01) than their American counterparts. Conclusions: Greater enrollment of Canadian women to NAARP, through enhanced clinician referrals, in particular from underrepresented provinces/territories, could lead to more accurate population-specific data and help identify gaps in the care of this vulnerable patient population.

scholarly journals The Epidemiology of Infantile Spasms

2001 ◽  
Vol 28 (4) ◽  
pp. 309-312 ◽  
Author(s):  
P.M. Brna ◽  
K.E. Gordon ◽  
J.M. Dooley ◽  
E.P. Wood
Keyword(s):  
Prince Edward Island ◽  
Disease Incidence ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Incidence Rates ◽  
Infantile Spasms ◽  
Clinical Impression ◽  
Birth Cohorts ◽  
Marked Variability ◽  
Canadian Provinces

Objective:The aim of this study was to estimate population based incidence rates for infantile spasms (IS) and to study our clinical impression that the incidence of IS has recently decreased in the Canadian Provinces of Nova Scotia and Prince Edward Island.Methods:Birth cohorts from 1978 to 1998, identified through the hospital health records, EEG records and physician computerized databases, were followed for two years for the development of IS. Disease incidence rates were calculated using denominators derived from Statistics Canada's reported annual live birth rates.Results:The inclusion criteria for IS were fulfilled by 75 patients. The overall incidence of IS was 30.7/100,000 live births (95% CI 24.3, 38.8). Etiologic classification was symptomatic for 51 cases (68%), cryptogenic for 18 (24%), and idiopathic in six children (8%). Although there were more males (N=44) than females (N=31), the incidence rates were similar. There was a marked variability in annual and five-year incidence rates.Conclusion:Although the clinical characteristics of our patients were similar to other reported IS populations, the instability in IS incidence rates indicates a need for caution in interpreting smaller IS epidemiologic studies.

scholarly journals Incidence of myeloid neoplasms in Spain (2002–2013): a population-based study of the Spanish network of cancer registries

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Marta Solans ◽  
Arantza Sanvisens ◽  
Alberto Ameijide ◽  
Susana Merino ◽  
Dolores Rojas ◽  
...  
Keyword(s):  
Myeloproliferative Neoplasms ◽  
Cancer Registries ◽  
Population Based ◽  
Incidence Rates ◽  
Incidence Data ◽  
Incidence Trends ◽  
Myeloid Neoplasms ◽  
Health Authorities ◽  
Hematological Cancers ◽  
Public Health Authorities

AbstractComprehensive population-based data on myeloid neoplasms (MNs) are limited, mainly because some subtypes were not recognized as hematological cancers prior to the WHO publication in 2001, and others are too rare to allow robust estimates within regional studies. Herein, we provide incidence data of the whole spectrum of MNs in Spain during 2002–2013 using harmonized data from 13 population-based cancer registries. Cases (n = 17,522) were grouped following the HAEMACARE groupings and 2013-European standardized incidence rates (ASRE), incidence trends, and estimates for 2021 were calculated. ASRE per 100,000 inhabitants was 5.14 (95% CI: 5.00–5.27) for myeloproliferative neoplasms (MPN), 4.71 (95% CI: 4.59–4.84) for myelodysplastic syndromes (MDS), 3.91 (95% CI: 3.79–4.02) for acute myeloid leukemia, 0.83 (95% CI: 0.78–0.88) for MDS/MPN, 0.35 (95% CI: 0.32–0.39) for acute leukemia of ambiguous lineage, and 0.58 (95% CI: 0.53–0.62) for not-otherwise specified (NOS) cases. This study highlights some useful points for public health authorities, such as the remarkable variability in incidence rates among Spanish provinces, the increasing incidence of MPN, MDS, and MDS/MPN during the period of study, in contrast to a drop in NOS cases, and the number of cases expected in 2021 based on these data (8446 new MNs).

scholarly journals Changes in Ultraviolet Radiation Exposure to the Ocular Region: A Population-Based Study

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 719 ◽  
Author(s):  
Ezekiel Weis ◽  
Sebastian Q. Vrouwe ◽  
David B. LeBaron ◽  
Matthew B. Parliament ◽  
Jerry Shields ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Ultraviolet Radiation ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Group Versus ◽  
Population Based ◽  
Incidence Rates ◽  
The Body ◽  
Incidence Trends ◽  
Males And Females

In contrast to the well-established association between ultraviolet radiation (UVR) exposure and skin cancers, the relationship between UVR and uveal malignant melanoma (UM) remains controversial. To address this controversy, we evaluated the incidence rates of cutaneous malignancies in the eyelids as a proxy for UVR exposure in the ocular region using a population-based cancer registry. Overall, 74,053 cases of eyelid basal cell carcinoma (BCC) and 7890 cases of melanoma over a 26-year period (1982–2007) were analyzed. The incidence of eyelid basal cell carcinoma and uveal melanoma remained stable, whereas other cutaneous areas demonstrated an increase in the rates. A comparability test demonstrated that BCC incidence trends were significantly different between the eyelid versus both chronically exposed (males p = 0.001; females p = 0.01) and intermittently exposed skin (males and females, p = 0.0002), as well as the skin of the face (males p = 0.002; females p = 0.02). Similarly, melanoma trends were significantly different between the UM group versus both chronically exposed cutaneous melanoma (CM) (males p = 0.001; females p = 0.04) and intermittently exposed CM (males p = 0.005), as well as facial skin CM (males and females p = 0.0002). The discrepancy of cancer incidence between tumors in the peri-ocular region versus the rest of the body suggests that the peri-ocular region might have a different or unique exposure pattern to ultraviolet radiation.

Epidemiology of ophthalmic lymphoma in Canada during 1992–2010

2019 ◽  
Vol 104 (8) ◽  
pp. 1176-1180 ◽  
Author(s):  
Rami Darwich ◽  
Feras M Ghazawi ◽  
Elham Rahme ◽  
Nebras Alghazawi ◽  
Andrei Zubarev ◽  
...  
Keyword(s):  
B Cell ◽  
Incidence Rate ◽  
Cell Lymphoma ◽  
Temporal Trends ◽  
B Cell Lymphoma ◽  
Cancer Registries ◽  
Population Based ◽  
Older Individuals ◽  
Independent Population ◽  
The Usa

BackgroundOphthalmic lymphoma (OL) is the most common orbital tumour, particularly in older individuals. Little is known about the epidemiology and geographic distribution of OL in Canada. Descriptive demographic statistics are an important first step in understanding OL burden and are necessary to inform comprehensive national cancer prevention programmes.MethodsWe determined patterns of incidence and geographical distribution of the three major subtypes of OL: extranodal marginal zone B cell lymphoma, follicular lymphoma (FL) and diffuse large B cell lymphoma. Here, we used cases that were diagnosed during 1992–2010 using two independent population-based cancer registries, the Canadian Cancer Registry and Le Registre Québécois du Cancer (LRQC).ResultsThe OL mean annual age-standardised incidence rate for 1992–2010 was 0.65 cases per million people per year with an average annual increase in the incidence rate of 4.5% per year. The mean age of diagnosis was 65 years. OL incidence rate was the highest in the cities located along the heavily industrialised Strait of Georgia in British Columbia.ConclusionsOur data on patient age, sex and temporal trends showed similarities with data reported in the USA and Denmark. Additional studies are needed to determine whether the observed increase in OL incidence is genuine or spurious.

Rapid transitions in the epidemiology of stroke and its risk factors in China from 2002 to 2013

Neurology ◽  
2017 ◽  
Vol 89 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Tianjia Guan ◽  
Jing Ma ◽  
Mei Li ◽  
Tao Xue ◽  
Zongmin Lan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Behavioral Interventions ◽  
Population Attributable Risk ◽  
Population Based ◽  
Incidence Rates ◽  
Mortality Data ◽  
Lifestyle Risk Factors ◽  
Incidence Trends ◽  
Stroke Prevalence ◽  
Lifestyle Risk

Objective:To estimate the current prevalence, temporal incidence trends, and contribution of risk factors for stroke in China.Methods:The China National Stroke Screening Survey (CNSSS) is an ongoing nationwide population-based program. A representative sample of 1,292,010 adults over 40 years old with 31,188 identified stroke cases from the 2013 and 2014 CNSSS database was analyzed to provide descriptive statistics of the prevalence and risk factors for stroke in 2014. In addition, a retrospective evaluation of 12,526 first-ever stroke cases in 2002–2013 and stroke mortality data from the 2002–2013 China Public Health Statistical Yearbook was conducted to estimate the incidence rates.Results:In 2014, the adjusted stroke prevalence was 2.06% in adults aged 40 years and older. After full adjustments, all risk factors assessed showed significant associations with stroke (p < 0.01); the largest contributor was hypertension (population-attributable risk 53.2%), followed by family history, dyslipidemia, atrial fibrillation, diabetes, physical inactivity, smoking, and overweight/obesity. The incidence of first-ever stroke in adults aged 40–74 years increased from 189/100,000 individuals in 2002 to 379/100,000 in 2013—an overall annual increase of 8.3%. Stroke-specific mortality in adults aged 40–74 years has remained stable, at approximately 124 deaths/100,000 individuals in both 2002 and 2013.Conclusions:In 2002–2013, the incidence of stroke in China increased rapidly. Combined with a high prevalence, a trend toward a younger age, and stable mortality, this finding suggests that additional clinical and behavioral interventions for metabolic and lifestyle risk factors are necessary to prevent stroke, particularly in certain populations.

Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs

Blood ◽  
2008 ◽  
Vol 112 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Dana E. Rollison ◽  
Nadia Howlader ◽  
Martyn T. Smith ◽  
Sara S. Strom ◽  
William D. Merritt ◽  
...  
Keyword(s):  
United States ◽  
Myelodysplastic Syndromes ◽  
Survival Rates ◽  
Myeloproliferative Disorders ◽  
Cancer Registries ◽  
The United States ◽  
Population Based ◽  
Incidence Rates ◽  
Chronic Myeloproliferative Disorders ◽  
The North

Abstract Reporting of myelodysplastic syndromes (MDSs) and chronic myeloproliferative disorders (CMDs) to population-based cancer registries in the United States was initiated in 2001. In this first analysis of data from the North American Association of Central Cancer Registries (NAACCR), encompassing 82% of the US population, we evaluated trends in MDS and CMD incidence, estimated case numbers for the entire United States, and assessed trends in diagnostic recognition and reporting. Based on more than 40 000 observations, average annual age-adjusted incidence rates of MDS and CMD for 2001 through 2003 were 3.3 and 2.1 per 100 000, respectively. Incidence rates increased with age for both MDS and CMD (P < .05) and were highest among whites and non-Hispanics. Based on follow-up data through 2004 from the Surveillance, Epidemiology, and End Results (SEER) Program, overall relative 3-year survival rates for MDS and CMD were 45% and 80%, respectively, with males experiencing poorer survival than females. Applying the observed age-specific incidence rates to US Census population estimates, approximately 9700 patients with MDS and 6300 patients with CMD were estimated for the entire United States in 2004. MDS incidence rates significantly increased with calendar year in 2001 through 2004, and only 4% of patients were reported to registries by physicians' offices. Thus, MDS disease burden in the United States may be underestimated.

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