scholarly journals 3341 Sex Differences in Vitamin D and Urinary Stone Disease

2019 ◽  
Vol 3 (s1) ◽  
pp. 54-54
Author(s):  
Damian Nicolas Di Florio ◽  
Erika J. Douglass ◽  
Katelyn A. Bruno ◽  
Anneliese R. Hill ◽  
Jessica E. Mathews ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sex Differences ◽  
Stone Formation ◽  
Calcium Supplementation ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Urinary Stone Disease ◽  
Men And Women ◽  
Icd 10

OBJECTIVES/SPECIFIC AIMS: More men than women develop urinary stones and their prevalence alters in women with menopause suggesting a steroidal influence. In men the incidence of stones is highest during July and August suggesting that environmental factors such as Vitamin D (VitD), a steroid, may affect stone formation. Previous studies have found differences in the development of stones between men and women; however, the reasons for sex differences in stone formation and type remain unclear. METHODS/STUDY POPULATION: We examined VitD levels in men and women (n = 18,753) that had no diseases based on a lack of an ICD-9 or ICD-10 code in their electronic medical record. We found that normal, healthy women had significantly higher levels of sera VitD compared to men (p = 6x10-6). We then examined whether sex differences existed for key endpoints/data from the Mayo Clinic Urinary Stone Disease (USD) Registry, which has around 1,600 urinary stone patients that are well-phenotyped according to sex, age and stone type. RESULTS/ANTICIPATED RESULTS: Control women were found to have higher sera VitD levels than men, but the sex difference no longer exists in kidney stone disease patients. When we further separated by race, we found that differences in VitD levels reappeared; this suggests that race also plays a role in sera VitD variances. DISCUSSION/SIGNIFICANCE OF IMPACT: We are developing a disease severity score, which we will use to correlate to sera VitD levels in patients according to sex, age and race. Future analyses will take into account whether subjects had VitD and calcium supplementation. This project begins to explore the mechanism behind the sex differences known to exist in urinary stone disease, which is critically needed to provide improved diagnosis and therapy for this debilitating disease.

scholarly journals The impact of metabolic risk management on recurrence of urinary stones

2012 ◽  
Vol 2 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Yigit Akin ◽  
Selcuk Yucel ◽  
Ahmet Danisman ◽  
Tibet Erdogru ◽  
Mehmet Baykara
Keyword(s):  
Risk Management ◽  
Risk Analysis ◽  
Stone Formation ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Metabolic Risk ◽  
Metabolic Abnormalities ◽  
Urinary Stone Disease ◽  
The Impact

Introduction: Urinary stone disease is a common urologic problem and recurrence in stone formation is a very familiar issue to urologists. Although recurrence in stone formation has been linked to metabolic abnormalities, it can be accessible by metabolic risk analysis studies.Methods: Herein, we present our experience in metabolic risk management on recurrence of urinary stones for 10 years in Akdeniz University School of Medicine department of Urology. We retrospectively analyzed Akdeniz University Urinary Stone Database between dates of January 2000 and December 2010. We found over 3500 patients who were managed by SWL (shock wave lithotripsy) or PCNL (percutaneus nephrolithotripsy) or URS (Ureterorenoscopic lithotripsy) or open surgery.Results: 525 patients’ metabolic risk analysis was ordered due to recurrent urinary stone disease. Only 134 (25.5 %) current metabolic analysis were returned. Mean patient age was 32.2 years (range: 19-82 years).Patients were 103 male and 31 female. Stone analysis results were CaOx monohydrate in 48 (35.8 %), CaOx dihydrate in 8 (5.9 %), CaOx mono and dihydrate in 70 (52.2 %), uric acid in 3, CaOx monohydrate and uricacid in 2, cystine in 2, and struvite in 1 patient, respectively. The  metabolic risk analysis showed some abnormality in 54 (40.2 %) patients.Conclusion: Although compliance to metabolic risk analysis studies is low among recurrent urinary stone formers, some significant metabolic abnormalities could be detected in those who are effectively screened.Recurrence of urinary stones in patients who are started on appropriate metabolic management can be prevented.

scholarly journals Nutrition and Kidney Stone Disease

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1917
Author(s):  
Roswitha Siener
Keyword(s):  
Kidney Stone ◽  
Fluid Intake ◽  
Stone Formation ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Dietary Therapy ◽  
Effective Prevention ◽  
Kidney Stone Disease ◽  
Nutrition And Diet

The prevalence of kidney stone disease is increasing worldwide. The recurrence rate of urinary stones is estimated to be up to 50%. Nephrolithiasis is associated with increased risk of chronic and end stage kidney disease. Diet composition is considered to play a crucial role in urinary stone formation. There is strong evidence that an inadequate fluid intake is the major dietary risk factor for urolithiasis. While the benefit of high fluid intake has been confirmed, the effect of different beverages, such as tap water, mineral water, fruit juices, soft drinks, tea and coffee, are debated. Other nutritional factors, including dietary protein, carbohydrates, oxalate, calcium and sodium chloride can also modulate the urinary risk profile and contribute to the risk of kidney stone formation. The assessment of nutritional risk factors is an essential component in the specific dietary therapy of kidney stone patients. An appropriate dietary intervention can contribute to the effective prevention of recurrent stones and reduce the burden of invasive surgical procedures for the treatment of urinary stone disease. This narrative review has intended to provide a comprehensive and updated overview on the role of nutrition and diet in kidney stone disease.

scholarly journals Open Surgery for Urinary Stones in a Resource Poor Setting: A Look at Dalhatu Araf Specialist Hospital, Lafia, Nigeria

2021 ◽  
Vol 2 (2) ◽  
pp. 79-81 ◽  
Author(s):  
Christian Agbo
Keyword(s):  
Open Surgery ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Endoscopic Management ◽  
Resource Poor Setting ◽  
Cost Of Treatment ◽  
Urinary Stone Disease ◽  
Resource Poor ◽  
The Cost

Urinary stone disease has afflicted humankind since antiquity[1]. It remains a common urological condition worldwide, including in our environment[2]. Although open surgery was previously the main option for stone removal, advances in technology mean that treatment is now largely through minimally invasive surgery, as recommended by a number of urological guidelines[3,4]. Unfortunately, at our centre, we still treat urinary stones solely through open surgery, mostly because we lack endoscopic equipment. In addition, most of our patients, even if referred to facilities where endoscopic management is possible, cannot afford the cost of treatment.

scholarly journals APLICAREA TEHNOLOGIEI LASER HOLMIUM ÎN TRATAMENTUL LITIAZEI RENOURETERALE

InterConf ◽  
2021 ◽  
pp. 294-301
Author(s):  
Dinari Cojocaru
Keyword(s):  
Endoscopic Treatment ◽  
New Technologies ◽  
Urinary Stone ◽  
Laser Lithotripsy ◽  
Stone Disease ◽  
Holmium Laser ◽  
Urinary Stones ◽  
Urinary Stone Disease ◽  
Substantial Role ◽  
Progressive Development

The efficiency and safety of the Holmium Laser has made this method of treatment a versatile multi-purpose instrument for use in the endoscopic treatment for variety of urologic disorders, in particular urinary stones. According to progressive development of new technologies - current endourologic laser lithotripsy applications, for treatment of urinary stone disease has a substantial role for urologist practitioner.

Methanaphylaxis of urolithiasis. Part 3. The factors associated with increase in incidence of urinary stone disease. Current views on the mechanisms of stone formation

Urologiia ◽  
2019 ◽  
Vol 1_2019 ◽  
pp. 105-112 ◽  
Author(s):  
V.S. Saenko Saenko ◽  
M.A. Gazimiev Gazimiev ◽  
S.V. Pesegov Pesegov ◽  
Yu.G. Alyaev Alyaev ◽  
Keyword(s):  
Stone Formation ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stone Disease ◽  
Factors Associated

scholarly journals Advantages of Herbal Over Allopathic Medicine in the Management of Kidney and Urinary Stones Disease

2020 ◽  
Vol 3 (3) ◽  
pp. 179-189
Author(s):  
Saurabh Nimesh ◽  
Vrish Dhwaj Ashwlayan ◽  
Rubi Rani ◽  
Om Prakash
Keyword(s):  
Urinary Tract ◽  
Side Effects ◽  
Herbal Medicines ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Common Disease ◽  
Herbal Therapy ◽  
Urinary Stone Disease ◽  
Based Medicine

Kidney and urinary stone disease (Nephrolithiasis and urolithiasis) are the condition where urinary stones or calculi are formed in the urinary tract. The problem of urinary stones is very ancient; these stones are found in all parts of the urinary tract, kidney, ureters, and the urinary bladder and may vary considerably in size. It is a common disease estimated to occur in approximately 12% of the population, with a recurrence rate of 70-81% in males and 47-60% in females. The treatment of kidney and urinary stone diseases such as a western (allopathy) medicine and surgery is now in trends. However, most people preferred plant-based (herbal) therapy because of the overuse of allopathic drugs, which results in a higher incidence rate of adverse or severe side effects. Therefore, people every year turn to herbal therapy because they believe plant-based medicine is free from undesirable side effects, although herbal medicines are generally considered to be safe and effective. In the present article, an attempt has been made to emphasize an herbal therapy is better than allopathic therapy for the management of the kidney and urinary stone disease.

Vitamin D and urinary stone disease: the current state of problem

Urologiia ◽  
2018 ◽  
Vol 5_2018 ◽  
pp. 122-127
Author(s):  
H.M. Ali Ali ◽  
V.S. Saenko Saenko ◽  
S.V. Pesegov Pesegov ◽  
S.H. Ali Ali ◽  
S.V. Vovdenko Vovdenko ◽  
...  
Keyword(s):  
Vitamin D ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stone Disease ◽  
Current State

scholarly journals A 13 year hospital based study on the Trend of Urinary Stone Disease in Uttarakhand, India

2021 ◽  
Vol 11 (1) ◽  
pp. 949-958
Author(s):  
Monica Kakkar ◽  
Rakesh Kakkar
Keyword(s):  
Retrospective Study ◽  
Renal Stones ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Religious Groups ◽  
Medical Sciences ◽  
Urinary Stone Disease ◽  
Disease Site ◽  
Keywords Urolithiasis

Background: The present retrospective study on urinary stone disease in the Uttarakhand state was necessitated as no study has been done yet. Methods: A retrospective study covering a period of about 13 years (2005-18) was conducted on the urinary stones removed from the patients, admitted at Himalayan Institute of Medical Sciences, Dehradun. The incidence of the disease, site of stones in urinary tract upon diagnosis, composition of removed stones and occurrence of a possible co-relationship between the incidence of the urinary stone disease at different times, age, sex, religion of the patients was investigated. Results: The frequency of occurrence of urinary stones in males was found to be almost three times more as compared to their female counterparts. The above trend was consistent over the entire period of the study. Interestingly, in the Muslim and Sikh population of the area, females were found to be less prone to the problem as compared to their Hindu counterparts.  However, in all religious groups, 21-40 years old subjects were found to be most susceptible to the problem and approximately 90% of the urinary stones were recovered from the kidneys and primarily composed of calcium oxalate. Conclusion: The co-relationship between the occurrence of urinary stones with age, sex of the patients, their religion & site of stones on diagnosis was found to be statistically significant.  Keywords: Urolithiasis, Urinary Stone disease, Urinary calculus, Renal stones.

Benefaction of Herbals in the Management of Urolithiasis

2020 ◽  
Vol 06 ◽  
Author(s):  
Ankit Yadav ◽  
Rina Das ◽  
Dinesh Kumar Mehta ◽  
Yatin
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Obstruction ◽  
Stone Formation ◽  
Herbal Medicines ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
High Recurrence Rate ◽  
Industrialized Countries ◽  
Forced Return

: Kidney stone formation or Urolithiasis is a common problem over many centuries with no guarantee of effective treatment and, a high recurrence rate. Urolithiasis is precipitation of insoluble and less soluble salt such as Oxalate and Phosphate in the urinary tract causing obstruction in the urethra resulting in renal colic and, hematuria. Approximately, 10-12% of the population in industrialized countries are severely affected by Urinary stones. In, only a few geographical areas is stone disease rare, e.g., in the coastal areas of Japan and Germany. It was believed that, 11% of people in India are suffering from urinary stone problems, and approximately 50% of these cases may lead to severe renal damage. Ultimately it causes severe health issues in terms of urinary tract obstruction, severe pain, and infection that adversely affects the health of individuals. Diuretics and narcotic analgesic like drugs which are used to prevent and cure urolithiasis are not effective in all cases and are costly, give quite common recurrences, risk long term fertility and, other potential side effects are observed. So, humans are forced return to Nature for safe remedies using herbal treatment. A great number of Indian medicinal plants have been investigated in the treatment of urolithiasis, and they have been reported to be safe and effective. In the present review, an effort has been made to highlight such herbal medicines which are potentially effective in the management of urolithiasis.

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