Benefaction of Herbals in the Management of Urolithiasis

2020 ◽  
Vol 06 ◽  
Author(s):  
Ankit Yadav ◽  
Rina Das ◽  
Dinesh Kumar Mehta ◽  
Yatin
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Obstruction ◽  
Stone Formation ◽  
Herbal Medicines ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
High Recurrence Rate ◽  
Industrialized Countries ◽  
Forced Return

: Kidney stone formation or Urolithiasis is a common problem over many centuries with no guarantee of effective treatment and, a high recurrence rate. Urolithiasis is precipitation of insoluble and less soluble salt such as Oxalate and Phosphate in the urinary tract causing obstruction in the urethra resulting in renal colic and, hematuria. Approximately, 10-12% of the population in industrialized countries are severely affected by Urinary stones. In, only a few geographical areas is stone disease rare, e.g., in the coastal areas of Japan and Germany. It was believed that, 11% of people in India are suffering from urinary stone problems, and approximately 50% of these cases may lead to severe renal damage. Ultimately it causes severe health issues in terms of urinary tract obstruction, severe pain, and infection that adversely affects the health of individuals. Diuretics and narcotic analgesic like drugs which are used to prevent and cure urolithiasis are not effective in all cases and are costly, give quite common recurrences, risk long term fertility and, other potential side effects are observed. So, humans are forced return to Nature for safe remedies using herbal treatment. A great number of Indian medicinal plants have been investigated in the treatment of urolithiasis, and they have been reported to be safe and effective. In the present review, an effort has been made to highlight such herbal medicines which are potentially effective in the management of urolithiasis.

scholarly journals Advantages of Herbal Over Allopathic Medicine in the Management of Kidney and Urinary Stones Disease

2020 ◽  
Vol 3 (3) ◽  
pp. 179-189
Author(s):  
Saurabh Nimesh ◽  
Vrish Dhwaj Ashwlayan ◽  
Rubi Rani ◽  
Om Prakash
Keyword(s):  
Urinary Tract ◽  
Side Effects ◽  
Herbal Medicines ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Common Disease ◽  
Herbal Therapy ◽  
Urinary Stone Disease ◽  
Based Medicine

Kidney and urinary stone disease (Nephrolithiasis and urolithiasis) are the condition where urinary stones or calculi are formed in the urinary tract. The problem of urinary stones is very ancient; these stones are found in all parts of the urinary tract, kidney, ureters, and the urinary bladder and may vary considerably in size. It is a common disease estimated to occur in approximately 12% of the population, with a recurrence rate of 70-81% in males and 47-60% in females. The treatment of kidney and urinary stone diseases such as a western (allopathy) medicine and surgery is now in trends. However, most people preferred plant-based (herbal) therapy because of the overuse of allopathic drugs, which results in a higher incidence rate of adverse or severe side effects. Therefore, people every year turn to herbal therapy because they believe plant-based medicine is free from undesirable side effects, although herbal medicines are generally considered to be safe and effective. In the present article, an attempt has been made to emphasize an herbal therapy is better than allopathic therapy for the management of the kidney and urinary stone disease.

scholarly journals Nutrition and Kidney Stone Disease

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1917
Author(s):  
Roswitha Siener
Keyword(s):  
Kidney Stone ◽  
Fluid Intake ◽  
Stone Formation ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Dietary Therapy ◽  
Effective Prevention ◽  
Kidney Stone Disease ◽  
Nutrition And Diet

The prevalence of kidney stone disease is increasing worldwide. The recurrence rate of urinary stones is estimated to be up to 50%. Nephrolithiasis is associated with increased risk of chronic and end stage kidney disease. Diet composition is considered to play a crucial role in urinary stone formation. There is strong evidence that an inadequate fluid intake is the major dietary risk factor for urolithiasis. While the benefit of high fluid intake has been confirmed, the effect of different beverages, such as tap water, mineral water, fruit juices, soft drinks, tea and coffee, are debated. Other nutritional factors, including dietary protein, carbohydrates, oxalate, calcium and sodium chloride can also modulate the urinary risk profile and contribute to the risk of kidney stone formation. The assessment of nutritional risk factors is an essential component in the specific dietary therapy of kidney stone patients. An appropriate dietary intervention can contribute to the effective prevention of recurrent stones and reduce the burden of invasive surgical procedures for the treatment of urinary stone disease. This narrative review has intended to provide a comprehensive and updated overview on the role of nutrition and diet in kidney stone disease.

scholarly journals 3341 Sex Differences in Vitamin D and Urinary Stone Disease

2019 ◽  
Vol 3 (s1) ◽  
pp. 54-54
Author(s):  
Damian Nicolas Di Florio ◽  
Erika J. Douglass ◽  
Katelyn A. Bruno ◽  
Anneliese R. Hill ◽  
Jessica E. Mathews ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sex Differences ◽  
Stone Formation ◽  
Calcium Supplementation ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Urinary Stone Disease ◽  
Men And Women ◽  
Icd 10

OBJECTIVES/SPECIFIC AIMS: More men than women develop urinary stones and their prevalence alters in women with menopause suggesting a steroidal influence. In men the incidence of stones is highest during July and August suggesting that environmental factors such as Vitamin D (VitD), a steroid, may affect stone formation. Previous studies have found differences in the development of stones between men and women; however, the reasons for sex differences in stone formation and type remain unclear. METHODS/STUDY POPULATION: We examined VitD levels in men and women (n = 18,753) that had no diseases based on a lack of an ICD-9 or ICD-10 code in their electronic medical record. We found that normal, healthy women had significantly higher levels of sera VitD compared to men (p = 6x10-6). We then examined whether sex differences existed for key endpoints/data from the Mayo Clinic Urinary Stone Disease (USD) Registry, which has around 1,600 urinary stone patients that are well-phenotyped according to sex, age and stone type. RESULTS/ANTICIPATED RESULTS: Control women were found to have higher sera VitD levels than men, but the sex difference no longer exists in kidney stone disease patients. When we further separated by race, we found that differences in VitD levels reappeared; this suggests that race also plays a role in sera VitD variances. DISCUSSION/SIGNIFICANCE OF IMPACT: We are developing a disease severity score, which we will use to correlate to sera VitD levels in patients according to sex, age and race. Future analyses will take into account whether subjects had VitD and calcium supplementation. This project begins to explore the mechanism behind the sex differences known to exist in urinary stone disease, which is critically needed to provide improved diagnosis and therapy for this debilitating disease.

scholarly journals Effect of Aegle marmelos on the growth of brushite crystals

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
G. Anushya ◽  
R. Mahesh ◽  
T. H. Freeda ◽  
R. Ramachandran ◽  
G. Raju
Keyword(s):  
Stone Formation ◽  
Peak Shift ◽  
Inhibitory Effect ◽  
Urinary Stone ◽  
Stone Disease ◽  
Point Of View ◽  
Urinary Stones ◽  
Major Constituent ◽  
Diabetic Patients ◽  
Aegle Marmelos

Abstract Background The urinary stone formation is a very common health problem due to the prolonged medication. Calcium Hydrogen Phosphate Dihydrate (CaHPO4.2H2O, CHPD and Brushite) is one of the major constituent of urinary stone crystals. The formation and deposition of brushite crystals is the central cause of recurrent kidney stone disease among the global population. The present study aims to investigate the effect of Aegle marmelos leaves on the growth of brushite crystals to explicate the inhibitory effect of urinary stones from a different point of view. Methods The CHPD crystals were grown by the Single Diffusion Gel growth technique. In order to inhibit the formation of urinary stones, CHPD crystals are grown in the laboratory in the pure form and by adding the prolonged medicine A. marmelos taken especially by diabetic patients. A comparative study of the pure and A. marmelos leaves added crystals has been carried out using the Growth factor, Powder X-ray diffraction, Microstructural parameters, FTIR and SEM-EDAX. Results Total mass of the grown crystals is found to decrease with increasing concentrations of leaf extract of the A. marmelos. On comparing with undoped, crystalline size of the A. marmelos doped samples is reduced. Disappearance of absorption band and peak shift in the FTIR shows the incorporation of functional groups of A. marmelos. The morphology changes of the treated crystals are assessed in SEM. Conclusions The result shows that herbal extracts prepared from A. marmelos have good inhibitory effect on the growth of the brushite urinary stone crystals considered.

scholarly journals The impact of metabolic risk management on recurrence of urinary stones

2012 ◽  
Vol 2 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Yigit Akin ◽  
Selcuk Yucel ◽  
Ahmet Danisman ◽  
Tibet Erdogru ◽  
Mehmet Baykara
Keyword(s):  
Risk Management ◽  
Risk Analysis ◽  
Stone Formation ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Metabolic Risk ◽  
Metabolic Abnormalities ◽  
Urinary Stone Disease ◽  
The Impact

Introduction: Urinary stone disease is a common urologic problem and recurrence in stone formation is a very familiar issue to urologists. Although recurrence in stone formation has been linked to metabolic abnormalities, it can be accessible by metabolic risk analysis studies.Methods: Herein, we present our experience in metabolic risk management on recurrence of urinary stones for 10 years in Akdeniz University School of Medicine department of Urology. We retrospectively analyzed Akdeniz University Urinary Stone Database between dates of January 2000 and December 2010. We found over 3500 patients who were managed by SWL (shock wave lithotripsy) or PCNL (percutaneus nephrolithotripsy) or URS (Ureterorenoscopic lithotripsy) or open surgery.Results: 525 patients’ metabolic risk analysis was ordered due to recurrent urinary stone disease. Only 134 (25.5 %) current metabolic analysis were returned. Mean patient age was 32.2 years (range: 19-82 years).Patients were 103 male and 31 female. Stone analysis results were CaOx monohydrate in 48 (35.8 %), CaOx dihydrate in 8 (5.9 %), CaOx mono and dihydrate in 70 (52.2 %), uric acid in 3, CaOx monohydrate and uricacid in 2, cystine in 2, and struvite in 1 patient, respectively. The  metabolic risk analysis showed some abnormality in 54 (40.2 %) patients.Conclusion: Although compliance to metabolic risk analysis studies is low among recurrent urinary stone formers, some significant metabolic abnormalities could be detected in those who are effectively screened.Recurrence of urinary stones in patients who are started on appropriate metabolic management can be prevented.

Use of non-contrast computed tomography determined urinary stone fragility in predicting the outcome of extracorporeal shockwave lithotripsy treatment: a single-center study

2020 ◽  
Vol 14 (2) ◽  
pp. 59-63
Author(s):  
Athar Hameed ◽  
Khazir Hayyat Gondal
Keyword(s):  
Shock Waves ◽  
Renal Stone ◽  
Plain Film ◽  
Renal Stones ◽  
Renal Calculus ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Fisher Exact Test

Background: Renal stones represent a common urological pathology where standard treatment advised is ESWL in current practice. However, NCCT based determination of stone fragility may help to predict the outcome of ESWL treatment, hence optimizing its clinical use. Therefore, this study evaluated the role of NCCT determined urinary stone fragility in predicting the outcome of ESWL treatment in local clinical settings. Patients and methods: One hundred patients with single renal calculus of 0.6-2 cm in size were included. NCCT based determination of stone fragility in HU units was done for all patients. Patients were then subjected to ESWL, with a maximum of 3000 shock waves given per ESWL session. Plain film and/or ultrasonography was used to monitor ESWL treatment progress with a final NCCT evaluation at 12 weeks to determine the clearance of the calculi for each patient. Association of NCCT based stone fragility and outcome of ESWL was statistically analyzed using Fisher exact test. Results: The mean age of the patients was 37.7 ± 10.9 years with 54% being male. Decreasing stone fragility on NCCT (high = <500HU, moderate = 500-1000HU, and high = 1000HU) required more number and intensity of ESWL sessions (1-2 visits and 3000-6000 shock waves for high stone fragility group, 3-5 visits and 7000-18000 shock waves for the moderate group, and 6 visits and >18000 shock waves for low fragility group, respectively) necessary for clearance of urinary stones (p<0.001). In 98% of patients, the clearance of urinary stones was excellent. Conclusion: Renal stone patients with NCCT determined high and moderate stone fragility show an optimal response after ESWL treatment, whereas, for low fragility renal stones attenuative treatment like percutaneous nephrolithotomy and/or ureteroscopy should be considered instead of ESWL. This approach can enable patient stratification before ESWL therapy ensuring better clinical management of the renal stone disease.

scholarly journals Proteus mirabilis Urease: Unsuspected Non-Enzymatic Properties Relevant to Pathogenicity

2021 ◽  
Vol 22 (13) ◽  
pp. 7205
Author(s):  
Matheus V. C. Grahl ◽  
Augusto F. Uberti ◽  
Valquiria Broll ◽  
Paula Bacaicoa-Caruso ◽  
Evelin F. Meirelles ◽  
...  
Keyword(s):  
Proteus Mirabilis ◽  
Stone Formation ◽  
Cell Types ◽  
Bioinformatic Analysis ◽  
Urinary Stone ◽  
Enzymatic Properties ◽  
Hek293 Cells ◽  
Urinary Stones ◽  
Isolated Cells ◽  
Tnf Α

Infection by Proteus mirabilis causes urinary stones and catheter incrustation due to ammonia formed by urease (PMU), one of its virulence factors. Non-enzymatic properties, such as pro-inflammatory and neurotoxic activities, were previously reported for distinct ureases, including that of the gastric pathogen Helicobacter pylori. Here, PMU was assayed on isolated cells to evaluate its non-enzymatic properties. Purified PMU (nanomolar range) was tested in human (platelets, HEK293 and SH-SY5Y) cells, and in murine microglia (BV-2). PMU promoted platelet aggregation. It did not affect cellular viability and no ammonia was detected in the cultures’ supernatants. PMU-treated HEK293 cells acquired a pro-inflammatory phenotype, producing reactive oxygen species (ROS) and cytokines IL-1β and TNF-α. SH-SY5Y cells stimulated with PMU showed high levels of intracellular Ca2+ and ROS production, but unlike BV-2 cells, SH-SY5Y did not synthesize TNF-α and IL-1β. Texas Red-labeled PMU was found in the cytoplasm and in the nucleus of all cell types. Bioinformatic analysis revealed two bipartite nuclear localization sequences in PMU. We have shown that PMU, besides urinary stone formation, can potentially contribute in other ways to pathogenesis. Our data suggest that PMU triggers pro-inflammatory effects and may affect cells beyond the renal system, indicating a possible role in extra-urinary diseases.

Urinary Tract Infection and Urinary Stone Disease

Urolithiasis ◽  
1989 ◽  
pp. 279-280
Author(s):  
S. Vasudevan ◽  
K. Sachidev ◽  
S. Sindhu ◽  
R. Vathsala ◽  
Y. M. Fazil Marickar
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stone Disease

scholarly journals Pediatric renal stone disease

2018 ◽  
Vol 146 (3-4) ◽  
pp. 218-225
Author(s):  
Amira Peco-Antic
Keyword(s):  
Renal Stone ◽  
Urinary Tract Obstruction ◽  
Cost Effective ◽  
Stone Disease ◽  
Renal Tubules ◽  
Industrialized Countries ◽  
Metabolic Evaluation ◽  
Urine Ph ◽  
Renal Stone Disease ◽  
Genetic Source

Pediatric renal stone disease is manifested as nephro/urolithiasis (UL) and/or nephrocalcinosis (NC). Compared to adults, UL in childhood is less common, and it is believed to be around 5% in industrialized countries, while the incidence of NC is even lower except for critically ill premature infants in whom it may reach 64%. The formation of UL and NC is caused by increased concentration of relevant solutes, and their aggregations and adherence to the renal tubules cell is facilitated by factors such as urine pH, inability of natural crystallization inhibitors, stasis of urine as well as renal tubule damage. UL is associated with significant morbidity because of pains, susceptibility to urinary tract obstruction and infections, and the necessity of surgical procedures. NC is usually asymptomatic but is frequently progressive, and more often than UL, leads to chronic renal failure. Although other imaging modalities can be used in the diagnosis of renal stone disease, ultrasound has the least risk and is most cost-effective. The majority cases of UL and NC in children are of metabolic origin and thus they are prone to recurrence and may cause chronic renal damage. Therefore, they deserve, even after their initial presentation a detailed metabolic evaluation. Genetic source of renal stone disease is suspected in the following conditions: early onset, familial prevalence, familial consanguinity, multiple or recurrent stones, and NC. For all UL/NC etiologies early identification and personalized treatment of the basic disorder is the most important.

scholarly journals Open Surgery for Urinary Stones in a Resource Poor Setting: A Look at Dalhatu Araf Specialist Hospital, Lafia, Nigeria

2021 ◽  
Vol 2 (2) ◽  
pp. 79-81 ◽  
Author(s):  
Christian Agbo
Keyword(s):  
Open Surgery ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Endoscopic Management ◽  
Resource Poor Setting ◽  
Cost Of Treatment ◽  
Urinary Stone Disease ◽  
Resource Poor ◽  
The Cost

Urinary stone disease has afflicted humankind since antiquity[1]. It remains a common urological condition worldwide, including in our environment[2]. Although open surgery was previously the main option for stone removal, advances in technology mean that treatment is now largely through minimally invasive surgery, as recommended by a number of urological guidelines[3,4]. Unfortunately, at our centre, we still treat urinary stones solely through open surgery, mostly because we lack endoscopic equipment. In addition, most of our patients, even if referred to facilities where endoscopic management is possible, cannot afford the cost of treatment.

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