Relationship between family history of alcohol problems and different clusters of depressive symptoms

2019 ◽  
pp. 1-9 ◽  
Author(s):  
J. M. Castaldelli-Maia ◽  
N. R. Silva ◽  
A. Ventriglio ◽  
F. Gil ◽  
J. Torales ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Family History ◽  
Alcohol Problems ◽  
Analysis Of Covariance ◽  
Major Depressive ◽  
Affective Symptoms ◽  
History Of ◽  
Genetic And Environmental Factors ◽  
Family History Of Depression ◽  
History Of Depression

Abstract Objectives: Major depressive disorder (MDD) is a multifactorial syndrome with significant interactions between genetic and environmental factors. This study specifically investigates the association between family history of alcohol problems (FHAP) and family history of depression (FHD), and how these relate to different clusters of depressive symptoms. Methods: Correlations between FHAP and FHD and different clusters of the Beck Depression Inventory (BDI) were studied. We sampled 333 employees from a general hospital who had been receiving a psychiatric consultation between 2005 and 2012. Analysis of variance (ANOVA) and Analysis of covariance (ANCOVA) models were conducted to explore these correlations. Results: There was a significant positive correlation between FHAP and BDI affective score. This result remained significant even after the adjustment for other variables considered as important factors for MDD, such as gender, age, marital status, education, ethnic group and FHD. More specifically, FHAP was correlated with dissatisfaction and episodes of crying among the affective symptoms. FHAP showed no statistical difference in any of the other clusters score or in the BDI total score. Moreover, as expected, we found a correlation between FHD and BDI total score and Somatic and Cognitive clusters. Conclusion: FHAP should be routinely investigated in individuals presenting with depressive symptoms. This is especially important in cases presenting with dissatisfaction and episodes of crying in patients who do not endorse criteria for MDD. Due to study limitations, the findings require replication by neurobiological, epidemiological and clinical studies.

scholarly journals Lymphocyte subsets and their association with the severity of patients with major depressive disorder (mdd)

2019 ◽  
Vol 3 (2) ◽  
pp. 80
Author(s):  
Noor Suryani Mohd Ashari ◽  
Siti Nor Fairus Mohamed Sanusi ◽  
Mohd Azhar Mohd Yasin ◽  
Rohimah Mohamud ◽  
Che Maraina Che Hussin
Keyword(s):  
Major Depressive Disorder ◽  
Family History ◽  
Depressive Disorder ◽  
Rural Area ◽  
Healthy Controls ◽  
Major Depressive ◽  
Chi Square ◽  
History Of ◽  
Family History Of Depression ◽  
History Of Depression

Introduction: Major Depressive Disorder (MDD) isexpected to become the second leading cause of worldwide disability by the year 2020 and the major contributor to the overall global burden of disease.Objective: This study was done to compare sociodemographicpredisposingfactors in MDD patients and controls in Kelantan, Malaysia.Methods: A total of 47 MDD patients and 47 healthy controls participated in this study. MDD patients were recruited from Psychiatric Clinic, HUSM and they were diagnosed according to DSM-V criteria. Patients’ biodata, medical and psychiatric history were taken by physician. Data were analysed using Pearson Chi-square and multiple logistic regression.Results: In MDD group, 61.7% were females and 38.3% were males. Forty two percent of MDD were in the age group of 45 to 65 years old and almost 12.8% of MDD patients had family history of depression, while all healthy controls were in good general health and had no family history of depression. Pearson Chi-square revealed that there were significant associations between smoking status (P=0.027), marital status (P=0.007) educational level (P=0.022) and area of living (P=0.0.036) with MDD. The results showed that unmarried person were less likely to have MDD compared to those married with adjusted odds ratio (OR) of 0.31. Smoker were 5.16 at odds of having MDD as compared to non-smoker, while individuals with a low education were more likely to have MDD compared to those highly educated with adjusted OR of 2.04. The result also showed those living in urban area were less likely to have MDD compared to those living in rural area with adjusted OR of 0.48.Conclusion: Higher age, female and positive family history possess a higher tendency of having MDD. In addition, smokers, married, less educated and living in rural area were more likely to have MDD compared to healthy controls.International Journal of Human and Health Sciences Vol. 03 No. 02 April’19. Page: 80-87

The Clinical Significance of the Thyrotropin-Releasing Hormone Test in Alcoholic Men

1992 ◽  
Vol 26 (4) ◽  
pp. 577-585 ◽  
Author(s):  
J. Douglas Sellman ◽  
Peter R. Joyce
Keyword(s):  
Depressive Symptoms ◽  
Family History ◽  
Past History ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone ◽  
The Past ◽  
History Of ◽  
Family History Of Depression ◽  
History Of Depression

Sixty-six alcoholic men who had been abstinent from alcohol for at least four weeks were assessed clinically and then investigated in terms of Thyroid-Stimulating Hormone (TSH) and prolactin responses to a Thyrotropin-Releasing Hormone (TRH) challenge. Consistent with other studies, a third of the subjects had a blunted TSH response to TRH. This blunted response was not associated with a family history of alcoholism, or current depressive symptoms, past history of depression or family history of depression. However, subjects with a blunted TSH response were more likely to have had an earlier onset of alcoholism and to have had shorter alcoholic remissions in the past.

Aetiology of Secondary Depression in Male Alcoholics

1996 ◽  
Vol 169 (6) ◽  
pp. 753-757 ◽  
Author(s):  
Alec Roy
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Life Events ◽  
Major Depressive Episode ◽  
Negative Impact ◽  
Major Depressive ◽  
Independent Events ◽  
History Of ◽  
Family History Of Depression ◽  
History Of Depression

BackgroundSecondary depression is common among primary alcoholics. However, its aetiology is poorly understood.MethodForty men with primary alcoholism, abstinent for two weeks or more, with a secondary major depressive episode were compared with forty matched never-depressed primary alcoholic controls for risk factors for depression and recent life events.ResultsIn the six months before the onset of depression depressed alcoholics had experienced significantly more life events, more life events with negative impact more dependent events caused by alcohol, and more independent events. Significantly more depressed alcoholics than controls had a family history of depression, a family history of suicidal behaviour and had themselves attempted suicide.ConclusionHaving recent life events, particularly events with negative impact, and a family history of depression are risk factors for secondary depression in alcoholics.

scholarly journals Comparing SociodemographicPredisposing Factors in Major Depressive Disorders (MDD) and Controlsin Kelantan, Malaysia

2019 ◽  
Vol 3 (2) ◽  
pp. 74
Author(s):  
Noor Suryani Mohd Ashari ◽  
Mohd Azhar Mohd Yasin ◽  
Siti Nor Fairus Mohamed Sanusi ◽  
Mohd Nazri Shafei
Keyword(s):  
Family History ◽  
Rural Area ◽  
Positive Family History ◽  
Psychiatric Clinic ◽  
Healthy Controls ◽  
Major Depressive ◽  
Chi Square ◽  
History Of ◽  
Family History Of Depression ◽  
History Of Depression

Introduction: Major Depressive Disorder (MDD) isexpected to become the second leading cause of worldwide disability by the year 2020 and the major contributor to the overall global burden of disease.Objective: This study was done to compare sociodemographicpredisposingfactors in MDD patients and controls in Kelantan, Malaysia.Methods: A total of 47 MDD patients and 47 healthy controls participated in this study. MDD patients were recruited from Psychiatric Clinic, HUSM and they were diagnosed according to DSM-V criteria. Patients’ biodata, medical and psychiatric history were taken by physician. Data were analysed using Pearson Chi-square and multiple logistic regression.Results: In MDD group, 61.7% were females and 38.3% were males. Forty two percent of MDD were in the age group of 45 to 65 years old and almost 12.8% of MDD patients had family history of depression, while all healthy controls were in good general health and had no family history of depression. Pearson Chi-square revealed that there were significant associations between smoking status (P=0.027), marital status (P=0.007) educational level (P=0.022) and area of living (P=0.0.036) with MDD. The results showed that unmarried person were less likely to have MDD compared to those married with adjusted odds ratio (OR) of 0.31. Smoker were 5.16 at odds of having MDD as compared to non-smoker, while individuals with a low education were more likely to have MDD compared to those highly educated with adjusted OR of 2.04. The result also showed those living in urban area were less likely to have MDD compared to those living in rural area with adjusted OR of 0.48.Conclusion: Higher age, female and positive family history possess a higher tendency of having MDD. In addition, smokers, married, less educated and living in rural area were more likely to have MDD compared to healthy controls.International Journal of Human and Health Sciences Vol. 03 No. 02 April’19. Page: 74-79

Effect on Neuropsychiatric Disorders of Organophosphate Pesticides Exposure among Rice Farmers in Sukoharjo, Central Java

2020 ◽  
Author(s):  
Ayu Laela Fitriyani ◽  
◽  
Setyo Sri Rahardjo ◽  
Bhisma Murti ◽  
◽  
...  
Keyword(s):  
Family History ◽  
Work Stress ◽  
Depression And Anxiety ◽  
High Exposure ◽  
Rice Farmers ◽  
Central Java ◽  
Loss And Grief ◽  
History Of ◽  
Family History Of Depression ◽  
History Of Depression

ABSTRACT Background: Chronic exposure to organophosphate pesticides can increase the risk of neuropsychiatric disorders, including depression and anxiety. Unsafe behavior from farmers will endanger the health of farmers, especially in the form of neuropsychiatric disorders (depression and anxiety). This study aimed to analyze the effects of pesticide exposure and psychosocial determinants on depression and anxiety. Subjects and Method: A retrospective cohort study was conducted in Sukoharjo, Central Java. The study population was rice farmers. A sample of 200 rice farmers who use organophospate pesticide was selected by fixed exposure sampling. The dependent variable was neuropsychiatry (anxiety and depression). The independent variables were exposure to organophospate pesticide, had family history of depression, loss and grief, post trauma, work stress, and the use of personal protective equipment (PPE). The data were collected by questionnaire and analyzed by a multiple linear regression. Results: The risk of depression increased with high exposure to organophospate pesticide (b= 0.15; 95% CI= 0.05 to 0.26; p= 0.005), had family history of depression (b= 5.10; 95% CI= 2.60 to 7.60; p<0.001), loss and grief (b= 2.94; 95% CI= 0.76 to 5.11; p= 0.008), post trauma (b= 2.57; 95% CI= 0.24 to 4.89; p= 0.031), and work stress (b= 0.16; 95% CI= 0.05 to 0.27; p= 0.005). The risk of depression decreased with the use of PPE (b= -0.69; 95% CI= -1.32 to -0.076; p= 0.028). The risk of anxiety increased with high exposure to organophospate pesticide (b= 0.13; 95% CI= 0.02 to 0.24; p= 0.025), post trauma (b= 5.96; 95% CI= 3.48 to 8.44; p<0.001), loss and grief (b= 3.39; 95% CI= 1.07 to 5.71; p<0.001), had family history of depression (b= 2.95; 95% CI= 0.29 to 5.62; p= 0.004), and work stress (b= 0.19; 95% CI= 0.07 to 0.30; p=0.002). The risk of anxiety decreased with the use of PPE (b= -0.09; 95% CI= -1.57 to -0.024; p=0.008). Conclusion: The risk of depression increases with high exposure to organophospate pesticide, family history of depression, loss and grief, post trauma, and work stress. The risk of depression decreases with the use of PPE. The risk of anxiety increases with high exposure to organophospate pesticide, post trauma, loss and grief, had family history of depression, and work stress. The risk of anxiety decreases with the use of PPE. Keywords: Neuropsychiatry disorder, depression, anxiety Correspondence: Ayu Laela Fitriyani. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: +625796333986. DOI: https://doi.org/10.26911/the7thicph.01.48

Anxious-retarded depression: relation to family history of depression

2004 ◽  
Vol 127 (1-2) ◽  
pp. 111-119 ◽  
Author(s):  
Remco F.P de Winter ◽  
Koos H Zwinderman ◽  
Jaap G Goekoop
Keyword(s):  
Family History ◽  
History Of ◽  
Family History Of Depression ◽  
History Of Depression
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