Treatment induced Mood Switching in Affective Disorders

2021 ◽  
pp. 1-50
Author(s):  
Siu Wa Tang ◽  
Wayne Hans Tang ◽  
Brian E Leonard
Keyword(s):  
Animal Models ◽  
Drug Treatment ◽  
Mood Disorders ◽  
Psychotropic Drugs ◽  
Affective Disorders ◽  
Mood States ◽  
Induced Mood

Abstract Many patients under treatment for mood disorders, in particular patients with bipolar mood disorders, experience episodes of mood switching from one state to another. Various hypotheses have been proposed to explain the mechanism of mood switching, spontaneously or induced by drug treatment. Animal models have also been used to test the role of psychotropic drugs in the switching of mood states. We examine the possible relationship between the pharmacology of psychotropic drugs and their reported incidents of induced mood switching, with reference to the various hypotheses of mechanisms of mood switching.

scholarly journals The role of the circadian clock in animal models of mood disorders.

2014 ◽  
Vol 128 (3) ◽  
pp. 344-359 ◽  
Author(s):  
Dominic Landgraf ◽  
Michael J. McCarthy ◽  
David K. Welsh
Keyword(s):  
Animal Models ◽  
Circadian Clock ◽  
Mood Disorders

Molecular Link between Circadian Rhythmicity and Mood Disorders

2021 ◽  
Vol 28 ◽  
Author(s):  
Frank Faltraco ◽  
Denise Palm ◽  
Andrew Coogan ◽  
Frederick Simon ◽  
Oliver Tucha ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Mood Disorders ◽  
Affective Disorders ◽  
Current Knowledge ◽  
Unipolar Depression ◽  
Internal Clock ◽  
Circadian Genes ◽  
Pubmed Database

Background: The internal clock is driven by circadian genes [e.g., Clock, Bmal1, Per1-3, Cry1-2], hormones [e.g., melatonin, cortisol], as well as zeitgeber [‘synchronisers’]. Chronic disturbances in the circadian rhythm in patients diagnosed with mood disorders have been recognised for more than 50 years. Objectives: The aim of this review is to summarise the current knowledge and literature regarding circadian rhythms in the context of mood disorders, focussing on the role of circadian genes, hormones, and neurotransmitters. Method: The review presents the current knowledge and literature regarding circadian rhythms in mood disorders using the Pubmed database. Articles with a focus on circadian rhythms and mood disorders [n=123], particularly from 1973 to 2020, were included. Results: The article suggests a molecular link between disruptions in the circadian rhythm and mood disorders. Circadian disturbances, caused by the dysregulation of circadian genes, hormones, and neurotransmitters, often result in a clinical picture resembling depression. Conclusion: Circadian rhythms are intrinsically linked to affective disorders, such as unipolar depression and bipolar disorder.

The Role of Specialised Units in the Treatment of Affective Disorders

1991 ◽  
Vol 25 (4) ◽  
pp. 491-498 ◽  
Author(s):  
R. William Lyndon
Keyword(s):  
Mood Disorders ◽  
Affective Disorders ◽  
Psychiatric Services ◽  
Bipolar Illness ◽  
Research And Education ◽  
And Function ◽  
Role And Function

Units which specialise in the treatment of affective (mood) disorders are gaining popularity in Australia and overseas. This paper examines the history, role and function of these units with particular reference to their benefits and disadvantages. Specialised units can offer advantages in the assessment and management of depression and bipolar illness, as well as being centres for research and education. Further research into their effectiveness is needed to enable their rational integration into existing psychiatric services.

scholarly journals Optogenetic Dissection of Neural Circuits Underlying Stress-Induced Mood Disorders

2021 ◽  
Vol 12 ◽  
Author(s):  
Qing Liu ◽  
Zhinuo Zhang ◽  
Wenjuan Zhang
Keyword(s):  
Mood Disorders ◽  
Stress Reactivity ◽  
Neural Circuits ◽  
Web Of Science ◽  
Anxiety And Depression ◽  
Social Avoidance ◽  
Optogenetic Stimulation ◽  
Induced Mood ◽  
Stimulation Of

Objectives: This review aims to (i) summarize the literature on optogenetic applications of different stress-induced mood disorder models of the medial prefrontal cortex (mPFC) and its projection circuits, and (ii) examine methodological variability across the literature and how such variations may influence the underlying circuits of stress-induced mood disorders.Methods: A variety of databases (PubMed, Web of Science, Elsevier, Springer, and Wiley) were systematically searched to identify optogenetic studies that applied to mood disorders in the context of stress.Results: Eleven studies on optogenetic stimulation of the mPFC and the effect of its efferent circuitry on anxiety- and depression-like behaviors in different rodent models were selected. The results showed that the optogenetics (i) can provide insights into the underlying circuits of mood disorders in the context of stress (ii) and also points out new therapeutic strategies for treating mood disorders.Conclusions: These findings indicate a clear role for the mPFC in social avoidance, and highlight the central role of stress reactivity circuitry that may be targeted for the treatment of stress-induced mood disorders.

Cellular and animal models in pheochromocytoma/paragangliomas research: role of microenvironment

2016 ◽  
Author(s):  
M Mannelli ◽  
E Rapizzi ◽  
L Canu ◽  
T Ercolino ◽  
V Giache
Keyword(s):  
Animal Models

1758-P: Type 2 Diabetes–Associated Mood Disorders: Role of Insulin Resistance in Serotonergic Neurons

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1758-P
Author(s):  
HUGO MARTIN ◽  
SÉBASTIEN BULLICH ◽  
FABIEN DUCROCQ ◽  
MARION GRALAND ◽  
CLARA OLIVRY ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mood Disorders ◽  
Serotonergic Neurons ◽  
P Type

EMDR as therapy for conditions other than PTSD: a systematic review.

2020 ◽  
Author(s):  
Charles Scelles ◽  
LUIS CARLO BULNES
Keyword(s):  
Mood Disorders ◽  
Obsessive Compulsive ◽  
Treatment As Usual ◽  
Compulsive Disorder ◽  
Adult Personality ◽  
Post Traumatic ◽  
Psychiatric Conditions ◽  
Research Criteria ◽  
Positive Effect

Eye Movement Desensitization and Reprocessing (EMDR) is a treatment for post-traumatic stressdisorder (PTSD). The technique is known to stimulate the capacity to reprocess maladaptive memoriesthat are thought to be central to this pathology. Here we investigate if EMDR therapy can be used in otherconditions than PTSD. We conducted a systematic literature search on PubMed, ScienceDirect, Scopus, and Web of Science. Wesearched for published empirical findings on EMDR, excluding those centred on trauma and PTSD,published up to 2020. The results were classified by psychiatric categories.   Ninety articles met our research criteria. A positive effect was reported in addictions, somatoformdisorders, sexual dysfunction, eating disorder, disorders of adult personality, mood disorders, reaction tosevere stress, anxiety disorders, performance anxiety, Obsessive-Compulsive Disorder (OCD), pain,neurodegenerative disorders, paedopsychiatry and sleep. The evidence was more consistent in pain, OCD,mood disorders, and reaction to severe stress.EMDR’s efficiency across numerous pathological situations, highlighted the central role of affectivememory in several psychiatric and non-psychiatric conditions. Furthermore, EMDR seems to besuccessful in usually uncooperative (e.g. Dementia) or unproductive cases (e.g. aphasia). Moreover, insome severe medical situations were psychologic distress was an obstacle, EMDR allowed thecontinuation of treatment-as-usual. Our review suggests that it is a safe and economical therapeuticoption, and its effect in non-pathological situations opens new avenues for translational research. Overallmore methodologically rigorous studies are needed.

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