Very high rates of vitamin D insufficiency in women of child-bearing age living in Beijing and Hong Kong

We aimed to describe the vitamin D status of young women living in two Chinese cities in the spring – Beijing in the north (latitude 39° north) and Hong Kong (latitude 22° north) in the south. We also examined the relationship between serum 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations to determine a threshold for serum 25-hydroxyvitamin D above which there is no further suppression of PTH. Finally, we examined whether dietary Ca intake influences this relationship. Non-pregnant women aged 18–40 years (n 441) were recruited between February and June. Fasting blood was collected and dietary intakes were assessed using 5 d food records. Mean serum 25-hydroxyvitamin D concentration was lower in Beijing than Hong Kong women (29 v. 34 nmol/l; P < 0·001). Vitamin D deficiency ( ≤ 25 nmol/l) was indicated in 40 % of Beijing and 18 % of Hong Kong women, and over 90 % of women in both cities were insufficient ( ≤ 50 nmol/l). Mean Ca and vitamin D intakes were 478 mg/d and 2·0 μg/d, respectively. The relationship between 25-hydroxyvitamin D concentration and PTH was linear throughout the range with a slope of − 0·36 (different from 0; P < 0·001; R 0·26), with no apparent threshold. There was no influence of Ca intake on the relationship between 25-hydroxyvitamin D and PTH concentration. Vitamin D deficiency is common and insufficiency is very common in non-pregnant women in Hong Kong and Beijing during spring. Serum 25-hydroxyvitamin D was inversely associated with PTH with no apparent threshold. Strategies such as vitamin D fortification or supplementation may be required.

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Vitamin D Status and Its Determinants in Healthy Slovenian Pregnant Women

Annals of Nutrition and Metabolism ◽

10.1159/000439093 ◽

2015 ◽

Vol 67 (2) ◽

pp. 96-103 ◽

Cited By ~ 5

Author(s):

Aneta Soltirovska Salamon ◽

Evgen Benedik ◽

Borut Bratanič ◽

Manca Velkavrh ◽

Irena Rogelj ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Sun Exposure ◽

Physical Activities ◽

Dietary Intakes ◽

Hydroxyvitamin D ◽

Day Range ◽

The Status ◽

25 Hydroxyvitamin D

Background/Aims: Vitamin D deficiency is a common underdiagnosed condition. The aim of this was to analyze the status of vitamin D and its determinants in healthy Slovenian pregnant women. Methods: A total of 132 volunteer pregnant women completed a questionnaire including baseline demographics, food frequency, physical activities; anthropometrical measurements, body mass index and levels of 25-(OH)D in serum were performed during the third trimester, and dietary intakes were assessed during the 27-28th week of gestation. Results: Vitamin D deficiency was present in 14% while insufficiency was present in 41% of women. The risk for inadequacy was higher in women older than 30 years (p = 0.01), in those with less frequent outdoor physical activity (p = 0.01) and in pregnancies during the low sun exposure season (p = 0.04). Insufficiency was not significantly more frequent in less educated women, unemployed and in those living in urban area. The median value of vitamin D from habitual dietary intake was 1.5 µg/day (range 0.1-13.4) and did not influence 25-hydroxyvitamin D level (p = 0.91). Conclusions: The prevalence of vitamin D inadequacy was 55% and was dependent on age, season and outdoor physical activities. The results suggest a discrepancy between vitamin D intake through habitual diet and the reference needs.

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Vitamin D in Therapeutics: Past, Present and Future

MVP Journal of Medical Sciences ◽

10.18311/mvpjms/2016/v3/i2/6390 ◽

2016 ◽

Vol 3 (2) ◽

pp. 128

Author(s):

Jeetendra Singh ◽

Sameer B. Dharrao ◽

Tushar Baheti

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Human Body ◽

Indian Population ◽

Vitamin D Insufficiency ◽

Direct Sunlight ◽

Hydroxyvitamin D ◽

Patients At Risk ◽

25 Hydroxyvitamin D ◽

In The Beginning

In the beginning of 20th century vitamin D was classified as a vitamin but later considered as a prohormone ("conditional" vitamin) which influences the expression of more than 200 genes in the human body. Worldwide vitamin D insufficiency affects about 50% of the population and in India about 80% of population has vitamin D level less than normal. In India sunshine is abundant but still Indians are deprived of this sunshine vitamin. Minimal exposure to direct sunlight, staying indoors, use of sunscreen lotions, pollution, clothing, dietary and cooking habits are most important factors for vitamin D deficiency in the Indian population. Serum 25 hydroxyvitamin D level is the initial diagnostic test in patients at risk for deficiency. Treatment with either vitamin D2 or vitamin D3 is recommended for patients having deficiency, keeping hypervitaminosis in mind.

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Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis

Dermatology ◽

10.1159/000517514 ◽

2021 ◽

pp. 1-8

Author(s):

Yusuf Hasamoh ◽

Kunlawat Thadanipon ◽

Premjit Juntongjin

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Inverse Association ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Newcastle Ottawa Scale ◽

25 Hydroxyvitamin D ◽

The Relationship ◽

Ottawa Scale

Background: Vitamin D deficiency is frequently associated with several medical conditions. However, a comprehensive meta-analysis assessing the association between vitamin D level and acne is lacking. Objective: To determine the relationship between vitamin D level and acne, and to assess the association between vitamin D level and acne severity. Methods: This meta-analysis was assessed by using the PubMed, EMBASE, Cochrane, and Scopus databases following the PRISMA guidelines. Serum/plasma 25-hydroxyvitamin D (25[OH]D) level, vitamin D deficiency, and the severity association between acne patients and healthy controls (HCs) were evaluated. The quality assessment was performed by using the Newcastle-Ottawa Scale. Results: Thirteen articles with a total of 1,362 acne patients and 1,081 HCs were included. The circulating 25(OH)D levels were significantly lower in patients with acne than in HCs (pooled MD = –9.02 ng/mL, 95% CI = –13.22 to –4.81, p < 0.0001). Vitamin D deficiency was more prevalent in acne patients than in HCs (pooled OR = 2.97, 95% CI = 1.68–5.23, I2 = 72%). Also, vitamin D levels were negatively correlated with acne severity. Conclusion: This meta-analysis demonstrated the significantly low vitamin D levels in acne patients. Also, there was evidence of an inverse association between vitamin D levels and acne severity. Therefore, vitamin D might be involved in the pathogenesis of acne.

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Vitamin D supply of patients with hip fracture

Orvosi Hetilap ◽

10.1556/oh.2014.29878 ◽

2014 ◽

Vol 155 (17) ◽

pp. 659-668 ◽

Cited By ~ 1

Author(s):

Antal Salamon ◽

Balázs Hepp ◽

Ákos Mátrai ◽

Csaba Biró ◽

Katalin Ágota ◽

...

Keyword(s):

Vitamin D ◽

Hip Fracture ◽

Vitamin D Deficiency ◽

Hip Fractures ◽

Hydroxyvitamin D ◽

Control Subjects ◽

25 Hydroxyvitamin D ◽

Few Data ◽

Prevention And Cure ◽

The Relationship

Introduction: Vitamin D deficiency is an important risk factor for fractures. However, there are few data available only on the relationship between serum 25-hydroxyvitamin D levels and recovery after surgery for hip fracture. Aim: The authors investigate the vitamin D supply of patients with hip fractures. Method: Between February and September 2013, serum 25-hydroxyvitamin D and parathyroid hormone levels were determined in 203 patients with hip fracture (74.8±11.5 ys; 67 men and 136 women) and in 74 control subjects. Results: Vitamin D deficiency and secondary hyperparathyroidism occurred significantly more frequently in patients with hip fracture than in control subjects (72% vs. 45%, and 33% vs. 17%, respectively). Patients with better condition after surgery showed higher 25-hydroxyvitamin D levels (p<0.001) than those with poor condition. Serum 25-hydroxyvitamin D were lower in the 31 patients who died [median of survival time: 19 (5–52) days] compared to those who survived [22.6 (9.5–45.0) vs. 33.0 (16.5–56.6) nmol/l]. Conclusions: The association between vitamin-D deficiency and mortality as well as the positive correlation between serum 25-hydroxyvitamin D levels and better postoperative condition confirm the importance of proper vitamin D supply in the prevention and cure of hip fractures, what is more in the increase of the chance of survival. Orv. Hetil., 2014, 155(17), 659–668.

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Significant Independent Predictors of Vitamin D Deficiency in Inpatients and Outpatients of a Nephrology Unit

International Journal of Endocrinology ◽

10.1155/2013/237869 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Recep Bentli ◽

Hulya Taskapan ◽

Halil Toktaş ◽

Ozkan Ulutas ◽

Adnan Ozkahraman ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Female Gender ◽

Vitamin D Insufficiency ◽

Vitamin D Supplementation ◽

Documentary Evidence ◽

Hydroxyvitamin D ◽

Nitrogen Levels ◽

25 Hydroxyvitamin D ◽

Higher Doses

Aims. Kidney disease was found to be a major risk factor for vitamin D deficiency in a population study of patients hospitalized. The aims of the study were to describe the prevalence of vitamin D deficiency inpatients and outpatients in a nephrology department during fall and to evaluate effect of assessing serum 25-hydroxyvitamin D (25(OH)D) levels and previous supplementation of cholecalciferol on vitamin D status.Methods. We studied 280 subjects in total, between October and January. The subjects were recruited from the following two groups: (a) inpatients and (b) outpatients in nephrology unit. We examined previous documentary evidence of vitamin D supplementation of the patients.Results. The prevalence of vitamin D deficiency among these 280 patients was 62,1% (174 patients). Fifty-three patients (18.9%) had severe vitamin D deficiency, 121 patients (43.2%) moderate vitamin D deficiency, and 66 patients (23.6%) vitamin D insufficiency. In logistic regression analysis female gender, not having vitamin D supplementation history, low serum albumin, and low blood urea nitrogen levels were significant independent predictors of vitamin D deficiency while no association of vitamin D deficiency with diabetes mellitus, serum creatinine, eGFR, and being hospitalized was found.Conclusion. Vitamin D deficiency, seems to be an important problem in both inpatients and outpatients of nephrology. Monitoring serum 25(OH)D concentrations regularly and replacement of vitamin D are important. Women in Turkey are at more risk of deficiency and may therefore need to consume higher doses of vitamin D.

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High prevalence of vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-03802-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Linda Ahenkorah Fondjo ◽

Worlanyo Tashie ◽

William K. B. A. Owiredu ◽

Enoch Appiah Adu-Gyamfi ◽

Laila Seidu

Keyword(s):

Vitamin D ◽

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Hypovitaminosis D ◽

Sub Saharan Africa ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

In Pregnancy

Abstract Background Hypovitaminosis D in pregnancy is associated with adverse health outcomes in mothers, newborns and infants. This study assessed the levels of 25-hydroxyvitamin D [25(OH)D] in normotensive pregnancies and in preeclampsia, evaluated the association between vitamin D deficiency and preeclampsia risk; and determined the foeto-maternal outcome in preeclamptic women with vitamin D deficiency. Methods This case-control study was conducted among pregnant women who visited the Comboni Hospital, in Ghana from January 2017 to May 2018 for antenatal care. A total of 180 pregnant women comprising 88 preeclamptic women (PE) and 92 healthy normotensive pregnant women (NP) were recruited. Socio-demographic, clinical and obstetric data were obtained using validated questionnaires. Blood pressure and anthropometrics were measured, and blood samples were collected for the estimation of 25- hydroxyvitamin D [25(OH)D] using enzyme-linked immunosorbent assay technique. Lipids (total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol) were also estimated. Results A total of 81.7% of the study participants had vitamin D deficiency. Of these, 88.6% of the women with PE had vitamin D deficiency compared to 75.0% in the NP. Vitamin D levels were significantly reduced in the PE women compared to the normotensive pregnant women (p = 0.001). A higher proportion of the preeclamptic women who were vitamin D deficient had preterm delivery (p < 0:0001) and delivered low birth weight infants (p < 0:0001), and infants with IUGR (p < 0:0001) compared to the control group (p < 0:0001). Pregnant women with PE presented with significant dyslipidemia, evidenced by significantly elevated TC (p = 0.008), LDL (p < 0.0001), triglycerides (p = 0.017) and a significantly reduced HDL (p = 0.001) as compared to NP. In the preeclamptic women, serum 25(OH) D showed an inverse, but not significant association with TC (β = − 0.043, p = 0.722, TG (β = − 0.144, p = 0.210) and LDL (β = − 0.076, p = 0.524) and a positive, but not significant association with HDL (β = 0.171, p = 0.156). Conclusion The prevalence of vitamin D deficiency is high in both normotensive pregnancies and pregnancies complicated by preeclampsia but amplified in preeclampsia. Higher proportion of pregnant women with hypovitaminosis D had preterm babies and delivered low birth weight neonates. Additional studies are needed to explore the potential benefits and optimal dosing of vitamin D use in pregnancy, especially in sub-Saharan Africa.

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Evaluation of Maternal Serum 25-Hydroxyvitamin D Levels in Patients with Hyperemesis Gravidarum at Early Gestational Weeks

Eurasian Journal of Family Medicine ◽

10.33880/ejfm.2020090302 ◽

2020 ◽

Vol 9 (3) ◽

pp. 123-130

Author(s):

Burcu Kayılı ◽

Muhammet Ali Oruç ◽

Yasemin Alan ◽

Murat Alan ◽

Deniz Can Öztekin

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Hyperemesis Gravidarum ◽

Control Group ◽

Hydroxyvitamin D ◽

Severe Deficiency ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Mean

Aim: The aim of this study was to compare vitamin D levels between pregnant women with hyperemesis gravidarum before 12 weeks of gestation and healthy pregnant women at similar ages. Methods: Sixty pregnancies with hyperemesis gravidarum and 60 age compatible healthy pregnancies applied to our facility were included in the study. Demographic characteristics, maternal thyroid function tests and 25-Hydroxyvitamin D levels were evaluated. Student t test was used for the variables with normal distribution and Mann-Whitney U test was used to analyze the variables without normal distribution. Results: Only one pregnant woman had normal vitamin D levels (>30ng/ml), whereas 71 patients had deficiency (10-30 ng/ml), and 48 had severe deficiency (<10 ng/ml). The mean vitamin D level of the total 120 pregnancies was 11.9±5.00 ng/ml (9.92±3.67 ng/ml in case group, 13.88±5.38 ng/ml in control group). The mean value of vitamin D was found to be significantly lower in hyperemesis gravidarum. 45% (n=27) of the pregnant women had vitamin D deficiency, whereas 55% (n=33) of them had severe deficiency. Free T3 and T4 levels were significantly higher than the control group, and thyroid-stimulating hormone level was significantly lower. Conclusion: Vitamin D levels of pregnant women with hyperemesis gravidarum were significantly lower. Vitamin D deficiency should be considered in patients with hyperemesis gravidarum. Keywords: pregnancy, hyperemesis gravidarum, Vitamin D deficiency

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Prevalensi Defisiensi Vitamin D Dan Faktor-Faktor Yang Mempengaruhinya Pada Orang Hidup Dengan HIV/AIDS (ODHA) di RSPI Prof. Dr. Sulianti Saroso

The Indonesian Journal of Infectious Diseases ◽

10.32667/ijid.v1i01.2 ◽

2017 ◽

Vol 1 (01) ◽

pp. 6

Author(s):

Maya M Montain ◽

Janto G. Sinulingga ◽

NFN Fatmawati ◽

NFN Herlina ◽

Nursanti Kurniastuti

Keyword(s):

Vitamin D ◽

Antiretroviral Therapy ◽

Vitamin D Deficiency ◽

Immune Reconstitution ◽

Vitamin D Insufficiency ◽

Immune Reconstitution Syndrome ◽

Hydroxyvitamin D ◽

The People ◽

25 Hydroxyvitamin D ◽

Hiv Aids

Abstract:Most people with HIV AIDS have been found with vitamin D deficiency, which is evidently influence by efavirenz as one of antiretroviral therapy (ART) regimen for HIV AIDS therapy, the characteristics of people with HIV AIDS, vitamin D intake, people with HIV AIDS life style, & drug intake that effect vitamin D level. 25-hydroxyvitamin D (D 25-OH) serumlevel measured vitamin D status at people with HIV AIDS. Vitamin D insufficiency was defined at 50-75 nmol/ml (20-30 ng/ml)D 25 OH , while vitamin D deficiency was defined under 50 nmol/ml (< 20 ng/ml) D 25-OH. Vitamin D is needed to maintain the health of bone and adequate immune function, that controled HIV infection. Vitamin D deficiency can increase the risk of bone fracture and Immune Reconstitution Syndrome(IRIS). Up to now, there has not been any data of the prevalence of vitamin D deficiency and its influencing factors on the people with HIV AIDS in Indonesia. The objective of this research is to understand the prevalence of vitamin D deficiency and its influencing factors on the people with HIV AIDS in Sulianti Saroso communicable disease hospital, that already have or not yet have ART intake . The results indicated that 88,8% people with HIV AIDS suffered vitamin D deficiency, and 11,2% suffered vitamin D insufficiency. The tested factors did not evidently influence the vitamin D deficiency.Abstrak. Defisiensi vitamin D ditemukan pada sebagian besar Orang Dengan HIV/AIDS (ODHA) dimana defisiensi ini dipengaruhi salah satunya oleh efavirenz sebagai rejimen NNRTI yang merupakan salah satu rejimen ART (Antiretroviral Therapy) dalam terapi pengobatan ODHA. Faktor-faktor lain yang juga diduga berpengaruh terhadap defisiensi vitamin D pada ODHA adalah karakteristik ODHA, asupan sumber vitamin D, perilaku ODHA, dan juga konsumsi obat-obatan yang dapat mempengaruhi kadar vitamin D. Kadar vitamin D diketahui dengan mengukur kadar serum 25-hydroxyvitamin D dan dikategorikan sebagai insufiensi atau ketidakcukupan vitamin D bila kadar D 25-OH mencapai 50-75 nmol/ml (20-30 ng/ml), dan dikategorikan sebagai defisiensi atau kekurangan vitamin D bila jika kadar D 25-OH mencapai < 50 nmol/ml (< 20 ng/ml). Vitamin D dibutuhkan untuk mempertahankan kesehatan tulang dan untuk fungsi imun yang adekuat, yang membantu mengendalikan infeksi HIV. Defisiensi vitamin D pada ODHA dapat meningkatkan resiko fraktur tulang dan terjadinya Immune Reconstitution Syndrome (IRIS). Hingga saat ini belum ada data di Indonesia tentang prevalensi defisiensi D pada ODHA, serta faktor-faktor yang mempengaruhinya. Penelitian ini bertujuan mengetahui prevalensi defisiensi vitamin D pada 107 ODHA di RSPI Prof. Dr. Sulianti Saroso tahun 2010, baik yang belum maupun yang sudah mendapat ART dengan faktor-faktor yang mempengaruhinya. Hasil penelitian menyebutkan bahwa 88,8% ODHA mengalami defisiensi vitamin D, dan yang mengalami insufisiensi vitamin D sebanyak 11,2%. Namun faktor-faktor yang diuji tidak menunjukkan pengaruh yang signifikan terhadap defisiensi vitamin D.

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Prevalence and determinants of vitamin D deficiency and insufficiency among three immigrant groups in Finland: evidence from a population-based study using standardised 25-hydroxyvitamin D data

Public Health Nutrition ◽

10.1017/s1368980019004312 ◽

2020 ◽

Vol 23 (7) ◽

pp. 1254-1265

Author(s):

Folasade A Adebayo ◽

Suvi T Itkonen ◽

Eero Lilja ◽

Tuija Jääskeläinen ◽

Annamari Lundqvist ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Migrant Health ◽

Population Based ◽

Vitamin D Insufficiency ◽

Dietary Vitamin ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

Dairy Consumption ◽

25 Hydroxyvitamin D

AbstractObjective:We investigated the determinants of serum 25-hydroxyvitamin D [S-25(OH)D] and dietary vitamin D sources among three immigrant groups in Finland and compared their S-25(OH)D to the general Finnish population.Design:Cross-sectional population-based Migrant Health and Wellbeing Study and the nationally representative Finnish Health 2011 Survey. S-25(OH)D was standardised according to the Vitamin D Standardisation Program. Vitamin D sources were assessed by interview.Setting:Six different municipalities in Finland (60°–63°N).Participants:Immigrants aged 18–64 years (446 Russians, 346 Somalis, 500 Kurds), 798 Finns aged 30–64 years.Results:The mean of S-25(OH)D was 64 (95 % CI 62, 66), 44 (95 % CI 41, 46), 35 (95 % CI 34, 37) and 64 (95 % CI 62, 66) nmol/l for Russians, Somalis, Kurds and Finns, respectively. S-25(OH)D among Somalis and Kurds was lower compared with Finns (P < 0·001). The prevalence of vitamin D deficiency (S-25(OH)D <30 nmol/l) and insufficiency (S-25(OH)D <50 nmol/l) was higher among immigrants than Finns (P < 0·001). Vitamin D-rich foods differed between the groups; vitamin D-fortified fat spread consumption was higher among Somalis (91 %) than among Russians (73 %) and Kurds (60 %); fish was less consumed among Kurds (17 %) than among Russians (43 %) and Somalis (38 %); and 57 % Russians, 56 % Kurds and 36 % Somalis consumed vitamin D-fortified dairy daily (P < 0·001 for all). Daily smoking, alcohol consumption and winter blood sampling were determinants of vitamin D insufficiency (P ≤ 0·03). Older age, physical activity, fish and vitamin D-fortified dairy consumption were associated with lower odds of insufficiency (P ≤ 0·04).Conclusions:Vitamin D status differed among immigrant groups and the determinants are, to some degree, associated with learned or existing cultural behaviours.

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The D-Lightful Vitamin D for Health / Vitamin D Za Dobro Zdravlje

Journal of Medical Biochemistry ◽

10.2478/v10011-012-0025-y ◽

2013 ◽

Vol 32 (1) ◽

pp. 1-58 ◽

Cited By ~ 12

Author(s):

Michael F. Holick

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Sun Exposure ◽

Vitamin D Insufficiency ◽

Skeletal Health ◽

Neurocognitive Dysfunction ◽

Hydroxyvitamin D ◽

Health And Wellbeing ◽

25 Hydroxy Vitamin D ◽

25 Hydroxyvitamin D

Summary Vitamin D is the sunshine vitamin that is not only important for children’s and adults’ skeletal health but is also important for their overall health and wellbeing. Vitamin D deficiency has been defined as a 25-hydroxyvitamin D < 20 ng/mL and vitamin D insufficiency as a 25-hydroxyvitamin D of 21-29 ng/mL. The major source of vitamin D is sensible sun exposure since very few foods naturally contain vitamin D. Vitamin D deficiency is associated with in - creased risk for many acute and chronic diseases including infectious diseases, autoimmune diseases, cardiovascular disease, type 2 diabetes, neurocognitive dysfunction and muscle weakness. To achieve a blood level of 25-hydroxy - vitamin D >30 ng/mL children require 600-1 000 IUs and adults 1 500-2 000 IUs of vitamin D daily.

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