Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis

Dermatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Yusuf Hasamoh ◽  
Kunlawat Thadanipon ◽  
Premjit Juntongjin
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Inverse Association ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Newcastle Ottawa Scale ◽  
25 Hydroxyvitamin D ◽  
The Relationship ◽  
Ottawa Scale

<b><i>Background:</i></b> Vitamin D deficiency is frequently associated with several medical conditions. However, a comprehensive meta-analysis assessing the association between vitamin D level and acne is lacking. <b><i>Objective:</i></b> To determine the relationship between vitamin D level and acne, and to assess the association between vitamin D level and acne severity. <b><i>Methods:</i></b> This meta-analysis was assessed by using the PubMed, EMBASE, Cochrane, and Scopus databases following the PRISMA guidelines. Serum/plasma 25-hydroxyvitamin D (25[OH]D) level, vitamin D deficiency, and the severity association between acne patients and healthy controls (HCs) were evaluated. The quality assessment was performed by using the Newcastle-Ottawa Scale. <b><i>Results:</i></b> Thirteen articles with a total of 1,362 acne patients and 1,081 HCs were included. The circulating 25(OH)D levels were significantly lower in patients with acne than in HCs (pooled MD = –9.02 ng/mL, 95% CI = –13.22 to –4.81, <i>p</i> &#x3c; 0.0001). Vitamin D deficiency was more prevalent in acne patients than in HCs (pooled OR = 2.97, 95% CI = 1.68–5.23, <i>I</i><sup>2</sup> = 72%). Also, vitamin D levels were negatively correlated with acne severity. <b><i>Conclusion:</i></b> This meta-analysis demonstrated the significantly low vitamin D levels in acne patients. Also, there was evidence of an inverse association between vitamin D levels and acne severity. Therefore, vitamin D might be involved in the pathogenesis of acne.

Prevalence of Vitamin D Deficiency among Patients Attending a General Otolaryngology Clinic in South Auckland

2009 ◽  
Vol 118 (5) ◽  
pp. 326-328 ◽  
Author(s):  
Jim Bartley ◽  
David Reid ◽  
Randall P. Morton
Keyword(s):  
Vitamin D ◽  
Statistical Analysis ◽  
Vitamin D Deficiency ◽  
Prospective Observational Study ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Relationship Of ◽  
The Relationship

Objectives: We performed a prospective observational study to estimate the prevalence of vitamin D deficiency in patients attending a general otolaryngology clinic in South Auckland, New Zealand. Methods: From July 21, 2008, to August 7, 2008, all new patients presenting to otolaryngology clinics at which one of the authors (D.R.) was present had their vitamin D status assessed by measurement of their plasma 25-hydroxyvitamin D [25(OH)D] level. Results: Of 48 patients, 2% had 25(OH)D levels of 17.5 nmol/L or less (a level associated with osteomalacia), 58% had 25(OH)D levels of 50 nmol/L or less (a level associated with vitamin D deficiency), and 100% had 25(OH)D levels of 80 nmol/L or less. Conclusions: Most of the patients attending a general otolaryngology clinic in South Auckland are vitamin D–deficient. It is unclear whether low vitamin D levels are associated more directly with otolaryngological disorders or skin type, because the small size of this study and the broad range of conditions seen precluded a meaningful statistical analysis. Further research into the relationship of vitamin D to specific otolaryngological presentations is required.

scholarly journals Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population

2019 ◽  
pp. 278-282
Author(s):  
Mahboobeh-Sadat Hosseini ◽  
Fereshteh Salarvand ◽  
Amir Houshang Ehsani ◽  
Pedram Noormohammadpour ◽  
Shadi Azizzadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Outdoor Environment ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
History Of ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Objective: To investigate the relationship between vitamin D levels and the incidence of skin SCC for the first time in Iran. Methods and Study Design: In this case-control study, 126 subjects were enrolled (63 in each group) out of referents to Razi Skin Hospital in Tehran in 2014. The risk factors for cancer gathered by self-reported questionnaires and blood samples were obtained to measure the level of 25-hydroxyvitamin D. Multivariate logistic regression was used to neutralize the effect of confounding factors. Results: Cases of SCC were more likely to be in men, older than 49 years and working in an outdoor environment, and with longtime exposure to sunlight and a personal history of skin cancers. Family history of skin cancer and of cigarette smoking were not significantly related to SCC. In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P < 0.001). Mean level of 25-hydroxyvitamin D was 40.99 ng/mL in the SCC group and 26.34 ng/mL in the control group (P < 0.05). In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk. In the adjusted model, vitamin D did not independently predict the likelihood of SCC. Conclusion: Vitamin D level and SCC risk are directly related, although not in an independent fashion. Indeed, this relation is severely confounded by exposure to sunlight, which was evidenced by an increased vitamin D level in the people working outside and the higher prevalence of SCC in the same population.

scholarly journals Role of Vitamin D Supplements in Prevention of Hungry Bone Syndrome after Successful Parathyroidectomy for Primary Hyperparathyroidism: A Prospective Study

2020 ◽  
pp. 145749692096260
Author(s):  
M. A. Salman ◽  
A. Rabiee ◽  
A. Salman ◽  
A. Youssef ◽  
H. E.-D. Shaaban ◽  
...  
Keyword(s):  
Vitamin D ◽  
Primary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Statistical Significance ◽  
Mineral Density ◽  
Hydroxyvitamin D ◽  
Group I ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements

Background: We postulated that the preoperative correction of vitamin D levels can significantly reduce the incidence of hunger bone syndrome among patients undergoing parathyroidectomy for primary hyperparathyroidism. Methods: We performed a prospective, randomized, open-label study on 102 patients with primary hyperparathyroidism and coexisting vitamin D deficiency who were scheduled to undergo parathyroidectomy. Patients were divided into the following two groups: group I which included 52 patients who did not receive preoperative vitamin D supplementation; and group II which included 50 patients who received cholecalciferol 1000–2000 IU daily or 50000 IU weekly until they achieve vitamin D levels >20 ng/mL (group IIa = 25 patients) or vitamin D levels >30 ng/mL (group IIb = 25 patients). Results: The incidence of hunger bone syndrome in group IIb was lower than group I and group IIa (8% versus 16% versus 23%, respectively); however, this difference did not reach the level of statistical significance (p = 0.22). Patients with hunger bone syndrome were significantly younger and had higher serum phosphorus, alkaline phosphatase, magnesium, and bone mineral density at baseline than patients without hunger bone syndrome. On the other hand, patients with hunger bone syndrome had significantly lower 25-hydroxyvitamin D at baseline than patients without hunger bone syndrome (p = 0.001). The ROC curve showed that the baseline level of serum 25-hydroxyvitamin D was not an independent discriminator of hunger bone syndrome (area under curve = 0.21 (95% CI: 0.06–0.34); p = 0.011). Conclusion: Preoperative course of vitamin D supplements has no preventive role on the postoperative incidence of hunger bone syndrome among patients with primary hyperparathyroidism and coexisting vitamin D deficiency undergoing parathyroidectomy.

scholarly journals Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis

Endocrinology ◽  
2016 ◽  
Vol 157 (4) ◽  
pp. 1341-1347 ◽  
Author(s):  
Jasmaine D. Williams ◽  
Abhishek Aggarwal ◽  
Srilatha Swami ◽  
Aruna V. Krishnan ◽  
Lijuan Ji ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cancer Metastasis ◽  
Receptor Expression ◽  
Inverse Association ◽  
Primary Tumors ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Signaling

Abstract Patients with breast cancer (BCa) frequently have preexisting vitamin D deficiency (low serum 25-hydroxyvitamin D) when their cancer develops. A number of epidemiological studies show an inverse association between BCa risk and vitamin D status in humans, although some studies have failed to find an association. In addition, several studies have reported that BCa patients with vitamin D deficiency have a more aggressive molecular phenotype and worse prognostic indicators. However, it is unknown whether this association is mechanistically causative and, if so, whether it results from systemic or tumor autonomous effects of vitamin D signaling. We found that ablation of vitamin D receptor expression within BCa cells accelerates primary tumor growth and enables the development of metastases, demonstrating a tumor autonomous effect of vitamin D signaling to suppress BCa metastases. We show that vitamin D signaling inhibits the expression of the tumor progression gene Id1, and this pathway is abrogated in vitamin D deficiency in vivo in 2 murine models of BCa. These findings are relevant to humans, because we discovered that the mechanism of VDR regulation of Inhibitor of differentiation 1 (ID1) is conserved in human BCa cells, and there is a negative correlation between serum 25-hydroxyvitamin D levels and the level of ID1 in primary tumors from patients with BCa.

scholarly journals Very high rates of vitamin D insufficiency in women of child-bearing age living in Beijing and Hong Kong

2008 ◽  
Vol 99 (6) ◽  
pp. 1330-1334 ◽  
Author(s):  
Jean Woo ◽  
Christopher W. K. Lam ◽  
Jason Leung ◽  
Winny Y. Lau ◽  
Edith Lau ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hong Kong ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Vitamin D Insufficiency ◽  
Dietary Intakes ◽  
Hydroxyvitamin D ◽  
The North ◽  
25 Hydroxyvitamin D ◽  
The Relationship

We aimed to describe the vitamin D status of young women living in two Chinese cities in the spring – Beijing in the north (latitude 39° north) and Hong Kong (latitude 22° north) in the south. We also examined the relationship between serum 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations to determine a threshold for serum 25-hydroxyvitamin D above which there is no further suppression of PTH. Finally, we examined whether dietary Ca intake influences this relationship. Non-pregnant women aged 18–40 years (n 441) were recruited between February and June. Fasting blood was collected and dietary intakes were assessed using 5 d food records. Mean serum 25-hydroxyvitamin D concentration was lower in Beijing than Hong Kong women (29 v. 34 nmol/l; P < 0·001). Vitamin D deficiency ( ≤  25 nmol/l) was indicated in 40 % of Beijing and 18 % of Hong Kong women, and over 90 % of women in both cities were insufficient ( ≤ 50 nmol/l). Mean Ca and vitamin D intakes were 478 mg/d and 2·0 μg/d, respectively. The relationship between 25-hydroxyvitamin D concentration and PTH was linear throughout the range with a slope of − 0·36 (different from 0; P < 0·001; R 0·26), with no apparent threshold. There was no influence of Ca intake on the relationship between 25-hydroxyvitamin D and PTH concentration. Vitamin D deficiency is common and insufficiency is very common in non-pregnant women in Hong Kong and Beijing during spring. Serum 25-hydroxyvitamin D was inversely associated with PTH with no apparent threshold. Strategies such as vitamin D fortification or supplementation may be required.

The Prevalence of 25-Hydroxyvitamin D Deficiency in Post-HSCT Pediatric Patients.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 2139-2139
Author(s):  
Christine Duncan ◽  
Lynda Vrooman ◽  
Lori Bechard ◽  
Elly Barry ◽  
Leslie E. Lehmann
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pediatric Patients ◽  
Bone Marrow Failure ◽  
Long Term Effects ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
The Mean ◽  
25 Oh Vitamin D

Abstract Children undergoing HSCT are at risk for vitamin D deficiency due to lack of sun exposure, the recommended use of sunscreen, dietary insufficiency, and the effects of medications such as glucocorticoids and calcineurin inhibitors. We assessed the prevalence of 25-hydroxyvitamin D (25-OH vitamin D) deficiency in pediatric post-HSCT patients in an outpatient oncology clinic during 4 weeks in May 2008. Patients found to have low 25-OH vitamin D levels were referred for dietary counseling and given supplementation or repletion as needed. 25-OH vitamin D and parathyroid hormone (PTH) levels were measured in 62 (88.6%) of 70 eligible patients. 83.8% of patients had a 25-OH vitamin D level less than the institutional lower limit of normal, 30 ng/mL. 29% of patients were 25-OH vitamin D insufficient with levels 20–29 ng/mL (range of 20–29). 54.8% of patients were 25-OH vitamin D deficient with levels &lt;20 ng/mL (range 5–19). The prevalence of insufficiency and deficiency was similar between male (87.8%; 57.6%) and female patients (57.6%; 55.2%).The mean duration of days following transplant was 532.6 days (median 251.5 days). The mean age at transplant was 3.7 years (median 3.5 years). 47% of patients were female. 75.8% were Caucasian. 90.3% received allogeneic transplants. The underlying diseases were as follows: ALL (27.4%), AML/MDS (24.2%), bone marrow failure (11.3%), nonmalignant hematologic diagnosis (8.1%), solid tumor (8.1%), immunodeficiency (6.5%), lymphoma (6.5%), and other diagnoses (8.1%). 8 patients regularly took either an over-the-counter multivitamin or vitamin D supplement and all 8 patients had 25-OH levels less than 30 ng/mL. There was a negative inverse correlation of (r= −0.3, p=0.029) between PTH and 25-OH vitamin D. There were no significant associations between 25-OH vitamin D level and any of the following: corticosteroid or calcineurin inhibitor use in the preceding year, time from transplant, age at transplant, current age, or graft-versus-host disease. 25-OH vitamin D insufficiency and deficiency are common following pediatric HSCT. We recommend vitamin D screening for all post-HSCT pediatric patients. Further investigation is needed to identify potential risk factors for vitamin D deficiency and the long-term effects of deficiency on bone health and development.

scholarly journals Circulating 25-hydroxyvitamin D levels in relation to blood pressure parameters and hypertension in the Shanghai Women's and Men's Health Studies

2012 ◽  
Vol 108 (3) ◽  
pp. 449-458 ◽  
Author(s):  
Tsogzolmaa Dorjgochoo ◽  
Xiao Ou Shu ◽  
Yong-Bing Xiang ◽  
Gong Yang ◽  
Qiuyin Cai ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Antihypertensive Drugs ◽  
Urban China ◽  
Inverse Association ◽  
Cross Sectional ◽  
Who Criteria ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Little is known about the association of circulating 25-hydroxyvitamin D (25(OH)D) and blood pressure (BP) parameters, including systolic and diastolic BP, pulse pressure (PP), mean arterial pressure (MAP) and hypertension in non-Western populations that have not yet been exposed to foods fortified with vitamins and seldom use vitamin D supplements. A cross-sectional analysis of plasma 25(OH)D levels in association with BP measures was performed for 1460 participants (1055 women and 405 men, aged 40–74 years) of two large cohort studies in Shanghai. Multivariable linear and logistic regressions were conducted. Overall, the prevalence of vitamin D deficiency was 55·8 % using National Health and Nutrition Examination Survey, USA criteria and 29·9 % using WHO criteria. The median plasma 25(OH)D level in the population was 38·0 nmol/l for men and 33·6 nmol/l for women (P < 0·01) among participants who were not on antihypertensive drugs. Among men, BP parameters (systolic BP, diastolic BP and MAP) were significantly and inversely associated with higher quintiles of 25(OH)D compared with the lowest quintile (Ptrend < 0·05 for all). Vitamin D non-deficient status (WHO criteria) was inversely associated with hypertension (ORadjusted = 0·29; 95 % CI 0·10, 0·82). An inverse association was also found between hypertension and the highest quintile of 25(OH)D (ORadjusted = 0·16; 95 % CI 0·04, 0·65 for ≥ 50·6 nmol/l; Ptrend = 0·02). Among women, no significant associations were found for BP parameters and hypertension. The present study shows that vitamin D deficiency is common among adults in urban China. Circulating 25(OH)D levels were inversely related to the levels of individual BP parameters and hypertension among middle-aged and elderly men but not among women. More research is needed to investigate the potential sex differential associations.

Correlation between vitamin D levels and hard-to-heal wounds: a systematic review

2020 ◽  
Vol 29 (Sup7) ◽  
pp. S24-S30 ◽  
Author(s):  
Karen Smith ◽  
Susan Hewlings
Keyword(s):  
Vitamin D ◽  
Financial Burden ◽  
Vitamin D Supplementation ◽  
Nutritional Deficiencies ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Venous Ulcers ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Objective: Hard-to-heal wounds are a major biological, psychological, social and financial burden on both individual patients and the broader health system. They are associated with a variety of comorbidities and have a complex aetiology, but are typically associated with nutritional deficiencies, such as low vitamin D levels. This systematic literature review evaluates the current research regarding the connection between inadequate vitamin D status and wound healing. Method: PubMed and EBSCO databases were searched following PRISMA guidelines for primary research studies relating to pressure ulcers, diabetic ulcers or venous ulcers and vitamin D status. Results: A total of 10 studies, involving 2359 participants, met the inclusion criteria. There was a strong correlation between low levels of 25-hydroxyvitamin D and the presence of all three types of hard-to-heal wounds. Conclusion: Research suggests a correlation between low vitamin D levels and hard-to-heal wounds. However, it is not clear if the relationship is causal or only correlational. There is also emerging evidence on the use of vitamin D supplementation for the treatment of hard-to-heal wounds. More research is needed to understand the correlation between vitamin D and hard-to-heal wounds.

scholarly journals P49 An audit of baseline vitamin D level tests for newly diagnosed paediatric haematology/oncology patients against trust guidelines

2020 ◽  
Vol 105 (9) ◽  
pp. e32-e33
Author(s):  
Lamia Samrin-Balch ◽  
Salma Mahmood
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
List Type ◽  
Oncology Patients ◽  
Hydroxyvitamin D ◽  
Treatment And Prevention ◽  
Health Report ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Haematology Patients

Aim100% of patients should have their vitamin D levels checked at diagnosis’ as stated in the current trust guideline for the management of vitamin D deficiency Treatment and Prevention.100% of patients who had a baseline vitamin D level had these acted upon if necessary following the recommendations in the trust guideline.All of the patients who were given treatment had been prescribed were given an appropriate dose as stated in the trust guideline.These standards are supported by the recommendations in 2016 by Public Health England (PHE) that everyone (regardless of age and ethnicity) needs vitamin D equivalent to an average daily intake of 10 micrograms via supplementation.2 3MethodThis retrospective audit was conducted using internal clinical and prescribing programmes to access patient records and medical histories to retrieve data. The inclusion criteria for patients included in this audit were all new diagnoses of malignant haematological and oncological disease over a 6 month period, from April 2018-October 2018. The data collected for these patients were: if they had been tested for Vitamin D, the date of the test and their level of total vitamin D level Serum total 25-hydroxyvitamin D concentration. Patient data from the electronic prescribing system was utilised to check if patients had been prescribed vitamin D. Once data completed, patients with vitamin D levels, assessed against trust guidelines to determine if appropriately treated.ResultsA total of 78 patients met the inclusion criteria, where 56% of patients were tested for vitamin D during admission. Of the 78 patient, 43 were oncology patients and 33 haematology patients.In the oncology cohort (n=15) only 35% were tested whereas 83% of haematology patients (n=28) were tested. Of the haematology cohort of patients who were tested (83%): 69% had sufficient levels of vitamin D (serum total 25-hydroxyvitamin D concentration >50 nmol/L); 11% had insufficient levels (25–50 nmol/L) and 3% were deficient (< 25 nmol/L). Of the oncology cohort who were tested (35%): 28% had sufficient levels of vitamin D; 5% of patients had insufficient levels; 2% were deficient. 6% of haematology patients and 5% of oncology patients with sufficient levels of vitamin D received treatment that was not indicated. Furthermore, the 5% of oncology patients with insufficient levels of vitamin D did not receive any treatment.ConclusionThe standards set for this audit were not met. It is concerning that those with low levels were not treated effectively and are at risk of complications. Although the findings of this audit may not be a true reflection of the entire patient population due to the small cohort size; the insight into at risk patients suggests there is a need to improve practice and reach 100% for all the aims of this audit.To improve smart and efficient prescribing of medication, clinicians should adhere to the revised trust ‘Guideline for the Management of vitamin D deficiency’ to guide their decisions on initiating therapy. Pharmacists should check vitamin D levels for all new admissions and follow up as appropriate for any pending tests. Having a default test built into the current new prescribing system will also support in improving the results.ReferencesHolick, M. ( 2019). Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. [online]Available at: https://academic.oup.com/ajcn/article/79/3/362/4690120Public Health England. Statistical Summary: National Diet and Nutrition Survey: results from Years 1 and 9 (combined) of the Rolling Programme (2008/09 – 2016/17). https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/772430/NDNS_Y1-9_statistical_summary.pdfGOV.UK. ( 2019). SACN vitamin D and health report. [online]Available at: https://www.gov.uk/government/publications/sacn-vitamin-d-and-health-reportGreat Ormond Street Hospital Trust guideline for the management of Vitamin D deficiency Treatment and Prevention.

Vitamin D supply of patients with hip fracture

2014 ◽  
Vol 155 (17) ◽  
pp. 659-668 ◽  
Author(s):  
Antal Salamon ◽  
Balázs Hepp ◽  
Ákos Mátrai ◽  
Csaba Biró ◽  
Katalin Ágota ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hip Fracture ◽  
Vitamin D Deficiency ◽  
Hip Fractures ◽  
Hydroxyvitamin D ◽  
Control Subjects ◽  
25 Hydroxyvitamin D ◽  
Few Data ◽  
Prevention And Cure ◽  
The Relationship

Introduction: Vitamin D deficiency is an important risk factor for fractures. However, there are few data available only on the relationship between serum 25-hydroxyvitamin D levels and recovery after surgery for hip fracture. Aim: The authors investigate the vitamin D supply of patients with hip fractures. Method: Between February and September 2013, serum 25-hydroxyvitamin D and parathyroid hormone levels were determined in 203 patients with hip fracture (74.8±11.5 ys; 67 men and 136 women) and in 74 control subjects. Results: Vitamin D deficiency and secondary hyperparathyroidism occurred significantly more frequently in patients with hip fracture than in control subjects (72% vs. 45%, and 33% vs. 17%, respectively). Patients with better condition after surgery showed higher 25-hydroxyvitamin D levels (p<0.001) than those with poor condition. Serum 25-hydroxyvitamin D were lower in the 31 patients who died [median of survival time: 19 (5–52) days] compared to those who survived [22.6 (9.5–45.0) vs. 33.0 (16.5–56.6) nmol/l]. Conclusions: The association between vitamin-D deficiency and mortality as well as the positive correlation between serum 25-hydroxyvitamin D levels and better postoperative condition confirm the importance of proper vitamin D supply in the prevention and cure of hip fractures, what is more in the increase of the chance of survival. Orv. Hetil., 2014, 155(17), 659–668.

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