Associations of early-life exposure to famine with abdominal fat accumulation are independent of family history of diabetes and physical activity

2020 ◽  
pp. 1-8
Author(s):  
Xiang Hu ◽  
Junping Wen ◽  
Weihui Yu ◽  
Lijuan Yang ◽  
Wei Pan ◽  
...  
Keyword(s):  
Physical Activity ◽  
Family History ◽  
Early Life ◽  
Central Obesity ◽  
Abdominal Fat ◽  
Family History Of Diabetes ◽  
Fat Accumulation ◽  
Early Life Exposure ◽  
History Of ◽  
And Function

Abstract The present study aimed to investigate the association of early-life exposure to famine with abdominal fat accumulation and function and further evaluate the influence of first-degree family history of diabetes and physical activity on this association. The present work analysed parts of the REACTION study. A total of 3033 women were enrolled. Central obesity was defined as waist circumferences (W) ≥ 85 cm. Chinese visceral adiposity index (CVAI) was used to evaluate visceral adipose distribution and function. Partial correlation analysis showed BMI, W, glycated Hb and CVAI were associated with early-life exposure to famine (both P < 0·05). Logistic regression showed that the risks of overall overweight/obesity and central obesity in fetal, early-childhood, mid-childhood and late-childhood exposed subgroups were increased significantly (all P < 0·05). Compared with the non-exposed group, the BMI, W and CVAI of fetal, early- to late-childhood exposed subgroups were significantly increased both in those with or without first-degree family history of diabetes and in those classified as physically active or inactive, respectively (all P < 0·05). The associations of BMI, W and CVAI with early-life exposure to famine were independent of their associations with first-degree family history of diabetes (all P < 0·01) or physical activity status (all P < 0·001). Early-life exposure to famine contributed to abdominal fat accumulation and dysfunction, which was independent of the influence of genetic background and exercise habits. Physical activity could serve as a supplementary intervention for women with high risk of central obesity.

scholarly journals Differing Contributions of Classical Risk Factors to Type 2 Diabetes in Multi-Ethnic Malaysian Populations

2018 ◽  
Vol 15 (12) ◽  
pp. 2813
Author(s):  
Noraidatulakma Abdullah ◽  
Nor Abdul Murad ◽  
John Attia ◽  
Christopher Oldmeadow ◽  
Mohd Kamaruddin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Family History ◽  
Characteristic Curve ◽  
Lifestyle Factors ◽  
Predictive Utility ◽  
Family History Of Diabetes ◽  
History Of

The prevalence of type 2 diabetes is escalating rapidly in Asian countries, with the rapid increase likely attributable to a combination of genetic and lifestyle factors. Recent research suggests that common genetic risk variants contribute minimally to the rapidly rising prevalence. Rather, recent changes in dietary patterns and physical activity may be more important. This nested case-control study assessed the association and predictive utility of type 2 diabetes lifestyle risk factors in participants from Malaysia, an understudied Asian population with comparatively high disease prevalence. The study sample comprised 4077 participants from The Malaysian Cohort project and included sub-samples from the three major ancestral groups: Malay (n = 1323), Chinese (n = 1344) and Indian (n = 1410). Association of lifestyle factors with type 2 diabetes was assessed within and across ancestral groups using logistic regression. Predictive utility was quantified and compared between groups using the Area Under the Receiver-Operating Characteristic Curve (AUC). In predictive models including age, gender, waist-to-hip ratio, physical activity, location, family history of diabetes and average sleep duration, the AUC ranged from 0.76 to 0.85 across groups and was significantly higher in Chinese than Malays or Indians, likely reflecting anthropometric differences. This study suggests that obesity, advancing age, a family history of diabetes and living in a rural area are important drivers of the escalating prevalence of type 2 diabetes in Malaysia.

Physical activity, family history of diabetes and risk of developing hyperglycaemia and diabetes among adults in Mainland China

2012 ◽  
Vol 29 (5) ◽  
pp. 593-599 ◽  
Author(s):  
F. Xu ◽  
Y. Wang ◽  
R. S. Ware ◽  
L. Ah Tse ◽  
D. W. Dunstan ◽  
...  
Keyword(s):  
Physical Activity ◽  
Family History ◽  
Mainland China ◽  
Family History Of Diabetes ◽  
History Of

scholarly journals Biopsychosocial Determinants of Diabetes Mellitus Type 2: Evidence from Surakarta, Central Java

2020 ◽  
Author(s):  
Anggi Putri Aria Gita ◽  
◽  
Isna Qadrijati ◽  
Bhisma Murti ◽  
◽  
...  
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Family History ◽  
Dietary Pattern ◽  
Central Obesity ◽  
Smoking Behavior ◽  
Central Java ◽  
Type 2 Dm ◽  
History Of

ABSTRACT Background: Stress has been shown to have major effects on metabolic activity. Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia that results from an alteration of the secretion or action of insulin. This study aimed to investigate biopsychosocial determinants of diabetes mellitus type 2 Subjects and Method: A case control study was conducted in Surakarta, Centra Java, Indonesia, from November 2019 to January 2020. A sample of 200 patients with type 2 DM was selected by fixed disease sampling. The dependent variable was type 2 DM. The independent variables were family history of DM, dietary pattern, physical activity, body mass index (BMI), central obesity, stress, hypertension, and smoking. The data were collected by medical record and questionnaire. The data were analyzed by a multiple logistic regression run on Stata 13. Results: The risk of type 2 DM increased with family history of tipe 2 DM (OR= 12.88; 95% CI= 5.18 to 32.04; p<0.001), poor dietary pattern (OR= 2.92; 95% CI= 1.16 to 7.36; p= 0.023), and low physical activity (OR= 3.15; 95% CI= 1.22 to 8.18; p= 0.018), central obesity (OR= 4.55; 95% CI= 1.55 to 13.41; p= 0.006), stress (OR= 3.07; 95% CI= 1.21 to 7.79; p= 0.018), history of hypertension (OR= 3.83; 95% CI= 1.49 to 9.79; p= 0.005), and smoking behavior (OR= 3.86; 95% CI= 1.29 to 11.57; p= 0.016). The risk of type 2 DM decreased with normal BMI (OR= 0.37; 95% CI= 0.13 to 1.01; p= 0.053). Conclusion: The risk of type 2 DM increases with family history of tipe 2 DM, poor dietary pattern, and low physical activity, central obesity, stress, history of hypertension, and smoking behavior. The risk of type 2 DM decreases with normal BMI. Keywords: Determinan biopsikososial, DM tipe 2. Correspondence: Anggi Putri Aria Gita. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: [email protected]. Mobile: +628975406464. DOI: https://doi.org/10.26911/the7thicph.01.46

scholarly journals Prevalence and associated risk factors of undiagnosed diabetes among adult Moroccan Sahraoui women

2006 ◽  
Vol 9 (6) ◽  
pp. 722-727 ◽  
Author(s):  
Mohamed Rguibi ◽  
Rekia Belahsen
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Family History ◽  
Undiagnosed Diabetes ◽  
Adult Women ◽  
Obese Women ◽  
Family History Of Diabetes ◽  
History Of ◽  
Independent Association ◽  
Associated Risk Factors

AbstractObjectiveThe goal of the present work was to examine the prevalence and associated risk factors of undiagnosed diabetes among urban Moroccan Sahraoui women.Design and settingRandomised sample of adult women living in the city of Laayoune in south Morocco who visited public health centres during an immunisation campaign. Body weight, height, waist and hip circumferences, blood pressure, fasting plasma glucose (FPG), triglycerides, dietary intake and physical activity were collected.SubjectsData were obtained on 249 urban women aged 15 years and older, who were not pregnant. Only subjects identified as of Sahraoui origin were eligible for this investigation.ResultsThe prevalence of impaired fasting glucose (IFG) was 5.5% and that of undiagnosed diabetes 6.4%. Diabetes and IFG were more common among older and obese women as well as among women with hypertension or a family history of diabetes. In addition, sucrose intakes were higher in women with diabetes than in those with normal FPG. Also, physical activity estimated as the time spent in walking was negatively associated with FPG. Regression analyses showed an independent association of age, obesity, family history of diabetes and triglycerides with diabetes.ConclusionThe high proportion of unknown diabetes suggests the need for increased diabetes awareness in this population. The data suggest also the involvement of obesity in diabetes and the potential importance of intervention strategies to reduce population adiposity for the prevention and management of cardiovascular risk factors.

scholarly journals Assessment of the influence of family history of type 2 diabetes or hypertension on the physical activity pattern among young Saudi population aged 15-25 years

2018 ◽  
Vol 5 (5) ◽  
pp. 1735
Author(s):  
Ibrahim M. Gosadi ◽  
Nouf M. AlOraini ◽  
Amerah M. Bin Zuair ◽  
Asmaa A. AlRusaies ◽  
Njoud A. AlRasheed ◽  
...  
Keyword(s):  
Physical Activity ◽  
Family History ◽  
Sedentary Behavior ◽  
Activity Pattern ◽  
Daily Routine ◽  
Family History Of Diabetes ◽  
Physical Activity Pattern ◽  
Validated Questionnaire ◽  
High Prevalence ◽  
History Of

Background: With a high prevalence of non communicable diseases and its risk factors among the Saudi Arabian population, the present study was conducted to determine the levels and pattern of physical activity behavior of the youth with reference to their parents’ diabetes/hypertension status.Methods: A cross sectional study was performed in higher secondary schools and university. Multistage cluster random sampling technique was used to obtain a sample of 450 subjects aged 15-25 years. All types of physical activity performed in daily routine were recorded using a validated questionnaire. Data was reported as mean or median physical activity hours for normal and skewed data and corresponding test of significance was applied.Results: There was a high prevalence of sedentary behavior among the overall population (76.5 median hours per week). Female gender (p<0.002) and transition to university (p<0.000) showed increased sedentarism. Subjects whose both parents were affected with diabetes showed least sedentary behavior [70 (19) mean hours per week] and higher levels of moderate (2.25 median hours per week; p<0.025) and strenuous physical activity (1.25 median hours per week; p<0.034). Maternal diabetes also showed significant influence in improving the physical activity of the subjects. Presence of maternal history of hypertension or both parents affected by hypertension did not make any significant impact on the physical activity pattern of their offsprings.Conclusions: Increased physical activity was observed only among those who had family history of diabetes. Otherwise the normal population showed a typical sedentary lifestyle reflecting on the questionable effectiveness of national programs on physical activity.

scholarly journals Study on prevalence of hypertension, diabetes mellitus and their few risk factors among rural women in Ghaziabad

2017 ◽  
Vol 4 (5) ◽  
pp. 1488
Author(s):  
Narendra Singh
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Family History ◽  
Rural Women ◽  
Life Style ◽  
Health Centre ◽  
Age Group ◽  
Family History Of Diabetes ◽  
History Of

Background: With rapid urbanisation in National Capital Region, Ghaziabad, associated life style diseases like hypertension, diabetes mellitus are also increasing. For an effective preventive program, it is mandatory to know prevalence and relevant risk factors. Many studies among men have been conducted, this study was undertaken to find out prevalence, and associated factors solely among   rural women in Ghaziabad. Methods: A pretested Performa was administered to all non-pregnant women coming to a health centre. Information on medical and family history, dietary habits, physical activity, blood pressure, blood sugar, height, weight etc. was recorded. For statistical analyses, SPSS-16 software was used. Results: Out of total 569 participants, 59 were having hypertension, showing a prevalence of 10.36 %, 44 were having family history of hypertension with a prevalence of 7.73%. 93 were found to be Diabetics, with a prevalence of 16.34% and family history of diabetes among 57, i.e. 10.36% in study group. Overall 134, (23.55%) had abnormally higher BMI, age group with highest prevalence of BMI was also having highest diabetes and hypertension cases. This age group was  found to be doing just  mild physical activity. Conclusions: This study gives insight in heavy burden of hypertension, diabetes, and associated risk factors in rural women folks in a rural health centre of Ghaziabad. Life style modifications, more physical activities, dietary modifications with lesser salt ,fats  will go in long way of reducing burden of these diseases and risk factors. 

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