Intermittent Fasting with a High Protein Diet Mitigated Osteoarthritis Symptoms by Increasing Lean Body Mass and Reducing Inflammation in Osteoarthritic rats with Alzheimer’s Disease-Like Dementia

2021 ◽  
pp. 1-38
Author(s):  
Sunmin Park ◽  
Bae Kun Shin
Keyword(s):  
Articular Cartilage ◽  
Lean Body Mass ◽  
Body Mass ◽  
Memory Impairment ◽  
Amyloid Β ◽  
High Protein ◽  
Treadmill Running ◽  
Intermittent Fasting ◽  
Middle Zone ◽  
Cellular Invasion

Abstract Menopausal women are susceptible to osteoarthritis and memory impairment. We hypothesized that Alzheimer’s-like disease (AD) exacerbates osteoarthritis and that intermittent fasting(IMF) with a high-protein(H-P) diet would enhance memory function and relieve osteoarthritis symptoms in estrogen-deficient animals with surgically induced AD and osteoarthritis. The action mechanism was also explored. Ovariectomized Sprague-Dawley rats were fed high-fat(H-F) or H-P diets for two weeks, and then they had a hippocampal infusion of β-amyloid(25-35) for 4 weeks to induce AD and an injection of monoidoacetate(MIA) into the articular cartilage to induce osteoarthritis. Four groups had AD symptoms, whereas two groups had non-AD symptoms by hippocampal amyloid-β(35-25) infusion. All rats had an MIA injection into the articular cartilage of the left knee. IMF suppressed memory impairment in AD rats, especially those fed H-P diets. Compared to Non-AD, AD exacerbated osteoarthritis symptoms, including swelling, limping, slowed treadmill running speed, and uneven weight distribution in the left leg. The exacerbations were linked to increased inflammation and pain, but IMF and H-P lessened inflammation and pain-related symptoms. Lean body mass(LBM) also decreased with AD and IMF, but H-P protected against LBM loss. Histological examination of the knee joint revealed the degree of the cellular invasion into the middle zone, and the changes in the tidemark plateau were greatest in the AD-AL with H-F, while non-AD-IMF improved the cellular invasion to as much as non-AD-AL. H-P reduced the infiltration into the middle-zone of the knee and promoted collagen production. In conclusion, AD exacerbated the articular cartilage deterioration and memory impairment, and IMF with H-P alleviated the memory impairment and osteoarthritic symptoms by decreasing hippocampal amyloid-β deposition and proinflammatory cytokine expressions and by increasing LBM.

scholarly journals The Effects of Intermittent Fasting Combined with Resistance Training on Lean Body Mass: A Systematic Review of Human Studies

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2349
Author(s):  
Stephen Keenan ◽  
Matthew B. Cooke ◽  
Regina Belski
Keyword(s):  
Body Composition ◽  
Resistance Training ◽  
Lean Body Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Energy Restriction ◽  
Human Studies ◽  
Future Research ◽  
Intermittent Fasting ◽  
Eligibility Criteria

Diets utilising intermittent fasting (IF) as a strategic method to manipulate body composition have recently grown in popularity, however, dietary practices involving fasting have also been followed for centuries for religious reasons (i.e., Ramadan). Regardless of the reasons for engaging in IF, the impacts on lean body mass (LBM) may be detrimental. Previous research has demonstrated that resistance training promotes LBM accrual, however, whether this still occurs during IF is unclear. Therefore, the objective of this review is to systematically analyse human studies investigating the effects of variations of IF combined with resistance training on changes in LBM in previously sedentary or trained (non-elite) individuals. Changes in body weight and fat mass, and protocol adherence were assessed as a secondary objective. This review followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. MEDLINE, CINAHL, PubMed and SportDiscus databases were searched for articles investigating IF, combined with resistance training that reported measures of body composition. Eight studies met the eligibility criteria. LBM was generally maintained, while one study reported a significant increase in LBM. Body fat mass or percentage was significantly reduced in five of eight studies. Results suggest that IF paired with resistance training generally maintains LBM, and can also promote fat loss. Future research should examine longer-term effects of various forms of IF combined with resistance training compared to traditional forms of energy restriction. Prospero registration CRD42018103867.

A Simple Test for the Assessment of Aerobic Fitness

1988 ◽  
Vol 74 (2) ◽  
pp. 107-114
Author(s):  
D. J. Smith ◽  
R. J. Pethybridge ◽  
A Duggan
Keyword(s):  
Heart Rate ◽  
Body Weight ◽  
Physical Fitness ◽  
Lean Body Mass ◽  
Body Mass ◽  
Test Score ◽  
Linear Regression Analysis ◽  
Treadmill Running ◽  
Step Test ◽  
Anthropometric Measures

SummaryThe relationship between physical fitness, anthropometric measures, and the scores in three submaximal step tests have been evaluated in a group of 30 male subjects. Physical fitness was assessed as VO2max measured directly during uphill treadmill running. Each submaximal exercise test was of six minutes duration and the heart rate recorded during the last minute (fH6) constituted the test score. Significant negative correlation coefficients were found between VO2max and each test score while lean body mass, gross body weight and body surface area were allpositively correlated with VO2max (1/min). The score in the least severe step test was included with anthropometric measures in multiple linear regression analysis for the prediction of VO2max and a number of prediction equations were derived. It was found that when lean body mass is calculated from skinfold measurements and weight, VO2max can be calculated from the equation:VO2max(1/min) = 1.470 + 0.0614 × Lean Body mass −0.0131 × fH6This equation accounts for 73% of the total variation of VO2max. If lean body mass cannot be calculated, a combination of gross body weight and age plus fH6 gives the equation:VO2max = 3.614 + 0.0349 × Weight – 0.0177 × fH6−0.0161 × Ageaccounting for 66% of the variance. The test has the following advantages over those currently employed:It is simple to administer requiring 6 minutes of stepping onto a 32 cm platform—the height of a gymnasium bench—20 times per minute.Although ideally an assessment oflean body mass is required, gross body weight plus age is a good second best.It is submaximal, minimising the stress on the individual (mean heart rate achieved 121 beats per minute).Its accuracy in terms of its ability to predict maximal aerobic power is better than either the Ohio or Harvard University tests.It is suggested that this test could be used where maximal testing is contraindicated or where currently used tests are insufficiently accurate.

Supplementing An Energy Adequate High Protein Diet With Additional Protein Is Not Necessary For Recovery Of Lean Body Mass After Short-term Starvation

2016 ◽  
Vol 48 ◽  
pp. 443
Author(s):  
John J. Sepowitz ◽  
Holly L. McClung ◽  
Claire E. Berryman ◽  
Nicholes J. Armstrong ◽  
Arny A. Ferrando ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Short Term ◽  
Additional Protein

Hypocaloric high-protein diet improves glucose oxidation and spares lean body mass: Comparison to hypocaloric high-carbohydrate diet

Metabolism ◽  
1994 ◽  
Vol 43 (12) ◽  
pp. 1481-1487 ◽  
Author(s):  
P.M. Piatti ◽  
L.D. Monti ◽  
Fulvio Magni ◽  
Isabella Fermo ◽  
L. Baruffaldi ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Glucose Oxidation ◽  
High Protein Diet ◽  
High Carbohydrate Diet ◽  
High Protein ◽  
Protein Diet ◽  
Carbohydrate Diet ◽  
High Carbohydrate ◽  
Mass Comparison

Effects of high protein, low-glycemic index diet on lean body mass, strength, and physical performance in late postmenopausal women

Menopause ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Thaís R. Silva ◽  
Suzana C. Lago ◽  
Andressa Yavorivski ◽  
Laís L. Ferreira ◽  
Tayane M. Fighera ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Lean Body Mass ◽  
Physical Performance ◽  
Body Mass ◽  
Glycemic Index ◽  
High Protein ◽  
Low Glycemic Index

scholarly journals The provision of recipes and single-use herb/spice packets to increase egg and protein intake in community-dwelling older adults: a randomised controlled trial

2020 ◽  
pp. 1-14
Author(s):  
E van den Heuvel ◽  
JL Murphy ◽  
KM Appleton
Keyword(s):  
Older Adults ◽  
Lean Body Mass ◽  
Body Mass ◽  
Protein Intake ◽  
Community Dwelling ◽  
High Protein ◽  
Single Use ◽  
Randomised Controlled ◽  
The Impact ◽  
Community Dwelling Older Adults

Abstract Objective: This study investigated the impact of recipe and single-use herb/spice packet provision on egg intake and protein intake in community-dwelling individuals aged over 55 years. Design: Using a randomised-controlled intervention design, 100 older adults were randomised to receive (n 53) or not receive (n 47) high-protein egg-based recipes and herb/spice packets through the post for 12 weeks, from June to December 2016. Egg intake, protein intake, adverse events, lean body mass and functional measures of lean body mass were measured at baseline, after the 12 weeks and after a further 12 weeks. Setting: Bournemouth, UK. Participants: Community-dwelling older adults. Results: Intention-to-treat data were analysed using regression, controlling for various demographic and lifestyle characteristics. Ninety-three individuals (intervention, n 50; control, n 43) completed assessments at all three time points. Egg intakes increased by end of intervention in both groups (mean: 4–5 eggs/month). After a further 12 weeks, higher egg intakes were sustained in the intervention group, while egg intakes in the control group returned to baseline levels (between-group difference: β = −0·124, P = 0·047). No differences were found in other measures (largest β = −0·106, P = 0·12). Conclusions: The provision of high-protein egg-based recipes and single-use herb/spice packets over 12 weeks increased egg intakes up to 12 weeks after end of intervention. Other factors may explain increased egg intakes during the intervention, but the sustained effects most plausibly result directly from recipe provision. Limited effects in other measures suggest that the recipes may have replaced as opposed to added to existing protein intakes.

Adaptations to endurance training at three intensities of exercise

1977 ◽  
Vol 42 (5) ◽  
pp. 753-757 ◽  
Author(s):  
G. L. Dohm ◽  
G. R. Beecher ◽  
T. P. Stephenson ◽  
M. Womack
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Body Fat ◽  
Exercise Intensity ◽  
Treadmill Running ◽  
Heart Weight ◽  
Mass Ratio ◽  
Gland Weight ◽  
Body Mass Ratio ◽  
Intensity Of Exercise

This study was undertaken to investigate the influence of exercise intensity (running speed) on a number of alterations that are known to occur with exercise training. Rats were trained on three treadmill running schedules: 20 m/min, 27 m/min, and 35 m/min for 1 h/day. After 6 wk, lean body mass and body fat content were decreased to the same extent in all three trained groups. Thus, exercise appears to lower body fat by some mechanism that is not related to the amount of energy expended during exercise. Heart and adrenal gland weight-to-lean body mass ratios were increased by training. Heart weight-to-lean body mass ratio increased with increasing intensity of exercise but the adrenal weight-to-lean body mass ratio was independent of exercise intensity. Training increased muscle succinate dehydrogenase activity to the same extent in all three trained groups which suggests that the adaptation in respiratory capacity is not altered greatly by the intensity of training.

scholarly journals High Protein Intake Affects Lean Body Mass but Not Energy Expenditure in Nonobese Neutered Cats

2004 ◽  
Vol 134 (8) ◽  
pp. 2084S-2086S ◽  
Author(s):  
Patrick Nguyen ◽  
Véronique Leray ◽  
Henri Dumon ◽  
Lucile Martin ◽  
Brigitte Siliart ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Lean Body Mass ◽  
Body Mass ◽  
Protein Intake ◽  
High Protein ◽  
High Protein Intake
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