Trematodiasis in Turkey: comparative efficacy of triclabendazole and niclofolan against natural infections of Fasciola hepatica and F. gigantica in sheep

1984 ◽  
Vol 58 (2) ◽  
pp. 113-116 ◽  
Author(s):  
N. Güralp ◽  
R. Tinar
Keyword(s):  
Body Weight ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Fasciola Hepatica ◽  
Recommended Dose ◽  
Comparative Efficacy ◽  
Dicrocoelium Dendriticum ◽  
Dose Rates ◽  
New Drug ◽  
Highly Effective

AbstractA new fasciolicide, triclabendazole, tested at single oral dose rates of 5 and lOmg/kg body-weight, proved to be highly effective (>99%) against chronic field infections of Fasciola hepatica and F. gigantica in sheep. The Performance of the new drug compared favourably with niclofolan at the recommended dose. Neither product was effective against Dicrocoelium dendriticum and Paramphistomum spp.

Toxic effect and oral acute LD50 study of Nerium oleander in male guineapigs

1970 ◽  
Vol 2 (2) ◽  
pp. 159-161 ◽  
Author(s):  
MGA Chowdhury ◽  
A Azizunnesa ◽  
MA Hossain ◽  
ML Rahman ◽  
Q Hasan
Keyword(s):  
Body Weight ◽  
Abdominal Pain ◽  
Oral Dose ◽  
Respiratory Distress ◽  
Toxic Effect ◽  
Single Oral Dose ◽  
Nerium Oleander ◽  
Male Adult ◽  
Experimental Animals ◽  
Group A

The toxic effect of Nerium oleander was studied in 36 male adult guineapigs during the period from July to December 1994. These 36 animals were divided into six equal groups (A to F), each consisting of six animals. Each animal of groups B to F was administered with a single oral dose of crude watery extract of sheath oleander @ 300, 450, 600, 750 and 900 mg / kg body weight, respectively whereas animals of group A served as control. Each of the experimental animals was carefully observed and the toxic signs recorded as nausea, anorexia, dullness, depression, restlessness, abdominal pain, salivation, reluctant to move, tremor, resting of chin on the ground, respiratory distress, paralysis of the limbs, recumbency, convulsion followed by death with characteristic groaning. It may be concluded that the lowest dose 300 mg / kg body weight is non lethal to the male guineapigs and the dose of 450, 600, 750 and 900 mg / kg body weight caused 17%, 50%, 83% and 100% mortality, respectively and the LD50 is 540 mg / kg body weight.Key words: Nerium oleander; toxic signs; oral acute LD50; guineapigsdoi: 10.3329/bjvm.v2i2.2562Bangl. J. Vet. Med. (2004). 2 (2): 159-161

Treatment of Gonorrhoea in Males with a Single Oral Dose of Ampicillin Combined with Probenecid

1974 ◽  
Vol 2 (2) ◽  
pp. 168-170
Author(s):  
Gilberto Talamo ◽  
Jose Espin
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Treatment Period ◽  
Recovery Rate ◽  
Post Treatment ◽  
Highly Effective

A total of sixty cases of acute and subacute gonorrhoeal urethritis in males were treated with a single oral dose of ampicillin combined with probenecid. All of the patients were examined at least twice during the post-treatment period and a recovery rate of 95% was obtained in the study. The treatment was shown to be not only highly effective but also well tolerated and accepted by the patients as well as being extremely easy of administration.

scholarly journals Effect of various oral dose levels of a trimethoprim/sulphadiazine mixture on Bordetella bronchiseptica infection and on the proliferation of trimethoprim-resistant faecal coliforms in pigs

1983 ◽  
Vol 90 (1) ◽  
pp. 41-47 ◽  
Author(s):  
L. Dassanayake ◽  
G. White
Keyword(s):  
Oral Dose ◽  
Dose Level ◽  
Bordetella Bronchiseptica ◽  
Faecal Coliforms ◽  
Antibacterial Drugs ◽  
Dose Rates ◽  
Resistant Population ◽  
Highly Effective ◽  
Dose Levels ◽  
Oral Doses

SUMMARYWhen a 1:5 mixture of trimethoprim (TMP) and sulphadiazine was fed to pigs intra-nasally infected with Bordetella bronchiseptica, 10 mg/kg/day was shown to be highly effective in suppressing the organism. This dose level had little effect on numbers of TMP-resistant coliforms in faeces, but oral doses of 30 mg/kg/day eventually selected a resistant population. It is suggested that the proliferation of resistant coliforms would be minimized by administration of the lowest oral dose rates of antibacterial drugs compatible with efficacy.

scholarly journals Evaluation of Nialamide on the Coagulation of Blood

Blood ◽  
1964 ◽  
Vol 24 (3) ◽  
pp. 289-298 ◽  
Author(s):  
CHAPOUR MASCHOUF ◽  
ROGER W. ROBINSON ◽  
RAOUL J. LEBEAU
Keyword(s):  
Body Weight ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Venous Blood ◽  
Glass Beads ◽  
Fine Glass ◽  
Prothrombin Activation

Abstract Nialamide at a single oral dose of about 3 mg./Kg. body weight produced decreased prothrombin activation by rendering the platelets less effective. It also decreased the adhesiveness of the platelets as measured by two different technics. A new technic for measuring the adhesiveness of the platelets has been described. It utilized a principle by which venous blood directly circulated through a column of fine glass beads, after which the platelets were reduced in number.

scholarly journals Effects of ibogaine per os application on redox homeostasis in rat liver and erythrocytes

2019 ◽  
Vol 71 (1) ◽  
pp. 133-144
Author(s):  
Teodora Vidonja-Uzelac ◽  
Nikola Tatalovic ◽  
Milica Mijovic ◽  
Gordana Kozelj ◽  
Aleksandra Nikolic-Kokic ◽  
...  
Keyword(s):  
Body Weight ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Rat Liver ◽  
Ex Vivo ◽  
Redox Homeostasis ◽  
Antioxidant Enzyme Activities ◽  
Glutathione S Transferase ◽  
Cellular Energy ◽  
Species Production

Ibogaine, administered as a single oral dose (1-25 mg/kg body weight), has been used as an addiction-interrupting agent. Its effects persist for up to 72 h. Ex vivo results showed that ibogaine induced cellular energy consumption and restitution, followed by increased reactive oxygen species production and antioxidant activity. Therefore, the aim of this work was to explore the effect of a single oral dose of ibogaine (1 or 20 mg/kg body weight) on antioxidative defenses in rat liver and erythrocytes. Six and 24 h after ibogaine administration, histological examination showed glycogenolytic activity in hepatocytes, which was highest after 24 h in animals that received 20 mg/kg ibogaine. There were no changes in the activities of superoxide dismutases, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase in the liver and erythrocytes after ibogaine treatment, regardless of the dose. Hepatic xanthine oxidase activity was elevated in rats that received 20 mg/kg compared to the controls (p<0.01), suggesting faster adenosine turnover. TBARS concentration was elevated in the group treated with 1 mg/kg after 24 h compared to the controls (p<0.01), suggesting mild oxidative stress. Our results show that ibogaine treatment influenced hepatic redox homeostasis, but not sufficiently to remodel antioxidant enzyme activities at 6 and 24 h post-ibogaine application.

N-[5-(4-Aminophenoxy)pentyl]phthalimide as a potential defleecing agent and its effect on wool growth

1980 ◽  
Vol 31 (4) ◽  
pp. 791
Author(s):  
DA Tunks ◽  
RDG Rigby ◽  
AM Downes ◽  
JA Lamberton ◽  
BA Panaretto ◽  
...  
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Oral Dose ◽  
Feed Intake ◽  
Merino Sheep ◽  
Dose Rates ◽  
Wool Growth

Merino sheep, offered feed at two levels of intake, were given an oral dose of N-[5-(4-am1nophenoxy)- pentyllphthahmide at rates varying over 100-800 mg/kg body weight. Consistent defleecing was obtained at dose rates of 400 nig/kg and above. Feed intake did not Influence defleecing activity. lntravenous infusion of smaller amounts also allowed defleecing. Wool growth rate following dosing was not affected by a dose of 100 mg/kg, but doses of 200 and 400 mg/kg caused depressions of c. 15 and c. 70% respectively in the rate of wool growth in the 2 weeks after dosing. Blindness was observed In one sheep dosed at 400 mg/kg and In all sheep dosed at higher rates

Chloroquine Induced Hepatotoxicity in Male Albino Mice: RCT

2021 ◽  
Vol 15 (10) ◽  
pp. 3070-3071
Author(s):  
Sumbal Khalid ◽  
Hamid Javaid Qureshi ◽  
Talha Laique
Keyword(s):  
Body Weight ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Controlled Study ◽  
Control Group ◽  
Trial Methodology ◽  
Clinical Trial Methodology ◽  
Group A ◽  
Albino Mice ◽  
Group B

Many drugs have been found to induce hepatotoxicity and acute liver failure. Chloroquine is one of those drugs, which can induce hepatotoxicity when it is given at higher dose Purpose: To find the effect of chloroquine on liver function tests (LFTs) Study Design: Randomized clinical trial Methodology: Sixty male albino mice were taken into this randomized controlled study. Those were divided into two groups of 30 each. Group A was the control group while group B mice were given single oral dose of 970 mg/kg of body weight of chloroquine on 9th day of experiment. Terminal intracardiac blood sample was obtained on 17th day of experiment Statistical analysis: SPSS version 23 was used for data analysis Results: When results of group B were compared with those of group A, they depicted highly significant (p=0.000) rise in serum ALP. Serum albumin decreased significantly (p= 0.007). Serum AST increased significantly (p=0.005). Serum ALT, however, did not rise significantly (p=0.285) in group B. Similarly, serum total proteins did not decrease significantly ( p=0.530) in group B Conclusion: It was concluded that chloroquine induced mild hepatotoxicity in male albino mice when a single oral dose of 970 mg/kg of body weight of it is given Key Words: Chloroquine, Hepatotoxicity and Alkaline Phosphatase.

scholarly journals PREVALENCE OF SUBCLINICAL GASTRO-INTESTINAL PARASITOSIS AND THEIR EFFECTS ON MILK PRODUCTION WITH THERAPEUTIC MANAGEMENT IN RED CHITTAGONG CATTLE

1970 ◽  
Vol 8 (1) ◽  
pp. 11-16 ◽  
Author(s):  
MM Rahman ◽  
MA Samad
Keyword(s):  
Body Weight ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Milk Production ◽  
Milk Yield ◽  
Intestinal Parasites ◽  
Age Groups ◽  
Therapeutic Management ◽  
Copper Sulfate Solution ◽  
Intestinal Parasitosis

The prevalence of sub-clinical gastro-intestinal parasitosis and their effects on health and milk production with therapeutic management were studied in 87 Red Chittagong cattle (RCC) reared at the Bangladesh Agricultural University Dairy Farm (BAUDF), Mymensingh during the period from March to July 2008. Of the 87 RCC aged between 1 to 96 months which included 22 milch cows, 15 pregnant cows, 8 dry cows, 18 weaned calves and 24 unweaned calves. Parasitological examination of faecal samples of all the selected 87 RCC showed that 51.72% (n = 45) animals affected with different types of gastro-intestinal parasites, of which 37.93% had single, 12.64% had dual and only 1.15% animals had triple types of infection. An overall 34.48% paramphistomiasis, 25.29% balantidiasis, 2.30% toxocariasis, 2.30% strongyloidiasis, 1.15% trichuriasis and 1.15% fascioliasis was recorded in RCC. However, toxocariasis (18.75%), strongyloidiasis (18.75%) and trichuriasis (6.25%) were recorded in calves up to 6 months old, and paramphistomiasis (34.48%) and fascioliasis (1.15%) in cattle more than 6 months of age whereas balantidiasis (25.29%) was recorded in all age groups of cattle. The anthelmintic efficacy of the combined commercial preparations with Tetramisole hydrochloride 2.0g and Oxyclozanide 1.4g per bolus (Levanid®, Acme ; Tetranid®, Techno Drugs) @ 1 bolus / 100 kg body weight with a single oral dose caused 100% reduction of faecal egg count at day 7 post-treatment. A single oral dose of 1% copper sulfate solution @ 10 ml / kg and metranidazole (Flagyl®, Aventis) @ 4 mg /kg body weight resulted 100% and 42.85% reduction of Balantidium coli trophozoites, respectively. The average milk production records of RCC affected with gastro-intestinal parasitosis (1.41litre / day / animal) were compared with the mean milk production records at day 7 post-anthelmintic treatment (1.73 liter / day / animal) and results showed an average increased milk yield +0.32 litre / day / animal. This study indicates that RCC affected with sub-clinical gastro-intestinal parasitosis caused ill-health and decrease milk yield like zebu and cross-bred cattle. It may be concluded from this study that the RCC should be regularly monitored through faecal examination for the presence of gastro-intestinal parasites in order to provide rational treatment and control management to make the RCC farming profitable. DOI = 10.3329/bjvm.v8i1.7395 Bangl. J. Vet. Med. (2010). 8(1): 11-16

scholarly journals Efficacy of a Single Oral Dose of Oxfendazole against Fasciola hepatica in Naturally Infected Sheep

2012 ◽  
Vol 86 (3) ◽  
pp. 486-488 ◽  
Author(s):  
Luis A. Gomez-Puerta ◽  
Maria T. Lopez-Urbina ◽  
Hector H. Garcia ◽  
Armando E. Gonzalez ◽  
Cesar Gavidia ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Fasciola Hepatica ◽  
Infected Sheep
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