scholarly journals The effect of feeding pigs on food naturally contaminated with salmonellae

1960 ◽  
Vol 58 (4) ◽  
pp. 381-389 ◽  
Author(s):  
H. Williams Smith

1. The course of events following the feeding of salmonella-free pigs on food naturally contaminated with salmonellae has been followed. The pigs were killed at varying times after the commencement of the experiment and their organs examined for salmonellae.2. None of the pigs showed any signs of ill-health and no pathological lesions were observed in them when they were killed. Salmonellae were found, however, in very small numbers in the mesenteric lymph nodes of some of them but not in any of their other internal organs or in their muscular tissue. The longer the pigs were fed on the contaminated food the more likely were their mesenteric lymph nodes to be infected.3. Salmonellae were isolated from time to time from the faeces of the pigs but there was no suggestion of any of the pigs becoming permanent faecal excreters of these organisms.4. Six pigs were retained for a short time after the use of the contaminated food was discontinued. Salmonellae were never found in their faeces and when they were killed the mesenteric lymph nodes of only one of them was found to be infected.5. The results are discussed from the agricultural and public health viewpoints.

1983 ◽  
Vol 17 (4) ◽  
pp. 311-320 ◽  
Author(s):  
L. F. Taffs ◽  
Glynis Dunn

A spontaneous outbreak of yersiniosis caused by Yersinia pseudotuberculosis serotype IIB occurred in a small indoor breeding colony of red-bellied tamarins ( Saguinus labiatus) during the winter of 1981. Of 3S monkeys at risk 6 died of an acute or subacute infection over a period of 23 days. Clinical signs were anorexia, weakness, listlessness and depression. The disease was characterized by focal necrosis of the liver, spleen, mesenteric lymph nodes, ulcerative enteritis, and the presence of colonies of Gram-negative bacilli in the lesions. Y. pseudotuberculosis was isolated from the liver, spleen, mesenteric lymph nodes and kidney but not from the blood, lung or intestine. Contaminated food was believed to be the source of infection.


1973 ◽  
Vol 71 (1) ◽  
pp. 43-48 ◽  
Author(s):  
S. Kumar ◽  
S. P. Saxena ◽  
B. K. Gupta

SUMMARYTo find out the salmonella carrier rate, 1980 samples comprising faeces, mesenteric lymph nodes, liver and spleen were collected from 812 sheep and 683 goats slaughtered for food. In all 72 salmonella strains from 51 animals (25 sheep and 26 goats) were isolated. These represented 22 salmonella serotypes. The public health significance of these findings is discussed.


2001 ◽  
Vol 120 (5) ◽  
pp. A183-A183
Author(s):  
H KOBAYASHI ◽  
H NAGATA ◽  
S MIURA ◽  
T AZUMA ◽  
H SUZUKI ◽  
...  

Author(s):  
Carolin Wiechers ◽  
Mangge Zou ◽  
Eric Galvez ◽  
Michael Beckstette ◽  
Maria Ebel ◽  
...  

AbstractIntestinal Foxp3+ regulatory T cell (Treg) subsets are crucial players in tolerance to microbiota-derived and food-borne antigens, and compelling evidence suggests that the intestinal microbiota modulates their generation, functional specialization, and maintenance. Selected bacterial species and microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), have been reported to promote Treg homeostasis in the intestinal lamina propria. Furthermore, gut-draining mesenteric lymph nodes (mLNs) are particularly efficient sites for the generation of peripherally induced Tregs (pTregs). Despite this knowledge, the direct role of the microbiota and their metabolites in the early stages of pTreg induction within mLNs is not fully elucidated. Here, using an adoptive transfer-based pTreg induction system, we demonstrate that neither transfer of a dysbiotic microbiota nor dietary SCFA supplementation modulated the pTreg induction capacity of mLNs. Even mice housed under germ-free (GF) conditions displayed equivalent pTreg induction within mLNs. Further molecular characterization of these de novo induced pTregs from mLNs by dissection of their transcriptomes and accessible chromatin regions revealed that the microbiota indeed has a limited impact and does not contribute to the initialization of the Treg-specific epigenetic landscape. Overall, our data suggest that the microbiota is dispensable for the early stages of pTreg induction within mLNs.


1997 ◽  
Vol 169 (5) ◽  
pp. 1253-1255 ◽  
Author(s):  
K N Chintapalli ◽  
C C Esola ◽  
S Chopra ◽  
A A Ghiatas ◽  
G D Dodd

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