scholarly journals Staphylococcus aureusin Antarctica: carriage and attempted eradication

1986 ◽  
Vol 97 (3) ◽  
pp. 427-444 ◽  
Author(s):  
S. J. Krikler
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Agents ◽  
Phage Type

SUMMARYThe carriage ofStaphylococcus aureuswas studied in a group of 28 men living in a totally isolated environment for a year. Initially, nasal, axillary and perineal swabs were taken at weekly intervals, but from week 24 throat swabs were taken from known nasal carriers. Several attempts were made during the study to eradicateS. aureus. Eight subjects consistently carried their own phage type throughout the study, despite the application of antibacterial agents. In three subjects strains were isolated late in the study of a phage type which had either not been isolated before in this study, or had not been found for a prolonged period. Nine of the 12 nasal carriers also yieldedS. aureusfrom the throat. It is apparent that following attempted eradication,S. aureusmay seem to disappear, only to reappear some time later; ‘eradication’ in this case would be an erroneous appellation.

scholarly journals Carriage ofStaphylococcus aureusamong 104 healthy persons during a 19-month period

1995 ◽  
Vol 115 (1) ◽  
pp. 51-60 ◽  
Author(s):  
N. H.Riewerts Eriksen ◽  
F. Espersen ◽  
V.Thamdrup Rosdahl ◽  
K. Jensen
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Susceptibility ◽  
Statistical Difference ◽  
Phage Type ◽  
Hospitalized Patients ◽  
Index Number ◽  
Carrier Rate ◽  
Type Distribution ◽  
Nasal Carrier ◽  
Healthy Persons

SummaryThe present study was undertaken to investigate the frequency of the nasal carrier rate ofStaphylococcus aureus. The investigation was performed on 104 healthy persons. The total number of swabs performed was 1498 and this resulted in isolation of 522S. aureusstrains. All strains have been identified, tested for antibiotic susceptibility, and phage-typed. The carrier-index (number of positive swabs/number of total swabs for each individual person) was compared with different sampling and culturing methods, phage type, age, and resistance to antibiotics. There was statistical difference in carrier rate according to sex (P·05). Among the 104 persons 15 (14·4%) were persistent carriers, 17 (16·3%) intermittent carriers, 55 (52·9%) occasional carriers and 17 (16·3%) non-carriers. Among intermittent and occasional carriers the phage-type distribution was different from theS. aureusstrains isolated from Danish hospitalized patients in 1992, while the persistent carriers had similar phage-type distribution.

PHAGE GROUPS AND ANTIBIOTIC SENSITIVITY OF STAPHYLOCOCCUS AUREUS ASSOCIATED WITH CYSTIC FIBROSIS OF THE PANCREAS

PEDIATRICS ◽  
1959 ◽  
Vol 24 (1) ◽  
pp. 40-42
Author(s):  
Fred E. Pittman ◽  
Calderon Howe ◽  
Louise Goode ◽  
Paul A. di Sant'Agnese
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Phage Type ◽  
Antibiotic Sensitivity ◽  
Phage Group ◽  
Staph Aureus ◽  
Group Iii

In this study, 198 strains of hemolytic, coagulase-positive Staph. aureus were recovered from 84 patients with cystic fibrosis of the pancreas and some of their relatives. The majority of the organisms fell into phage group III and were resistant in vitro to penicillin and other antibiotics. No single phage type seemed to be unduly prevalent in this group of patients with cystic fibrosis of the pancreas.

scholarly journals Bacteriophage-Derived PeptidaseCHAPKEliminates and Prevents Staphylococcal Biofilms

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Mark Fenton ◽  
Ruth Keary ◽  
Olivia McAuliffe ◽  
R. Paul Ross ◽  
Jim O'Mahony ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Biofilm Formation ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Bovine Mastitis ◽  
Economic Losses ◽  
Food Sector ◽  
Staphylococcal Infections ◽  
Prevention And Treatment

New antibacterial agents are urgently needed for the elimination of biofilm-forming bacteria that are highly resistant to traditional antimicrobial agents. Proliferation of such bacteria can lead to significant economic losses in the agri-food sector. This study demonstrates the potential of the bacteriophage-derived peptidase,CHAPK, as a biocidal agent for the rapid disruption of biofilm-forming staphylococci, commonly associated with bovine mastitis. PurifiedCHAPKapplied to biofilms ofStaphylococcus aureusDPC5246 completely eliminated the staphylococcal biofilms within 4 h. In addition,CHAPKwas able to prevent biofilm formation by this strain. TheCHAPKlysin also reducedS. aureusin a skin decolonization model. Our data demonstrates the potential ofCHAPKas a biocidal agent for prevention and treatment of biofilm-associated staphylococcal infections or as a decontaminating agent in the food and healthcare sectors.

Neonatal Staphylococcal Scalded Skin Syndrome: Massive Outbreak Due to an Unusual Phage Type

PEDIATRICS ◽  
1980 ◽  
Vol 66 (2) ◽  
pp. 285-290
Author(s):  
John P. Curran ◽  
Farouk L. Al-Salihi
Keyword(s):  
Staphylococcus Aureus ◽  
Phage Type ◽  
Staphylococcal Infection ◽  
Epidemic Strain ◽  
Female Ratio ◽  
Staphylococcal Scalded Skin Syndrome ◽  
Exfoliative Dermatitis ◽  
Male To Female ◽  
And Staphylococcus Aureus ◽  
Cultural Data

A massive outbreak of the staphylococcal scalded skin syndrome due to an organism with an unusual phage pattern, occurred during a 115-day period and involved 68 newborns. Generalized exfoliative dermatitis was seen in 24 babies, and Staphylococcus aureus was isolated from 23. Fourteen isolates were phage typed, with 13 reported as the epidemic strain 29/79/80/3A/3C/54/75. Eight babies had generalized scarlatiniform eruption without exfoliation (staphylococcal scarlet fever). Cultural data were available from six, all positive for S aureus. Four organisms were typed and reported as the epidemic strain. Of 34 infants with bullous impetigo 20 had cultures that were positive for S aureus, and four were phage typed, revealing the epidemic strain. Illness was mild in all patients; there were no deaths and no invasive forms of staphylococcal infection. The male to female ratio of generalized exfoliative disease was 5:1. The concept of a neonatal staphylococcal scalded skin syndrome, comprised of a triad of skin disorders induced by an exotoxin elaborated by certain strains of coagulase positive S aureus, is confirmed.

scholarly journals A Pilot Study of the Synergy between Two Antimicrobial Peptides and Two Common Antibiotics

Antibiotics ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 60 ◽  
Author(s):  
Franziska Kampshoff ◽  
Mark D. P. Willcox ◽  
Debarun Dutta
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Agents ◽  
Inhibitory Concentration ◽  
Synergistic Activity ◽  
Fractional Inhibitory Concentration ◽  
First Line ◽  
Checkerboard Assay ◽  
Resistant Strains ◽  
And Staphylococcus Aureus ◽  
Broth Dilution

Background: Frequent and unrestricted use of antibiotics has been associated with the development of antibiotic resistance by microorganisms. Thus, there is a need to find novel antibacterial agents or a combination of agents as the first line of treatment for various infections. This study aimed to investigate the synergy between antimicrobial peptide (AMP) combinations or between AMP-antibiotics combinations using two common pathogens, Pseudomonas aeruginosa and Staphylococcus aureus. Methods: The AMPs melimine, Mel4 and protamine, and antibiotics cefepime and ciprofloxacin were used in this study. The minimum inhibitory concentration (MIC) of each were evaluated against P. aeruginosa and S. aureus strains by a microtiter broth dilution. Based on the MIC of each antimicrobial agent, a checkerboard assay was performed to investigate the synergy between them, which was expressed as the fractional inhibitory concentration (FIC). Results: The combination of melimine and ciprofloxacin showed synergistic activity against antibiotic sensitive or resistant strains of P. aeruginosa and with FIC values ≤0.5. Conclusion: Combinations of AMPs and the fluoroquinolone ciprofloxacin is a promising method for reducing resistance to the fluoroquinolone of P. aeruginosa.

Promising antibacterial agents against multidrug resistant Staphylococcus aureus

2019 ◽  
Vol 92 ◽  
pp. 103252 ◽  
Author(s):  
Srikanth Gatadi ◽  
Y.V. Madhavi ◽  
Sidharth Chopra ◽  
Srinivas Nanduri
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Agents ◽  
Multidrug Resistant
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