A parapharyngeal myxoid liposarcoma

1999 ◽  
Vol 113 (2) ◽  
pp. 179-182 ◽  
Author(s):  
Johannes J. Fagan ◽  
Eugene N. Myers ◽  
Leon Barnes
Keyword(s):  
Surgical Resection ◽  
Parapharyngeal Space ◽  
Myxoid Liposarcoma ◽  
Histological Diagnosis ◽  
Resection Margins

AbstractWe present a case of a parapharyngeal space myxoid liposarcoma. This case highlights the importance of wide surgical resection margins, and the difficult histological diagnosis.

Metastatic Liposarcoma of the Skull Base: A Case Report and Review of Literature

Neurosurgery ◽  
2017 ◽  
Vol 80 (4) ◽  
pp. 219-223 ◽  
Author(s):  
Nirmeen Zagzoog ◽  
Greta Ra ◽  
Alex Koziarz ◽  
John Provias ◽  
Doron Sommer ◽  
...  
Keyword(s):  
Case Report ◽  
Skull Base ◽  
Surgical Resection ◽  
Nerve Palsy ◽  
Myxoid Liposarcoma ◽  
Resection Margins ◽  
Subtotal Resection ◽  
Sixth Nerve Palsy ◽  
Scapular Region ◽  
Sixth Nerve

Abstract BACKGROUND AND IMPORTANCE: Myxoid liposarcoma is not an uncommon form of sarcoma. However, it usually affects the lower extremity long bones. Scapular involvement is extremely rare, as is a metastasis to the parasellar region. We present a case of liposarcoma of the skull base originating in the scapular region and metastasizing to the sellar and parasellar regions and provide a review of the pertinent literature. CLINICAL PRESENTATION: A 43-year-old female patient diagnosed with left scapular myxoid liposarcoma was treated with surgical resection. She had clear resection margins and was treated pre- and postoperatively with radiotherapy to the region. She remained asymptomatic for 2 years following surgery, after which she abruptly developed diplopia with right lateral gaze. There were no symptoms of raised intracranial pressure or impaired vision. Her examination was normal apart from complete right sixth nerve palsy. Imaging studies of the brain showed a large mass in the clivus eroding into the floor of the sella, encircling the right internal carotid artery in the cavernous sinus. The mass also displaced the sellar contents superiorly. An endonasal, endoscopic skull base approach was undertaken, and a subtotal resection was performed in an effort to avoid multiple cranial nerve pareses. CONCLUSION: Our literature search revealed that this case report is the first to document liposarcoma metastasis to the skull base originating from the scapular region. Subtotal surgical resection resulted in minimal improvement of the patient's sixth nerve palsy. Postoperative radiation was undertaken. A multidisciplinary approach on an individual patient basis is recommended.

Redefining Adequate Surgical Resection Margins for Oral Squamous Cell Carcinoma: Our Institutional Experience in 5 Consecutive Years

2021 ◽  
Vol 04 (03) ◽  
Author(s):  
Irene Urquiza-Fornovi ◽  
Mario Santás-Alegret ◽  
Ana Ramos-Zayas ◽  
Irene Ruiz-Martín ◽  
María Mejía-Nieto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Squamous Cell ◽  
Resection Margins ◽  
Institutional Experience

scholarly journals Pancreatic Cancer Surgical Resection Margins: Molecular Assessment by Mass Spectrometry Imaging

PLoS Medicine ◽  
2016 ◽  
Vol 13 (8) ◽  
pp. e1002108 ◽  
Author(s):  
Livia S. Eberlin ◽  
Katherine Margulis ◽  
Ivette Planell-Mendez ◽  
Richard N. Zare ◽  
Robert Tibshirani ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Pancreatic Cancer ◽  
Surgical Resection ◽  
Mass Spectrometry Imaging ◽  
Resection Margins ◽  
Molecular Assessment

scholarly journals 18F-Fluorodeoxyglucose Positron Emission Tomography Is Useful in the Evaluation of Prognosis in Retroperitoneal Sarcoma

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4611
Author(s):  
Toru Wakamatsu ◽  
Yoshinori Imura ◽  
Hironari Tamiya ◽  
Toshinari Yagi ◽  
Naohiro Yasuda ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Surgical Resection ◽  
Fdg Pet ◽  
Histological Diagnosis ◽  
Retroperitoneal Sarcoma ◽  
Emission Tomography ◽  
Dedifferentiated Liposarcoma ◽  
Effective Treatment Option ◽  
Standardized Uptake Values ◽  
Positron Emission

Background: Retroperitoneal sarcomas are rare neoplasms that occur in the retroperitoneum. Complete surgical resection is the only effective treatment option. The prediction of prognosis by histological diagnosis has not yet been established. The purpose of this study was to identify the usefulness of [18-F] fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging for validating the prognosis of retroperitoneal sarcoma (RPS) established by histological diagnosis. Methods: We retrospectively reviewed 201 patients with RPS treated at the Osaka International Cancer Institute between 2010 and 2021. We extracted the clinical data, including standardized uptake values (SUVs), evaluated with FDG-PET, and statistically analyzed the data. Results: The median age of patients was 64 years (range, 31–85 years). A total of 101 (50.2%) patients were men, and 100 (49.8%) were women. Surgical resection was performed in 155 (77.1%) patients. On histological analysis, 75 (37.3%), 52 (25.9%), and 29 (14.4%) patients were diagnosed with dedifferentiated liposarcoma, well-differentiated liposarcoma, and leiomyosarcoma, respectively. The median survival time for patients with high maximum SUV (SUVmax) (≥4) or low SUVmax (<4) was 275.8 months and 79.5 months, respectively. Furthermore, among the patients with dedifferentiated liposarcoma, the overall survival rate for patients with high SUVmax (≥4) was significantly lower than that of those with low SUVmax (<4). Conclusions: The present study demonstrated that SUVmax calculated with FDG-PET was useful as a prognostic factor in RPS, especially in dedifferentiated liposarcoma and Grade2 RPS. To devise a treatment strategy for RPS, SUVmax during FDG-PET scan may be considered for clinical assessment.

Diffuse Giant Inflammatory Polyposis: A Challenging Clinicopathologic Diagnosis

2004 ◽  
Vol 128 (11) ◽  
pp. 1286-1288
Author(s):  
Mohammad-Reza Sheikholeslami ◽  
Robert F. Schaefer ◽  
Perkins Mukunyadzi
Keyword(s):  
Surgical Resection ◽  
Acute Inflammation ◽  
Postoperative Recovery ◽  
Resection Margins ◽  
Colonoscopic Examination ◽  
Presenting Symptoms ◽  
Adjacent Mucosa ◽  
Segmental Colectomy ◽  
Inflammatory Bowel ◽  
Inflammatory Polyposis

Abstract Giant inflammatory polyposis of the colon is an uncommon manifestation of inflammatory bowel disease. We report a unique case of localized diffuse giant inflammatory polyposis in a 58-year-old white man, which was characterized by recurrence following initial surgical resection. The patient presented with symptoms of abdominal pain and passing blood per rectum. Colonoscopic examination revealed a near-obstructing, “fungating” mass in the sigmoid colon, which clinically was thought to represent colon carcinoma. Histology of several colon biopsies revealed marked acute inflammation with microabscess formation of the polyps and the adjacent mucosa. There was no evidence of dysplasia or malignancy. Because malignancy was strongly suspected and to relieve the obstructive symptoms, the patient underwent a segmental colectomy. The histologic features of the resected mass showed giant polyps with acute inflammation diagnostic of giant inflammatory polyposis. Again, there was no evidence of malignancy. Seven months later, following an uneventful initial postoperative recovery, the patient developed a recurrence of the mass with obstructive symptoms and required further surgical resection. The gross and histologic features of the lesion were similar to the previous findings. This case highlights the varied presenting symptoms and deceptive gross colonoscopic and radiologic features of localized diffuse giant inflammatory polyposis. Finally, the presence of inflammation at the resection margins appears to predict recurrence or persistence of the disease.

scholarly journals Site-wise Differences in Adequacy of the Surgical resection Margins in Head and Neck Cancers

2014 ◽  
Vol 5 (3) ◽  
pp. 227-231 ◽  
Author(s):  
Sivakumar Vidhyadharan ◽  
Indhu Augustine ◽  
Akshay S Kudpaje ◽  
Subramania Iyer ◽  
Krishnakumar Thankappan
Keyword(s):  
Head And Neck ◽  
Surgical Resection ◽  
Head And Neck Cancers ◽  
Resection Margins

Intracranial angiosarcoma arising from a schwannoma

2006 ◽  
Vol 121 (1) ◽  
pp. 68-71 ◽  
Author(s):  
T Ito ◽  
T Tsutsumi ◽  
K Ohno ◽  
T Takizawa ◽  
K Kitamura
Keyword(s):  
Surgical Resection ◽  
Vestibular Schwannoma ◽  
Histological Diagnosis ◽  
Review Of The Literature ◽  
First Report ◽  
Cd34 Antigen ◽  
S 100 ◽  
Base Of The Skull

Angiosarcomas rarely arise from schwannomas, but we describe here a case of angiosarcoma that arose from a remnant of a benign vestibular schwannoma that had been removed 10 years earlier. The patient was a 66-year-old man with no sign of neurofibromatosis. Although we attempted surgical resection, we could not totally remove the tumour. The patient died nine months after diagnosis, primarily as result of an abscess in the cerebellum and base of the skull. The histological diagnosis was confirmed by the immunohistochemical findings of positivity for CD34 antigen and S-100 protein in the resected tumour.A review of the literature revealed four other cases of angiosarcoma with schwannoma, all of which arose from an extracranial nerve. The present case is the first report of an angiosarcoma with schwannoma arising from an intracranial locus.

scholarly journals Adjuvant Therapy in Adrenocortical Carcinoma: Reflections and Future Directions

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 508 ◽  
Author(s):  
Sara Bedrose ◽  
Marilyne Daher ◽  
Lina Altameemi ◽  
Mouhammed Amir Habra
Keyword(s):  
Adjuvant Therapy ◽  
Surgical Resection ◽  
Adrenocortical Carcinoma ◽  
Genetic Alterations ◽  
Disease Stage ◽  
Proliferation Index ◽  
Resection Margins ◽  
Ki 67 ◽  
Platinum Based Chemotherapy

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with high risk of recurrence despite macroscopically complete surgical resection. The main predictors of ACC recurrence include advanced disease stage, incomplete surgical resection, cortisol production, certain genetic alterations, and high proliferation rate (Ki-67 proliferation index). Mitotane has been the mainstay adjuvant therapy of ACC. However, the use of mitotane is based on retrospective and occasionally conflicting evidence. As mitotane levels can take a few months before reaching therapeutic levels, there is an emerging practice of combining platinum-based chemotherapy with mitotane in the adjuvant setting. Retrospective data indicate that radiotherapy is an option for select patients, particularly those with positive resection margins. There are multiple knowledge gaps in selecting patients for adjuvant therapy. It is of great importance to establish risk calculators to predict recurrence and to implement molecular profiling of ACC to guide adjuvant therapy. The role of immunotherapy in metastatic ACC is emerging and if deemed efficacious, then future studies will be needed to ascertain the role of adjuvant immunotherapy in ACC.

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