Paradoxical long-term enhancement of distortion product otoacoustic emission amplitude after repeated exposure to moderate level, wide band noise in awake guinea pigs

2009 ◽  
Vol 123 (10) ◽  
pp. 1090-1096 ◽  
Author(s):  
L Mei ◽  
Z-W Huang ◽  
Z-Z Tao
Keyword(s):  
Guinea Pigs ◽  
Noise Exposure ◽  
Wide Band ◽  
Otoacoustic Emission ◽  
Threshold Shift ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Band Noise ◽  
Wide Band Noise

AbstractObjective:Hearing sensitivity usually diminishes with noise exposure. In the present study, we examined the effect of 93 dB(A) wide band noise on cochlear micromechanical sensitivity in awake guinea pigs.Methods:Animals were randomly assigned to groups receiving either single or repeated noise exposure. Distortion product otoacoustic emission amplitudes were recorded before, during and after noise exposure.Results:Ninety-three decibel(A) wide band noise reduced the distortion product otoacoustic emission amplitudes at all tested frequencies. The distortion product otoacoustic emission amplitudes for higher frequencies showed a permanent reduction, whereas those for lower frequencies showed a temporary reduction. Distortion product otoacoustic emission amplitudes for middle frequencies showed prolonged enhancement after repeated noise exposure.Conclusion:Our results suggest that (1) it is likely that there are intermediate stages between permanent threshold shift and temporary threshold shift, and (2) long-term enhancement of distortion product otoacoustic emission amplitudes may be an indication of tinnitus generation.

Distortion-product otoacoustic emission (DPOAE) following pure tone and wide-band noise exposures

2001 ◽  
Vol 30 (1) ◽  
pp. 138-140 ◽  
Author(s):  
József Géza Kiss ◽  
Ferenc Tóth ◽  
László Rovó ◽  
Kincso Venczel ◽  
Donát Drexler ◽  
...  
Keyword(s):  
Pure Tone ◽  
Wide Band ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Band Noise ◽  
Wide Band Noise

Comparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure

2015 ◽  
Vol 129 (12) ◽  
pp. 1174-1181 ◽  
Author(s):  
N Wooles ◽  
M Mulheran ◽  
P Bray ◽  
M Brewster ◽  
A R Banerjee
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Noise Exposure ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product

AbstractObjective:To examine whether distortion product otoacoustic emissions can serve as a replacement for pure tone audiometry in longitudinal screening for occupational noise exposure related auditory deficit.Methods:A retrospective review was conducted of pure tone audiometry and distortion product otoacoustic emission data obtained sequentially during mandatory screening of brickyard workers (n = 16). Individual pure tone audiometry thresholds were compared with distortion product otoacoustic emission amplitudes, and a correlation of these measurements was conducted.Results:Pure tone audiometry threshold elevation was identified in 13 out of 16 workers. When distortion product otoacoustic emission amplitudes were compared with pure tone audiometry thresholds at matched frequencies, no evidence of a robust relationship was apparent. Seven out of 16 workers had substantial distortion product otoacoustic emissions with elevated pure tone audiometry thresholds.Conclusion:No clinically relevant predictive relationship between distortion product otoacoustic emission amplitude and pure tone audiometry threshold was apparent. These results do not support the replacement of pure tone audiometry with distortion product otoacoustic emissions in screening. Distortion product otoacoustic emissions at frequencies associated with elevated pure tone audiometry thresholds are evidence of intact outer hair cell function, suggesting that sites distinct from these contribute to auditory deficit following ototrauma.

Electrocochleography is More Sensitive than Distortion-Product Otoacoustic Emission Test for Detecting Noise-Induced Temporary Threshold Shift

2005 ◽  
Vol 133 (4) ◽  
pp. 619-624 ◽  
Author(s):  
Jin Sook Kim ◽  
Eui-Cheol Nam ◽  
Sung Il Park
Keyword(s):  
Sensitivity And Specificity ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Threshold Shift ◽  
Specific Information ◽  
Temporary Threshold Shift ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Summating Potential ◽  
A Prospective Study

OBJECTIVE: We investigated and compared the usefulness of the electrocochleography and distortion product otoacoustic emission tests for detecting the earliest noise-induced damage by analyzing the sensitivity and specificity of the 2 tests. STUDY DESIGN: A prospective study. METHODS: After listening to music at 90.3 ± 4.2 dB in the same night-club for 2 hours continuously, 23 healthy normal ears experienced a temporary threshold shift exceeding 5 dB. Pure-tone audiometry, the distortion product otoacoustic emission test, and electrocochleography were performed before, immediately after, and 24 hours after the exposure. RESULTS: Before exposure, the measured distortion product/noise floor was 9.8 ± 10.4, 23.5 ± 6.4, 18.7 ± 6.4, and 19.1 ± 5.6 dB sound pressure level (SPL) at frequencies of 1, 2, 3, and 4 kHz, respectively. Immediately after exposure, it decreased significantly at 2, 3, and 4 kHz to 16.6 ± 7.6, 12.5 ± 6.8, and 14.8 ± 7.7 dB SPL, respectively. Marked increases in the amplitude of the summating potential and summating potential/action potential ratio were recorded from 0.15 ± 0.06 to 0.32 ± 0.11 and 0.23 ± 0.06 to 0.44 ± 0.08, respectively. The respective sensitivity and specificity of electrocochleography were 76.7% to 88.5% and 91.0% to 100%. Those of the distortion product otoacoustic emission test were 54.8% to 62.2% and 75.5% to 87.0%, respectively. CONCLUSION: Electrocochleography appears to provide more sensitive and specific information than the distortion product otoacoustic emission test for detecting a noise-induced temporary threshold shift.

scholarly journals Evoked Potentials Reveal Noise Exposure–Related Central Auditory Changes Despite Normal Audiograms

2020 ◽  
Vol 29 (2) ◽  
pp. 152-164 ◽  
Author(s):  
Naomi F. Bramhall ◽  
Christopher E. Niemczak ◽  
Sean D. Kampel ◽  
Curtis J. Billings ◽  
Garnett P. McMillan
Keyword(s):  
Auditory System ◽  
Noise Exposure ◽  
Otoacoustic Emission ◽  
Auditory Brainstem ◽  
Auditory Nerve Fiber ◽  
Central Auditory System ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Brainstem Response ◽  
Latency Response

Purpose Complaints of auditory perceptual deficits, such as tinnitus and difficulty understanding speech in background noise, among individuals with clinically normal audiograms present a perplexing problem for audiologists. One potential explanation for these “hidden” auditory deficits is loss of the synaptic connections between the inner hair cells and their afferent auditory nerve fiber targets, a condition that has been termed cochlear synaptopathy . In animal models, cochlear synaptopathy can occur due to aging or exposure to noise or ototoxic drugs and is associated with reduced auditory brainstem response (ABR) wave I amplitudes. Decreased ABR wave I amplitudes have been demonstrated among young military Veterans and non-Veterans with a history of firearm use, suggesting that humans may also experience noise-induced synaptopathy. However, the downstream consequences of synaptopathy are unclear. Method To investigate how noise-induced reductions in wave I amplitude impact the central auditory system, the ABR, the middle latency response (MLR), and the late latency response (LLR) were measured in 65 young Veterans and non-Veterans with normal audiograms. Results In response to a click stimulus, the MLR was weaker for Veterans compared to non-Veterans, but the LLR was not reduced. In addition, low ABR wave I amplitudes were associated with a reduced MLR, but with an increased LLR. Notably, Veterans reporting tinnitus showed the largest mean LLRs. Conclusions These findings indicate that decreased peripheral auditory input leads to compensatory gain in the central auditory system, even among individuals with normal audiograms, and may impact auditory perception. This pattern of reduced MLR, but not LLR, was observed among Veterans even after statistical adjustment for sex and distortion product otoacoustic emission differences, suggesting that synaptic loss plays a role in the observed central gain. Supplemental Material https://doi.org/10.23641/asha.11977854

scholarly journals The Immediate and Long-Term Impact of Military Aircraft Noise on Hearing: A Cross-Sectional Comparison of Fighter Pilots and Ground Staff

2021 ◽  
Vol 18 (6) ◽  
pp. 2982
Author(s):  
Chao-Yin Kuo ◽  
Chia-Lien Hung ◽  
Hsin-Chien Chen ◽  
Cheng-Ping Shih ◽  
Rou-Huei Lu ◽  
...  
Keyword(s):  
High Frequency ◽  
Noise Exposure ◽  
Pure Tone Audiometry ◽  
Aircraft Noise ◽  
Distortion Product Otoacoustic Emission ◽  
Military Aircraft ◽  
Cross Sectional ◽  
Distortion Product ◽  
Hearing Thresholds

We examined the immediate and long-term impacts of military aircraft noise exposure on noise-induced hearing loss (NIHL) in fighter pilots and ground staff. We recruited 40 pilots, 40 ground staff, and 136 age-matched controls; all participants underwent hearing tests, including conventional pure-tone audiometry (PTA) (0.25–8.0 kHz), extended high-frequency (EHF) audiometry (9.0–18.0 kHz), and distortion-product otoacoustic emission (DPOAE) as a recent reference. A subsequent hearing test immediately after flight-mission noise exposure was requested. The results revealed higher recent hearing thresholds in pilots and ground staff than in controls. Threshold shifts at many octave band frequencies were also significantly elevated in ground staff. The grouped frequency threshold was significantly elevated in the 4–8 kHz high-frequency range. After a single flight-mission noise exposure, both ground staff and pilots showed decreased signal-to-noise ratios for DPOAE (1–8 kHz), whereas only ground staff showed significantly elevated left-ear hearing thresholds at 3, 11.2, and 12.5 kHz by conventional and EHF PTA. Fighter pilots and ground staff serve in hazardous noise-exposed environments that cause hearing damage and subsequent NIHL, but ground staff may be more vulnerable. A comprehensive hearing conservation program should be implemented to protect high-risk service members, and especially ground staff, from high-intensity noise exposure.

scholarly journals Noise Exposure and Distortion Product Otoacoustic Emission Suprathreshold Amplitudes: A Genome-Wide Association Study

2021 ◽  
pp. 1-9
Author(s):  
Joel Lavinsky ◽  
Guilherme Kasperbauer ◽  
Ricardo F. Bento ◽  
Aline Mendonça ◽  
Juemei Wang ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Noise Exposure ◽  
Association Studies ◽  
Otoacoustic Emission ◽  
Inbred Strains ◽  
Genome Wide Association ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Genome Wide ◽  
Before And After

<b><i>Background:</i></b> Although several candidate-gene association studies have been conducted to investigate noise-induced hearing loss (NIHL) in humans, most are underpowered, unreplicated, and account for only a fraction of the genetic risk. Mouse genome-wide association studies (GWASs) have revolutionized the field of genetics and have led to the discovery of hundreds of genes involved in complex traits. The hybrid mouse diversity panel (HMDP) is a collection of classic inbred and recombinant inbred strains whose genomes have been either genotyped at high resolution or sequenced. To further investigate the genetics of NIHL, we report the first GWAS based on distortion product otoacoustic emission (DPOAE) measurements and the HMDP. <b><i>Methods:</i></b> A total of 102 strains (<i>n</i> = 635) from the HMDP were evaluated based on DPOAE suprathreshold amplitudes before and after noise exposure. DPOAE amplitude variation was set at 60 and 70 dB SPL of the primary tones for each frequency separately (8, 11.3, 16, 22.6, and 32 kHz). These values provided an indirect assessment of outer hair cell integrity. Six-week-old mice were exposed for 2 h to 10 kHz octave-band noise at 108 dB SPL. To perform local expression quantitative trait locus (eQTL) analysis, gene expression microarray profiles were generated using cochlear RNA from 64 hybrid mouse strains (<i>n</i> = 3 arrays per strain). <b><i>Results:</i></b> Several new loci were identified and positional candidate-genes associated with NIHL were prioritized, especially after noise exposure (1 locus at baseline and 5 loci after exposure). A total of 35 candidate genes in these 6 loci were identified with at least 1 probe whose expression was regulated by a significant <i>cis</i>-eQTL in the cochlea. After careful analysis of the candidate genes based on cochlear gene expression, 2 candidate genes were prioritized: <i>Eya1</i> (baseline) and <i>Efr3a</i> (post-exposure). <b><i>Discussion and Conclusion:</i></b> For the first time, an association analysis with correction for population structure was used to map several loci for hearing traits in inbred strains of mice based on DPOAE suprathreshold amplitudes before and after noise exposure. Our results identified a number of novel loci and candidate genes for susceptibility to NIHL, especially the <i>Eya1</i> and <i>Efr3a</i> genes. Our findings validate the power of the HMDP for detecting NIHL susceptibility genes.

scholarly journals Dietary Supplement Comprised of β-Carotene, Vitamin C, Vitamin E, and Magnesium: Failure to Prevent Music-Induced Temporary Threshold Shift

2016 ◽  
Vol 6 (2) ◽  
pp. 20-39 ◽  
Author(s):  
Colleen G. Le Prell ◽  
Angela Fulbright ◽  
Christopher Spankovich ◽  
Scott K. Griffiths ◽  
Edward Lobarinas ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Otoacoustic Emission ◽  
Threshold Shift ◽  
Double Blind Study ◽  
Temporary Threshold Shift ◽  
Distortion Product Otoacoustic Emission ◽  
Double Blind ◽  
Distortion Product ◽  
Significant Difference ◽  
Β Carotene

This study examined potential prevention of music-induced temporary threshold shift (TTS) in normal-hearing participants. A dietary supplement composed of β-carotene, vitamins C and E, and magnesium was assessed using a randomized, placebo-controlled, double-blind study design. Dosing began 3 days prior to the music exposure with the final dose consumed approximately 30-min pre-exposure. Post-exposure TTS was measured, with no significant difference as a function of treatment. Distortion product otoacoustic emission amplitudes were suppressed after music exposure in both groups, with no significant difference as a function of treatment. Tinnitus was more likely to be reported by the treatment group, but there were no group differences in perceived loudness or bothersomeness. Taken together, this supplement had no effect on noise-induced changes in hearing. Recommendations for future clinical trials are discussed.

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