Hypopharyngeal cancer associated with synchronous oesophageal cancer: risk factors and benefits of image-enhanced endoscopic screening

2017 ◽  
Vol 132 (2) ◽  
pp. 154-161 ◽  
Author(s):  
X-G Ni ◽  
Q-Q Zhang ◽  
J-Q Zhu ◽  
G-Q Wang
Keyword(s):  
Risk Factors ◽  
Oesophageal Cancer ◽  
Odds Ratio ◽  
Narrow Band Imaging ◽  
Heavy Drinking ◽  
Hypopharyngeal Cancer ◽  
Second Primary ◽  
Endoscopic Screening ◽  
Cancer Risk Factors ◽  
Early Oesophageal Cancer

AbstractObjectives:To explore the risk factors associated with the occurrence of synchronous oesophageal cancer in patients with hypopharyngeal cancer, and to investigate the roles of image-enhanced endoscopic screening in the prediction and diagnosis of early oesophageal cancer.Methods:The clinical characteristics of patients with hypopharyngeal cancer (n = 160) were analysed. All patients underwent laryngoscopic and gastroscopic examination using image-enhanced endoscopic techniques before treatment.Results:Of 160 hypopharyngeal cancer patients, 43 (27 per cent) had synchronous oesophageal cancer. Heavy drinking (odds ratio = 4.787, p = 0.029) and local invasion of three or more anatomical sites (odds ratio = 14.391, p = 0.000) were independent risk factors for synchronous oesophageal cancer. Narrow-band imaging laryngoscopy could detect more invaded anatomical sites than ordinary white light endoscopy (t = 8.532, p = 0.000). More early oesophageal cancer cases were detected with Lugol chromoendoscopy than with non-Lugol iodine staining examination (χ2 = 4.925, p = 0.026).Conclusion:Synchronous oesophageal cancer is common in patients with hypopharyngeal cancer. The heavy drinking patients with hypopharyngeal cancer should undergo intensive monitoring. Image-enhanced endoscopic screening is helpful in the prediction and early detection of second primary oesophageal cancer.

scholarly journals Risk Models Based On Populations In High-Risk Areas of Oesophageal Cancer In China For Improving The Oesophageal Cancer Diagnosis Rate

2021 ◽  
Author(s):  
Guodong Yang ◽  
Xiaogang Yu ◽  
Xiaoqi Long ◽  
Xiaoming Zhang ◽  
Weiwei Du ◽  
...  
Keyword(s):  
High Risk ◽  
Oesophageal Cancer ◽  
Narrow Band Imaging ◽  
Precancerous Lesions ◽  
Characteristic Curve ◽  
Univariate Analysis ◽  
High Risk Population ◽  
Severe Dysplasia ◽  
Risk Areas ◽  
Early Oesophageal Cancer

Abstract Background: To improve the diagnostic efficiency of early oesophageal cancer, it is of great significance to develop an effective risk prediction model. This study aimed to identify a high-risk population with oesophageal squamous cell carcinoma (ESCC) based on a population screening model.Methods: From 120 target townships randomly selected from 150 villages selected in Nanchong City, Sichuan Province, China, from Jan 2016 to Sep 2019, a total of 6409 subjects were screened. Each patient underwent standard endoscopy and narrow band imaging (NBI) and iodine staining indicator biopsies to evaluate oesophageal cancer and precancerous lesions. Before endoscopy, the subjects completed a questionnaire about ESCC risk factors. Variables were evaluated by univariate analysis, and variables significantly related to ESCC were extracted by using a logistic regression model. We used the Akaike information criterion to develop the final model structure and the coding form of variables with multiple metrics. We developed two sets of models to define severe dysplasia and above (SDA) and moderate dysplasia and above (MDA) as prognostic events, respectively. Results: The areas under the receiver operating characteristic curve (AUROC) were0.896 (95%CI, 0.888-0.903) and 0.825 (95% CI, 0.816-0.835) for our SDA and MDA models, respectively. MDA-related and SDA-related factors included age, sex, cigarette smoking, alcohol drinking, pharyngeal foreign body sensation, swallowing obstruction, pain behind the sternum, and discomfort behind the breastbone.Conclusions: we developed an easy-to-use model to identify individuals with high risk of dysplasia or oesophageal cancer in high-risk areas of oesophageal cancer in China.

Time from incident primary cancer until recurrence or second primary cancer: Risk factors and impact in general practice

2019 ◽  
Vol 28 (5) ◽  
Author(s):  
Linda Aagaard Rasmussen ◽  
Henry Jensen ◽  
Line Flytkjær Virgilsen ◽  
Alina Zalounina Falborg ◽  
Henrik Møller ◽  
...  
Keyword(s):  
Risk Factors ◽  
General Practice ◽  
Cancer Risk ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Cancer Risk Factors

Association between Laryngopharyngeal Reflux and Vocal Fold Leukoplakia

ORL ◽  
2021 ◽  
Vol 83 (3) ◽  
pp. 159-166
Author(s):  
Guowei Lu ◽  
Xiu Ding ◽  
Wen Xu
Keyword(s):  
Risk Factors ◽  
Odds Ratio ◽  
Vocal Fold ◽  
Laryngopharyngeal Reflux ◽  
Ph Monitoring ◽  
Critical Role ◽  
Heavy Drinking ◽  
General Information ◽  
Underlying Mechanisms ◽  
Vocal Fold Leukoplakia

<b><i>Introduction:</i></b> Vocal fold leukoplakia (VFL) has a risk of malignant transformation, and the underlying mechanisms are currently unrecognized. Some clinical evidence has indicated that laryngopharyngeal reflux (LPR) probably plays a critical role. <b><i>Objective:</i></b> To explore the risk factors associated with the occurrence of VFL and to investigate the importance of LPR in VFL and its different pathological types using 24-h multichannel intraluminal impedance-pH monitoring. <b><i>Materials and Methods:</i></b> Eighty-one patients with VFL and 27 healthy volunteers were recruited. General information and LPR parameters were analyzed. <b><i>Results:</i></b> The monitoring showed that 35.8% (29/81) of patients had acidic LPR and that 43.2% (35/81) had weakly acidic LPR. Heavy drinking (odds ratio = 4.004, <i>p</i> = 0.037) and acidic LPR (odds ratio = 4.471, <i>p</i> = 0.029) were independent risk factors for the occurrence of VFL. Acidic LPR showed a strong correlation with the Reflux Finding Score (<i>p</i> &#x3c; 0.05) in patients suspected of having LPR based on the scale score. Meanwhile, weakly acidic LPR parameters increased with the severity of pathological degrees which were higher in high-grade dysplasia (<i>p</i> &#x3c; 0.05). <b><i>Conclusion:</i></b> Our study confirms the importance of LPR in VFL. Heavy drinking patients with VFL, particularly those with acidic LPR, should undergo intensive treatment. Meanwhile, weakly acidic LPR may play a critical role in the pathological changes in VFL.

A pilot case control study: Could a gastric cancer risk screening tool help identify high risk patients for endoscopic screening in the United States?

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 64-64
Author(s):  
Haejin In ◽  
Marisa Langdon-Embry ◽  
Lauren Gordon ◽  
Judith Wylie-Rosett ◽  
Clyde Schechter ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Cancer Risk ◽  
Foreign Born ◽  
Gastric Cancer Risk ◽  
Daily Consumption ◽  
Endoscopic Screening ◽  
Cancer Risk Factors ◽  
The Us ◽  
Community Controls

64 Background: Gastric cancer incidence varies greatly among US racial/ethnic groups. Few studies have examined ethnicity, birth country, immigration and cultural diet as gastric cancer risk factors in the US. These factors, in combination with known risk factors may narrow a target population for gastric cancer screening. Methods: Two racially diverse hospital systems were used to recruit gastric cancer cases using the cancer registry, and primary care (PC) controls from waiting rooms or phone. Community controls were recruited at community gatherings. Participants were eligible if 40-85 years old, not under endoscopic surveillance and without genetic syndromes. The survey items (n = 227) included conventional risk factors, plus items about ethnicity, birth country, acculturation, and ethnic diet. Results: Of 150 participants, 39 cases, 41 PC-controls, and 44 community controls were eligible for analysis. PC-controls generally completed phone interviews (72% vs 28%), while community controls generally completed paper surveys (92% vs 8%). Gastric cancer cases were more likely to be foreign born (85% vs. 49%, p = < 0.01), from a country with gastric cancer incidence > 5 per 100,000: (62% vs. 30%, p = < 0.01) and report daily consumption of cultural food at ages 15 to 18 (69% vs. 35%, p = < 0.01) compared to controls. Cases were also older, male, Hispanic, and had stronger family history of gastric cancer. Cases and controls had similar frequency of alcohol consumption, smoking, acculturation, and barbequed food consumption. In multivariate analysis, increased age (per year, aOR 1.4, 95%CI 1.07-1.21), daily consumption of cultural foods at ages 15 to 18 (aOR 19.58, 95%CI 1.54-248.99), having less than high school education (aOR 7.24, 95%CI 1.49-35.10), and being foreign born (aOR 11.81, 95%CI 1.69-82.64) were associated with case status. Conclusions: A risk assessment tool that addresses awareness of gastric cancer risk factors, ethnicity, cultural habits and immigration patterns has potential to identify high-risk persons from multicultural areas within the US, who might benefit from endoscopic screening for gastric cancer. (Support: UG1CA189823)

Risk factors for the development of oesophageal cancer as a second primary tumour

1995 ◽  
Vol 31 (11) ◽  
pp. 1836-1839 ◽  
Author(s):  
H.K. van Halteren ◽  
B.G. Taal ◽  
H. van Tinteren ◽  
F.E. van Leeuwen
Keyword(s):  
Risk Factors ◽  
Oesophageal Cancer ◽  
Primary Tumour ◽  
Second Primary ◽  
Second Primary Tumour

Early Mortality in Patients with Lung Cancer: Risk Factors for Death within 30 Days or 60 Days of Initial Diagnosis

2019 ◽  
Author(s):  
A Tufman ◽  
S Schneiderbauer ◽  
D Kauffmann-Guerrero ◽  
F Manapov ◽  
C Schneider ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Early Mortality ◽  
Initial Diagnosis ◽  
Cancer Risk Factors

Colon cancer: risk factors and screening

2020 ◽  
pp. 13-22
Author(s):  
Mark Natanson
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cancer Risk ◽  
Clinical Manifestations ◽  
Dysplastic Lesion ◽  
Test Analysis ◽  
Cancer Risk Factors ◽  
Colon Cancer Risk ◽  
Neoplastic Process ◽  
Rectal Cancers

Colon and rectal cancers are usually combined under the same term "colorectal cancer". It should be noted that the lesion of the colon is much more common. Colorectal cancer ranks fourth in the overall structure of oncological pathology in terms of prevalence, and in some countries even comes third after lung and stomach cancer. Risk factors that contribute to the development of colorectal cancer include bowel polyps, ulcerative colitis and Crohn's disease, and a genetic predisposition. Most often, neoplastic transformation occurs at the site of an adenoma or dysplastic lesion of the intestinal mucosa. Due to the high risk of neoplastic process in a sufficiently large number of elderly people, it is recommended that every person over the age of 50 should undergo compulsory screening to detect latent cancer. The simplest, but at the same time insufficiently informative method is a blood culture test - analysis for the presence of blood in the feces. Method of total colonoscopy and double-contrast radiography is distinguished by a higher information content, but at the same time a higher cost. It is recommended to have these examinations every three to five years after the age of 50 years without clinical manifestations, and after the age of 40 for those at risk for colorectal cancer.

Sign in / Sign up

Export Citation Format

Share Document