Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62

Parasitology ◽  
2005 ◽  
Vol 130 (S1) ◽  
pp. S63-S68 ◽  
Author(s):  
W. HARNETT ◽  
H. S. GOODRIDGE ◽  
M. M. HARNETT
Keyword(s):  
Signal Transduction ◽  
B Lymphocytes ◽  
Immune Cell ◽  
Filarial Nematode ◽  
Signal Transduction Pathways ◽  
Immunomodulatory Effects ◽  
Filarial Nematodes ◽  
Intracellular Signal ◽  
Cell Signal Transduction ◽  
Immunomodulatory Properties

Filarial nematodes achieve longevity within the infected host by suppressing and modulating the host immune response. To do this, the worms actively secrete products that have been demonstrated to possess immunomodulatory properties. In this article we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode secreted glycoprotein ES-62. In particular we describe how it modulates intracellular signal transduction pathways in a number of different cells of the immune system, in particular B-lymphocytes, T-lymphocytes, macrophages and dendritic cells.

scholarly journals Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways

FEBS Letters ◽  
2010 ◽  
Vol 584 (11) ◽  
pp. 2455-2460 ◽  
Author(s):  
Geoffrey Guittard ◽  
Eva Mortier ◽  
Hélène Tronchère ◽  
Guylène Firaguay ◽  
Audrey Gérard ◽  
...  
Keyword(s):  
Signal Transduction ◽  
T Cell ◽  
Signal Transduction Pathways ◽  
Positive Role ◽  
Cell Signal ◽  
Cell Signal Transduction

Intracellular signal transduction pathways in sponges

1990 ◽  
Vol 3 (1) ◽  
pp. 97-114 ◽  
Author(s):  
Werner E.G. Müller ◽  
Durdica Ugarković ◽  
Vera Gamulin ◽  
Barbara E. Weiler ◽  
Heinz C. Schröder
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Pathways ◽  
Intracellular Signal Transduction ◽  
Intracellular Signal

scholarly journals Visual Cortex Plasticity: A Complex Interplay of Genetic and Environmental Influences

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
José Fernando Maya-Vetencourt ◽  
Nicola Origlia
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Nervous System ◽  
Sensory Deprivation ◽  
Environmental Influences ◽  
Signal Transduction Pathways ◽  
Gene Promoters ◽  
Complex Interplay ◽  
Intracellular Signal Transduction ◽  
Intracellular Signal

The central nervous system architecture is highly dynamic and continuously modified by sensory experience through processes of neuronal plasticity. Plasticity is achieved by a complex interplay of environmental influences and physiological mechanisms that ultimately activate intracellular signal transduction pathways regulating gene expression. In addition to the remarkable variety of transcription factors and their combinatorial interaction at specific gene promoters, epigenetic mechanisms that regulate transcription have emerged as conserved processes by which the nervous system accomplishes the induction of plasticity. Experience-dependent changes of DNA methylation patterns and histone posttranslational modifications are, in fact, recruited as targets of plasticity-associated signal transduction mechanisms. Here, we shall concentrate on structural and functional consequences of early sensory deprivation in the visual system and discuss how intracellular signal transduction pathways associated with experience regulate changes of chromatin structure and gene expression patterns that underlie these plastic phenomena. Recent experimental evidence for mechanisms of cross-modal plasticity following congenital or acquired sensory deprivation both in human and animal models will be considered as well. We shall also review different experimental strategies that can be used to achieve the recovery of sensory functions after long-term deprivation in humans.

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