Tankyrase inhibitors hinder Trypanosoma cruzi infection by altering host-cell signalling pathways

Parasitology ◽  
2021 ◽  
pp. 1-41
Author(s):  
Laura Lafon-Hughes ◽  
Silvia H. Fernández Villamil ◽  
Salomé C. Vilchez Larrea
Keyword(s):  
Trypanosoma Cruzi ◽  
Host Cell ◽  
Cell Signalling ◽  
Signalling Pathways ◽  
Cruzi Infection

scholarly journals Host Cell Lipid Bodies Triggered by Trypanosoma cruzi Infection and Enhanced by the Uptake of Apoptotic Cells Are Associated With Prostaglandin E2 Generation and Increased Parasite Growth

2011 ◽  
Vol 204 (6) ◽  
pp. 951-961 ◽  
Author(s):  
Heloisa D’Avila ◽  
Célio G. Freire-de-Lima ◽  
Natalia R. Roque ◽  
Livia Teixeira ◽  
Christina Barja-Fidalgo ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Prostaglandin E2 ◽  
Host Cell ◽  
Parasite Growth ◽  
Apoptotic Cells ◽  
Lipid Bodies ◽  
Cell Lipid ◽  
Cruzi Infection

scholarly journals Trypanosoma cruzi Infection Induces a Global Host Cell Response in Cardiomyocytes

2011 ◽  
Vol 79 (8) ◽  
pp. 3471-3471 ◽  
Author(s):  
Patricio A. Manque ◽  
Christian M. Probst ◽  
Mirian C. S. Pereira ◽  
Rita C. P. Rampazzo ◽  
Luiz Shozo Ozaki ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Host Cell ◽  
Cell Response ◽  
Host Cell Response ◽  
Cruzi Infection

scholarly journals Host Cell Poly(ADP-Ribose) Glycohydrolase Is Crucial for Trypanosoma cruzi Infection Cycle

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e67356 ◽  
Author(s):  
Salomé C. Vilchez Larrea ◽  
Mariana Schlesinger ◽  
María L. Kevorkian ◽  
Mirtha M. Flawiá ◽  
Guillermo D. Alonso ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Host Cell ◽  
Infection Cycle ◽  
Cruzi Infection

Targeting of host-cell ubiquitin pathways by viruses

2005 ◽  
Vol 41 ◽  
pp. 139-156 ◽  
Author(s):  
Julia Shackelford ◽  
Joseph S. Pagano
Keyword(s):  
Host Cell ◽  
Cell Biology ◽  
Cell Signalling ◽  
Ubiquitin Proteasome System ◽  
Life Cycles ◽  
Therapeutic Interventions ◽  
Signalling Pathways ◽  
Cellular Functions ◽  
Ubiquitin Proteasome ◽  
Do So

The ability of viruses to co-opt cell signalling pathways has, over millions of years of co-evolution, come to pervade nearly every facet of cellular functions. Recognition of the extent to which the ubiquitin–proteasome system can be directed or subverted by viruses is relatively recent. Viral products interact with, and adjust, the ubiquitin–proteasome machinery precisely and at many levels, and they do so at distinct stages of viral life-cycles. The implications for both cells and viruses are fundamental, and understanding viral strategies in this context opens up fascinating new areas for research that span from basic cell biology to therapeutic interventions against both viruses and malignancies.

Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules

2002 ◽  
Vol 44 (4) ◽  
pp. 1095-1107 ◽  
Author(s):  
Brendan Kenny ◽  
Sarah Ellis ◽  
Alan D. Leard ◽  
Jonathan Warawa ◽  
Harry Mellor ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Host Cell ◽  
Cell Signalling ◽  
Signalling Pathways ◽  
Enteropathogenic Escherichia Coli ◽  
Effector Molecules

A conserved domain of the gp85/trans-sialidase family activates host cell extracellular signal-regulated kinase and facilitates Trypanosoma cruzi infection

2007 ◽  
Vol 313 (1) ◽  
pp. 210-218 ◽  
Author(s):  
Margaret H. Magdesian ◽  
Renata R. Tonelli ◽  
Melissa R. Fessel ◽  
Mariana S. Silveira ◽  
Robert I. Schumacher ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Host Cell ◽  
Extracellular Signal Regulated Kinase ◽  
Conserved Domain ◽  
Extracellular Signal ◽  
Cruzi Infection

Differential activation of host cell signalling pathways through infection with two variants of influenza A/Puerto Rico/8/34 (H1N1) in MDCK cells

Vaccine ◽  
2010 ◽  
Vol 28 (51) ◽  
pp. 8210-8218 ◽  
Author(s):  
B. Heynisch ◽  
T. Frensing ◽  
K. Heinze ◽  
C. Seitz ◽  
Y. Genzel ◽  
...  
Keyword(s):  
Puerto Rico ◽  
Host Cell ◽  
Influenza A ◽  
Mdck Cells ◽  
Cell Signalling ◽  
Signalling Pathways ◽  
Differential Activation

scholarly journals P100W4-2 Analysis of host cell apoptosis in vitro and in vivo by Trypanosoma cruzi infection

2001 ◽  
Vol 52 (Supplement) ◽  
pp. 102
Author(s):  
Junko SHIMADA ◽  
Chunbin ZOU ◽  
Takeshi NARA ◽  
Miriam PONSTAN ◽  
Takashi AOKI ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Host Cell ◽  
Cell Apoptosis ◽  
Host Cell Apoptosis ◽  
Cruzi Infection

The induction of host cell autophagy triggers defense mechanisms against Trypanosoma cruzi infection in vitro

2020 ◽  
Vol 99 (1) ◽  
pp. 151060
Author(s):  
Thabata L.A. Duque ◽  
Mariana S. Siqueira ◽  
Leonardo H. Travassos ◽  
Otacílio C. Moreira ◽  
Patrícia T. Bozza ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Host Cell ◽  
Defense Mechanisms ◽  
Cruzi Infection
Sign in / Sign up

Export Citation Format

Share Document