The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies

2005 ◽  
Vol 36 (2) ◽  
pp. 159-165 ◽  
Author(s):  
STEPHEN V. FARAONE ◽  
JOSEPH BIEDERMAN ◽  
ERIC MICK
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Meta Analysis ◽  
Control Group ◽  
Adhd Symptoms ◽  
Hyperactivity Disorder ◽  
Follow Up Studies ◽  
Age Dependent ◽  
Definition Of

Background. This study examined the persistence of attention deficit hyperactivity disorder (ADHD) into adulthood.Method. We analyzed data from published follow-up studies of ADHD. To be included in the analysis, these additional studies had to meet the following criteria: the study included a control group and it was clear from the methods if the diagnosis of ADHD included subjects who did not meet full criteria but showed residual and impairing signs of the disorder. We used a meta-analysis regression model to separately assess the syndromatic and symptomatic persistence of ADHD.Results. When we define only those meeting full criteria for ADHD as having ‘persistent ADHD’, the rate of persistence is low, ~15% at age 25 years. But when we include cases consistent with DSM-IV's definition of ADHD in partial remission, the rate of persistence is much higher, ~65%.Conclusions. Our results show that estimates of ADHD's persistence rely heavily on how one defines persistence. Yet, regardless of definition, our analyses show that evidence for ADHD lessens with age. More work is needed to determine if this reflects true remission of ADHD symptoms or is due to the developmental insensitivity of diagnostic criteria for the disorder.

scholarly journals Predictors of Depressive Symptoms in Caregivers of Children with Attention-Deficit/Hyperactivity Disorder: A One-Year Follow-Up Study

2021 ◽  
Vol 18 (16) ◽  
pp. 8835
Author(s):  
Wen-Jiun Chou ◽  
Ray C. Hsiao ◽  
Chih-Cheng Chang ◽  
Cheng-Fang Yen
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Depressive Symptoms ◽  
Family Support ◽  
Attention Deficit ◽  
Stress Coping ◽  
Adhd Symptoms ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Follow Up Study

This 1-year follow-up study examined the predictive values of the demographics, depressive symptoms, stress-coping orientations, and perceived family support of caregivers as well as the internalizing, externalizing and ADHD symptoms of children with attention-deficit/hyperactivity disorder (ADHD) at baseline on the depressive symptoms of the caregivers after 1 year. A total of four hundred caregivers of children with ADHD were recruited. The baseline levels of the caregivers’ depressive symptoms, stress-coping orientations, and perceived family support and the internalizing and externalizing problems of the children were assessed using the Center for Epidemiological Studies Depression Scale, the Coping Orientation to Problems Experienced, Family Adaptation, Partnership, Growth, Affection, Resolve Index, and the Child Behavior Checklist For Ages 6–18, respectively. Their predictions for the caregiver’s depressive symptoms 1 year after the baseline were examined using linear regression analysis. In total, 382 caregivers of children with ADHD underwent the follow-up assessment 1 year from the baseline. A marital status of being separated or divorced, less effective coping and depressive symptoms orientation, and children with internalizing problems and ADHD symptoms at baseline were positively associated with the caregivers’ depressive symptoms at follow-up, whereas the caregivers’ perceived family support and an emotion-focused coping orientation at baseline were negatively associated with depressive symptoms at follow-up. Multiple characteristics of the caregivers and children with ADHD at baseline predicted the caregivers’ depressive symptoms 1 year later.

Efficacy, Acceptability, and Tolerability of Lisdexamfetamine, Mixed Amphetamine Salts, Methylphenidate, and Modafinil in the Treatment of Attention-Deficit Hyperactivity Disorder in Adults: A Systematic Review and Meta-analysis

2018 ◽  
Vol 53 (2) ◽  
pp. 121-133 ◽  
Author(s):  
Matej Stuhec ◽  
Petar Lukić ◽  
Igor Locatelli
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Clinical Trials ◽  
Effect Size ◽  
Attention Deficit ◽  
Data Extraction ◽  
Meta Analysis ◽  
Sole Source ◽  
Adhd Symptoms ◽  
Double Blind ◽  
Hyperactivity Disorder

Objective: Psychostimulants are the first-line treatment in adults with attention-deficit hyperactivity disorder (ADHD). This meta-analysis aimed to evaluate the efficacy, acceptability, and tolerability of lisdexamfetamine (LDX), mixed amphetamine salts (MASs), modafinil (MDF), and methylphenidate (MPH) in comparison with placebo. Data Sources: We systematically searched PubMed/MEDLINE and Clinicaltrials.gov in May 2016, along with CENTRAL and EU Clinical Trials Register in February 2016, for the randomized, double-blind, placebo-controlled, parallel-group clinical trials conducted on adults diagnosed with ADHD. Study Selection and Data Extraction: Substantial comorbidity, substance abuse or dependence, and nonpharmacological interventions represented grounds for exclusion. Published reports were the sole source for data extraction. Improvement in ADHD symptoms was the primary outcome. Random-effects model meta-analysis was applied to calculate the standardized mean difference (SMD) with 95% CIs. Data Synthesis: The search retrieved 701 records, of which 20 studies were eligible for analysis. High effect size (expressed as SMD) in reducing ADHD symptoms was observed for LDX (−0.89; 95% CI = −1.09, −0.70), whereas MASs (−0.64; 95% CI = −0.83, −0.45) and MPH (−0.50; 95% CI = −0.58, −0.41) reduced symptoms moderately compared with placebo. No efficacy was shown for MDF (0.08; 95% CI; −0.18, 0.34). Relevance to Patient Care and Clinical Practice: In this meta-analysis, the efficacy, tolerability, and acceptability of psychostimulants were compared with that for placebo. Five of the included trials have not been evaluated in any of the previously published meta-analyses. Conclusions: The results suggest that LDX has the largest effect size and has a promising potential for treating adults with ADHD.

Are attention-deficit/hyperactivity disorder symptoms associated with a more severe course of substance use? A longitudinal study with young Swiss men

2016 ◽  
Vol 33 (S1) ◽  
pp. S21-S21
Author(s):  
F. Moggi
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Substance Use ◽  
Drug Use ◽  
Attention Deficit ◽  
Population Sample ◽  
Self Report ◽  
Adhd Group ◽  
Adhd Symptoms ◽  
Hyperactivity Disorder

IntroductionAdults with attention-deficit/hyperactivity disorder (ADHD) symptoms show higher prevalence rates for substance use disorders (SUD).ObjectivesFew longitudinal studies have been conducted to observe the course of substance use among adults with ADHD.AimsThis study examined the predictive value of ADHD symptoms during the course of substance use in a population sample.MethodsIn two waves data from a representative sample of 5103 Swiss men in their early 20s were collected (baseline and 15-month follow-up) in the longitudinal “Cohort Study on Substance Use Risk Factors” (C-SURF). ADHD symptoms and substance use were assessed using the adult ADHD Self-Report Scale (ASRS-v1.1) and self-administered SUD questionnaires, respectively. Individuals who screened positive for ADHD (ADHD+) were compared to those who screened negative (ADHD−).ResultsAt baseline, the 215 individuals in the ADHD+ group (4.2%) showed considerably higher prevalence and frequency of substance use and prevalence of alcohol, tobacco, and cannabis use disorders relative to the ADHD− group. While alcohol, tobacco, cannabis, and heroin use remained stable from baseline to follow-up, the ADHD+ group was more likely to begin using illicit drugs (i.e. amphetamines, speed, ecstasy, hallucinogens, and cocaine) and initiate nonmedical use of prescription drugs (i.e. stimulants/amphetamines, hypnotics, and tranquilizers) relative to the ADHD− group.ConclusionsYoung men with ADHD symptoms displayed more severe substance use patterns and were at a high risk of initiating drug use within 15 months. The identification of ADHD symptoms during early adulthood may be relevant in early interventions to lower the risk of drug use.Disclosure of interestThe author has not supplied his declaration of competing interest.

scholarly journals Comparison of the Effectiveness of Motivational Manipulation and Neurofeedback Methods on Sensitivity to Reward, Delay Discounting and Impulsivity in Children with Attention Deficit / Hyperactivity Disorder

2021 ◽  
Author(s):  
Siyamak Tahmasebi Garmtani ◽  
◽  
Alireza Karimpour Vazifehkhorani ◽  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Delay Discounting ◽  
Attention Deficit ◽  
Control Group ◽  
Sensitivity To Reward ◽  
Hyperactivity Disorder ◽  
Post Test ◽  
The Difference ◽  
Reward Delay

Purpose; The aim of this study was to comparison of the effectiveness of two methods of motivational manipulation and neurofeedback on sensitivity to reward, delay discounting and impulsivity in children with attention deficit / hyperactivity disorder. Methods; The present study was an experimental study with pre-test, post-test, follow-up and control group. The study population consisted of children aged 7 to 12 years with ADHD. Available sampling method was used for sampling in this study. Sample size was selected based on the purpose and method of research (in experimental research, the sample size of at least 30 people in each group is recommended) 90 people. In this study, neurofeedback and motivational manipulation were performed on the intervention group as an intervention, each session was performed for 12 sessions and each session was performed for 45 minutes. Balloon risk test and delay discounting test were used to collect data in pre-test, post-test and follow-up stages and the data were analyzed using MANCOVA statistical method in SPSS-23. Results; By controlling the effects of pretest on posttest, the difference between the groups in the posttest was statistically significant between the variables of impulsivity and delay at the level of P <0.01 and between the variables of reward sensitivity at the level of P <0.05. The results also showed that neurofeedback method (M = 4.66) had a greater effect on reward processing than motivational manipulation method (M = 2.31) compared to the control group, which was significant at the level of P <0.01. But the difference between the mean of motivational manipulation (M = 2.31) in comparison with the control group was not significant. Conclusion; Voluntary activation of dopaminergic regions of the brain by neurofeedback and motivational manipulation leads to endogenous dopamine control in these structures, leading to successful regulation or inhibitory control and reduced cravings, which reduces impulsivity, delay discounting, and sensitivity to reward.

scholarly journals An Exercise Program Designed for Children with Attention Deficit/Hyperactivity Disorder for Use in School Physical Education: Feasibility and Utility

Healthcare ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 102 ◽  
Author(s):  
Taylor ◽  
Novo ◽  
Foreman
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Physical Education ◽  
Attention Deficit ◽  
School Environment ◽  
Exercise Program ◽  
Control Group ◽  
Adhd Symptoms ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Reported Data

Moderate to high intensity exercise can improve cognitive function and behavior in children including those with attention-deficit/hyperactivity disorder (ADHD). However, exercise with long periods of the same activity, or inactivity can fail to engage or maintain their attention. This study examined the effect of exercise sessions developed to engage children with ADHD. Twelve children (10–11 years), six with a diagnosis of ADHD and six with no diagnosis, undertook 40-minute sessions of short-duration, mixed activities bi-weekly for eleven weeks. ADHD symptoms and exercise enjoyment were recorded before six and eleven weeks of intervention. Teacher-reported data showed ADHD symptoms were significantly decreased in the children with ADHD, with a moderate to large effect size. There were no changes in the control group. All children indicated equal enjoyment of the exercise sessions. Specially designed exercise sessions stimulate and maintain engagement by children with ADHD and may reduce ADHD symptom levels in the school environment. The method that supports inclusive practice in physical education (PE) was successfully transferred to the study school and led by the usual class teacher. Children evaluated the exercises as acceptable and enjoyable for those with and without ADHD. This inclusive exercise method might help children manage ADHD symptoms.

scholarly journals Behavioral and Cognitive Impacts of Mindfulness-Based Interventions on Adults with Attention-Deficit Hyperactivity Disorder: A Systematic Review

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Hélène Poissant ◽  
Adrianna Mendrek ◽  
Nadine Talbot ◽  
Bassam Khoury ◽  
Jennifer Nolan
Keyword(s):  
Systematic Review ◽  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Performance Criteria ◽  
Individual Treatment ◽  
Control Group ◽  
Adhd Symptoms ◽  
Grade Point ◽  
Hyperactivity Disorder

Mindfulness-based interventions (MBIs) are becoming increasingly popular as treatments for physical and psychological problems. Recently, several studies have suggested that MBIs may also be effective in reducing symptoms of attention-deficit hyperactivity disorder (ADHD). Most studies have examined the effectiveness in children, but there are now a sufficient number of individual treatment trials to consider a systematic review in adults. Majority of existing systematic reviews and meta-analyses only consider ADHD symptoms as an outcome, and most of them do not fully report potential biases of included studies, thus limiting considerably their conclusions. This is an important facet because some studies could be found ineligible to be included in future analysis due to their low quality. In this systematic review, we followed the PRISMA/PICO criteria and we thoroughly assessed the risks of bias for each of the selected studies according to Cochrane guidelines. We searched the available literature concerning MBIs in adult participants with ADHD using PsycINFO, PubMed, Scopus, and ERIC databases. In total, 13 studies conducted with 753 adults (mean age of 35.1 years) were identified as eligible. Potential moderators such as participants’ age, ADHD subtypes, medication status, comorbidity, intervention length, mindfulness techniques, homework amount, and training of therapists were carefully described. Aside from measuring the symptoms of ADHD, outcome measures were categorized into executive/cognitive functioning, emotional disturbances, quality of life, mindfulness, and grade point average at school. According to presented descriptive results, all the studies (100%) showed improvement of ADHD symptoms. In addition, mindfulness meditation training improves some aspects of executive function and emotion dysregulation. Although these are promising findings to support treatment efficacy of MBIs for ADHD, various biases such as absence of randomization and lack of a control group may affect the actual clinical value and implications of the studies. Moreover, the relatively low quality of selection and performance criteria in several studies, as well as relatively high attrition bias across studies, call for caution before considering conducting further analysis.

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