scholarly journals ‘At risk mental state’ clinics for psychosis – an idea whose time has come – and gone!

2018 ◽  
Vol 49 (4) ◽  
pp. 529-534 ◽  
Author(s):  
Olesya Ajnakina ◽  
Anthony S. David ◽  
Robin M. Murray

AbstractAt Risk Mental State (ARMS) clinics are specialised mental health services for young, help-seeking people, thought to be at ultra-high risk of developing psychosis. Their stated purpose is to reduce transitions from the ARMS state to clinical psychotic disorder. Reports of ARMS clinics provide ‘evidence-based recommendations’ or ‘guidance’ for the treatment of such individuals, and claim that such clinics prevent the development of psychosis. However, we note that in an area with a very well-developed ARMS clinic (South London), only a very small proportion (4%) of patients with first episode psychosis had previously been seen at this clinic with symptoms of the ARMS. We conclude that the task of reaching sufficient people to make a major contribution to the prevention of psychosis is beyond the power of ARMS clinics. Following the preventative approaches used for many medical disorders (e.g. lung cancer, coronary artery disease), we consider that a more effective way of preventing psychosis will be to adopt a public health approach; this should attempt to decrease exposure to environmental factors such as cannabis use which are known to increase risk of the disorder.

2019 ◽  
pp. 1-7 ◽  
Author(s):  
Alison R. Yung ◽  
Stephen J. Wood ◽  
Ashok Malla ◽  
Barnaby Nelson ◽  
Patrick McGorry ◽  
...  

AbstractBackgroundIn the 1990s criteria were developed to detect individuals at high and imminent risk of developing a psychotic disorder. These are known as the at risk mental state, ultra high risk or clinical high risk criteria. Individuals meeting these criteria are symptomatic and help-seeking. Services for such individuals are now found worldwide. Recently Psychological Medicine published two articles that criticise these services and suggest that they should be dismantled or restructured. One paper also provides recommendations on how ARMS services should be operate.MethodsIn this paper we draw on the existing literature in the field and present the perspective of some ARMS clinicians and researchers.ResultsMany of the critics' arguments are refuted. Most of the recommendations included in the Moritz et al. paper are already occurring.ConclusionsARMS services provide management of current problems, treatment to reduce risk of onset of psychotic disorder and monitoring of mental state, including attenuated psychotic symptoms. These symptoms are associated with a range of poor outcomes. It is important to assess them and track their trajectory over time. A new approach to detection of ARMS individuals can be considered that harnesses broad youth mental health services, such as headspace in Australia, Jigsaw in Ireland and ACCESS Open Minds in Canada. Attention should also be paid to the physical health of ARMS individuals. Far from needing to be dismantled we feel that the ARMS approach has much to offer to improve the health of young people.


2009 ◽  
Vol 31 (4) ◽  
pp. 392-401 ◽  
Author(s):  
Seza Özgürdal ◽  
Ekhart Littmann ◽  
Marta Hauser ◽  
Heinrich von Reventlow ◽  
Yehonala Gudlowski ◽  
...  

2010 ◽  
Vol 40 (12) ◽  
pp. 1987-1999 ◽  
Author(s):  
M. R. Broome ◽  
P. Fusar-Poli ◽  
P. Matthiasson ◽  
J. B. Woolley ◽  
L. Valmaggia ◽  
...  

BackgroundImpaired spatial working memory (SWM) is a robust feature of schizophrenia and has been linked to the risk of developing psychosis in people with an at-risk mental state (ARMS). We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had just developed schizophrenia.MethodfMRI was used to study 17 patients with an ARMS, 10 patients with a first episode of psychosis and 15 age-matched healthy comparison subjects. The blood oxygen level-dependent (BOLD) response was measured while subjects performed an object–location paired-associate memory task, with experimental manipulation of mnemonic load.ResultsIn all groups, increasing mnemonic load was associated with activation in the medial frontal and medial posterior parietal cortex. Significant between-group differences in activation were evident in a cluster spanning the medial frontal cortex and right precuneus, with the ARMS groups showing less activation than controls but greater activation than first-episode psychosis (FEP) patients. These group differences were more evident at the most demanding levels of the task than at the easy level. In all groups, task performance improved with repetition of the conditions. However, there was a significant group difference in the response of the right precuneus across repeated trials, with an attenuation of activation in controls but increased activation in FEP and little change in the ARMS.ConclusionsAbnormal neural activity in the medial frontal cortex and posterior parietal cortex during an SWM task may be a neural correlate of increased vulnerability to psychosis.


2012 ◽  
Vol 136 ◽  
pp. S199-S200
Author(s):  
Shinsuke Koike ◽  
Yoshihiro Satomura ◽  
Yukika Nishimura ◽  
Yosuke Takano ◽  
Norichika Iwashiro ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149875 ◽  
Author(s):  
Yumiko Hamaie ◽  
Noriyuki Ohmuro ◽  
Masahiro Katsura ◽  
Chika Obara ◽  
Tatsuo Kikuchi ◽  
...  

2007 ◽  
Vol 191 (S51) ◽  
pp. s69-s75 ◽  
Author(s):  
Stefan J. Borgwardt ◽  
Philip K. McGuire ◽  
Jacqueline Aston ◽  
Gregor Berger ◽  
Paola Dazzan ◽  
...  

BackgroundNeuroanatomical abnormalities are a well-established feature of schizophrenia. However, the timing of their emergence and the extent to which they are related to vulnerability to the disorder as opposed to psychotic illness itself is unclearAimsTo assess regional grey matter volume in the at-risk individuals who subsequently developed psychosisMethodMagnetic resonance imaging data from at-risk individuals who developed psychosis (n = 12) within the following 25 months were compared with data from healthy volunteers (n=22) and people with first-episode psychosis (n=25)ResultsCompared with healthy volunteers, individuals who subsequently developed psychosis had smaller grey matter volume in the posterior cingulate gyrus, precuneus, and paracentral lobule bilaterally and in the left superior parietal lobule, and greater grey matter volume in a left parietal/posterior temporal region. Compared with first-episode patients, they had relatively greater grey matter volume in the temporal gyrus bilaterally and smaller grey matter volume in the right lentiform nucleusConclusionsSome of the structural brain abnormalities in individuals with an at-risk mental state may be related to an increased vulnerability to psychosis, while others are associated with the development of a psychotic illness


2012 ◽  
Vol 7 (2) ◽  
pp. 187-192
Author(s):  
Anna Comparelli ◽  
Daniela Pucci ◽  
Valeria Savoja ◽  
Giorgio D. Kotzalidis ◽  
Ilaria Falcone ◽  
...  

2017 ◽  
Vol 13 (3) ◽  
pp. 582-588 ◽  
Author(s):  
Ulrike Heitz ◽  
Erich Studerus ◽  
Stephanie Menghini‐Müller ◽  
Martina Papmeyer ◽  
Laura Egloff ◽  
...  

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