Trajectory Curves of post-COVID Anxiety/Depressive Symptoms and Sleep Quality in Previously Hospitalized COVID-19 Survivors: The LONG-COVID-EXP-CM Multicenter Study

AbstractObjectivesThis study has been designed to elucidate the prevalence of stress, depression and poor sleep among medical students in a Pakistani medical school. There is a paucity of data on social support among medical students in Pakistan; an important predictor of depressive symptoms. Therefore, this study was also aimed to demonstrate the direct and indirect impact of social support in alleviating depressive symptoms in the study sample.MethodsThis observational cross-sectional study was conducted in Lahore, Pakistan, where a total of 400 students at a medical school were approached between 1st January to 31st March 2018 to participate in the study. The study sample comprised of medical and dental students enrolled at a privately financed Pakistani medical and dental school. The participants responded to a self-administered survey comprising of five parts: a) demographics, b) Pittsburgh Sleep Quality Index (PSQI), c) Patient Health Questionnaire-9 (PHQ-9), d) Multidimensional Scale of Perceived Social Support (MSPSS) and e) Perceived Stress Scale-4 (PSS-4). All data were analysed using SPSS v. 20. Linear regression analysis was used to reveal the predictors of depression.ResultsIn total, 353 medical students participated, yielding a response rate of 88.25%. Overall, poor sleep quality was experienced by 205 (58.1%) students. Mild to severe depression was reported by 83% of the respondents: mild depression by 104 (29.5%), moderate depression by 104 (29.5%), moderately severe depression by 54 (15.3%) and severe depression by 31 (8.8%) respondents. Subjective sleep quality, sleep latency, daytime dysfunction and stress levels were significantly associated with depression symptoms. Social support was not significantly associated with depressive symptoms in the regression model (Beta = -0.08, P < 0.09); however, it acted as a significant mediator, reducing the strength of the relationship between depressive symptoms and sleep quality and stress.ConclusionsAccording to our study, a large proportion of healthcare (medical and dental) students were found to be suffering from mild to moderate depression and experienced poor sleep quality. It is concluded that social support is an important variable in predicting depressive symptomatology by ameliorating the effects of poor sleep quality and high stress levels.

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The prevalence and risk factors for depressive symptoms in frontline nurses under COVID-19 pandemic based on a large cross-sectional study using the propensity score-matched method

BMC Psychiatry ◽

10.1186/s12888-021-03143-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Hongyan Wang ◽

Xiaoling Dai ◽

Zichuan Yao ◽

Xianqing Zhu ◽

Yunzhong Jiang ◽

...

Keyword(s):

Risk Factors ◽

Depressive Symptoms ◽

Sleep Quality ◽

Psychological Capital ◽

Cross Sectional Study ◽

Poor Sleep ◽

Sectional Study ◽

Poor Sleep Quality ◽

Related Factors ◽

Cross Sectional

Abstract Introduction To explore the prevalence of depressive symptoms and the associated risk factors in frontline nurses under COVID-19 pandemic. Methods This cross-sectional study was conducted from February 20, 2020 to March 20, 2020 and involved 562 frontline nurses. The effective response rate was 87.68%. After propensity score matched, there were 498 participants left. Extensive characteristics, including demographics, dietary habits, life-related factors, work-related factors, and psychological factors were collected based on a self-reported questionnaire. Specific scales measured the levels of sleep quality, physical activity, depressive symptoms, perceived organization support and psychological capital. Adjusted odds ratios and 95% confidence intervals were determined by binary paired logistic regression. Results Of the nurses enrolled in the study, 50.90% had depressive symptoms. Three independent risk factors were identified: poor sleep quality (OR = 1.608, 95% CI: 1.384–1.896), lower optimism of psychological capital (OR = 0.879, 95% CI: 0.805–0.960) and no visiting friend constantly (OR = 0.513, 95% CI: 0.286–0.920). Conclusions This study revealed a considerable high prevalence of depressive symptoms in frontline nurses during the COVID-19 outbreak, and identified three risk factors, which were poor sleep quality, lower optimism of psychological capital, and no visiting friend constantly. Protecting mental health of nurses is important for COVID-19 pandemic control and their wellbeing. These findings enrich the existing theoretical model of depression and demonstrated a critical need for additional strategies that could address the mental health in frontline nurses for policymakers.

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Association between socioeconomic status and longitudinal sleep quality patterns mediated by depressive symptoms

SLEEP ◽

10.1093/sleep/zsab044 ◽

2021 ◽

Author(s):

Ga Bin Lee ◽

Hyeon Chang Kim ◽

Ye Jin Jeon ◽

Sun Jae Jung

Keyword(s):

Socioeconomic Status ◽

Depressive Symptoms ◽

Sleep Quality ◽

Household Income ◽

Pittsburgh Sleep Quality Index ◽

Multinomial Logistic Regression ◽

Mental Healthcare ◽

Mediation Effect ◽

Multinomial Logistic Regression Model ◽

Mediating Role

Abstract Study Objectives We aimed to examine whether associations between socioeconomic status (SES) and longitudinal sleep quality patterns are mediated by depressive symptoms. Methods We utilized data on 3347 participants in the Korean Genome and Epidemiology Study aged 40–69 years at baseline from 2001 to 2002 who were followed up for 16 years. A group-based modeling approach was used to identify sleep quality trajectories using the Pittsburgh Sleep Quality Index (years 2, 6, 8, 10, and 12). Educational attainment (college graduated or less), monthly household income (≥$2500 or less), and occupation (unemployed, manual labor, and professional labor) at baseline (year 0) were used for analyses. Depressive symptoms were assessed using Beck’s Depression Inventory at year 4. Associations between SES and sleep quality patterns were examined using a multinomial logistic regression model. The mediation effect of depressive symptoms was further examined using PROC CAUSALMED. Results We identified five distinct sleep quality trajectories: “normal-stable” (n = 1697), “moderate-stable” (n = 1157), “poor-stable” (n = 320), “developing to poor” (n = 84), and “severely poor-stable” (n = 89). Overall, associations between SES levels and longitudinal sleep patterns were not apparent after full adjustment for sociodemographic and lifestyle factors measured at baseline. Depressive symptoms, however, tended to fully mediate associations between SES levels and sleep quality patterns (odds ratio range for indirect effects of depressive symptoms: for education, 1.05-1.17; for income, 1.05-1.15). Conclusion A significant mediating role for depressive symptoms between SES levels and longitudinal sleep quality warrants consideration among mental healthcare professionals.

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Left superior temporal sulcus morphometry mediates the impact of anxiety and depressive symptoms on sleep quality in healthy adults

Social Cognitive and Affective Neuroscience ◽

10.1093/scan/nsab012 ◽

2021 ◽

Author(s):

Yanlin Wang ◽

Ping Jiang ◽

Shi Tang ◽

Lu Lu ◽

Xuan Bu ◽

...

Keyword(s):

Depressive Symptoms ◽

Sleep Quality ◽

Sleep Problems ◽

Superior Temporal Sulcus ◽

Healthy Adults ◽

Poor Sleep ◽

Emotional Symptoms ◽

Neural Basis ◽

Poor Sleep Quality ◽

The Impact

Abstract Anxiety and depressive symptoms may predispose individuals to sleep disturbance. Understanding how these emotional symptoms affect sleep quality, especially the underlying neural basis, could support the development of effective treatment. The aims of the present study were therefore to investigate potential changes in brain morphometry associated with poor sleep quality and whether this structure played a mediating role between the emotional symptoms and sleep quality. One hundred and forty-one healthy adults (69 women, mean age = 26.06 years, SD = 6.36 years) were recruited. A structural magnetic resonance imaging investigation was performed, and self-reported measures of anxiety, depressive symptoms and sleep quality were obtained for each participant. Whole-brain regression analysis revealed that worse sleep quality was associated with thinner cortex in left superior temporal sulcus (STS). Furthermore, the thickness of left STS mediated the association between the emotional symptoms and sleep quality. A subsequent commonality analysis showed that physiological component of the depressive symptoms had the greatest influence on sleep quality. In conclusion, thinner cortex in left STS may represent a neural substrate for the association between anxiety and depressive symptoms and poor sleep quality and may thus serve as a potential target for neuromodulatory treatment of sleep problems.

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O107 Depressive symptoms mediate the relationship between sleep quality and health-related quality of life in heart failure

Global Heart ◽

10.1016/j.gheart.2014.03.1319 ◽

2014 ◽

Vol 9 (1) ◽

pp. e29

Author(s):

An-Yun Yeh ◽

Susan J. Pressler ◽

Seongkum Heo ◽

Debra K. Moser ◽

Sandra B. Dunbar ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Depressive Symptoms ◽

Sleep Quality ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

The Relationship

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Depressive symptoms and functional status are associated with sleep quality after stroke

Topics in Stroke Rehabilitation ◽

10.1080/10749357.2020.1864964 ◽

2020 ◽

pp. 1-8

Author(s):

Leonardo Carvalho Silva ◽

Andressa Silva ◽

Marcela Ferreira De Andrade Rangel ◽

Lívia Cristina Guimarães Caetano ◽

Luci Fuscaldi Teixeira-Salmela ◽

...

Keyword(s):

Depressive Symptoms ◽

Sleep Quality ◽

Functional Status

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Depressive symptoms are associated with poor sleep quality rather than apnea-hypopnea index or hypoxia during sleep in patients with obstructive sleep apnea

Sleep And Breathing ◽

10.1007/s11325-017-1550-1 ◽

2017 ◽

Vol 21 (4) ◽

pp. 997-1003 ◽

Cited By ~ 5

Author(s):

Sang Hun Lee ◽

Yu Jin Lee ◽

Soohyun Kim ◽

Jae-Won Choi ◽

Do-Un Jeong

Keyword(s):

Obstructive Sleep Apnea ◽

Depressive Symptoms ◽

Sleep Apnea ◽

Sleep Quality ◽

Apnea Hypopnea Index ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Obstructive Sleep

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The influence of subjective sleep quality on the association between eveningness and depressive symptoms.

10.31234/osf.io/qkrsg ◽

2018 ◽

Author(s):

Charlotte Mary Horne ◽

Ray Norbury

Keyword(s):

Depressive Symptoms ◽

Sleep Quality ◽

Mediation Analysis ◽

Depression Scale ◽

Well Being ◽

Poor Sleep ◽

Subjective Sleep Quality ◽

Subjective Sleep ◽

Increased Risk ◽

Healthy Participants

Increasing evidence suggests that eveningness is associated with increased risk for depression. Eveningness, however, is also associated with poor sleep quality and the unique role of eveningness in depressive symptomatology remains to be elucidated. The goal of the current study, therefore, was to examine the inter-relationships between eveningness, subjective sleep quality and depressive symptoms in healthy participants free of current or previous depression and sleep disorder. Here, 167 healthy participants (mean age 24.16, 129/38 females/males) completed the reduced Morningness-Eveningness Questionnaire (rMEQ), the Pittsburgh Sleep Quality Index (PSQI) and the Centre for Epidemiological Studies Depression Scale (CES-D). Bootstrap mediation analysis for a simple mediation model including rMEQ, PSQI and CES-D was applied. Eveningness was associated with increased depressive symptoms and mediation analysis showed that this relationship was partly mediated by sleep quality. Our results suggest that indicators of depression observed in evening-type individuals cannot be attributed exclusively to disturbed sleep. We suggest that interventions that target both sleep quality and dysfunctionl cognitive styles would be optimal to promote well-being in evening-type individuals.

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