scholarly journals A longitudinal study of the effects of syllabic structure on the development of reading and spelling skills in French

1997 ◽  
Vol 18 (4) ◽  
pp. 485-505 ◽  
Author(s):  
Liliane Sprenger-Charolles ◽  
Linda S. Siegel
Keyword(s):  
Longitudinal Study ◽  
Simple Structure ◽  
First Graders ◽  
Complex Structure ◽  
Critical Role ◽  
Short Term ◽  
Phonological Structure ◽  
Central Hypothesis ◽  
Reading And Spelling ◽  
Phonological Mediation

ABSTRACTThe central hypothesis of this study was that phonological mediation plays a critical role in the early development of reading and spelling in French. Therefore, the phonological structure of items, as opposed to their visual characteristics, was expected to be a significant determinant of performance. This hypothesis was tested in a short-term longitudinal study with a group of first graders (N = 57) who were administered a reading and a spelling task involving pseudowords of different syllabic structures. The first prediction was that there would be better performance on pseudowords with a simple structure (CVCVCV) than on pseudowords with a complex structure (CCVCVC or CVCCVC), and that errors on syllables with a complex structure would involve the deletion of codas or the simplification of complex onsets. We also predicted that errors would be consistent with a sonority hierarchy; for example, we expected more deletions of liquids than obstruents in clusters.

Crystal structures of Magnaporthe oryzae trehalose-6-phosphate synthase (MoTps1) suggest a model for catalytic process of Tps1

2019 ◽  
Vol 476 (21) ◽  
pp. 3227-3240 ◽  
Author(s):  
Shanshan Wang ◽  
Yanxiang Zhao ◽  
Long Yi ◽  
Minghe Shen ◽  
Chao Wang ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Conformational Changes ◽  
Magnaporthe Oryzae ◽  
Structural Information ◽  
Complex Structure ◽  
Critical Role ◽  
Catalytic Process ◽  
Structural Basis ◽  
Salt Bridges ◽  
Terminal Domain

Trehalose-6-phosphate (T6P) synthase (Tps1) catalyzes the formation of T6P from UDP-glucose (UDPG) (or GDPG, etc.) and glucose-6-phosphate (G6P), and structural basis of this process has not been well studied. MoTps1 (Magnaporthe oryzae Tps1) plays a critical role in carbon and nitrogen metabolism, but its structural information is unknown. Here we present the crystal structures of MoTps1 apo, binary (with UDPG) and ternary (with UDPG/G6P or UDP/T6P) complexes. MoTps1 consists of two modified Rossmann-fold domains and a catalytic center in-between. Unlike Escherichia coli OtsA (EcOtsA, the Tps1 of E. coli), MoTps1 exists as a mixture of monomer, dimer, and oligomer in solution. Inter-chain salt bridges, which are not fully conserved in EcOtsA, play primary roles in MoTps1 oligomerization. Binding of UDPG by MoTps1 C-terminal domain modifies the substrate pocket of MoTps1. In the MoTps1 ternary complex structure, UDP and T6P, the products of UDPG and G6P, are detected, and substantial conformational rearrangements of N-terminal domain, including structural reshuffling (β3–β4 loop to α0 helix) and movement of a ‘shift region' towards the catalytic centre, are observed. These conformational changes render MoTps1 to a ‘closed' state compared with its ‘open' state in apo or UDPG complex structures. By solving the EcOtsA apo structure, we confirmed that similar ligand binding induced conformational changes also exist in EcOtsA, although no structural reshuffling involved. Based on our research and previous studies, we present a model for the catalytic process of Tps1. Our research provides novel information on MoTps1, Tps1 family, and structure-based antifungal drug design.

The capacity of short term memory from an evolutionary perspective

2019 ◽  
Author(s):  
Majid Manoochehri
Keyword(s):  
Short Term Memory ◽  
Memory Span ◽  
Critical Role ◽  
Experimental Studies ◽  
Cognitive System ◽  
Evolutionary Approach ◽  
Evolutionary Perspective ◽  
Short Term ◽  
Term Memory

Memory span in humans has been intensely studied for more than a century. In spite of the critical role of memory span in our cognitive system, which intensifies the importance of fundamental determinants of its evolution, few studies have investigated it by taking an evolutionary approach. Overall, we know hardly anything about the evolution of memory components. In the present study, I briefly review the experimental studies of memory span in humans and non-human animals and shortly discuss some of the relevant evolutionary hypotheses.

scholarly journals A Novel Load Forecasting Approach Based on Smart Meter Data Using Advance Preprocessing and Hybrid Deep Learning

2021 ◽  
Vol 11 (6) ◽  
pp. 2742
Author(s):  
Fatih Ünal ◽  
Abdulaziz Almalaq ◽  
Sami Ekici
Keyword(s):  
Deep Learning ◽  
Energy Consumption ◽  
Prediction Models ◽  
Short Term Memory ◽  
Critical Role ◽  
Load Forecasting ◽  
Unified Framework ◽  
Short Term ◽  
Planning And Scheduling ◽  
Short Term Load Forecasting

Short-term load forecasting models play a critical role in distribution companies in making effective decisions in their planning and scheduling for production and load balancing. Unlike aggregated load forecasting at the distribution level or substations, forecasting load profiles of many end-users at the customer-level, thanks to smart meters, is a complicated problem due to the high variability and uncertainty of load consumptions as well as customer privacy issues. In terms of customers’ short-term load forecasting, these models include a high level of nonlinearity between input data and output predictions, demanding more robustness, higher prediction accuracy, and generalizability. In this paper, we develop an advanced preprocessing technique coupled with a hybrid sequential learning-based energy forecasting model that employs a convolution neural network (CNN) and bidirectional long short-term memory (BLSTM) within a unified framework for accurate energy consumption prediction. The energy consumption outliers and feature clustering are extracted at the advanced preprocessing stage. The novel hybrid deep learning approach based on data features coding and decoding is implemented in the prediction stage. The proposed approach is tested and validated using real-world datasets in Turkey, and the results outperformed the traditional prediction models compared in this paper.

Prognostic indicators of short-term survival of ineffective airway clearance in children with acute respiratory infection: a longitudinal study

2020 ◽  
Vol 56 (4) ◽  
pp. 376-387
Author(s):  
Lívia Maia Pascoal ◽  
Marcos Venícios de Oliveira Lopes ◽  
Viviane Martins da Silva ◽  
Daniel Bruno Resende Chaves ◽  
Beatriz Amorim Beltrão ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Prognostic Indicators ◽  
Short Term ◽  
Term Survival ◽  
Airway Clearance ◽  
Short Term Survival

scholarly journals Explaining semantic short-term memory deficits: Evidence for the critical role of semantic control

2011 ◽  
Vol 49 (3) ◽  
pp. 368-381 ◽  
Author(s):  
Paul Hoffman ◽  
Elizabeth Jefferies ◽  
Matthew A. Lambon Ralph
Keyword(s):  
Short Term Memory ◽  
Critical Role ◽  
Memory Deficits ◽  
Short Term ◽  
Term Memory

Cyclosporine increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system

2008 ◽  
Vol 294 (3) ◽  
pp. R811-R818 ◽  
Author(s):  
Chao-Hung Wang ◽  
Wen-Jin Cherng ◽  
Ning-I Yang ◽  
Chia-Ming Hsu ◽  
Chi-Hsiao Yeh ◽  
...  
Keyword(s):  
Critical Role ◽  
Serum Levels ◽  
Blood Levels ◽  
Short Term ◽  
Endothelial Progenitor ◽  
Beneficial Effects ◽  
Dpp Iv ◽  
Before And After ◽  
Cell Mobilization

Cyclosporin A (CsA) improves the success rate of transplantation. The CD26/dipeptidylpeptidase IV (DPP IV) system plays a critical role in mobilizing endothelial progenitor cells (EPCs) from bone marrow. This study investigated whether CsA manipulates CD26/DPP IV activity and increases EPC mobilization. C57BL/6 mice were divided into control and CsA-treated groups. Before and after hindlimb ischemia was induced, circulating EPC number and serum levels of different cytokines were measured. Compared with the controls, CsA treatment significantly increased the blood levels of stroma-derived factor-1α and stem cell factor after ischemic stress ( P < 0.001). The CsA group displayed a significant increase in the number of circulating EPCs (sca-1+KDR+ and c-kit+CD31+ EPCs, both P < 0.05). In vivo, CsA caused a significant increase in the numbers of EPCs incorporated into the Matrigel and ischemic limbs ( P < 0.05). In the peripheral blood, CsA significantly decreased CD26+ cell numbers and attenuated the plasma CD26/DPP IV activity ( P < 0.001). Furthermore, short-term CsA treatment significantly improved the perfusion of ischemic limbs and decreased the spontaneous digital amputation rate. In summary, CsA manipulates the mobilization of EPCs into the circulation via the CD26/DPP IV system. Short-term CsA treatment has beneficial effects on angiogenesis of ischemic tissues.

scholarly journals Decreased connexin43 expression in the mouse heart potentiates pacing-induced remodeling of repolarizing currents

2008 ◽  
Vol 295 (5) ◽  
pp. H1905-H1916 ◽  
Author(s):  
Andrianos Kontogeorgis ◽  
Xiaodong Li ◽  
Eunice Y. Kang ◽  
Jonathan E. Feig ◽  
Marc Ponzio ◽  
...  
Keyword(s):  
Gap Junction ◽  
Ventricular Myocytes ◽  
Critical Role ◽  
Mouse Heart ◽  
Wild Type ◽  
Short Term ◽  
Wild Type Littermate ◽  
Cx43 Expression ◽  
Significant Prolongation ◽  
Electrophysiological Effects

Gap junction redistribution and reduced expression, a phenomenon termed gap junction remodeling (GJR), is often seen in diseased hearts and may predispose toward arrhythmias. We have recently shown that short-term pacing in the mouse is associated with changes in connexin43 (Cx43) expression and localization but not with increased inducibility into sustained arrhythmias. We hypothesized that short-term pacing, if imposed on murine hearts with decreased Cx43 abundance, could serve as a model for evaluating the electrophysiological effects of GJR. We paced wild-type (normal Cx43 abundance) and heterozygous Cx43 knockout (Cx43+/−; 66% mean reduction in Cx43) mice for 6 h at 10–15% above their average sinus rate. We investigated the electrophysiological effects of pacing on the whole animal using programmed electrical stimulation and in isolated ventricular myocytes with patch-clamp studies. Cx43+/− myocytes had significantly shorter action potential durations (APD) and increased steady-state ( Iss) and inward rectifier ( IK1) potassium currents compared with those of wild-type littermate cells. In Cx43+/− hearts, pacing resulted in a significant prolongation of ventricular effective refractory period and APD and significant diminution of Iss compared with unpaced Cx43+/− hearts. However, these changes were not seen in paced wild-type mice. These data suggest that Cx43 abundance plays a critical role in regulating currents involved in myocardial repolarization and their response to pacing. Our study may aid in understanding how dyssynchronous activation of diseased, Cx43-deficient myocardial tissue can lead to electrophysiological changes, which may contribute to the worsened prognosis often associated with pacing in the failing heart.

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