A. J. J. Gilmore, A. Svanborg, M. Marois, W. M. Beattie, and J. Piotrowski (eds.), Aging: a Challenge to Science and Society, Volume 2: Medicine and Social Science. Published on behalf of L'Institut de la Vie and the World Health Organisation Regional Office for Europe by Oxford University Press, Oxford, 1981. 403 pp. £30.00. ISBN 0 19 261255 7.

1982 ◽  
Vol 2 (2) ◽  
pp. 271-272
Author(s):  
Peter Coleman
Keyword(s):  
Social Science ◽  
World Health Organisation ◽  
World Health ◽  
Science And Society ◽  
Regional Office ◽  
Oxford University ◽  
The World ◽  
Oxford University Press

A Collaborative Study to Establish the Second International Standard for Streptokinase

1990 ◽  
Vol 64 (02) ◽  
pp. 267-269 ◽  
Author(s):  
A B Heath ◽  
P J Gaffney
Keyword(s):  
High Purity ◽  
Collaborative Study ◽  
World Health Organisation ◽  
World Health ◽  
Clot Lysis ◽  
Current Standard ◽  
International Standard ◽  
Accelerated Degradation ◽  
The World ◽  
International Collaborative Study

SummaryAn International Standard for Streptokinase - Streptodomase (62/7) has been used to calibrate high purity clinical batches of SK since 1965. An international collaborative study, involving six laboratories, was undertaken to replace this standard with a high purity standard for SK. Two candidate preparations (88/826 and 88/824) were compared by a clot lysis assay with the current standard (62/7). Potencies of 671 i.u. and 461 i.u. were established for preparations A (88/826) and B (88/824), respectively.Either preparation appeared suitable to serve as a standard for SK. However, each ampoule of preparation A (88/826) contains a more appropriate amount of SK activity for potency testing, and is therefore preferred. Accelerated degradation tests indicate that preparation A (88/826) is very stable.The high purity streptokinase preparation, coded 88/826, has been established by the World Health Organisation as the 2nd International Standard for Streptokinase, with an assigned potency of 700 i.u. per ampoule.

Book Reviews

2013 ◽  
Vol 1 (1) ◽  
pp. 91-106
Author(s):  
Janet Klein ◽  
David Romano ◽  
Michael M. Gunter ◽  
Joost Jongerden ◽  
Atakan İnce ◽  
...  
Keyword(s):  
New York ◽  
Middle Eastern ◽  
Nation Building ◽  
Eastern Anatolia ◽  
Oxford University ◽  
National Movement ◽  
The World ◽  
Modern Turkey ◽  
Oxford University Press

Uğur Ümit Üngör, The Making of Modern Turkey: Nation and State in Eastern Anatolia, 1913-1950, Oxford: Oxford University Press, 2011, 352 pp. (ISBN: 9780199603602).Mohammed M. A. Ahmed, Iraqi Kurds and Nation-Building. New York: Palgrave Macmillan, 2012, 294 pp., (ISBN: 978-1-137-03407-6), (paper). Ofra Bengio, The Kurds of Iraq: Building a State within a State. Boulder, CO and London, UK: Lynne Rienner Publishers, 2012, xiv + 346 pp., (ISBN 978-1-58826-836-5), (hardcover). Cengiz Gunes, The Kurdish National Movement in Turkey, from Protest to Resistance, London: Routledge, 2012, 256 pp., (ISBN: 978-0-415—68047-9). Aygen, Gülşat, Kurmanjî Kurdish. Languages of the World/Materials 468, München: Lincom Europa, 2007, 92 pp., (ISBN: 9783895860706), (paper).Barzoo Eliassi, Contesting Kurdish Identities in Sweden: Quest for Belonging among Middle Eastern Youth, Oxford: New York: Palgrave Macmillan, 2013, 234 pp. (ISBN: 9781137282071).

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Use of Phosphatidylcholine in the Treatment of Localized Fat Deposits. Results and expectations

2017 ◽  
Vol 68 (7) ◽  
pp. 1438-1441 ◽  
Author(s):  
Sorin Berbece ◽  
Dan Iliescu ◽  
Valeriu Ardeleanu ◽  
Alexandru Nicolau ◽  
Radu Cristian Jecan
Keyword(s):  
World Health Organisation ◽  
Normal Weight ◽  
World Health ◽  
Basic Substance ◽  
Physical Exercises ◽  
Fat Deposits ◽  
The World ◽  
The Common ◽  
Global Health Problem ◽  
Over Time

Obesity represents a global health problem. According to the latest studies released by the World Health Organisation (WHO), 1.7 billion currently in excess of normal weight individuals, of which approx. 75% are overweight (body mass index - BMI 25 to 30). The common form of excess adipose tissue manifestation in overweight individuals is localized fat deposits with high (abdominal) or low (buttocks and thighs) disposition. Although the overweight can be corrected relatively easy by changing behavioral habits or food, a constant physical exercises program or following a diet food are not accessible to all through the efforts of will, financial and time involved. Several methods have been studied and tested over time to eliminate more or less invasive fat deposits with varying efficacy and adverse effects. Chemical lipolysis using phosphatidylcholine as the basic substance was initially used in hypercholesterolemia and its complications and was rapidly adopted in mesotherapy techniques for the treatment of fat deposits. This study reveals the results obtained using Dermastabilon on a sample of 16 patients, the time allocated to treatment and discomfort being minimal, and rapid and notable results. There were no side effects.

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