Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

World Health ◽

Lung Cells ◽

The Novel ◽

High Modulation ◽

Main Protease ◽

The World ◽

Novel Coronavirus ◽

Viral Receptors ◽

Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Year of the Mask; COVID-19 Challenges for Orthopaedic Surgery

Reconstructive Review ◽

10.15438/rr.10.1.241 ◽

2020 ◽

Vol 10 ◽

Author(s):

Evert Smith

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Orthopaedic Surgery ◽

World Health ◽

The Novel ◽

Virus Spread ◽

Central Hospital ◽

The World ◽

Respiratory Physician ◽

As a response to the viral pneumonias and severe illnesses that were emerging in patients, an ophthalmologist November 2019 a novel coronavirus emerged in Wuhan, Hubei, China Dr Li Wenliang, working at Wuhan Central Hospital, voiced his concerns only to be severely admonished by the authorities. The accelerated spread of the Severe Acute Respiratory Syndrome (SARS) in Wuhan, and then globally, as a result of the novel coronavirus was acute and pronounced. China alerted the World Health Organisation to several pneumonia cases at the end of December 2019 and the first death was recorded in early January 2020. The respiratory physician Dr Nanshan Zhong, announced human-to-human spread and a few days later on the 23 January 2020, Wuhan was placed under quarantine. The virus spread outside China and the WHO declared the outbreak a global health emergency on 30 January 2020. Tragically Dr Li Wenliang died on 7 February 2020 as a result of exposure to the virus, leaving a five-year-old son and a pregnant wife.

The Socio-Economic Ramifications of the Covid-19 Pandemic: The Case of Ghana

10.31222/osf.io/c9vma ◽

2021 ◽

Author(s):

Richmond Sam Quarm ◽

Rosemond Sam-Quarm ◽

Richmond Sam-Quarm

Keyword(s):

Rational Choice Theory ◽

Choice Theory ◽

Respiratory Illness ◽

World Health ◽

The Novel ◽

Cross Sectional ◽

The World ◽

The Government ◽

The novel, dreaded, disruptive, and disastrous Covid-19 pandemic took the world by storm in January, 2020. The Covid-19 pandemic in Ghana is part of the worldwide coronavirus disease caused by “severe acute respiratory syndrome (SARS-CoV-2)”. On 12th January, 2020 the World Health Organisation (WHO) confirmed that the novel coronavirus was the cause of a respiratory illness that affected a cluster of people in Wuhan City, Hubei Province, China. This was reported to the WHO on 31st December, 2019. On 11th March, 2020, WHO declared the novel Covid-19 a global pandemic (Graphic Online, 2020a). It is worthy to note how the Government of Ghana, political parties, citizens, scientists and academia, corporate entities, faith based organisations, traditional rulers, have offered varied forms of interventions to combat the scourge. The Theoretical Framework of this research was underpinned by the Theory of Epidemics, the Agency Theory, the Rational Choice Theory, and the Stakeholder Theory. We conducted a cross-sectional research through non-probability and purposive sampling with 250 respondents. We also employed face-to-face interviews, structured closed-ended and open-ended Questionnaires (Braun and Clarke, 2012; Denzin, 2017), which were administered online through email application via Google Forms. One of our major findings was that with the approval of Pfizer/BioNTech Covid-19 vaccine by the UK’s MHRA on 1st December, 2020 (Graphic Online, 2020b); and subsequently by the US FDA a week later on 8th December, 2020 (Graphic Online, 2020c), all governments around the globe in general, but Africa in particular, must make conscious efforts backed by adequate budgetary allocations to secure maximum quantities of the vaccines for their vulnerable teeming population.

The Socio-Economic Ramifications of the Covid-19 Pandemic: The Case of Ghana

10.31219/osf.io/6q2fm ◽

2021 ◽

Author(s):

Richmond Sam Quarm ◽

Rosemond Sam-Quarm ◽

Richmond Sam-Quarm

Keyword(s):

Rational Choice Theory ◽

Choice Theory ◽

Respiratory Illness ◽

World Health ◽

The Novel ◽

Cross Sectional ◽

The World ◽

The Government ◽

The novel, dreaded, disruptive, and disastrous Covid-19 pandemic took the world by storm in January, 2020. The Covid-19 pandemic in Ghana is part of the worldwide coronavirus disease caused by “severe acute respiratory syndrome (SARS-CoV-2)”. On 12th January, 2020 the World Health Organisation (WHO) confirmed that the novel coronavirus was the cause of a respiratory illness that affected a cluster of people in Wuhan City, Hubei Province, China. This was reported to the WHO on 31st December, 2019. On 11th March, 2020, WHO declared the novel Covid-19 a global pandemic (Graphic Online, 2020a). It is worthy to note how the Government of Ghana, political parties, citizens, scientists and academia, corporate entities, faith based organisations, traditional rulers, have offered varied forms of interventions to combat the scourge. The Theoretical Framework of this research was underpinned by the Theory of Epidemics, the Agency Theory, the Rational Choice Theory, and the Stakeholder Theory. We conducted a cross-sectional research through non-probability and purposive sampling with 250 respondents. We also employed face-to-face interviews, structured closed-ended and open-ended Questionnaires (Braun and Clarke, 2012; Denzin, 2017), which were administered online through email application via Google Forms. One of our major findings was that with the approval of Pfizer/BioNTech Covid-19 vaccine by the UK’s MHRA on 1st December, 2020 (Graphic Online, 2020b); and subsequently by the US FDA a week later on 8th December, 2020 (Graphic Online, 2020c), all governments around the globe in general, but Africa in particular, must make conscious efforts backed by adequate budgetary allocations to secure maximum quantities of the vaccines for their vulnerable teeming population.

The Socio-Economic Ramifications of the Covid-19 Pandemic: The Case of Ghana

Journal of Economics and Business ◽

10.31014/aior.1992.04.01.319 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Richmond Sam Quarm ◽

◽

Rosemond Sam-Quarm ◽

Richmond Sam-Quarm ◽

◽

...

Keyword(s):

Rational Choice Theory ◽

Choice Theory ◽

Respiratory Illness ◽

World Health ◽

The Novel ◽

Cross Sectional ◽

The World ◽

The Government ◽

The novel, dreaded, disruptive, and disastrous Covid-19 pandemic took the world by storm in January, 2020. The Covid-19 pandemic in Ghana is part of the worldwide coronavirus disease caused by “severe acute respiratory syndrome (SARS-CoV-2)”. On 12th January, 2020 the World Health Organisation (WHO) confirmed that the novel coronavirus was the cause of a respiratory illness that affected a cluster of people in Wuhan City, Hubei Province, China. This was reported to the WHO on 31st December, 2019. On 11th March, 2020, WHO declared the novel Covid-19 a global pandemic (Graphic Online, 2020a). It is worthy to note how the Government of Ghana, political parties, citizens, scientists and academia, corporate entities, faith based organisations, traditional rulers, have offered varied forms of interventions to combat the scourge. The Theoretical Framework of this research was underpinned by the Theory of Epidemics, the Agency Theory, the Rational Choice Theory, and the Stakeholder Theory. We conducted a cross-sectional research through non-probability and purposive sampling with 250 respondents. We also employed face-to-face interviews, structured closed-ended and open-ended Questionnaires (Braun and Clarke, 2012; Denzin, 2017), which were administered online through email application via Google Forms. One of our major findings was that with the approval of Pfizer/BioNTech Covid-19 vaccine by the UK’s MHRA on 1st December, 2020 (Graphic Online, 2020b); and subsequently by the US FDA a week later on 8th December, 2020 (Graphic Online, 2020c), all governments around the globe in general, but Africa in particular, must make conscious efforts backed by adequate budgetary allocations to secure maximum quantities of the vaccines for their vulnerable teeming population.

Worldwide Trend Analysis and Potential Spread Prediction of SARS-CoV-2

10.21203/rs.3.rs-39125/v1 ◽

2020 ◽

Author(s):

Arohi Jain ◽

Aswin S ◽

Jais Jose ◽

Deepa Nathalia ◽

Arjun Suresh

Keyword(s):

Meteorological Factors ◽

World Health ◽

The Novel ◽

Actual Number ◽

Pollution Levels ◽

Major Disaster ◽

The World ◽

Novel Coronavirus ◽

Almost All

Abstract Covid-19 declared as a pandemic by the World Health Organisation on January 30, 2020, is a major disaster which shook the roots of almost all the economies around the globe. The outbreak began in a city of China, Wuhan majorly due to consumption of bats during December. The symptoms, the ways of spreading of infection are quite similar to that of influenza. The areas with higher pollution levels of particulate matter have reported a higher number of deaths as compared to the number of deaths in the cases from comparatively less polluted areas. The meteorological factors have also played a major role in the extent of spread of disease and the ability of humans living in the area to fight against the disease. Social distancing and lockdown all over the nation have proved to be major weapons to fight against the further spread of disease. The lockdown, on the other hand, has given relief from the high levels of pollution resulting in good air quality and clean rivers. This study focuses on the spread of the novel coronavirus all over the world with the trend in the number of confirmed cases, deaths and the cured from the onset and also highlighting the situations in five countries. The study further gives a prediction of the number of cases for ten days and correlates the values with the actual number of cases reported and throws light on the future aspects of the infection.

Political Discourse on China's Stigmatization in the Context of COVID-19 Pandemic

MGIMO Review of International Relations ◽

10.24833/2071-8160-2021-2-77-22-46 ◽

2021 ◽

Vol 14 (2) ◽

pp. 22-46

Author(s):

I. I. Arsentyeva

Keyword(s):

International Relations ◽

Social Identity Theory ◽

Political Discourse ◽

Social Stigma ◽

World Politics ◽

World Health ◽

Research Approach ◽

The Novel ◽

The World ◽

The COVID-19 pandemic has led to an increased interest in studying social stigma. The concept of stigma is also included in political discourse, as evidenced, among other things, by Xi Jinping’s speeches, in which the Chinese President urges to abandon further politicization and stigmatization of COVID-19. In this regard, the main aim of the article is to analyze the correlation between the novel coronavirus and stigmatization, not only from the traditional point of view (stigma associated with certain diseases), but also in terms of world politics. To explain the nature of social stigma, the author relies on evolutionary psychol- ogy, terror management theory and social identity theory. To analyze ongoing processes in international relations, some provisions of “rogue states” concept, leadership theories, and biopolitics are applied. The primary sources are documents of the World Health Organiza- tion (WHO) and the Group of Seven (G7), statements by UN and WHO officials, speeches of Chinese President Xi Jinping and US President Donald Trump, public opinion polls, and media publications. During the course of the study, the following scientific results were ob- tained: the works on COVID-19-related stigma have been systematized, the issues consid- ered in them and research gaps are highlighted; the consequences of stigma due the novel coronavirus have been summarized; some differences between stigma during the pandem- ic and stigma associated with other diseases are also identified; it is suggested to consider COVID-19 stigma not only at the level of interpersonal interactions, but also in international relations; the possible impact of the pandemic on the China’s role on the world stage has been revealed. It is concluded that this research approach allows to take a fresh look at the possibility of restoring ties between states and their citizens in a post-COVID-19 world, as well as to assess the likelihood of a change of global leader. In the final part of the article, possible ways of further development of the situation are predicted and prospects for study on the issue are outlined.

Cutaneous presentation of COVID-19 Case Report

General medicine and Clinical Practice ◽

10.31579/2639-4162/034 ◽

2020 ◽

Vol 3 (3) ◽

pp. 01-02

Author(s):

Khadiga Ismail

Keyword(s):

Public Health Emergency ◽

World Health ◽

The Novel ◽

Scientific Journals ◽

Global Public Health ◽

The World ◽

Global Spread ◽

Novel Coronavirus ◽

Health Organization ◽

Recent Attention

COVID-19 has high transmissibility and infectivity among human. On January 30, 2020, the World Health Organization (WHO) in an effort to slow down the global spread of the virus declared the outbreak, “A global public health emergency of international concern". The skin manifestations of the novel coronavirus COVID-19 were not recognized at the early stages of the pandemic but have received much recent attention in scientific journals. Reported manifestations range from pseudo-chilblains to a morbilliform (measles-like) exanthem, urticaria, vesicular eruptions, a dengue-like petechial rash and ovate scaling macules, and plaques mimicking pityriasis rosea.

Face masks are an essential tool to mitigate the ongoing SARS-CoV-2 pandemic: a call to action

Rhinology online ◽

10.4193/rhinol/20.065 ◽

2020 ◽

Vol 3 (3) ◽

pp. 157-159

Author(s):

P. Dehgani-Mobaraki ◽

A. Kamber Zaidi ◽

J.M. Levy ◽

Keyword(s):

Upper Airway ◽

World Health ◽

Contact Tracing ◽

The Novel ◽

Call To Action ◽

Public Health Emergencies ◽

Current Spread ◽

The World ◽

Health And Disease ◽

Over the past several months, an increasing volume of infor- mation has expanded awareness regarding the transmission of SARS-CoV-2, the novel coronavirus associated with COVID-19. Following the pandemic declaration by the World Health Orga- nization (WHO), global authorities immediately took measures to reduce the transmission and subsequent morbidity associa- ted with this highly contagious disease. However, despite initial success in “flattening the curve” of viral transmission, many areas of the world are currently experiencing an increase in com- munity transmission, threatening to replicate the early public health emergencies experienced by Italy (1,2). In addition, the possibility of contact tracing through geosocial applications and public service platforms have been met with variable interest (3). Given current spread and the upcoming influenza season, it is essential that we use our voices as experts in upper airway health and disease to educate and encourage all communities to adopt appropriate protective measures, including the routine use of facemasks.

The Online Education Mode and Reopening Plans for Chinese Schools During the COVID-19 Pandemic: A Mini Review

Frontiers in Public Health ◽

10.3389/fpubh.2020.566316 ◽

2020 ◽

Vol 8 ◽

Author(s):

Xuanzhen Cen ◽

Dong Sun ◽

Ming Rong ◽

Gusztáv Fekete ◽

Julien S. Baker ◽

...

Keyword(s):

Online Education ◽

Prevention And Control ◽

World Health ◽

Classroom Teaching ◽

Full Time ◽

The Novel ◽

The World ◽

Novel Coronavirus ◽

Health Organization ◽

And Control

Recently, an unprecedented coronavirus pandemic has emerged and has spread around the world. The novel coronavirus termed COVID-19 by the World Health Organization has posed a huge threat to human safety and social development. This mini review aimed to summarize the online education mode and plans for schools to resume full-time campus study in China during COVID-19. Chinese schools have made significant contributions to the prevention and control of the transmission of COVID-19 by adopting online learning from home. However, normal opening and classroom teaching have been affected. For education systems at all levels, online education may be an effective way to make up for the lack of classroom teaching during the epidemic. To protect staff and students from COVID-19, the timing of students returning to full-time campus study needs to be considered carefully. Reviewing and summarizing of the Chinese education system's response to the virus would be of great value not only in developing educational policy but also in guiding other countries to formulate educational countermeasures.