scholarly journals Neurenteric Cysts of the Spinal Cord Mimicking Multiple Sclerosis

1981 ◽  
Vol 8 (2) ◽  
pp. 159-161 ◽  
Author(s):  
H.V. Vinters ◽  
J.J. Gilbert
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Congenital Abnormalities ◽  
Unique Combination ◽  
Neurologic Symptoms

SUMMARY:A 54-year-old man died following a 20-year course of intermittent neurologic symptoms. He carried a diagnosis of multiple sclerosis, with most severe involvement thought to be in the spinal cord. At autopsy, two neurenteric (enterogenous) cysts were found to indent the anterior spinal cord — at the T4 and Tl I cord levels. Partial diplomyelia was present in the lumbosacral cord. These findings represent a unique combination of congenital abnormalities. Their embryogenesis and pathogenesis are discussed.

Failure to develop multiple sclerosis in patients with neurologic symptoms without objective evidence

2008 ◽  
Vol 14 (6) ◽  
pp. 804-808 ◽  
Author(s):  
A Boster ◽  
C Caon ◽  
J Perumal ◽  
S Hreha ◽  
R Zabad ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Evoked Potentials ◽  
Cervical Cord ◽  
Neurologic Symptoms ◽  
Objective Evidence ◽  
Mri Scans ◽  
Thoracic Cord ◽  
Spinal Cord Imaging

Background Many patients referred to multiple sclerosis (MS) centers with symptoms suggestive of MS are found to have normal neurologic examinations, normal or non-specific brain magnetic resonance imaging (MRI) scan findings, and normal cerebrospinal fluid (CSF). Persistent symptoms often lead to multiple consultations and repeated diagnostic investigations. We performed a study to evaluate the diagnostic utility of repeated evaluations in patients with normal initial assessments and persistent neurologic symptoms. Methods 143 patients were evaluated initially and 109 returned for a second evaluation after a mean interval of 4.4 years. Results All 143 patients had normal initial examinations, brain MRI scans, screening blood tests, and CSF studies. Spinal cord imaging was normal in all patients tested (cervical cord, n = 126; 88.1%; thoracic cord, n = 58; 40.6%). Evoked potential studies were abnormal in a small percentage of patients: visual evoked potentials, VEP (8.1%), somatosensory evoked potentials, SSEP (4.9%), and brainstem auditory evoked potentials, BAEP (2.8%). All follow-up patients ( n = 109) had normal examinations and MRI scans. Repeat CSF studies ( n = 35; 32.1%) and spinal cord imaging (cervical cord n = 57; 52.3%; thoracic cord n = 32; 29.4%) were normal in all follow-up patients tested. No patients at initial presentation or at follow-up fulfilled diagnostic criteria for MS. Conclusions Patients and clinicians may be reassured that persistent neurologic symptoms in the absence of objective clinical evidence do not lead to the development of MS. Costly serial investigations should be carefully considered, particularly in the presence of normal neurologic examination at follow-up.

scholarly journals CKD-506: A novel HDAC6-selective inhibitor that exerts therapeutic effects in a rodent model of multiple sclerosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daekwon Bae ◽  
Ji-Young Lee ◽  
Nina Ha ◽  
Jinsol Park ◽  
Jiyeon Baek ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Immune Responses ◽  
Therapeutic Potential ◽  
Autoimmune Encephalitis ◽  
Selective Inhibitor ◽  
Therapeutic Effects ◽  
Treatment Regimens ◽  
Ifn Γ ◽  
Experimental Autoimmune

AbstractDespite advances in therapeutic strategies for multiple sclerosis (MS), the therapy options remain limited with various adverse effects. Here, the therapeutic potential of CKD-506, a novel HDAC6-selective inhibitor, against MS was evaluated in mice with myelin oligodendrocyte glycoprotein35–55 (MOG35–55)-induced experimental autoimmune encephalitis (EAE) under various treatment regimens. CKD-506 exerted prophylactic and therapeutic effects by regulating peripheral immune responses and maintaining blood–brain barrier (BBB) integrity. In MOG35–55-re-stimulated splenocytes, CKD-506 decreased proliferation and downregulated the expression of IFN-γ and IL-17A. CKD-506 downregulated the levels of pro-inflammatory cytokines in the blood of EAE mice. Additionally, CKD-506 decreased the leakage of intravenously administered Evans blue into the spinal cord; CD4+ T cells and CD4−CD11b+CD45+ macrophage/microglia in the spinal cord was also decreased. Moreover, CKD-506 exhibited therapeutic efficacy against MS, even when drug administration was discontinued from day 15 post-EAE induction. Disease exacerbation was not observed when fingolimod was changed to CKD-506 from day 15 post-EAE induction. CKD-506 alleviated depression-like behavior at the pre-symptomatic stage of EAE. In conclusion, CKD-506 exerts therapeutic effects by regulating T cell- and macrophage-mediated peripheral immune responses and strengthening BBB integrity. Our results suggest that CKD-506 is a potential therapeutic agent for MS.

scholarly journals MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1424
Author(s):  
Esben Nyborg Poulsen ◽  
Anna Olsson ◽  
Stefan Gustavsen ◽  
Annika Reynberg Langkilde ◽  
Annette Bang Oturai ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Brain Mri ◽  
Anatomical Location ◽  
Spinal Cord Lesions ◽  
Chi Square ◽  
Exact Test ◽  
Mcdonald Criteria ◽  
Chi Square Test

Spinal cord lesions are included in the diagnosis of multiple sclerosis (MS), yet spinal cord MRI is not mandatory for diagnosis according to the latest revisions of the McDonald Criteria. We investigated the distribution of spinal cord lesions in MS patients and examined how it influences the fulfillment of the 2017 McDonald Criteria. Seventy-four patients with relapsing-remitting MS were examined with brain and entire spinal cord MRI. Sixty-five patients received contrast. The number and anatomical location of MS lesions were assessed along with the Expanded Disability Status Scale (EDSS). A Chi-square test, Fischer’s exact test, and one-sided McNemar’s test were used to test distributions. MS lesions were distributed throughout the spinal cord. Diagnosis of dissemination in space (DIS) was increased from 58/74 (78.4%) to 67/74 (90.5%) when adding cervical spinal cord MRI to brain MRI alone (p = 0.004). Diagnosis of dissemination in time (DIT) was not significantly increased when adding entire spinal cord MRI to brain MRI alone (p = 0.04). There was no association between the number of spinal cord lesions and the EDSS score (p = 0.71). MS lesions are present throughout the spinal cord, and spinal cord MRI may play an important role in the diagnosis and follow-up of MS patients.

scholarly journals Initial Neurologic Symptoms Among Bangladeshi Multiple Sclerosis Patients

1970 ◽  
Vol 24 (1) ◽  
pp. 9-16
Author(s):  
Md Bahadur Ali Miah ◽  
Abdul Kader Sheikh ◽  
Akhlaque Hosain Khan ◽  
Md Rafiqul Islam ◽  
AKM Anwar Ullah ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Acute Onset ◽  
Motor Weakness ◽  
Neurologic Symptoms ◽  
Data Collection Sheet ◽  
Tonic Spasm ◽  
Male Patients ◽  
Restricted Activity ◽  
Multiple Sclerosis Patients ◽  
Medical University

This study was undertaken in the Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from January 2002 to December 2003. The objective of this study was to determine the initial neurologic symptoms of multiple sclerosis among Bangladeshi patients. A total of 25 respondents of multiple sclerosis patients as cases selected by McDonald et al. (2001) diagnostic criteria for multiple sclerosis were enlisted during the study period. The clinical details, investigations of the respondents were reviewed. Data were recorded in predesigned data collection sheet. Out of 25 cases, male patients were 12 (48%) and females were 13 (52%), ratio being 1:1.08. Majority of the patients presented at second, third and fourth decades of life. Most of the patients (56%) had acute onset, followed by subacute (28%) and insidious (16%). Certain clinical characteristics among Bangladeshi multiple sclerosis patients are noteworthy, namely, number of male and female patients almost equal (48% vs 52%), a higher rate of impaired vision (optic nerve involvement, 64%), motor weakness (92%), sphincteric disturbances (92%) and a lower rate of brainstem and cerebellar involvement. Painful tonic spasm was a prominent feature among Bangladeshi patients with multiple sclerosis (8 out of 25, 32%). Out of 25 patients, one (4%) expired due to aspiration pneumonia. Twenty four (96%) survived. Among them 9 (36%) has restricted activity, 7 (28%) were bedridden, 5 (20%) were chairbound, 2 (8%) had minor disability and were in work and 1 (4%) was completely normal. DOI: http://dx.doi.org/10.3329/bjn.v24i1.3035 Bangladesh Journal of Neuroscience 2008; Vol. 24 (1) :9-16

Spinal cord MRI using multi-array coils and fast spin echo: II. Findings in multiple sclerosis

Neurology ◽  
1993 ◽  
Vol 43 (12) ◽  
pp. 2632-2632 ◽  
Author(s):  
D. Kidd ◽  
J. W. Thorpe ◽  
A. J. Thompson ◽  
B. E. Kendall ◽  
I. F. Moseley ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Spin Echo ◽  
Fast Spin Echo ◽  
Fast Spin ◽  
Array Coils
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