scholarly journals Calcium Antagonists, Cerebral Ischemia and Vasospasm

1984 ◽  
Vol 11 (2) ◽  
pp. 239-246 ◽  
Author(s):  
Bryce Weir
Keyword(s):  
Clinical Trials ◽  
Cerebral Ischemia ◽  
Calcium Ions ◽  
Calcium Antagonists ◽  
Animal Experiments ◽  
Arterial Occlusion ◽  
Transmembrane Transport ◽  
The Past ◽  
Systemic Arteries

ABSTRACT:The past fifteen years has seen the classification of diverse substances into a group known as calcium antagonists (CAs). They have a common ability to reduce the transmembrane transport of extracellular calcium ions (CAe2+). This flow of calcium into vascular smooth muscle is ultimately associated with the development of tension and vasoconstriction. Some CAs appear to have a predilection for cerebral as opposed to systemic arteries and so may function as specific cerebral arterial vasodilators. It has been proposed that they might be useful in certain types of cerebral ischemia such as that due to arterial occlusion or prolonged vasoconstriction. Animal experiments and initial clinical trials give grounds for cautious optimism that CAs may become as useful in neurology as they have recently become in cardiology.

scholarly journals ANCA Status or Clinical Phenotype — What Counts More?

2021 ◽  
Vol 23 (6) ◽  
Author(s):  
Martin Windpessl ◽  
Erica L. Bettac ◽  
Philipp Gauckler ◽  
Jae Il Shin ◽  
Duvuru Geetha ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Granulomatosis With Polyangiitis ◽  
Clinical Phenotype ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Cardiovascular Death ◽  
Genetic Associations ◽  
Ongoing Debate ◽  
The Past ◽  
Anca Associated Vasculitis

Abstract Purpose of Review There is ongoing debate concerning the classification of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. That is, whether classification should be based on the serotype (proteinase 3 (PR3)- or myeloperoxidase (MPO)-ANCA) or on the clinical phenotype (granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA)). To add clarity, this review focused on integration of the most recent literature. Recent Findings Large clinical trials have provided evidence that a serology-based risk assessment for relapses is more predictive than distinction based on the phenotype. Research conducted in the past decade indicated that a serology-based approach more closely resembles the genetic associations, the clinical presentation (i.e., lung involvement), biomarker biology, treatment response, and is also predicting comorbidities (such as cardiovascular death). Summary Our review highlights that a serology-based approach could replace a phenotype-based approach to classify ANCA-associated vasculitides. In future, clinical trials and observational studies will presumably focus on this distinction and, as such, translate into a “personalized medicine.”

Antibiotic Treatment—Much Better than Nothing

2019 ◽  
pp. 135-154
Author(s):  
Janet R. Gilsdorf
Keyword(s):  
Clinical Trials ◽  
Bacterial Meningitis ◽  
Antibiotic Treatment ◽  
Animal Experiments ◽  
Effective Management ◽  
Basic Principles ◽  
Duration Of Therapy ◽  
The Past ◽  
Drug Doses ◽  
Better Than

Over the past five decades, many animal experiments as well as clinical trials of antibiotics in humans treated for meningitis have defined the levels of antibiotics that are present in infected meninges and in the blood, thus informing the drug doses necessary to successfully treat the infection. In spite of the different kinds of bacteria that cause meningitis and the availability of various antibiotics to treat it, several basic principles of effective management for all common forms of bacterial meningitis have emerged from the decades of research. As a result of these studies, most children with meningitis in America receive appropriate antibiotic treatment (the correct antibiotic and the correct dose for the correct duration of therapy), and their outcomes are much, much better than the disastrous outcomes of earlier eras.

Global Impact of Danish Headache Research

Cephalalgia ◽  
2001 ◽  
Vol 21 (7) ◽  
pp. 753-756
Author(s):  
JW Lance
Keyword(s):  
Clinical Trials ◽  
Global Impact ◽  
The Past ◽  
Ihs Classification ◽  
Made In

Over the past 40 years, Denmark has established a world reputation for the comprehensive nature and excellence of its headache research. Advances have been made in epidemiology, genetics, pathophysiology and treatment across the whole spectrum of headache entities. Moreover, the IHS classification of headache, the guidelines for clinical trials and text books on the basic mechanisms and management of headaches were initiated from Denmark. These achievements are a tribute to all those who have participated and to the continuing leadership of Jes Olesen.

scholarly journals Research Trends in Hair-related Dissertations over the Past Decade - Focused on papers published in 2011~2020 -

2021 ◽  
Vol 27 (5) ◽  
pp. 1196-1205
Author(s):  
Ho-Jin Lee ◽  
Young-Hee Noh
Keyword(s):  
Clinical Trials ◽  
Academic Research ◽  
Experimental Studies ◽  
Information Service ◽  
Research Trends ◽  
Research Information ◽  
Research Papers ◽  
The Past ◽  
Master's Thesis

In this study, we will analyze academic research trends over the past 10 years in line with the development and education of the beauty industry and provide direction and basic data for future especially hair research. It was limited to master's and doctorate papers registered in the Research Information Service System (RISS) in March 2021 among beauty and beauty research papers published in 2011 and 2020. The keyword (Keyword) was categorized by hair, makeup, skin, and nail majors that can currently obtain a national technical certificate, and 2,878 were first searched. The research was conducted three times a week on March 8, 15, and March 22, 2021, with no difference in search results. The analysis of the papers studied was conducted for four months from March 2021 to June 2021. There were 1,558 skin-related thesis (54.1%), 610 hair-related thesis (21.2%), 379 makeup-related thesis (13.2%), and 331 nail-related thesis (11.5%). Among them, the distribution of hair-related thesis found to be 518 masters and 92 doctors. Looking at the topic of master's thesis, hair behaviors 217 (41.8%), hair design 208 (40.1%). doctor's thesis by topic, hair behaviors 39 (44.3%), hair design 29 (32.2%). According to a survey of research methods, 255 surveys (49.2%), 138 literature studies (26.6%), and 80 works (15.4%). The Ph.D. thesis showed 41 surveys (45.6%), 24 works (26.7%) and 9 literature studies (10%). In addition, 278 of the master's thesis were surveyed and 177 (63.7%) for consumers and 83 (29.9%) for workers. According to the classification of 47 doctoral thesis, 25consumers (53.2%) and 17 workers (36.2%). According to a survey of 34 master's experimental studies, 21 clinical trials (61.8%), 13 non-clinical trials (38.2%), 14 doctoral experimental studies (35.7%), and 9 non-clinical trials (64.3%). In the future, the scope of analysis will be expanded to major fields such as skin, makeup, and nails, and academic papers as well as academic papers will be required to be analyzed. Furthermore, it is possible to conduct a more diverse and objective analysis of research trends in the beauty field if research trends at home and abroad are grasped.

Basic Studies of Various 99mTc-Labelled Renal Agents and Clinical Application of 99mTc-Malate

1977 ◽  
Vol 16 (01) ◽  
pp. 36-41 ◽  
Author(s):  
T. Machida ◽  
M. Miki ◽  
M. Ueda ◽  
A. Tanaka ◽  
I. Ikeda
Keyword(s):  
Excretion Rate ◽  
Animal Experiments ◽  
Imaging Agents ◽  
Half Time ◽  
Clinical Experiences ◽  
Labelling Efficiency ◽  
Urinary Excretion Rate ◽  
Renal Imaging ◽  
The Past ◽  
Basic Studies

SummaryVarious renal imaging agents that were reported in the past and a new agent, 99mTc-malate as well as 99mTc-cystein acetazolamide complex were prepared using electrolysis and electrochemical methods. These were studied for their labelling efficiency. After animal experiments with selected 99mTc-com- pounds, 99mTc-rnalate proved to be sufficient for renal imaging with adequate concentration. 99mTcmalate differs from other renal imaging agents in the utilization of endogeneous metabolic product.The first half time of 99mTc-malate in humans is 17 minutes, on the average, and the urinary excretion rate of 99mTc-malate is 36±6.05% in 1 hour after intravenous administration, 44 ± 3.41% in 2 hours and 50 + 5.62% in 3 hours.In our 40 clinical experiences of 99m-Tc-rnalate, most cases demonstrated quite clear renal images in the serial scintiphotos except cases whose serum creatinines were over 4.5 mg/dl.

Second international scientific conference «Present fundamental problems of vegetation classification» (Yalta, 15–20 September 2019)

2019 ◽  
pp. 135-142
Author(s):  
K. V. Ivanova ◽  
A. M. Lapina ◽  
V. V. Neshataev
Keyword(s):  
Plant Communities ◽  
National Archive ◽  
Botanical Garden ◽  
Vegetation Classification ◽  
Scientific Conference ◽  
Scientific Journals ◽  
Time Dynamics ◽  
The Past ◽  
Research Organizations

The 2nd international scientific conference «Fundamental problems of vegetation classification» took place at the Nikitskiy Botanical Garden (Yalta, Republic of Crimea, Russia) on 15–20 September 2019. There were 56 participants from 33 cities and 43 research organizations in Russia. The conference was mostly focused on reviewing the success in classification of the vegetation done by Russian scientists in the past three years. The reports covered various topics such as classification, description of new syntaxonomical units, geobotanical mapping for different territories and types of vegetation, studies of space-time dynamics of plant communities. The final discussion on the last day covered problems yet to be solved: establishment of the Russian Prodromus and the National archive of vegetation, complications of higher education in the profile of geobotany, and the issue of the data leakage to foreign scientific journals. In conclusion, it was announced that the 3rd conference in Nikitskiy Botanical Garden will be held in 2022.

The Poetry and Music of Science

2019 ◽  
Author(s):  
Tom McLeish
Keyword(s):  
School Leaver ◽  
Creative People ◽  
Creative Processes ◽  
Arts And Sciences ◽  
The Past ◽  
The Arts ◽  
The Two Cultures ◽  
Personal Accounts ◽  
Poetry And Music

‘I could not see any place in science for my creativity or imagination’, was the explanation, of a bright school leaver to the author, of why she had abandoned all study of science. Yet as any scientist knows, the imagination is essential to the immense task of re-creating a shared model of nature from the scale of the cosmos, through biological complexity, to the smallest subatomic structures. Encounters like that one inspired this book, which takes a journey through the creative process in the arts as well as sciences. Visiting great creative people of the past, it also draws on personal accounts of scientists, artists, mathematicians, writers, and musicians today to explore the commonalities and differences in creation. Tom McLeish finds that the ‘Two Cultures’ division between the arts and the sciences is not after all, the best classification of creative processes, for all creation calls on the power of the imagination within the constraints of form. Instead, the three modes of visual, textual, and abstract imagination have woven the stories of the arts and sciences together, but using different tools. As well as panoramic assessments of creativity, calling on ideas from the ancient world, medieval thought, and twentieth-century philosophy and theology, The Poetry and Music of Science illustrates its emerging story by specific close-up explorations of musical (Schumann), literary (James, Woolf, Goethe) mathematical (Wiles), and scientific (Humboldt, Einstein) creation. The book concludes by asking how creativity contributes to what it means to be human.

scholarly journals Morphological Characteristics, Classifications and Difficulties in the Use of Diagnostic Criteria for Serrated Lesions of the Large Intestine

2021 ◽  
Author(s):  
Cesar de Souza Bastos Junior ◽  
Vera Lucia Nunes Pannain ◽  
Adriana Caroli-Bottino
Keyword(s):  
Diagnostic Criteria ◽  
Morphological Characteristics ◽  
World Health ◽  
Diagnostic Tools ◽  
Serrated Adenoma ◽  
The Past ◽  
The World ◽  
Serrated Lesions ◽  
Health Organization

Abstract Introduction Colorectal carcinoma (CRC) is the most common gastrointestinal neoplasm in the world, accounting for 15% of cancer-related deaths. This condition is related to different molecular pathways, among them the recently described serrated pathway, whose characteristic entities, serrated lesions, have undergone important changes in their names and diagnostic criteria in the past thirty years. The multiplicity of denominations and criteria over the last years may be responsible for the low interobserver concordance (IOC) described in the literature. Objectives The present study aims to describe the evolution in classification of serrated lesions, based on the last three publications of the World Health Organization (WHO) and the reproducibility of these criteria by pathologists, based on the evaluation of the IOC. Methods A search was conducted in the PubMed, ResearchGate and Portal Capes databases, with the following terms: sessile serrated lesion; serrated lesions; serrated adenoma; interobserver concordance; and reproducibility. Articles published since 1990 were researched. Results and Discussion The classification of serrated lesions in the past thirty years showed different denominations and diagnostic criteria. The reproducibility and IOC of these criteria in the literature, based on the kappa coefficient, varied in most studies, from very poor to moderate. Conclusions Interobserver concordance and the reproducibility of microscopic criteria may represent a limitation for the diagnosis and appropriate management of these lesions. It is necessary to investigate diagnostic tools to improve the performance of the pathologist's evaluation, for better concordance, and, consequently, adequate diagnosis and treatment.

scholarly journals Mesenchymal stem cells and oncolytic viruses: joining forces against cancer

2021 ◽  
Vol 9 (2) ◽  
pp. e001684
Author(s):  
Rafael Moreno
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Mesenchymal Stem Cells ◽  
Immune System ◽  
Oncolytic Viruses ◽  
Immunogenic Cell Death ◽  
The Past ◽  
Physical Barriers ◽  
Immunogenic Properties ◽  
New Strategies

The development of oncolytic viruses (OVs) has increased significantly in the past 20 years, with many candidates entering clinical trials and three of them receiving approval for some indications. Recently, OVs have also gathered interest as candidates to use in combination with immunotherapies for cancer due to their immunogenic properties, which include immunogenic cell death and the possibility to carry therapeutic transgenes in their genomes. OVs transform non-immunogenic ‘cold’ tumors into inflamed immunogenic ‘hot’ tumors, where immunotherapies show the highest efficacy. However, in monotherapy or in combination with immunotherapy, OVs face numerous challenges that limit their successful application, in particular upon systemic administration, such as liver sequestration, neutralizing interactions in blood, physical barriers to infection, and fast clearance by the immune system. In this regard, the use of mesenchymal stem cells (MSCs) as cells carrier for OV delivery addresses many of these obstacles acting as virus carriers and factories, expressing additional transgenes, and modulating the immune system. Here, I review the current progress of OVs-loaded MSCs in cancer, focusing on their interaction with the immune system, and discuss new strategies to improve their therapeutic efficacy.

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