Effect of Thyroxine and Estrogens on Collagen Synthesis in Rats: A Transmission and Scanning Electron Microscopy Study
Recent light and electron microscopic studies showed that corticosteroids and testosterone induced changes in the structure of fibroblasts and collagen synthesis. Our previous investigations demonstrate that also calcitonin significantly interferes with collagen synthesis and fibroblast growth in wounded rabbits.Conflicting findings were reported by using biochemical and light microscopic studies following estrogens and thyroxine administration. This report concerns some investigations with regard to the role of estradiol and thyroxine on collagen synthesis in rats.Adult male rats were used in these experiments. They were divided in three groups of 10 rats each. A) Thyroxine-treated rats: each rat received intramuscularly (im) 100 μg thyroxine (Synthroid), every other day, for one month. B) Estrogen-treated rats: each rat received 500 μg estradiol dipropionate, every other day, for one month. C) Controls, received only the diluent.