scholarly journals Bending the epidemic curve: advancements and opportunities to reduce the threat of emerging pathogens

2019 ◽  
Vol 147 ◽  
Author(s):  
Angel N. Desai ◽  
Lawrence C. Madoff

AbstractThis invited editorial introduces a special issue of Epidemiology & Infection while also discussing advances in emerging infectious diseases.

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2382
Author(s):  
João R. Mesquita

More than 61% of all human pathogens are zoonotic, representing 75% of all emerging pathogens during the past decade. Albeit significant technological leaps in diagnostics development and disease surveillance, zoonotic emerging infectious diseases are evermore a matter of concern, particularly in modern days where global warming keeps providing ideal climatic conditions to the introduction of exotic infectious agents or disease vectors in new territories. Worryingly, the 2019 novel coronavirus epidemic acts as an extreme reminder of the role animal reservoirs play in public health, accounting for over 4,200,000 deaths worldwide until today. In this Special Issue, we approach a myriad of zoonotic infectious diseases and their complex mechanisms. This Special Issue is composed of three reviews on zoonotic diseases of African Lions, hemogregarine classification, and hepatitis E virus in Brazil, followed by one letter and one opinion piece that broadens the spectrum of disease emergence to mechanistic aspects of emerging non-communicable diseases. The Special Issue is completed by six research papers covering a wide array of emerging and re-emerging diseases of poultry, bovine, poultry and tortoises, of various nature such as parasitic, bacterial, and viral. This is a brief but assertive collection that showcases the need to address health at the animal–human–environment interface, in a One Health perspective.


Author(s):  
Aida Mencía-Ripley ◽  
Robert Paulino-Ramírez ◽  
Leandro Féliz-Matos ◽  
Carlos B. Ruiz-Matuk ◽  
Laura V. Sánchez-Vincitore

Emerging pathogens, especially those related to infectious diseases require behavior change as well as engaging the population in participating in healthy behaviors. Psychological responses are thus of vital importance to disease prevention. While the stress of a pandemic has been associated to many psychological symptoms, these symptoms have not been systematically explored in a broader sociopolitical context. Psychological responses may be linked to the perceptions of health professionals and may also relate to trust in public institutions. As such, psychopathology is not only a consequence of stress associated with pandemics but rather, the result of an interplay of personal and sociopolitical contexts. This study showed that members of the general population are experiencing significant symptoms of psychological distress. Regression analyses showed that psychological distress was associated with negative attitudes towards healthcare professionals as well as distrust in public health authorities. This study is relevant because a lack of trust in health officials may impact the degree to which the population adheres to public health guidelines to prevent and manage COVID-19.


2011 ◽  
Vol 6 (4) ◽  
pp. 371-371
Author(s):  
Fumiko Kasuga

Recent developments in medicine and anti-microbial treatment based on intensive research on basic microbiology have successfully been controlling many infectious diseases to be nonfatal. As stated by Dr. Nobuhiko Okabe in the first section of this issue, emerging and re-emerging infectious diseases still threaten human lives and health both in developing and industrialized countries. A multiprefectural outbreak of enterohemorrhagic E. coli (EHEC) O111 and O157 due to raw beef consumption took the lives of victims, including young children, earlier this year in Japan, following which people worldwide were panicked by news from Europe of a huge outbreak of EHEC O104. Infectious diseases result from interaction between pathogens and humans including our behaviors. The Journal of Disaster Research has already drawn readers’ attention to infectious diseases in its special issue on “Our Social Activities Are Always Related to Outbreaks of Infectious Diseases,” with Guest Editor Dr. Masayuki Saijo in JDR Vol.4, No.5, October, 2009. That issue reviewed the background behind infectious disease emergence and reemergence using examples of viral diseases that could cause serious public health concerns, and emphasized the need for preparedness and responses, including against bioterrorism. The present issue again reminds readers of the threat of infectious diseases by demonstrating bacterial and viral infections, focusing more on basic knowledge about these pathogens. Disease history, and epidemiology and the microbiological nature of pathogens and infection pathways are summarized. Treatment, vaccination and other control measures, and law and other social systems for controlling disease are also reviewed. We believe that a better understanding of pathogens will enable society to build better strategies for overcoming problems with emerging and reemerging infectious diseases, such as appropriate preventive measures, treatment and control for preventing outbreaks from expanding. We also hope that such considerations are also useful to disaster control experts in other areas. I would like to express my sincere gratitude to the authors and reviewers for their great contributions to this issue, and to the Editorial Board and the Secretariat of the Journal of Disaster Research for their continuous encouragement and assistance.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
C. Brandon Ogbunugafor ◽  
Miles D. Miller-Dickson ◽  
Victor A. Meszaros ◽  
Lourdes M. Gomez ◽  
Anarina L. Murillo ◽  
...  

AbstractVariation in free-living microparasite survival can have a meaningful impact on the ecological dynamics of established and emerging infectious diseases. Nevertheless, resolving the importance of indirect and environmental transmission in the ecology of epidemics remains a persistent challenge. It requires accurately measuring the free-living survival of pathogens across reservoirs of various kinds and quantifying the extent to which interaction between hosts and reservoirs generates new infections. These questions are especially salient for emerging pathogens, where sparse and noisy data can obfuscate the relative contribution of different infection routes. In this study, we develop a mechanistic, mathematical model that permits both direct (host-to-host) and indirect (environmental) transmission and then fit this model to empirical data from 17 countries affected by an emerging virus (SARS-CoV-2). From an ecological perspective, our model highlights the potential for environmental transmission to drive complex, nonlinear dynamics during infectious disease outbreaks. Summarizing, we propose that fitting alternative models with indirect transmission to real outbreak data from SARS-CoV-2 can be useful, as it highlights that indirect mechanisms may play an underappreciated role in the dynamics of infectious diseases, with implications for public health.


2018 ◽  
Author(s):  
Wang Liu-Wei ◽  
Şenay Kafkas ◽  
Robert Hoehndorf

AbstractMotivationIdentification of host-pathogen interactions (HPIs) can reveal mechanistic insights of infectious diseases for potential treatments and drug discoveries. Current computational methods for the prediction of HPIs often rely on our knowledge on the sequences and functions of pathogen proteins, which is limited for many species, especially for emerging pathogens. Matching the phenotypes elicited by pathogens with phenotypes associated with host proteins might improve the prediction of HPIs.ResultsWe developed an ontology-based machine learning method that predicts potential interaction protein partners for pathogens. Our method exploits information about disease mechanisms through features learned from phenotypic, functional and taxonomic knowledge about pathogens and human proteins. Additionally, by embedding the phenotypic information of the pathogens within a formal representation of pathogen taxonomy, we demonstrate that our model can accurately predict interaction partners for pathogens without known phenotypes, using a combination of their taxonomic relationships with other pathogens and information from ontologies as background knowledge. Our results show that the integration of phenotypic, functional and taxonomic knowledge not only improves the prediction of HPIs, but also enables us to investigate novel pathogens in emerging infectious diseases.Availabilityhttps://github.com/bio-ontology-research-group/[email protected]


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 86-93
Author(s):  
Dhirajsingh Sumersingh Rajput

Evolution is continuous process of changes in structural and physiological mechanism in living being. Microbes/pathogens can evolve naturally or artificially and become resistant to various medicines. Novel coronavirus is such evolved pathogen of coronavirus group. Enough strong immunity is needed to prevent or survive from COVID-19 pandemic. Ayurveda provides ways for evolving physiological responses to built immunity. Present work is brief attempt to increase insight in this filed.Present review was done based on simple theory of evolution, recent updates regarding prevention of COVID-19, Ayurveda aspect toward infectious diseases and Ayurveda ways towards prevention of infectious diseases with special reference to COVID-19. Person with impaired immunity is more susceptible for COVID-19 and thus immunity is an important preventing factor. Ayurveda Rasayana (rejuvanation) herbs, Yoga exercises, Pranayama (special breathing exercise), daily regimens and personal hygiene guidelines can be helpful strategies in controlling the spread of COVID-19.The preventive aspects of pandemic situations are narrated in Ayurveda with enough details. These ways need to be scientifically explored and refined for precision. As prevention is always better than cure hence Ayurveda ways can be considered for future strategies to avoid pandemics such as COVID-19.  There is great need of research on Ayurveda medicines on COVID-19 like diseases.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1026-1033
Author(s):  
Nivedha Valliammai Mahalingam ◽  
Abilasha R ◽  
Kavitha S

Enormous successes have been obtained against the control of major epidemic diseases, such as SARS, MERS, Ebola, Swine Flu in the past. Dynamic interplay of biological, socio-cultural and ecological factors, together with novel aspects of human-animal interphase, pose additional challenges with respect to the emergence of infectious diseases. The important challenges faced in the control and prevention of emerging and re-emerging infectious diseases range from understanding the impact of factors that are necessary for the emergence, to development of strengthened surveillance systems that can mitigate human suffering and death. The aim of the current study is to assess the awareness of symptomatic differences between viral diseases like COVID-19, SARS, Swine flu and common cold among dental students that support the prevention of emergence or re-emergence. Cross-sectional type of study conducted among the undergraduate students comprising 100 Subjects. A questionnaire comprising 15 questions in total were framed, and responses were collected in Google forms in SPSS Software statistical analysis. The study has concluded that dental students have an awareness of the symptomatic differences between infectious viral disease. The study concluded that the awareness of symptomatic differences between viral diseases like COVID-19, SARS, Swine flu, Common cold is good among the dental students who would pave the way for early diagnosis and avoid spreading of such diseases. A further awareness can be created by regular webinars, seminars and brainstorming sessions among these healthcare professionals.


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