scholarly journals Nutritional strategies to counteract muscle atrophy caused by disuse and to improve recovery

2013 ◽  
Vol 26 (2) ◽  
pp. 149-165 ◽  
Author(s):  
Hugues Magne ◽  
Isabelle Savary-Auzeloux ◽  
Didier Rémond ◽  
Dominique Dardevet
Keyword(s):  
Mass Loss ◽  
Muscle Mass ◽  
Muscle Atrophy ◽  
Whey Proteins ◽  
Leucine Supplementation ◽  
Positive Effects ◽  
Muscle Disuse ◽  
Muscle Mass Loss ◽  
Nutritional Strategies ◽  
Mass Recovery

Periods of immobilisation are often associated with pathologies and/or ageing. These periods of muscle disuse induce muscle atrophy which could worsen the pathology or elderly frailty. If muscle mass loss has positive effects in the short term, a sustained/uncontrolled muscle mass loss is deleterious for health. Muscle mass recovery following immobilisation-induced atrophy could be critical, particularly when it is uncompleted as observed during ageing. Exercise, the best way to recover muscle mass, is not always applicable. So, other approaches such as nutritional strategies are needed to limit muscle wasting and to improve muscle mass recovery in such situations. The present review discusses mechanisms involved in muscle atrophy following disuse and during recovery and emphasises the effect of age in these mechanisms. In addition, the efficiency of nutritional strategies proposed to limit muscle mass loss during disuse and to improve protein gain during recovery (leucine supplementation, whey proteins, antioxidants and anti-inflammatory compounds, energy intake) is also discussed.

scholarly journals Muscle Wasting and Resistance of Muscle Anabolism: The “Anabolic Threshold Concept” for Adapted Nutritional Strategies during Sarcopenia

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Dominique Dardevet ◽  
Didier Rémond ◽  
Marie-Agnès Peyron ◽  
Isabelle Papet ◽  
Isabelle Savary-Auzeloux ◽  
...  
Keyword(s):  
Mass Loss ◽  
Muscle Mass ◽  
Muscle Protein ◽  
Anabolic Resistance ◽  
Negative Results ◽  
Skeletal Muscle Loss ◽  
Muscle Mass Loss ◽  
Nutritional Strategies

Skeletal muscle loss is observed in several physiopathological situations. Strategies to prevent, slow down, or increase recovery of muscle have already been tested. Besides exercise, nutrition, and more particularly protein nutrition based on increased amino acid, leucine or the quality of protein intake has generated positive acute postprandial effect on muscle protein anabolism. However, on the long term, these nutritional strategies have often failed in improving muscle mass even if given for long periods of time in both humans and rodent models. Muscle mass loss situations have been often correlated to a resistance of muscle protein anabolism to food intake which may be explained by an increase of the anabolic threshold toward the stimulatory effect of amino acids. In this paper, we will emphasize how this anabolic resistance may affect the intensity and the duration of the muscle anabolic response at the postprandial state and how it may explain the negative results obtained on the long term in the prevention of muscle mass. Sarcopenia, the muscle mass loss observed during aging, has been chosen to illustrate this concept but it may be kept in mind that it could be extended to any other catabolic states or recovery situations.

Jiangnan Dietary Pattern Actively Prevents Muscle Mass Loss: Based on a Cohort Study

2021 ◽  
Author(s):  
Zhengyuan Wang ◽  
Xinyi Dong ◽  
Qi Song ◽  
Xueying Cui ◽  
Zehuan Shi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Mass Loss ◽  
Muscle Mass ◽  
Dietary Pattern ◽  
Muscle Mass Loss

scholarly journals Racial Differences in Relative Skeletal Muscle Mass Loss During Diet-Induced Weight Loss in Women

Obesity ◽  
2018 ◽  
Vol 26 (8) ◽  
pp. 1255-1260 ◽  
Author(s):  
Gary R. Hunter ◽  
David R. Bryan ◽  
Juliano H. Borges ◽  
M. David Diggs ◽  
Stephen J. Carter
Keyword(s):  
Skeletal Muscle ◽  
Weight Loss ◽  
Mass Loss ◽  
Racial Differences ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Muscle Mass Loss

Application of transcutaneous ultrasonography for the diagnosis of muscle mass loss in patients with liver cirrhosis

2017 ◽  
Vol 53 (5) ◽  
pp. 652-659 ◽  
Author(s):  
Kazufumi Kobayashi ◽  
Hitoshi Maruyama ◽  
Soichiro Kiyono ◽  
Sadahisa Ogasawara ◽  
Eiichiro Suzuki ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Mass Loss ◽  
Muscle Mass ◽  
Muscle Mass Loss

scholarly journals Increasing autophagy does not affect neurogenic muscle atrophy

2018 ◽  
Vol 28 (3) ◽  
Author(s):  
Eva Pigna ◽  
Krizia Sanna ◽  
Dario Coletti ◽  
Zhenlin Li ◽  
Ara Parlakian ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Muscle Atrophy ◽  
Ubiquitin Proteasome System ◽  
Autophagic Flux ◽  
Molecular Pathways ◽  
Muscle Loss ◽  
Relative Contribution ◽  
Ubiquitin Proteasome ◽  
Muscle Mass Loss ◽  
Kinetics Of

Physiological autophagy plays a crucial role in the regulation of muscle mass and metabolism, while the excessive induction or the inhibition of the autophagic flux contributes to the progression of several diseases. Autophagy can be activated by different stimuli, including cancer, exercise, caloric restriction and denervation. The latter leads to muscle atrophy through the activation of catabolic pathways, i.e. the ubiquitin-proteasome system and autophagy. However, the kinetics of autophagy activation and the upstream molecular pathways in denervated skeletal muscle have not been reported yet. In this study, we characterized the kinetics of autophagic induction, quickly triggered by denervation, and report the Akt/mTOR axis activation. Besides, with the aim to assess the relative contribution of autophagy in neurogenic muscle atrophy, we triggered autophagy with different stimuli along with denervation, and observed that four week-long autophagic induction, by either intermitted fasting or rapamycin treatment, did not significantly affect muscle mass loss. We conclude that: i) autophagy does not play a major role in inducing muscle loss following denervation; ii) nonetheless, autophagy may have a regulatory role in denervation induced muscle atrophy, since it is significantly upregulated as early as eight hours after denervation; iii) Akt/mTOR axis, AMPK and FoxO3a are activated consistently with the progression of muscle atrophy, further highlighting the complexity of the signaling response to the atrophying stimulus deriving from denervation.

Exercising to offset muscle mass loss in hemodialysis patients: The disconnect between intention and intervention

2019 ◽  
Vol 32 (4) ◽  
pp. 379-385 ◽  
Author(s):  
Colleen F. McKenna ◽  
Amadeo F. Salvador ◽  
Floris K. Hendriks ◽  
Alana P. Y. Harris ◽  
Luc J. C. van Loon ◽  
...  
Keyword(s):  
Mass Loss ◽  
Muscle Mass ◽  
Hemodialysis Patients ◽  
Muscle Mass Loss

scholarly journals The Effect of Estradiol Administration on Muscle Mass Loss and Cachexia Progression in Female ApcMin/+ Mice

2019 ◽  
Vol 10 ◽  
Author(s):  
Brittany R. Counts ◽  
Dennis K. Fix ◽  
Kimbell L. Hetzler ◽  
James A. Carson
Keyword(s):  
Mass Loss ◽  
Muscle Mass ◽  
Muscle Mass Loss
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