Mnemonics Usage and Cognitive Decline in Age-Associated Memory Impairment

1997 ◽  
Vol 9 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Gary W. Small ◽  
Asenath La Rue ◽  
Scott Komo ◽  
Andrea Kaplan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Cognitive Decline ◽  
Memory Impairment ◽  
Memory Function ◽  
Subjective Memory ◽  
Memory Measure ◽  
History Of

To determine predictors of cognitive deterioration, the authors performed baseline and 1- to 5-year follow-up (mean ± SD = 2.5 ± 1.2 years) neuropsychological assessments on 36 persons (mean age ± SD = 62.1 ± 8.0; range = 50 to 81 years) with age-associated memory impairment. Subjects were recruited from a larger group of volunteers, had minimal medical comorbidity, and 25 of them had a family history of Alzheimer's disease. Baseline age and a subjective memory measure indicating reported frequency of mnemonics usage were significant decline predictors. Subjects reporting more frequent mnemonics use at baseline were more likely to show objective cognitive decline at follow-up. Baseline full-scale IQ, educational level, and family history of Alzheimer's disease failed to predict decline. These findings suggest that although age is the strongest decline predictor in some people with age-associated memory impairment, self-perception of memory function may also predict subsequent cognitive loss.

scholarly journals Family History of Alzheimer’s Disease and Subjective Memory Performance

2018 ◽  
Vol 33 (7) ◽  
pp. 458-462 ◽  
Author(s):  
Robert Haussmann ◽  
Steffi Ganske ◽  
Antonia Gruschwitz ◽  
Annett Werner ◽  
Antje Osterrath ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Family History ◽  
Cognitive Deficits ◽  
Memory Impairment ◽  
Subjective Memory ◽  
Healthy Older Adults ◽  
Subjective Memory Impairment ◽  
History Of

People with a first-degree family history of Alzheimer’s disease are at an increased risk of developing dementia. Subjective memory impairment among individuals with no measurable cognitive deficits may also indicate elevated dementia risk. It remains unclear whether nondemented people with a positive family history of Alzheimer’s disease are more likely to experience cognitive deficits and whether such an association reflects underlying neuropathology. We therefore investigated subjective memory impairment and hippocampal cortical thickness in 40 healthy older adults and 35 patients with amnestic mild cognitive impairment. We found greater subjective memory impairment and left hemispheric hippocampal cortical thinning associated with a first-degree family history of Alzheimer’s disease in healthy older adults. This suggests that subjective memory impairment could reflect preclinical stage neurodegeneration among individuals with the family history risk factor.

A-5 Examining the Interactive Effects of Traumatic Brain Injury and Apolipoprotein E on Cognitive Decline in Alzheimer’s Disease

2021 ◽  
Vol 36 (6) ◽  
pp. 1044-1044
Author(s):  
Claire Alexander ◽  
Julie Suhr
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Apolipoprotein E ◽  
Negative Impact ◽  
Interactive Effects ◽  
Decline Rate ◽  
History Of ◽  
Positive Effect

Abstract Objective Little research has focused on possible effects of TBI on cognitive decline rate after Alzheimer’s disease (ad) diagnosis. We examined whether Apolipoprotein E (APOE) status and TBI history interact to predict cognitive decline. Method We used data from the National Alzheimer’s Coordinating Centers (N = 463; 42.3% APOE e4 carriers, 7.8% with TBI history, mean baseline age 79.3). Inclusion criteria included normal cognition at baseline with diagnosis of ad at a follow-up visit; baseline age 50 or older; and at least 3 years of follow-up data. Mixed models (random intercept, random slope) were used, with TBI history, APOE status, and their interaction as predictors of interest. Education, race, and history of TIA, stroke, or hypertension were included as covariates. Cognitive measures included mental status exam scores and immediate/delayed story memory. Results After accounting for covariates, TBI history had a positive effect on cognitive decline rate on the screener and immediate memory measures. APOE status did not affect rate of cognitive decline on the screener, but presence of e4 predicted faster decline on immediate and delayed memory. TBI history and APOE status interacted to predict delayed memory decline, such that history of TBI was associated with a reduced rate of decline for e4 non-carriers but there was no effect of TBI for e4 carriers. Conclusion When examining cognitive decline trajectory, TBI history predicted slower decline (a positive effect) while APOE had either a negative impact or no effect, depending on the measure. Future study should examine cognitive decline in the context of demographic and genetic factors.

P2-210: Subjective memory complaints in middle-aged adults with a family history of Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_12) ◽  
pp. P573-P574
Author(s):  
Christopher R. Nicholas ◽  
N. Maritza Dowling ◽  
Lindsay R. Clark ◽  
Annie M. Racine ◽  
Rebecca L. Koscik ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Subjective Memory Complaints ◽  
Middle Aged ◽  
Subjective Memory ◽  
Memory Complaints ◽  
History Of ◽  
Middle Aged Adults

Risk of progression from mild memory impairment to clinically diagnosable Alzheimer's disease in a Japanese community (from the Nakayama Study)

2010 ◽  
Vol 23 (5) ◽  
pp. 772-779 ◽  
Author(s):  
Naomi Sonobe ◽  
Ryuji Hata ◽  
Tomohisa Ishikawa ◽  
Kantaro Sonobe ◽  
Teruhisa Matsumoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Memory Impairment ◽  
Significant Risk ◽  
The Elderly ◽  
Elderly Subjects ◽  
Risk Of Progression ◽  
History Of

ABSTRACTBackground: Memory impairment has been proposed as the most common early sign of Alzheimer's disease (AD). The aims of this work were to evaluate the risk of progression from mild memory impairment/no dementia (MMI/ND) to clinically diagnosable AD in a community-based prospective cohort and to establish the risk factors for progression from MMI/ND to AD in the elderly.Methods: Elderly subjects aged over 65 years were selected from the participants in the first Nakayama study. MMI/ND was defined as memory deficit on objective memory assessment, without dementia, impairment of general cognitive function, or disability in activities of daily living. A total of 104 MMI/ND subjects selected from 1242 community-dwellers were followed longitudinally for five years.Results: During the five-year follow-up, 11 (10.6%) subjects were diagnosed with AD, five (4.8%) with vascular dementia (VaD), and six (5.8%) with dementia of other etiology. Logistic regression analysis revealed that diabetes mellitus (DM) and a family history of dementia (within third-degree relatives) were positively associated with progression to AD, while no factor was significantly associated with progression to VaD or all types of dementia.Conclusions: DM and a family history of dementia were significant risk factors for progression from MMI/ND to clinically diagnosable AD in the elderly in a Japanese community.

O3-03-08: The association between family history of Alzheimer's disease, APOE status, and cognitive decline

2008 ◽  
Vol 4 ◽  
pp. T164-T165
Author(s):  
Kathleen M. Hayden ◽  
Peter P. Zandi ◽  
Nancy A. West ◽  
JoAnn T. Tschanz ◽  
Maria C. Norton ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Cognitive Decline ◽  
History Of
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