Circadian Rhythm Sleep Disorders as a Possible Side Effect of Fluvoxamine

CNS Spectrums ◽  
2001 ◽  
Vol 6 (6) ◽  
pp. 511-513 ◽  
Author(s):  
Haggai Hermesh ◽  
Hadas Lemberg ◽  
Judith Abadi ◽  
Yaron Dagan
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Circadian Rhythm ◽  
Sleep Disorders ◽  
Psychotropic Drugs ◽  
Side Effect ◽  
Sleep Problems ◽  
Sleeping Pills ◽  
Circadian Rhythm Sleep Disorders ◽  
The Central Nervous System

AbstractSleep problems, day somnolence, and fatigue as a result of psychotropic drugs are very common. Psychiatrists usually consider these effects a result of insomnia and treat them by prescribing sleeping pills or other benzodiazepine agents.We describe here 10 cases of circadian rhythm sleep disorders (CRSD)—and not merely insomnia—as a possible side effect of fluvoxamine (FVA). Two other serotonin reuptake inhibitors, fluoxetine and clomipramine, did not induce CRSD in any of these 10 patients. We speculate that FVA-induced CRSD is caused by the effect of FVA on serotonin and melatonin levels in the central nervous system.CRSD as a side effect of FVA can be treated by replacing the suspected FVA or adding melatonin to a beneficial FVA treatment. Thus, it is important to be aware of possible iatrogenic CRSD in order to treat appropriately. Prospective studies are needed to confirm our observation and to study the influence of other psychotropic drugs on sleep-wake schedule.

scholarly journals Optimization of correction of sleep, speech and cognitive development in children as a result of perinatal injury of the central nervous system

2020 ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Development ◽  
Sleep Disorders ◽  
Dietary Supplement ◽  
Sleep Disturbances ◽  
Speech Therapy ◽  
Main Group ◽  
Sleeping Pills ◽  
The Central Nervous System

The article presents the results of a clinical study on the efficacy and tolerability of the Anantavati® Kids dietary supplement (Ananta Medicare, UK) in children with speech, cognitive and sleep disorders as a result of perinatal lesions of the central nervous system (CNS). The peculiarities of the effect of Bacopa Monier and Vitania sleeping pills on functional changes in the brain in the main group of children receiving Anantavati® Kids and the comparison group are shown. During the study of the results of the use of the phytocomplex Anantavati® Kids (a fixed combination of Bacopa Monier - 150 mg and Vitania sleeping pills - 300 mg), 38 children aged 4 to 12 years were examined who received Anantavati® Kids in addition to rehabilitation psychological and speech therapy measures. For comparison, 20 children were examined who had similar syndromes and received only rehabilitation psychological and speech therapy measures, the groups were comparable in terms of gender and age. The efficacy, tolerability and safety of the dietary supplement "Anantavati® Kids" for behavioral disorders, impaired speech cognitive development and sleep disturbances due to perinatal CNS damage in children were assessed using neurophysiological methods and neuropsychological indicators, statistical methods. Children of the main group received Anantavati® Kids syrup for 30 days, and underwent two clinical-neurological, neuropsychological, speech therapy and neurophysiological examinations: immediately before the start of the course and 1 month after taking Anantavati® Kids. A positive effect, according to an individual assessment of the clinical state in dynamics after 1 month of using Anantavati® Kids, was registered in most children. In the main group, the prevalence of complaints of sleep disorders decreased by 71%, speech impairment – by 47.37%, hyperactivity – by 55.26%, memory impairment - by 42.11%, attention impairment - by 65.79%, emotional disorders spheres by 63.16%. Positive dynamics of speech therapy indicators, in the form of an increase and active use of vocabulary, an increase in the structure of the word and the volume of coherent speech, was observed in 18 (47.37%) children. After the end of the course Anantavati® Kids in 28 (73.68%) children of the main group, a pronounced positive dynamics of EEG indicators was determined. A good safety profile was noted with the use of Anantavati® Kids, which is manifested by good tolerance during the study. Thus, the analysis of the data obtained after the use of Anantavati® Kids in children with the consequences of perinatal CNS lesions demonstrate the profound effect of the Anantavati® Kids phytocomplex on sleep disturbances, symptoms of cognitive and speech and psychoemotional disorders against the background of a course intake.

Photic sensitivity of the rhinophore in Aplysia

1979 ◽  
Vol 57 (3) ◽  
pp. 698-701 ◽  
Author(s):  
Ronald Chase
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Circadian Rhythm ◽  
Locomotor Activity ◽  
Peripheral Nerve ◽  
Aplysia Californica ◽  
Optic Nerves ◽  
Peripheral Location ◽  
The Central Nervous System

A response to the onset of light was recorded electrophysiologically from the rhinophore nerve of Aplysia californica. Except for the optic nerves, no other peripheral nerve is known to carry photic information to the central nervous system. The result suggests a peripheral location for the extraocular photoreceptors which are known to be capable of controlling the circadian rhythm of locomotor activity.

Dissociation of circadian rhythms in rats with a hypothalamic island

1984 ◽  
Vol 246 (6) ◽  
pp. R949-R954
Author(s):  
S. Honma ◽  
K. Honma ◽  
T. Hiroshige
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Circadian Rhythm ◽  
Locomotor Activity ◽  
Corticosterone Level ◽  
Direct Consequence ◽  
Plasma Corticosterone ◽  
Spontaneous Locomotor Activity ◽  
Medial Basal Hypothalamus ◽  
The Central Nervous System

Complete isolation of the medial basal hypothalamus, including the suprachiasmatic nuclei in the isolated island, from the rest of the central nervous system was performed in rats. The circadian rhythm of plasma corticosterone level remained essentially intact in 5 of 16 rats with complete islands, whereas that of spontaneous locomotor activity was decomposed into ultradian bursts in 15 rats, resulting in a clear dissociation of the two rhythms in four rats. One rat, whose circadian rhythm of both variables persisted after the hypothalamic isolation, showed a diurnal activity. The 24-h patterns of plasma corticosterone of the other rats could be characterized as either episodic or continuously low throughout the day. A prefeeding corticosterone peak was detected under restricted feeding in rats with episodic fluctuations but not in those with continuously low hormone levels. It is concluded that the hypothalamic island includes the fundamental structures necessary for the manifestation of the entrained circadian rhythm of plasma corticosterone in rats under ad libitum feeding, whereas it contains only a part of that for spontaneous locomotor activity. The coupling pathways from the circadian oscillator(s) to these overt rhythms seem to be separate in the central nervous system, and the circadian rhythm of plasma corticosterone is not a direct consequence of that of locomotor activity.

THE INFLUENCE OF DIPHENYLHYDANTOIN AND CARBAMAZEPINE ON THE CIRCADIAN RHYTHM OF FREE URINARY CORTICOIDS AND ON THE SUPPRESSIBILITY OF THE BASAL AND THE "IMPULSIVE" ACTIVITY BY DEXAMETHASONE

1973 ◽  
Vol 72 (2) ◽  
pp. 308-318 ◽  
Author(s):  
J. Köbberling ◽  
A. v. zur Mühlen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Circadian Rhythm ◽  
Feedback Mechanism ◽  
Essential Condition ◽  
The Central Nervous System ◽  
Competitive Protein Binding ◽  
Pre Treatment ◽  
Higher Doses

ABSTRACT In eight normal volunteers the circadian rhythm of cortisol was established by the determination of free urinary corticoids in 2 h urine samples by the competitive protein binding method. After two control days dexamethasone was infused between 10 p. m. and 4 a. m. in doses between 50 and 400 μg/h. These experiments were repeated after pre-treatment with 400 mg diphenylhydantion/day for one week and again after pre-treatment with 800 mg carbamazepine/day. Under the influence of these anti-convulsant drugs the circadian rhythm of free urinary corticoids was still present but showed more irregularities and sometimes additional peaks in the course of the day. The 24 h excretion values, the peak and the nadir values and the time of the morning peaks were not significantly different from the control days. The degree of suppression by dexamethasone was dose related both with and without the application of the anti-convulsants but under the influence of both these drugs comparable effects could only be achieved by 2 to 4 fold higher doses of dexamethasone. The suppression of basal and impulsive cortisol activities was inhibited in a similar way. According to these results it can be assumed that the anti-convulsants interfere with the feedback mechanism by decreasing the sensitivity of the central nervous system to changes in plasma glucocorticoid concentrations. An intact feedback mechanism does not seem to be an essential condition for the circadian rhythm.

Anterograde Amnesia in Triazolam Overdose Despite Flumazenil Treatment: A Case Report

1992 ◽  
Vol 11 (4) ◽  
pp. 289-290 ◽  
Author(s):  
Dong-Zong Hung ◽  
Wei-Jen Tsai ◽  
Jou-Fang Deng
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Memory Consolidation ◽  
Side Effect ◽  
Anterograde Amnesia ◽  
Benzodiazepine Antagonist ◽  
Potential Side Effect ◽  
Highly Effective ◽  
The Central Nervous System

Anterograde amnesia, possibly accompanied by acute brain syndrome, is a potential side-effect of certain benzodiazepines, particularly triazolam. Flumazenil is a benzodiazepine antagonist that is highly effective in reversing the central nervous system effects of benzodiazepine overdose. We report a case of triazolam overdose resulting in anterograde amnesia after flumazenil administration had restored clear consciousness. The defect in memory may have been due to too little flumazenil being given or failure of memory consolidation affected by the character of triazolam during the induced lucent period. We feel that physicians should be aware of the potential occurrence of acute brain syndrome in patients with benzodiazepine overdose despite treatment with flumazenil.

scholarly journals Proceedings of the Sleep and Epilepsy Workgroup: Section 2 Comorbidities: Sleep Related Comorbidities of Epilepsy

2021 ◽  
pp. 153575972110045
Author(s):  
Milena K. Pavlova ◽  
Marcus Ng ◽  
Rebecca M. Allen ◽  
Melanie Boly ◽  
Sanjeev Kothare ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Disease ◽  
Circadian Rhythms ◽  
Sleep Disorders ◽  
Treatment Options ◽  
Interdisciplinary Approach ◽  
Sleep Medicine ◽  
The Central Nervous System ◽  
Treatment Priorities

Epilepsy is a chronic disease with multiple, complex comorbidities. Bidirectional relationships exist among seizures, sleep, circadian rhythms, and diseases within and outside of the central nervous system. Seizures fragment sleep and can contribute to development of sleep disorders, which in turn leads to worse overall health and more seizures. Moreover, treatment options are often limited by interactions with anti-seizure medications. Advances in the fields of epilepsy and in sleep medicine have been made separately, and therefore treating patients with these comorbidities necessitates interdisciplinary approach. The focus of this section of the Sleep and Epilepsy Workgroup was to identify methods of collaboration and outline investigational, educational, and treatment priorities to mutually advance what we consider a combined field.

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