scholarly journals Optimization of correction of sleep, speech and cognitive development in children as a result of perinatal injury of the central nervous system

2020 ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Development ◽  
Sleep Disorders ◽  
Dietary Supplement ◽  
Sleep Disturbances ◽  
Speech Therapy ◽  
Main Group ◽  
Sleeping Pills ◽  
The Central Nervous System

The article presents the results of a clinical study on the efficacy and tolerability of the Anantavati® Kids dietary supplement (Ananta Medicare, UK) in children with speech, cognitive and sleep disorders as a result of perinatal lesions of the central nervous system (CNS). The peculiarities of the effect of Bacopa Monier and Vitania sleeping pills on functional changes in the brain in the main group of children receiving Anantavati® Kids and the comparison group are shown. During the study of the results of the use of the phytocomplex Anantavati® Kids (a fixed combination of Bacopa Monier - 150 mg and Vitania sleeping pills - 300 mg), 38 children aged 4 to 12 years were examined who received Anantavati® Kids in addition to rehabilitation psychological and speech therapy measures. For comparison, 20 children were examined who had similar syndromes and received only rehabilitation psychological and speech therapy measures, the groups were comparable in terms of gender and age. The efficacy, tolerability and safety of the dietary supplement "Anantavati® Kids" for behavioral disorders, impaired speech cognitive development and sleep disturbances due to perinatal CNS damage in children were assessed using neurophysiological methods and neuropsychological indicators, statistical methods. Children of the main group received Anantavati® Kids syrup for 30 days, and underwent two clinical-neurological, neuropsychological, speech therapy and neurophysiological examinations: immediately before the start of the course and 1 month after taking Anantavati® Kids. A positive effect, according to an individual assessment of the clinical state in dynamics after 1 month of using Anantavati® Kids, was registered in most children. In the main group, the prevalence of complaints of sleep disorders decreased by 71%, speech impairment – by 47.37%, hyperactivity – by 55.26%, memory impairment - by 42.11%, attention impairment - by 65.79%, emotional disorders spheres by 63.16%. Positive dynamics of speech therapy indicators, in the form of an increase and active use of vocabulary, an increase in the structure of the word and the volume of coherent speech, was observed in 18 (47.37%) children. After the end of the course Anantavati® Kids in 28 (73.68%) children of the main group, a pronounced positive dynamics of EEG indicators was determined. A good safety profile was noted with the use of Anantavati® Kids, which is manifested by good tolerance during the study. Thus, the analysis of the data obtained after the use of Anantavati® Kids in children with the consequences of perinatal CNS lesions demonstrate the profound effect of the Anantavati® Kids phytocomplex on sleep disturbances, symptoms of cognitive and speech and psychoemotional disorders against the background of a course intake.

Circadian Rhythm Sleep Disorders as a Possible Side Effect of Fluvoxamine

CNS Spectrums ◽  
2001 ◽  
Vol 6 (6) ◽  
pp. 511-513 ◽  
Author(s):  
Haggai Hermesh ◽  
Hadas Lemberg ◽  
Judith Abadi ◽  
Yaron Dagan
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Circadian Rhythm ◽  
Sleep Disorders ◽  
Psychotropic Drugs ◽  
Side Effect ◽  
Sleep Problems ◽  
Sleeping Pills ◽  
Circadian Rhythm Sleep Disorders ◽  
The Central Nervous System

AbstractSleep problems, day somnolence, and fatigue as a result of psychotropic drugs are very common. Psychiatrists usually consider these effects a result of insomnia and treat them by prescribing sleeping pills or other benzodiazepine agents.We describe here 10 cases of circadian rhythm sleep disorders (CRSD)—and not merely insomnia—as a possible side effect of fluvoxamine (FVA). Two other serotonin reuptake inhibitors, fluoxetine and clomipramine, did not induce CRSD in any of these 10 patients. We speculate that FVA-induced CRSD is caused by the effect of FVA on serotonin and melatonin levels in the central nervous system.CRSD as a side effect of FVA can be treated by replacing the suspected FVA or adding melatonin to a beneficial FVA treatment. Thus, it is important to be aware of possible iatrogenic CRSD in order to treat appropriately. Prospective studies are needed to confirm our observation and to study the influence of other psychotropic drugs on sleep-wake schedule.

scholarly journals Proceedings of the Sleep and Epilepsy Workgroup: Section 2 Comorbidities: Sleep Related Comorbidities of Epilepsy

2021 ◽  
pp. 153575972110045
Author(s):  
Milena K. Pavlova ◽  
Marcus Ng ◽  
Rebecca M. Allen ◽  
Melanie Boly ◽  
Sanjeev Kothare ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Disease ◽  
Circadian Rhythms ◽  
Sleep Disorders ◽  
Treatment Options ◽  
Interdisciplinary Approach ◽  
Sleep Medicine ◽  
The Central Nervous System ◽  
Treatment Priorities

Epilepsy is a chronic disease with multiple, complex comorbidities. Bidirectional relationships exist among seizures, sleep, circadian rhythms, and diseases within and outside of the central nervous system. Seizures fragment sleep and can contribute to development of sleep disorders, which in turn leads to worse overall health and more seizures. Moreover, treatment options are often limited by interactions with anti-seizure medications. Advances in the fields of epilepsy and in sleep medicine have been made separately, and therefore treating patients with these comorbidities necessitates interdisciplinary approach. The focus of this section of the Sleep and Epilepsy Workgroup was to identify methods of collaboration and outline investigational, educational, and treatment priorities to mutually advance what we consider a combined field.

scholarly journals Leptin participation in the processes of nervous impulse transmission and its influence on the formation of neuro-mental development of children

2022 ◽  
pp. 21-25
Author(s):  
G. O. Momot ◽  
E. V. Krukovich ◽  
T. N. Surovenko
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lipid Metabolism ◽  
Cognitive Development ◽  
Cognitive Functions ◽  
Cognitive Abilities ◽  
Nervous Impulse ◽  
Leptin Receptors ◽  
The Central Nervous System ◽  
Functional Features

Review of publications on the functional features of leptin in the central nervous system in children. The participation of leptin mechanisms in the transmission of nerve impulses, the effect of leptin on cognitive functions in children. The article reveals the general mechanisms of maturation of the central nervous system in children, the participation of leptin and leptin receptors in the formation of cognitive abilities in children. Possible interrelationships of impairments in cognitive development and lipid metabolism including obesity are revealed.

scholarly journals TO THE QUESTION OF THE NEED FOR THE DEVELOPMENT OF INTEGRATED REHABILITATION MEASURES IN PATIENTS WITH NEURODEGENERATION

2019 ◽  
Vol 85 (4) ◽  
pp. 72-77
Author(s):  
M.E. Chernenko
Keyword(s):  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Behavioral Therapy ◽  
Clinical Manifestations ◽  
Biological Rhythms ◽  
Rehabilitation Program ◽  
Main Group ◽  
Control Group ◽  
The Central Nervous System ◽  
The Individual

It is known that sleep disorders adversely affect the processes of brain neuroplasticity. Wakefulness and night sleep are functional states that are closely interrelated and equally mediate and provide the adaptive activity of the individual. Human biological rhythms are hierarchically dependent on the main pacemaker located in the suprachiasmatic nuclei of the hypothalamus. The role of a mediator that delivers regulatory signals to organs is played by the hormone melatonin, which is synthesized by pineal gland cells. Sleep disorders seriously affect a person's quality of life: emotional stress, anxiety, irritation increase and, as a result, stress resistance decreases, the need for communication, entertainment decreases. In the vast majority of cases, insomnia is secondary, that is, it is formed against the background of the development of diseases and/or adverse circumstances. Quite often, sleep disturbances occur in demyelinating/ neurodegenerative diseases of the central nervous system. We examined 30 patients with a diagnosis of multiple sclerosis, which were divided into two groups. The main group received therapy with a melatonin- containing drug in combination with cognitive-behavioral therapy. Patients in the control group received only therapy with melatonin-containing drug. It was shown that cortisol levels in patients of the main group decreased more than in patients who did not receive CBT. Reduction of clinical manifestations, along with improvements in laboratory indices of day and night melatonin expression, as well as cortisol expression, were already observed on the 14th day of treatment, and on the 21st day of the study, these indices improved significantly. Clinical efficacy in the main group was achieved in 86,6 % of cases, in the control group - in 60,0 % of cases. It is planned to use this method in the development of a comprehensive rehabilitation program in patients with neurodegeneration.

scholarly journals Features of treatment of asthenic-neurotic syndrome and sleep disorders in patients with chronic cerebrovascular accident

2016 ◽  
pp. 52-58
Author(s):  
N. Svyrydova ◽  
T. Parnikosa ◽  
V. Sereda ◽  
I. Kucheieva ◽  
N. Ingula
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Therapy ◽  
Sleep Disorders ◽  
Cerebrovascular Accident ◽  
Main Tool ◽  
Comprehensive Approach ◽  
Mental Strain ◽  
The Central Nervous System ◽  
Complex Drug

Asthenic syndrome can be regarded as pathologically modified version of the adaptation of the nervous system in response to physical and mental strain, exogenous or endogenous intoxication, vascular disorders. Of particular importance in recent years given asthenic syndrome and limits of neuroses, the need for complex drug therapy in the treatment of asthenic-neurotic states. In view of the fact that the leading element of the pathogenesis of asthenic syndrome are disorders of the central nervous system, the main tool of pharmacological correction in this situation should be considered a comprehensive approach neurotropic action.

scholarly journals THE ROLE OF MAGNETIC RESONANCE IMAGING IN THE PERINATAL ASSESSMENT OF THE CONDITION FETAL CNS WITH HEMOLYTIC DISEASE, WHO RECEIVED TREATMENT BY INTRAUTERINE INTRAVASCULAR BLOOD TRANSFUSION

2018 ◽  
pp. 36-42
Author(s):  
A. A. Berman ◽  
A. V. Vazhenin ◽  
O. N. Chernova ◽  
N. V. Bashmakova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Transfusion ◽  
Pregnant Women ◽  
Comparison Group ◽  
Main Group ◽  
Hemolytic Disease ◽  
Before And After ◽  
The Central Nervous System

Objective: to determine the role of magnetic resonance imaging (MRI) in the pathomorphological evaluation of focal changes in the central nervous system (CNS) of fetuses with hemolytic disease before and after treatment, by intrauterine intravascular blood transfusion, and to compare the MRI data of fetuses with ultrasound neurosonography (NSH) newborns. The study included 45 pregnant women and their 45 newborns. Patients are divided into 2 groups. The main group: 30 pregnant women (mean gestation period 32,1 weeks) with hemolytic disease of the fetus who underwent intrauterine intravascular blood transfusion and their 30 newborns with hemolytic disease of the newborn. In this group, comparative MRI examinations of the central nervous system were performed using a protocol including fast MP sequences based on T1 and T2-weighted images, as well as the DWI pulse sequence, both before treatment (intrauterine intravascular blood transfusion of the fetus), and after treatment (regardless of the multiplicity of intrauterine intravascular transfusion — before delivery). The comparison group comprised 15 pregnant women (mean gestation period of 38,6 weeks) with no signs of hemolytic disease, examined by MRI for other indications (concomitant pathology of pregnancy) and their 15 newborns, comparable in gestational age to the main group. The obstetric anamnesis, the MRI data of the central nervous system of fetuses before the treatment (the first intrauterine intravascular transfusion) and after the treatment (before the delivery) and the results of ultrasound for the first day of life were analyzed. When comparing the MRI data of changes in the central nervous system, in the main group (in fetuses with bladder) in relation to the comparison group before treatment (the first intrauterine, intravascular transfusion), a high incidence of focal changes in the brain substance in the main group was revealed. The use of MRIdiagnostics demonstrates a decrease in the risk of development of PCNC in ischemic type, in dynamics before and after treatment. Based on the MRI diagnostic data of the fetal CNS, it is possible to judge the prognosis of the outcomes of hemolytic disease of the fetus, in comparison with the neonatal neurosonography data for the first day.

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