The Current Course of Mood Disorders: A 3-Year Follow-Up

CNS Spectrums ◽  
1999 ◽  
Vol 4 (5) ◽  
pp. 77-82
Author(s):  
Alessandro Lenzi ◽  
Fabrizio Lazzerini ◽  
Donatella Marazziti
Keyword(s):  
Mortality Rate ◽  
General Population ◽  
Mood Disorders ◽  
Depressive Episode ◽  
Natural Course ◽  
Response To Treatment ◽  
Bipolar I Disorder ◽  
Hyperthymic Temperament

AbstractThe aim of this study was to evaluate the natural course of mood disorders in 157 patients admitted consecutively to the Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie at Pisa University for an affective or schizoaffective episode and followed for 3 years.During the follow-up, three patients committed suicide and three died of natural causes. The three suicide patients were diagnosed as suffering from a depressive episode deriving from Bipolar I disorder. Of the remaining 104 patients, 42% had no relapses, 35% had up to three relapses, and 23% had more than three relapses; there were no significant differences between these three groups.In conclusion, recent treatments seem able to reduce the length and number of relapses in patients with mood disorders. The hyperthymic temperament seems to be a characteristic of compliant patients and a predictor of a good response to treatment. The mortality rate connected with somatic or accidental causes appears to be similar to that of the general population, while the rate of suicide is higher.

Neck/Shoulder Disorders in a General Population. Natural Course and Influence of Physical Exercise: A 5-Year Follow-up

Spine ◽  
2005 ◽  
Vol 30 (13) ◽  
pp. E363-E368 ◽  
Author(s):  
Gunilla Pernold ◽  
Monica Mortimer ◽  
Christina Wiktorin ◽  
Ewa Wigaeus Tornqvist ◽  
Eva Vingård
Keyword(s):  
General Population ◽  
Physical Exercise ◽  
Natural Course ◽  
Shoulder Disorders

scholarly journals COVID 19 in Patients With Primary Immunodeficiency

2021 ◽  
Author(s):  
Saliha Esenboga ◽  
Melike Ocak ◽  
Ayşegul Akarsu ◽  
Hacer Neslihan Bildik ◽  
Deniz Cagdas ◽  
...  
Keyword(s):  
Mortality Rate ◽  
General Population ◽  
Primary Immunodeficiency ◽  
Normal Population ◽  
Primary Immunodeficiencies ◽  
Curative Treatment ◽  
Future Studies ◽  
Complicated Course

Abstract The results and the complications following SARS-CoV2 infection in individuals with primary immunodeficiency(PID) remain unclear. The objective of this study is to report the course, follow-up, outcome of COVID 19 in 26 patients with PIDs from a tertiary PID center in Turkey. Infection mortality rate was found to be %7.69 which is eight times higher than infection mortality rate (%0.97) in general population in Turkey. Although it is clear that mortality in patients with PID is higher than in the normal population, it is difficult to suggest a more risky group among primary immunodeficiencies for COVID-19 with a complicated course according to the data published so far. The groups are quite heterogeneous regarding age, sex and comorbidities, but it is remarkable that patients who underwent HSCT with curative treatment had an uncomplicated course despite comorbidities. Future studies as metaanalysis getting data together may help to get a more reliable conclusion.

Group-based trajectory modeling a good model to explore sub-groups of recovery during acute bipolar mood episodes

2011 ◽  
Vol 26 (S2) ◽  
pp. 233-233
Author(s):  
K. M’bailara ◽  
O. Cosnefroy ◽  
A. Desage ◽  
S. Gard ◽  
L. Zanouy ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Response To Treatment ◽  
Longitudinal Outcomes ◽  
Trajectory Modeling ◽  
Short Period ◽  
Trajectories Of Change ◽  
Dsm Iv ◽  
Bipolar Patients ◽  
Hypomanic Episode

Group-based trajectory modeling (GBTM) is a statistical method created to explore the heterogeneity of clinical groups based on their longitudinal outcomes by identifying distinct trajectories of change. This model can be applied to assess heterogeneity in responses to treatment. This pilot study explored the relevance of the GBTM associated with the dimensional evaluation of mood (MATHYS) to define trajectory of recovery in acute bipolar mood episodes on a short period of time during a naturalistic study.MethodThe sample consisted in 118 bipolar patients and all patients were recruited during an acute phase: 56% had a major depressive episode, 26% a manic or hypomanic episode, and 18% a mixed state using the DSM-IV criteria. Patients were assessed four times with MATHYS during a three weeks follow-up period. It is an observational study and treatment was prescribed as usual. We applied the GBTM method and MATHYS total score to define trajectories of recovery.ResultsThis method allows identifying 4 trajectories of recovery. At Baseline, two of them started with a score of inhibition but with quite different evolutive profiles (stable inhibition versus improvement). The two others trajectories started with a score of activation (mild versus moderate) and showed a linear improvement of symptoms but with a more rapid recovery for the patients with the higher activation at baseline.ConclusionWhen considering the diagnosis of patients belonging in each trajectory, there model seems particular relevant to explore the high heterogeneity in response to treatment in bipolar patients during an acute depressive episode.

P2664Long-term follow-up in a large cohort of survivors after out-of-hospital cardiac arrest: global mortality and comparison with age-specific mortality rate in the general population

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Caro Codon ◽  
L Rodriguez Sotelo ◽  
J R Rey Blas ◽  
S O Rosillo Rodriguez ◽  
O Gonzalez Fernandez ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mortality Rate ◽  
General Population ◽  
Hospital Discharge ◽  
Shockable Rhythm ◽  
Specific Mortality ◽  
Hospital Cardiac Arrest ◽  
Long Term Mortality

Abstract Background Data regarding long-term clinical outcomes after out-of-hospital cardiac arrest (OHCA) are scarce. Purpose To assess long-term mortality rate in OHCA patients, compare it with the general population age-specific mortality rate and identify relevant predictive factors. Methods All consecutive patients admitted to the Acute Cardiac Care Unit after OHCA from August 2007 to January 2019 and surviving until hospital discharge were included. All patients received targeted-temperature management according to our local protocol. Stepwise regression techniques and Cox proportional hazards models were used to investigate clinical variables related to long-term survival. The study population was divided into four quartiles according to their age and their mortality rate was compared with age-specific data from the Spanish National Statistics Institute. Results The final analysis included 201 patients. Mean age was 57.6±14.2 years and 168 (83.6%) were male. The majority of patients experienced witnessed arrests related to shockable rhythms (176, 87.6%). Median time to ROSC was 18 (IQR 12–27) minutes and 14 patients (7.0%) were discharged in a poor neurological condition (CPC 3–4). Thirty-six patients (17.9%) died after a median follow-up of 40.3 months (18.9–69.1). A prognostic multivariate Cox model was developed and is shown in Table 1. Mortality was mainly driven by neurologic (33.%), cardiovascular (30.6%) and oncologic (30.6%) causes. Annual mortality rate per 1000 patients was statistically superior to that in the general population among the first three age quartiles: 18.08 (6.78–48.16) vs 0.64; 29.62 (12.33–71.16) vs 3.30; 63.07 (33.94–117.22) vs 7.77. Nevertheless, no significant differences were observed among the oldest patients, ranging from 68.6 to 90.7 years: 70.93 (43.45–115.78) vs 54.95. Table 1. Cox proportional hazard model Variable Hazard Ratio Std. Err. p value 95% Confidence Interval Time from CA to CPR (per minute) 1.06 0.03 0.06 1.00–1.13 Non-shockable rhythm 2.93 1.11 0.01 1.39–6.16 Poor LVEF at discharge (per %) 1.03 0.01 0.01 1.01–1.06 Age at time of CA (per year) 1.04 0.01 0.01 1.01–1.06 CPC 3–4 at hospital discharge 3.50 1.43 <0.01 1.58–7.78 Figure 1 Conclusions OHCA survivors face significant mortality during follow-up, and its long term prognostic impact may be higher among younger patients. Age at the time of CA, time from CA to CPR, non-shockable rhythm, poor LVEF and poor neurological condition at discharge are independent predictors of long term mortality.

Temperament and character traits among suicidal patients during depressive episode of bipolar disorder

2017 ◽  
Vol 41 (S1) ◽  
pp. s890-s891
Author(s):  
A. Petek Eric ◽  
I. Eric ◽  
K. Dodig-Curkovic ◽  
K. Kralik ◽  
P. Filakovic
Keyword(s):  
Bipolar Disorder ◽  
General Population ◽  
Mood Disorders ◽  
Depressive Episode ◽  
Attempted Suicide ◽  
Suicide Attempts ◽  
Psychiatric Treatment ◽  
Bipolar Patients ◽  
Personality Features ◽  
Suicidal Patients

IntroductionBoth suicide and mood disorders represent current and future global burden on public health system. Bipolar disorder (BD), part of a diagnostic group of mood disorders, is characterized by manic, depressive and mixed episodes with life-expectancy much shorter than in general population. Patients with BD have 30 times higher suicide rate than the general population and 25–50% of these patients attempts suicide. About 15% of patients who attempted suicide eventually end their lives with completed suicide.AimThe aim of our research was to distinguish personality features among bipolar patients with current depressive episode (BD-D) who attempted suicide.Materials and methodsThe research was conducted among patients with depressive episode of BD (according to diagnostic criteria of ICD–10) who attempted suicide and had been admitted for hospital psychiatric treatment. For assessment of personality, we used the Temperament and Character Inventory (TCI, Cloninger R.) upon admittance. Our sample consisted of 31 (n = 31) patient who met the above mentioned criteria. All patients given their written informed consent. The statistical analysis was performed using SPSS 17.0.ResultsIn our sample, we found, higher scores on harm-avoidance (HA), significantly higher scores on novelty seeking (NS) with significantly lower scores on persistence (P), self-directedness (SD) and cooperativeness (C) scales of the TCI. The Mann–Whitney-U test was used to compare samples.ConclusionIn our sample, suicide attempts are associated with temperament and character dimensions. These results confirmed our initial hypotheses on existence of specific personality features among that group of suicidal patients with BD–D.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals COPD and risk of venous thromboembolism and mortality in a general population

2015 ◽  
Vol 47 (2) ◽  
pp. 473-481 ◽  
Author(s):  
Trond Børvik ◽  
Sigrid K. Brækkan ◽  
Kristin Enga ◽  
Henrik Schirmer ◽  
Ellen E. Brodin ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Mortality Rate ◽  
General Population ◽  
Cox Regression ◽  
Stage Iii ◽  
Chronic Obstructive ◽  
Copd Patients ◽  
Increased Risk ◽  
Time Varying Covariates

The relationship between chronic obstructive pulmonary disease (COPD) and risk of venous thromboembolism (VTE) has been scarcely studied in the general population. We aimed to investigate the association between COPD and risk of VTE and mortality in a population-based cohort.Spirometry was conducted in 8646 males and females, participating in the fifth (2001–02) and sixth (2007–08) surveys of the Tromsø Study. Incident VTE events during follow-up were registered from the date of inclusion to December 31, 2011. Cox-regression models with COPD stages and confounders as time varying covariates were used to calculate hazard ratios with 95% confidence intervals for VTE and all-cause mortality.During a median follow-up of 6.2 years, 215 subjects developed VTE. Subjects with COPD stage III/IV had a two-fold higher risk of secondary VTE compared to subjects with normal airflow (HR 2.05, 95% CI 1.02–4.10). COPD patients, particularly those with stage III/IV disease, with VTE had a higher mortality rate than COPD patients without VTE (50.2% versus 5.6% per year).Our findings suggest that patients with severe COPD may have increased risk of secondary VTE, and that COPD patients with VTE have a higher mortality rate than COPD patients without VTE.

scholarly journals ‘Elderly graduates' and a hospital closure programme

1994 ◽  
Vol 18 (9) ◽  
pp. 534-537 ◽  
Author(s):  
Frank Holloway ◽  
Joan Rutherford ◽  
Jerome Carson ◽  
Lynda Dunn
Keyword(s):  
Mortality Rate ◽  
General Population ◽  
Health Authority ◽  
Unmet Need ◽  
Regional Health Authority ◽  
Level Of Care ◽  
Regional Health ◽  
Supported Accommodation ◽  
Hospital Closure

A sample of 49 ‘elderly graduate’ residents of a hospital designated for closure were surveyed in 1987 and followed up five years later. Twenty-two patients (45%) had died: the mortality rate was much lower than that predicted by the regional health authority and approximated to that of the general population. All but one of the survivors was living in supported accommodation at the time of follow-up. The majority were satisfied with the move and were receiving an appropriate level of care. However there was significant unmet need for structured activities and companionship. During the follow-up period the survivors had declined in functioning.

Response to Treatment of Alcoholism; a Follow-Up Study

1968 ◽  
Vol 29 (2) ◽  
pp. 364-381 ◽  
Author(s):  
Alex D. Pokorny ◽  
Byron A. Miller ◽  
Sidney E. Cleveland
Keyword(s):  
Response To Treatment ◽  
Follow Up Study
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