Properties of the Cognitive Function Battery for the MIND Diet Intervention to Prevent Alzheimer’s Disease

2021 ◽  
pp. 1-8
Author(s):  
Kristin R. Krueger ◽  
Klodian Dhana ◽  
Neelum T. Aggarwal ◽  
Konstantinos Arfanakis ◽  
Vincent J. Carey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Activity ◽  
Principal Component ◽  
Late Life ◽  
Cognitive Domains ◽  
Diet Intervention ◽  
The Mind ◽  
Mind Diet

Abstract Objective: To evaluate the properties of the cognitive battery used in the MIND Diet Intervention to Prevent Alzheimer’s Disease. The MIND Diet Intervention is a randomized control trial to determine the relative effectiveness of the MIND diet in slowing cognitive decline and reducing brain atrophy in older adults at risk for Alzheimer’s dementia. Methods: The MIND cognitive function battery was administered at baseline to 604 participants of an average age of 70 years, who agreed to participate in the diet intervention study, and was designed to measure change over time. The battery included 12 cognitive tests, measuring the 4 cognitive domains of executive function, perceptual speed, episodic memory, and semantic memory. We conducted a principal component analysis to examine the consistency between our theoretical domains and the statistical performance of participants in each domain. To further establish the validity of each domain, we regressed the domain scores against a late-life cognitive activity score, controlling for age, race, sex, and years of education. Results: Four factors emerged in the principal component analyses that were similar to the theoretical domains. In regression equations, we found the expected associations with age, education, and late-life cognitive activity with each of the four cognitive domains. Conclusions: These results indicate that the MIND cognitive battery is a comprehensive and valid battery of four separate domains of cognitive function that can be used in diet intervention trials for older adults.

scholarly journals Properties of the cognitive function battery for the MIND diet intervention to prevent Alzheimer’s disease

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Kristin R. Krueger ◽  
Klodian Dhana ◽  
Neelum T. Aggarwal ◽  
Konstantinos Arfanakis ◽  
Vincent Carey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Diet Intervention ◽  
The Mind ◽  
Mind Diet

scholarly journals Association of AKAP6 and MIR2113 with cognitive performance in a population based sample of older adults

2016 ◽  
Author(s):  
Shea J. Andrews ◽  
Debjani Das ◽  
Kaarin J. Anstey ◽  
Simon Easteal
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Cognitive Function ◽  
Episodic Memory ◽  
Cognitive Performance ◽  
Cognitive Change ◽  
European Ancestry ◽  
Substantial Contribution ◽  
Perceptual Speed ◽  
Cognitive Domains

AbstractGenetic factors make a substantial contribution to inter-individual variability in cognitive function. A recent meta-analysis of genome-wide association studies identified two loci, AKAP6 and MIR2113 that are associated with general cognitive function. Here, we extend this previous research by investigating the association of MIR2113 and AKAP6 with baseline and longitudinal nonlinear change across a broad spectrum of cognitive domains in community-based cohort of 1,570 older adults without dementia. Two SNPs, MIR211-rs10457441 and AKAP6-rs17522122 were genotyped in 1,570 non-demented older Australians of European ancestry, who were examined up to 4 times over 12 years. Linear mixed effects models were used to examine the association between AKAP6 and MIR2113 with cognitive performance in episodic memory, working memory, vocabulary, perceptual speed and reaction time at baseline and with linear and quadratic rates of change. AKAP6-rs17522122*T was associated with worse baseline performance in episodic memory, working memory, vocabulary and perceptual speed, but it was not associated with cognitive change in any domain. MIR2113-rs10457441*T was associated with accelerated decline in episodic memory. No other associations with baseline cognitive performance or with linear or quadratic rate or cognitive changes was observed for this SNP. These results confirm the previous finding that, AKAP6 is associated with performance across multiple cognitive domains at baseline but not with cognitive decline, while MIR2113 primarily affects the rate at which memory declines over time.

Duration of Poverty and Subsequent Cognitive Function and Decline Among Older Adults in China, 2005–2018

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012343
Author(s):  
Xuexin Yu ◽  
Wei Zhang ◽  
Lindsay C. Kobayashi
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Late Life ◽  
Tobit Regression ◽  
Annual Household Income ◽  
Middle Income ◽  
Healthy Longevity ◽  
Rate Of Decline ◽  
Statistical Yearbook

Objective:To investigate the relationship between late-life duration of poverty exposure and cognitive function and decline among older adults in China.Methods:Data were from 3,209 participants aged ≥64 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Duration of poverty, defined according to urban and rural regional standards from the China Statistical Yearbook, was assessed based on annual household income from 2005-2011 (never in poverty; 1/3 of the period in poverty; ≥2/3 of the period in poverty). Cognitive function was measured by the Chinese Mini Mental State Exam (CMMSE) from 2011-2018. We used attrition-weighted, multivariable mixed-effects Tobit regression to examine the association of duration of poverty with cognitive function and rate of decline.Results:A total of 1,162 individuals (36.21%) were never in poverty over the period from 2005-2011, 1,172 (36.52%) were in poverty 1/3 of the period, and 875 (27.27%) were in poverty ≥2/3 of the period. A longer poverty duration was associated with lower subsequent CMMSE scores with a dose-response relationship (1/3 vs. never in poverty: β = -0.98; 95% CI: -1.61 to -0.35; ≥2/3 vs. never in poverty: β = -1.55; 95% CI: -2.29 to -0.81). However, a longer duration of poverty was associated with a slower rate of CMMSE score decline over time from 2011-2018.Conclusion:These findings provide valuable evidence on the role of cumulative late-life poverty in relation to cognitive health among older adults in a rapidly urbanizing and aging middle-income country. Our findings may support a compensation hypothesis for cognitive reserve in this setting.

scholarly journals Engagement in Lifestyle Activities is Associated with Increased Alzheimer’s Disease-Associated Cortical Thickness and Cognitive Performance in Older Adults

2020 ◽  
Vol 9 (5) ◽  
pp. 1424 ◽  
Author(s):  
Seongryu Bae ◽  
Sangyoon Lee ◽  
Kenji Harada ◽  
Keitaro Makino ◽  
Ippei Chiba ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Cognitive Function ◽  
Direct Effect ◽  
Cortical Thickness ◽  
Social Activities ◽  
Direct Path ◽  
Cognitive Activities ◽  
Lifestyle Activities ◽  
The Relationship

The aim of this study was to examine the association between lifestyle activities, including physical, cognitive, and social activities, and Alzheimer’s disease (AD) signature cortical thickness, as well as to examine the mediating role of AD signature cortical thickness in lifestyle activities and cognitive function in community-dwelling healthy older adults. Participants were 1026 older adults who met the study inclusion criteria. The physical, cognitive, and social activities of daily life were assessed using a self-reporting questionnaire. AD signature cortical thickness was determined using FreeSurfer software. Cognitive function was evaluated using the National Center for Geriatrics and Gerontology-Functional Assessment Tool. Path analysis (based on structural equation modeling (SEM)) of cognitive activities indicated that the direct path from cognitive activities to cognitive function was significant (p < 0.001), as was the direct path from AD signature cortical thickness to cognitive function (p < 0.001). Physical (p < 0.05) or social activities (p < 0.05) had a direct effect on cognitive function. However, AD signature cortical thickness did not mediate the relationship between physical or social activities and cognitive function. Our findings suggest that higher levels of cognitive activities later in life have a significant and positive direct effect on cognitive function. Additionally, AD signature cortical thickness significantly mediates the relationship between cognitive activities and cognitive function.

P2-131: Relationships between cognitive activity, Alzheimer's disease pathological biomarkers and cognitive functioning in normal older adults

2013 ◽  
Vol 9 ◽  
pp. P393-P394 ◽  
Author(s):  
Miranka Wirth ◽  
Claudi M Haase ◽  
Sylvia Villeneuve ◽  
Cindee Madison ◽  
Hwamee Oh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Functioning ◽  
Cognitive Activity

Is Social Network a Protective Factor for Cognitive Impairment in US Chinese Older Adults? Findings from the PINE Study

Gerontology ◽  
2017 ◽  
Vol 64 (3) ◽  
pp. 246-256 ◽  
Author(s):  
Mengting Li ◽  
Xinqi Dong
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Cognitive Impairment ◽  
Social Network ◽  
Cognitive Function ◽  
Protective Factor ◽  
Network Size ◽  
Chinese Older Adults ◽  
Cognitive Domains ◽  
Global Cognition

Background: Social network has been identified as a protective factor for cognitive impairment. However, the relationship between social network and global and subdomains of cognitive function remains unclear. Objective: This study aims to provide an analytic framework to examine quantity, composition, and quality of social network and investigate the association between social network, global cognition, and cognitive domains among US Chinese older adults. Methods: Data were derived from the Population Study of Chinese Elderly (PINE), a community-engaged, population-based epidemiological study of US Chinese older adults aged 60 and above in the greater Chicago area, with a sample size of 3,157. Social network was assessed by network size, volume of contact, proportion kin, proportion female, proportion co-resident, and emotional closeness. Cognitive function was evaluated by global cognition, episodic memory, executive function, working memory, and Chinese Mini-Mental State Examination (C-MMSE). Linear regression and quantile regression were performed. Results: Every 1-point increase in network size (b = 0.048, p < 0.001) and volume of contact (b = 0.049, p < 0.01) and every 1-point decrease in proportion kin (b = -0.240, p < 0.01) and proportion co-resident (b = -0.099, p < 0.05) were associated with higher level of global cognition. Similar trends were observed in specific cognitive domains, including episodic memory, working memory, executive function, and C-MMSE. However, emotional closeness was only significantly associated with C-MMSE (b = 0.076, p < 0.01). Social network has differential effects on female versus male older adults. Conclusion: This study found that social network dimensions have different relationships with global and domains of cognitive function. Quantitative and structural aspects of social network were essential to maintain an optimal level of cognitive function. Qualitative aspects of social network were protective factors for C-MMSE. It is necessary for public health practitioners to consider interventions that enhance different aspects of older adults' social network.

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