scholarly journals Possible heliogeophysical effects on human physiological state

2008 ◽  
Vol 4 (S257) ◽  
pp. 65-67 ◽  
Author(s):  
Svetla Dimitrova
Keyword(s):  
Blood Pressure ◽  
Cosmic Rays ◽  
Healthy Volunteers ◽  
Geomagnetic Activity ◽  
Pulse Pressure ◽  
Pressure Pulse ◽  
Physiological State ◽  
Activity Increase ◽  
Hourly Data ◽  
The Mean

AbstractA group of 86 healthy volunteers was examined in periods of high solar and geomagnetic activity. In this study hourly Dst-index values and hourly data about intensity of cosmic rays were used. Results revealed statistically significant increments for the mean systolic and diastolic blood pressure, pulse pressure and subjective psycho-physiological complaints of the group with geomagnetic activity increase and cosmic rays intensity decrease.

Elevation of pulse pressure in middle age is associated with the risk of dementia: data from a population-based cohort

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D Kim ◽  
H Jung ◽  
P.S Yang ◽  
H.T Yu ◽  
T.H Kim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pulse Pressure ◽  
Middle Age ◽  
Population Based ◽  
Entire Cohort ◽  
Incident Dementia ◽  
Increased Risk ◽  
Diagnosis Of Dementia ◽  
History Of ◽  
The Mean

Abstract Aims Pulse pressure (PP) is a well-known risk factor for cardiovascular disease. However, the association between the PP and dementia is not well identified. This study aimed to determine the effect of PP on the risk of dementia development in different age subgroups using a longitudinal, population-based, and stroke-free cohort from the general population. Methods The association of PP with the development of incident dementia was assessed from January 1, 2005, to December 31, 2013, in 433,154 participants without a history of dementia or stroke from the Korea National Health Insurance Service-Health Screening cohort. The diagnosis of dementia was defined using the 10th revision of the International Classification of Disease codes. Results The mean age of the cohort was 55.7±9.2 years, 45.7% were women. Hypertension was 23.6%. The mean systolic and diastolic blood pressure of the entire cohort were 125.9±16.6 and 78.4±10.7 mmHg, respectively. Mean PP was 47.5±10.9 mmHg. In the middle-age group (40 to 50 year-old), increasing of 10 mmHg of PP was associated with incident dementia after adjusting mean blood pressure and clinical variables with a hazard ratio (HR) of 1.21 (95% confidence interval [CI]: 1.19–1.23, p<0.001). The association was still significant even after censoring for stroke (HR: 1.16, 95% CI: 1.08–1.22, p<0.001). In the older population, elevation of PP was not associated with dementia development (HR: 0.98, 95% CI: 0.95–1.01, p=0.247) Conclusion PP was associated with increased risk of dementia only in middle-aged population beyond that of mean arterial pressure. Funding Acknowledgement Type of funding source: None

PM337 Relationship of age and underweight with systolic and diastolic blood pressure, pulse pressure and heart rate among blacks schoolchildren in Central Africa Country

Global Heart ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e130
Author(s):  
Bertrand F. Ellenga Mbolla ◽  
Thierry R. Gombet ◽  
Annie R. Okoko ◽  
Christian M. Koula Landa ◽  
suzy-Gisèle Kimbally-Kaky ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Diastolic Blood Pressure ◽  
Pulse Pressure ◽  
Pressure Pulse ◽  
Central Africa ◽  
Relationship Of

scholarly journals Subclinical hyperthyroidism and blood pressure in a population-based prospective cohort study

2009 ◽  
Vol 161 (4) ◽  
pp. 615-621 ◽  
Author(s):  
Henry Völzke ◽  
Till Ittermann ◽  
Carsten O Schmidt ◽  
Marcus Dörr ◽  
Ulrich John ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Pulse Pressure ◽  
Prospective Cohort ◽  
Pressure Pulse ◽  
Population Based ◽  
Subclinical Hyperthyroidism ◽  
Serum Tsh ◽  
Tsh Levels

ObjectivesThere is current controversy on the association between subclinical hyperthyroidism and hypertension. Data from cohort studies have not been available yet. The present study was designed to longitudinally investigate possible associations of subclinical hyperthyroidism with blood pressure, pulse pressure and the risk of hypertension.MethodsWe used data from the population-based, prospective cohort Study of Health in Pomerania and included 2910 subjects (1469 women) aged 20–79 years with completed 5-year examination follow-up. Subjects with increased serum TSH levels or overt hyperthyroidism were excluded. Serum TSH levels below 0.25 mIU/l with free triiodothyronine and free thyroxine levels within the reference range were defined as subclinical hyperthyroidism. Blood pressure was measured according to standard methods.ResultsMultivariable analyses adjusted for age, sex, overweight, obesity, smoking status and time between the examinations did not reveal any statistically significant association between subclinical hyperthyroidism and any of the blood pressure-related variables in the whole study population. Although the 5-year hypertension incidence was higher in subjects with subclinical hyperthyroidism compared with those without (31.4 vs 19.2%; risk ratio 1.64; 95% confidence interval (CI) 1.17–2.28, P=0.006), both groups did not differ with respect to the risk of hypertension, after analyses were adjusted for confounders (relative risk 1.23, 95% CI 0.91–1.68, P=0.182). Analyses yielded similar results in subjects without thyroid disease and in those who took no antihypertensive medication.ConclusionSubclinical hyperthyroidism is not associated with changes in blood pressure, pulse pressure or incident hypertension.

Pharmacokinetics and Arteriovenous Differences in Clevidipine Concentration following a Short- and a Long-term Intravenous Infusion in Healthy Volunteers

2000 ◽  
Vol 92 (4) ◽  
pp. 993-1001 ◽  
Author(s):  
Hans Ericsson ◽  
Ulf Bredberg ◽  
Ulf Eriksson ◽  
Åse Jolin-Mellgård ◽  
Margareta Nordlander ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Steady State ◽  
Healthy Volunteers ◽  
Venous Blood ◽  
Volume Of Distribution ◽  
Pharmacokinetic Parameters ◽  
Blood Levels ◽  
Blood Concentrations ◽  
Arterial Blood ◽  
The Mean

Background Clevidipine is an ultra-short-acting calcium antagonist developed for reduction and control of blood pressure during cardiac surgery. The objectives of the current study were to determine the pharmacokinetics of clevidipine after 20-min and 24-h intravenous infusions, and to determine the relation between the arterial and venous concentrations and the hemodynamic responses to clevidipine in healthy volunteers. Methods Four volunteers received clevidipine for 20 min, and eight subjects were administered clevidipine intravenously for 24 h at two different dose rates. Arterial and venous blood samples were drawn for pharmacokinetic evaluation, and blood pressure and heart rate were recorded. Results A triexponential disposition model described the pharmacokinetics of clevidipine. The mean arterial blood clearance of clevidipine was 0.069l/kg-1/min-1 and the mean volume of distribution at steady state was 0.19 l/kg. The duration of the infusion had negligible effect on the pharmacokinetic parameters, and the context-sensitive half-time for clevidipine, simulated from the mean pharmacokinetic parameters derived after 24 h infusion at the highest dose, was less than 1 min. The arterial blood levels reached steady state within 2 min of the start of infusion and were about twice as high as those in the venous blood at steady state. The peak response preceded the peak venous concentration and was slightly delayed from the peak arterial blood concentration. Conclusion Clevidipine is a high clearance drug with a small volume of distribution, resulting in extremely short half-lives in healthy subjects. The initial rapid increase in the arterial blood concentrations and the short equilibrium time between the blood and the biophase suggest that clevidipine can be rapidly titrated to the desired effect.

scholarly journals The Association of 25(OH)D with Blood Pressure, Pulse Pressure and Carotid-Radial Pulse Wave Velocity in African Women

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e54554 ◽  
Author(s):  
Iolanthé M. Kruger ◽  
Marlena C. Kruger ◽  
Colleen M. Doak ◽  
Aletta E. Schutte ◽  
Hugo W. Huisman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Pressure ◽  
Pressure Pulse ◽  
Pulse Wave ◽  
African Women ◽  
Radial Pulse

ACUTE TOXICITY STUDIES ON ETHANOL, PROPANOL, AND BUTANOL

1964 ◽  
Vol 42 (6) ◽  
pp. 689-696 ◽  
Author(s):  
D. C. MacGregor ◽  
E. Schönbaum ◽  
W. G. Bigelow
Keyword(s):  
Blood Pressure ◽  
Pressure Pulse ◽  
Constant Infusion ◽  
Blood Levels ◽  
Blood Alcohol ◽  
Nitrous Oxide Anaesthesia ◽  
Oxide Anaesthesia ◽  
Blood Alcohol Levels ◽  
The Mean ◽  
Lethal Doses

Three series of 10 dogs each were used to study the effects of intravenously administered ethanol, propanol-1, and butanol-1. In normothermic dogs, with supported respiration and nitrous oxide anaesthesia (after induction), the mean lethal doses for ethanol, propanol-1, and butanol-1 were 4.90, 2.42, and 1.26 g/kg respectively. At a constant infusion rate, the blood alcohol levels increased almost linearly with time. Relationships between ethanol, propanol-1, and butanol-1 blood levels and blood pressure, pulse, and electrocardiogram were established. Two minutes cardiac standstill occurred at the following blood levels: ethanol, 1499 mg/100 ml; propanol-1, 713 mg/100 ml; butanol-1, 279 mg/100 ml.

Comparing the effects of cold compress and Xyla-p cream on hemodynamic changes in hemodialysis patients during venipuncture

2019 ◽  
Vol 17 (2) ◽  
Author(s):  
Ziba Ghoreyshi ◽  
Monireh Amerian ◽  
Farzaneh Amanpour ◽  
Reza Mohammadpourhodki ◽  
Hossein Ebrahimi
Keyword(s):  
Blood Pressure ◽  
Physiological State ◽  
Vital Signs ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Intermittent Hemodialysis ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
The Difference

AbstractBackgroundThe vital signs reflect the physiological state of patients in various clinical conditions. The purpose of this study was to compare the effects of cold compress and Xyla-P cream on hemodynamical changes during venipuncture in hemodialysis patients.Methods and MaterialIn this clinical trial study, 50 patients under hemodialysis were selected by simple random sampling. The patients were then randomly assigned to either Xyla-P cream, cold compress or placebo groups. The vital signs (blood pressure and pulse) were measured upon two intermittent hemodialysis sessions before and after venipuncture. Data were analyzed using repeated measures analysis of variance.ResultsThe mean alternation in systolic blood pressure was significantly different comparing the placebo and cold compress groups before and after intervention (p<0.001). However, the difference was not significant between the Xyla-P cream group and either placebo (p=0.402) or ice compress (p=0.698) groups. The difference of the mean diastolic blood pressure was significant comparing the placebo group with either the Xyla-P cream group (p=0.003) or cold compress group (p<0.001) before and after intervention. In addition, there was a significant difference in the mean number of heartbeats comparing the control group with either the Xyla-P cream group (p<0.001) or cold compress group (p<0.001) before and after the intervention.ConclusionsConsidering the beneficial effects of ice compress and the Xyla-P cream on reduction of cardiovascular parameters, it is recommended to use these methods in hemodialysis patients during venipuncture.

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