scholarly journals Metabolomics reveals the mechanism of (−)-hydroxycitric acid promotion of protein synthesis and inhibition of fatty acid synthesis in broiler chickens

animal ◽  
2018 ◽  
Vol 12 (4) ◽  
pp. 774-783 ◽  
Author(s):  
M.L. Peng ◽  
J. Han ◽  
L.L. Li ◽  
H.T. Ma
Keyword(s):  
Protein Synthesis ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Broiler Chickens ◽  
Acid Synthesis ◽  
Hydroxycitric Acid

scholarly journals Aurintricarboxylic acid is a potent inhibitor of phosphofructokinase

1989 ◽  
Vol 259 (3) ◽  
pp. 925-927 ◽  
Author(s):  
S A McCune ◽  
L G Foe ◽  
R G Kemp ◽  
R R Jurin
Keyword(s):  
Protein Synthesis ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Potent Inhibitor ◽  
Rat Hepatocytes ◽  
Acid Synthesis ◽  
Rabbit Liver ◽  
Irreversible Binding ◽  
Aurintricarboxylic Acid ◽  
Inhibitory Site

Aurintricarboxylic acid (ATA) was found to be a very potent inhibitor of purified rabbit liver phosphofructokinase (PFK), giving 50% inhibition at 0.2 microM. The inhibition was in a manner consistent with interaction at the citrate-inhibitory site of the enzyme. The data suggest that inhibition of PFK by ATA was not due to denaturation of the enzyme or the irreversible binding of inhibitor, since the inhibition could be reversed by addition of allosteric activators of PFK, i.e. fructose 2,6-bisphosphate or AMP. Two other tricarboxylic acids, agaric acid and (-)-hydroxycitrate, were found to inhibit PFK. ATA at much higher concentrations (500 microM) was shown to inhibit fatty acid synthesis from endogenous glycogen in rat hepatocytes; however, protein synthesis was not altered.

Assessment of De-Novo Fatty Acid Synthesis in Broiler Chickens Fed Diets Containing Different Mixtures of Beef Tallow and Soybean Oil

2007 ◽  
Vol 6 (11) ◽  
pp. 800-806 ◽  
Author(s):  
Sasiphan Wongsuthav ◽  
Chalermpon Yuangklang ◽  
Kraisit Vasupen ◽  
Jamlong Mitchaotha ◽  
Paiwan Srenanual ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Soybean Oil ◽  
Fatty Acid Synthesis ◽  
Beef Tallow ◽  
Broiler Chickens ◽  
De Novo ◽  
Acid Synthesis

Specific inhibition of iturin biosynthesis by cerulenin

1990 ◽  
Vol 36 (3) ◽  
pp. 164-168 ◽  
Author(s):  
Marie-Laure Hourdou ◽  
Françoise Besson ◽  
Georges Michel
Keyword(s):  
Fatty Acids ◽  
Protein Synthesis ◽  
Bacillus Subtilis ◽  
Fatty Acid ◽  
Amino Acid ◽  
Fatty Acid Synthesis ◽  
Lipid Synthesis ◽  
Acid Synthesis ◽  
Specific Inhibition ◽  
Malonyl Coa

Cerulenin, an inhibitor of fatty acid synthesis, inhibits the biosynthesis of iturin by Bacillus subtilis. With a cerulenin concentration of 2 μg/mL, 50% inhibition was achieved. At this concentration, cerulenin does not affect growth or total protein synthesis but does inhibit the incorporation of sodium [14C]acetate, [14C]myristic acid, and [14C]asparagine into iturin. Since cerulenin is known to block the condensation of malonyl-CoA subunits in the formation of fatty acids, the inhibition of iturin and β-amino acid syntheses by cerulenin is discussed in relation with lipid synthesis. Key words: iturin antibiotic, Bacillus subtilis, cerulenin, β-amino acid, lipid biosynthesis.

Energy balances of beef tallow and soyabean oil in broiler chickens

2007 ◽  
Vol 2007 ◽  
pp. 240-240
Author(s):  
Sasiphan Wongsuthavas ◽  
Chalermpol Yuangklang ◽  
Jamlong Mitchaothai ◽  
Kraisit Vasupen ◽  
Anton Beynen
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acids ◽  
Body Fat ◽  
Fatty Acid Synthesis ◽  
Beef Tallow ◽  
Broiler Chickens ◽  
Saturated Fatty Acids ◽  
Acid Synthesis ◽  
Abdominal Fat

From previous reports indicate that broiler chickens fed diets enriched with polyunsaturated fatty acids have less abdominal fat or total body fat (Sanz et al., 1999) deposition than do broiler chickens fed diets containing saturated fatty acids. In general, body fat accumulation may be considered the net result of the balance among dietary absorbed fat, endogenous fat synthesis (lipogenesis) and fat catabolism via β-oxidation (lypolysis). Thus, if the amount of absorbed fat is the same, lower body fat deposition may be attributed to increased fat catabolism or diminished endogenous fatty acid synthesis or to both process. Differences in lipid oxidation rates seem to be the main mechanism involved in this effect. Supplementation of unsaturated fatty acids in diets can be enhanced fat catabolism and reduced fatty acid synthesis were reported to occur in rats fed polyunsaturated fatty acid rich in diets compared with rats fed diets enriched with saturated fatty acids (Crespo and Esteve-Garcia, 2002). Polyunsaturated fatty acids rich in diet effect on fat absorption were increased. In, contrast amount of abdominal fat deposition was decreased. It may be that the polyunsaturated fatty acid was higher rate fat oxidation or lower rate of fatty acid synthesis or both. The present study was undertaken to determine the effect of amount of beef tallow versus soybean oil absorbed is the same on energy intake, energy excretion, energy retention and energy expenditure of broiler chickens.

Effect of nigericin and varying potassium concentrations on the prolactin-stimulated synthesis of milk fat in explants of mammary alveolar tissue from rabbits

1983 ◽  
Vol 99 (2) ◽  
pp. 261-268 ◽  
Author(s):  
J. V. Smith ◽  
I. R. Falconer
Keyword(s):  
Protein Synthesis ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Milk Fat ◽  
Second Messenger ◽  
Acid Synthesis ◽  
Alveolar Tissue ◽  
The Media ◽  
Low K

The possible role of K+ as a 'second messenger' for prolactin was investigated. Explants obtained from mammary glands of pseudopregnant rabbits were cultured (a) in media with varying potassium concentrations and (b) in the presence of the potassium-specific ionophore, nigericin. The explants were examined histologically and the rate of protein synthesis was measured to determine the viability of the tissue. Increase in the rate of fatty acid synthesis in the presence of prolactin was used as a marker of prolactin stimulation. At low K+ concentrations prolactin-stimulated fatty acid synthesis decreased with the decrease in K+ concentration of the media, whereas there was no similar trend in the rate of protein synthesis. Nigericin (0·01–0·1 μmol/l) inhibited fatty acid synthesis and protein synthesis in the presence or absence of prolactin without significantly affecting tissue K+ content. The mechanism of nigericin inhibition is hence unclear and the results do not provide support for K+ as a 'second messenger' for prolactin.

In silico Mapping and Structure Analysis of Key Enzyme Genes in Fatty Acid Synthesis of Soybean

2009 ◽  
Vol 35 (10) ◽  
pp. 1942-1947
Author(s):  
Wan-Kun SONG ◽  
Ming-Xi ZHU ◽  
Yang-Lin ZHAO ◽  
Jing WANG ◽  
Wen-Fu LI ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Structure Analysis ◽  
Fatty Acid Synthesis ◽  
In Silico ◽  
Acid Synthesis ◽  
In Silico Mapping ◽  
Key Enzyme
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