Interference-Enhanced Raman Spectroscopy as a Promising Tool for the Detection of Biomolecules on Raman-Compatible Surfaces

Raman spectroscopy has emerged as a promising tool in biomedical analysis and clinical diagnosis. The development of surface-enhanced Raman scattering spectroscopy (SERS) improved the detection limit with ultrahigh sensitivity and simplicity. More and more Raman spectroscopy clinical trials (R-PCT) have been conducted recently. However, there is a lack of an up-to-date review summarizing the current status of Raman clinical trials performed until now. Hence, the clinical trials for Raman were retrieved from the International Clinical Trials Registration Platform. We summarized the clinical characteristics of 55 registered Raman spectroscopy clinical trials (R-RSCTs) and 44 published Raman spectroscopy clinical trials (P-RSCTs). This review could assist researchers and clinicians to understand the current status of Raman spectroscopy clinical research and perhaps could benefit the reasonable and accurate design of future SERS studies.

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Vertical Graphene Growth on AlCu4Mg Alloy by PECVD Technique

Coatings ◽

10.3390/coatings11091108 ◽

2021 ◽

Vol 11 (9) ◽

pp. 1108

Author(s):

Ales Polzer ◽

Josef Sedlak ◽

Jan Sedlacek ◽

Libor Benes ◽

Katerina Mouralova

Keyword(s):

Raman Spectroscopy ◽

Vapor Deposition ◽

Base Material ◽

Chemical Vapor ◽

Plasma Power ◽

Transmission Microscopy ◽

Promising Tool ◽

Atomic Force ◽

Factor Design ◽

Setting Parameters

Vertical graphene, which belongs to nanomaterials, is a very promising tool for improving the useful properties of long-used and proven materials. Since the growth of vertical graphene is different on each base material and has specific deposition setting parameters, it is necessary to examine each base material separately. For this reason, a full factor design of experiment was performed with 26 = 64 rounds, which contained additional 5 central points, i.e., a total of 69 rounds of individual experiments, which was to examine the effect of input factors Temperature, Pressure, Flow, CH4, Plasma Power, and Annealing in H2 on the growth of vertical graphene on aluminum alloy AlCu4Mg. The deposition was performed using plasma-enhanced chemical vapor deposition (PECVD) technology. Mainly, the occurrence of graphene was analyzed, which was confirmed by Raman spectroscopy, as well as its thickness. The characterization was performed using electron and transmission microscopy, including an atomic force microscope. It was found that the growth of graphene occurred in 7 cases and its thickness is affected only by the interaction flow (sccm) × pretreatment H2 (sccm).

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Features of Measuring Low CO Concentrations in N2-Containing Mixtures at Different Temperatures Using Spontaneous Raman Spectroscopy

Applied Spectroscopy ◽

10.1177/0003702820957009 ◽

2020 ◽

Vol 75 (1) ◽

pp. 81-86

Author(s):

Dmitry V. Petrov

Keyword(s):

Carbon Monoxide ◽

Raman Spectroscopy ◽

Rapid Determination ◽

Promising Tool ◽

Fitting Procedure ◽

Correct Determination ◽

Different Temperatures ◽

Emission Limits ◽

Combustion Processes

Raman spectroscopy is a promising tool for combustion processes optimization, due to the possibility of rapid determination of the exhaust gases composition. An important gas component in this task is carbon monoxide whose emission limits vary from 100 to 200 parts per million (ppm), depending on the heat generator technology. However, for the correct determination of its concentration from the sample Raman spectrum, it is necessary to take into account the contribution of nitrogen lines intensity due to their mutual overlap. This paper discusses a technique for deriving carbon monoxide intensity based on fitting the nitrogen spectrum at various temperatures. It is shown that ignoring the Herman–Wallis factors in the fitting procedure lead to an additional measurement error, which increases with temperature and exceeds 350 ppm at T = 1800 K.

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Rapid detection of the aspergillosis biomarker triacetylfusarinine C using interference-enhanced Raman spectroscopy

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-020-02571-2 ◽

2020 ◽

Vol 412 (24) ◽

pp. 6351-6360 ◽

Cited By ~ 3

Author(s):

Susanne Pahlow ◽

Thomas Orasch ◽

Olga Žukovskaja ◽

Thomas Bocklitz ◽

Hubertus Haas ◽

...

Keyword(s):

Raman Spectroscopy ◽

Rapid Detection ◽

Triacetylfusarinine C ◽

Interference Enhanced Raman Spectroscopy

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Plasmonic Hybrid Biocomposite as an Effective Substrate for Detection of Biomolecules by Surface-Enhanced Raman Spectroscopy

Russian Physics Journal ◽

10.1007/s11182-018-1531-2 ◽

2018 ◽

Vol 61 (7) ◽

pp. 1288-1293 ◽

Cited By ~ 1

Author(s):

R. V. Chernozem ◽

M. A. Surmeneva ◽

V. Atkin ◽

B. Krause ◽

T. Baumbach ◽

...

Keyword(s):

Raman Spectroscopy ◽

Surface Enhanced Raman Spectroscopy ◽

Surface Enhanced ◽

Surface Enhanced Raman ◽

Detection Of Biomolecules ◽

Hybrid Biocomposite

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Raman spectroscopy as a promising noninvasive tool in brain cancer detection

Journal of Innovative Optical Health Sciences ◽

10.1142/s1793545817300129 ◽

2017 ◽

Vol 10 (05) ◽

pp. 1730012 ◽

Cited By ~ 6

Author(s):

Piyush Kumar

Keyword(s):

Raman Spectroscopy ◽

Cancer Detection ◽

Ex Vivo ◽

Human Subjects ◽

Intensive Therapy ◽

Brain Tumor Surgery ◽

Noninvasive Technique ◽

Therapy Regimen ◽

Promising Tool

Despite intensive therapy regimen, brain cancers present with a poor prognosis, with an estimated median survival time of less than 15 months in case of glioblastoma. Early detection and improved surgical resections are suggested to enhance prognosis; several tools are being explored to achieve the purpose. Raman spectroscopy (RS), a nondestructive and noninvasive technique, has been extensively explored in brain cancers. This review summarizes RS-based studies in brain cancers, categorized into studies on animal models, ex vivo human samples, and in vivo human subjects. Findings suggest RS as a promising tool which can aid in improving the accuracy of brain tumor surgery. Further advancements in instrumentation, market-assessment, and clinical trials can facilitate translation of the technology as a noninvasive intraoperative guidance tool.

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