Crystallization-Induced Polymer Scaffold Formation in the Polymer/Drug Delivery System Poly(l-lactic acid)/Ethyl Butylacetylaminopropionate (PLLA/IR3535)

2021 ◽  
Author(s):  
Fanfan Du ◽  
Hande Ece Yener ◽  
Georg Hillrichs ◽  
Regine Boldt ◽  
René Androsch
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymer Scaffold

Surface Engineered Poly(lactic acid) (PLA) Microspheres by Chemical Treatment for Drug Delivery System

2013 ◽  
Vol 594-595 ◽  
pp. 214-218 ◽  
Author(s):  
C.Y. Tham ◽  
Zuratul Ain Abdul Hamid ◽  
Z.A. Ahmad ◽  
H. Ismail
Keyword(s):  
Drug Delivery ◽  
Contact Angle ◽  
Lactic Acid ◽  
Drug Delivery System ◽  
Water Contact Angle ◽  
Delivery System ◽  
Alkaline Solution ◽  
Alkaline Hydrolysis ◽  
Poly Lactic Acid ◽  
Water Contact

Poly (lactic acid) (PLA) is well known for their biodegradability and bioresorbable properties and these properties made them suitable in drug delivery system as drug carriers. PLA is relatively hydrophobic and lack of cell-recognition group to interact with biologically active molecules which reduce the surface compatibility of microspheres. In this project, alkaline hydrolysis was used to induce hydrophilic functional group on the microspheres surface. Alkaline solution at 0.01M and 0.1M was used to modify microspheres surfaces. The engineered surfaces were evaluated using Scanning Electron Microscopy and Water Contact Angle. 0.1M alkaline solution hydrolyzed microspheres at higher extends as compared to 0.01M, where partial microspheres disintegrated and porous structure was revealed. The water contact angle of PLA films shows decreased from 65 ̊ to range 42 47 ̊ after alkaline hydrolysis.

Fabrication of Hydroxyapatite Microcapsules by Biomimetic Method

2007 ◽  
Vol 330-332 ◽  
pp. 1029-1032 ◽  
Author(s):  
Yasuhiro Tabe ◽  
Mitsuhiro Hibino ◽  
Takeshi Yao
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Body Fluid ◽  
Poly Lactic Acid ◽  
Biomimetic Method

Apatite nuclei were synthesized by raising pH of simulated body fluid (SBF). Poly (lactic acid) (PLA) microspheres were soaked in apatite nuclei suspension, and then apatite nuclei were attached to surfaces of the PLA microspheres. When these PLA microspheres were soaked in SBF, apatite nuclei on the PLA microspheres induced HAp. As a result, PLA microspheres coated with HAp were fabricated. The HAp-coated PLA microspheres were soaked in acetone. The PLA core was dissolved out, and then consequently hollow microcapsules constructed of HAp were fabricated. As HAp microcapsules have properties of bioaffinity and non-toxicity, they were expected to be applicable to an excellent carrier of drug delivery system.

An evaluation of a new lactic acid polymer drug delivery system: a preliminary report

1994 ◽  
Vol 47 (3) ◽  
pp. 158-161 ◽  
Author(s):  
Yukimasa Sawada ◽  
Tadashi Ohkubo ◽  
Masazumi Kudoh ◽  
Kazunobu Sugawara ◽  
Koichi Otani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Preliminary Report ◽  
System A

scholarly journals Correction: In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 3623-3623
Author(s):  
Junyan Yao ◽  
Shijie Zhang ◽  
Wudan Li ◽  
Zhi Du ◽  
Yujie Li
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
System P

Correction for ‘In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system’ by Junyan Yao et al., RSC Adv., 2016, 6, 515–521.

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