scholarly journals Rationale and Safety Assessment of a Novel Intravaginal Drug-Delivery System with Sustained DL-Lactic Acid Release, Intended for Long-Term Protection of the Vaginal Microbiome

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153441 ◽  
Author(s):  
Hans Verstraelen ◽  
Chris Vervaet ◽  
Jean-Paul Remon
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Safety Assessment ◽  
Vaginal Microbiome ◽  
Acid Release

Development of biodegradable polyesters based on a hydroxylated coumarin initiator towards fluorescent visible paclitaxel-loaded microspheres

2019 ◽  
Vol 7 (14) ◽  
pp. 2261-2276 ◽  
Author(s):  
Yufei Bian ◽  
Zhiyong Wei ◽  
Zefeng Wang ◽  
Zhu Tu ◽  
Liuchun Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Physical Properties ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Biodegradable Polyesters ◽  
Biomedical Field

A facile method of end-functionalization was used to synthesize a series of fluorescent biodegradable polyesters with tailorable physical properties, which can promisingly be applied in the biomedical field as a controllable and traceable drug delivery system, especially for long-term controlled drug release.

Surface Engineered Poly(lactic acid) (PLA) Microspheres by Chemical Treatment for Drug Delivery System

2013 ◽  
Vol 594-595 ◽  
pp. 214-218 ◽  
Author(s):  
C.Y. Tham ◽  
Zuratul Ain Abdul Hamid ◽  
Z.A. Ahmad ◽  
H. Ismail
Keyword(s):  
Drug Delivery ◽  
Contact Angle ◽  
Lactic Acid ◽  
Drug Delivery System ◽  
Water Contact Angle ◽  
Delivery System ◽  
Alkaline Solution ◽  
Alkaline Hydrolysis ◽  
Poly Lactic Acid ◽  
Water Contact

Poly (lactic acid) (PLA) is well known for their biodegradability and bioresorbable properties and these properties made them suitable in drug delivery system as drug carriers. PLA is relatively hydrophobic and lack of cell-recognition group to interact with biologically active molecules which reduce the surface compatibility of microspheres. In this project, alkaline hydrolysis was used to induce hydrophilic functional group on the microspheres surface. Alkaline solution at 0.01M and 0.1M was used to modify microspheres surfaces. The engineered surfaces were evaluated using Scanning Electron Microscopy and Water Contact Angle. 0.1M alkaline solution hydrolyzed microspheres at higher extends as compared to 0.01M, where partial microspheres disintegrated and porous structure was revealed. The water contact angle of PLA films shows decreased from 65 ̊ to range 42 47 ̊ after alkaline hydrolysis.

Preparation of keratin/chlorhexidine complex nanoparticles for long-term and dual stimuli-responsive release

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 82334-82341 ◽  
Author(s):  
Xuelian Zhi ◽  
Yanfang Wang ◽  
Pengfei Li ◽  
Jiang Yuan ◽  
Jian Shen
Keyword(s):  
Drug Delivery ◽  
Complex Formation ◽  
Drug Delivery System ◽  
Delivery System ◽  
Convenient Method ◽  
Stimuli Responsive ◽  
Polyion Complex

Nanoscale polyion complex formation via the electrostatic complexation of a polyelectrolyte and a charged drug is the most convenient method for building a drug delivery system that simultaneously realizes the carrier preparation and drug embedding.

Safety assessment of a new nanoemulsion-based drug-delivery system reveals unexpected drug-free anticoagulant activity

Nanomedicine ◽  
2020 ◽  
Vol 15 (14) ◽  
pp. 1361-1373
Author(s):  
James J Hobson ◽  
Steve P Rannard ◽  
Andrew Owen ◽  
Neill J Liptrott
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Safety Assessment ◽  
Cell Function ◽  
Immune Cell ◽  
Anticoagulant Activity ◽  
Drug Free ◽  
Preclinical Safety

Aim: A preclinical safety assessment of a novel nanoemulsion drug-delivery system, initially developed to improve the posology of efavirenz (EFV), was conducted with a specific focus on possible immunological and hematological complications. Materials & methods: Assessment of common acute toxicities, such as complement activation and cytokine secretion, was performed using validated assays known to have good correlation with in vivo end points. Results & conclusion: Compared with a standard aqueous solution of EFV, the EFV nanoemulsion showed no significant effect on immune cell function or phenotype. Prolongation of activated partial thromboplastin time was observed for EFV-loaded nanoemulsions (88% at 4 μg/ml) as well as unloaded nanoemulsions (52%) highlighting the potential for drug-free anticoagulant activity and warranting further investigation of the mechanism and utility of these materials.

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