scholarly journals Correction: In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 3623-3623
Author(s):  
Junyan Yao ◽  
Shijie Zhang ◽  
Wudan Li ◽  
Zhi Du ◽  
Yujie Li
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
System P

Correction for ‘In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system’ by Junyan Yao et al., RSC Adv., 2016, 6, 515–521.

In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (1) ◽  
pp. 515-521 ◽  
Author(s):  
Junyan Yao ◽  
Shijie Zhang ◽  
Wudan Li ◽  
Zhi Du ◽  
Yujie Li
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Release ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
System P ◽  
Carrier Materials ◽  
Coaxial Fibers

BAC-loaded electrospun uniaxial and coaxial fibers were achieved with different drug release patterns whose carrier materials were PLLA and PLLA/PLL.

PLGA nanoparticle-based docetaxel/LY294002 drug delivery system enhances antitumor activities against gastric cancer

2019 ◽  
Vol 33 (10) ◽  
pp. 1394-1406 ◽  
Author(s):  
Juan Cai ◽  
Keyang Qian ◽  
Xueliang Zuo ◽  
Wuheng Yue ◽  
Yinzhu Bian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Delivery ◽  
Controlled Release ◽  
Mouse Model ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Poly Lactic Acid ◽  
Antitumor Effects

Docetaxel (TXT) is acknowledged as one of the most important chemotherapy agents for gastric cancer (GC). PI3K/AKT signaling is frequently activated in GC, and its inhibitor LY294002 exerts potent antitumor effects. However, the hydrophobicity of TXT and the poor solubility and low bioavailability of LY294002 limit their clinical application. To overcome these shortcomings, we developed poly(lactic acid/glycolic) (PLGA) nanoparticles loaded with TXT and LY294002. PLGA facilitated the accumulation of TXT and LY294002 at the tumor sites. The in vitro functional results showed that PLGA(TXT+LY294002) exhibited controlled-release and resulted in a markedly reduced proliferative capacity and an elevated apoptosis rate. An in vivo orthotopic GC mouse model and xenograft mouse model confirmed the anticancer superiority and tumor-targeting feature of PLGA(TXT+LY294002). Histological analysis indicated that PLGA(TXT+LY294002) was biocompatible and had no toxicity to major organs. Characterized by the combined slow release of TXT and LY294002, this novel PLGA-based TXT/LY294002 drug delivery system provides controlled release and tumor targeting and is safe, shedding light on the future of targeted therapy against GC.

scholarly journals Development and in vitro Evaluation of Gastro-protective Aceclofenac-loaded Self-emulsifying Drug Delivery System

2020 ◽  
Vol Volume 15 ◽  
pp. 5217-5226 ◽  
Author(s):  
Chen Jianxian ◽  
Kalsoom Saleem ◽  
Muhammad Ijaz ◽  
Masood Ur-Rehman ◽  
Ghulam Murtaza ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Evaluation ◽  
System P

Surface Engineered Poly(lactic acid) (PLA) Microspheres by Chemical Treatment for Drug Delivery System

2013 ◽  
Vol 594-595 ◽  
pp. 214-218 ◽  
Author(s):  
C.Y. Tham ◽  
Zuratul Ain Abdul Hamid ◽  
Z.A. Ahmad ◽  
H. Ismail
Keyword(s):  
Drug Delivery ◽  
Contact Angle ◽  
Lactic Acid ◽  
Drug Delivery System ◽  
Water Contact Angle ◽  
Delivery System ◽  
Alkaline Solution ◽  
Alkaline Hydrolysis ◽  
Poly Lactic Acid ◽  
Water Contact

Poly (lactic acid) (PLA) is well known for their biodegradability and bioresorbable properties and these properties made them suitable in drug delivery system as drug carriers. PLA is relatively hydrophobic and lack of cell-recognition group to interact with biologically active molecules which reduce the surface compatibility of microspheres. In this project, alkaline hydrolysis was used to induce hydrophilic functional group on the microspheres surface. Alkaline solution at 0.01M and 0.1M was used to modify microspheres surfaces. The engineered surfaces were evaluated using Scanning Electron Microscopy and Water Contact Angle. 0.1M alkaline solution hydrolyzed microspheres at higher extends as compared to 0.01M, where partial microspheres disintegrated and porous structure was revealed. The water contact angle of PLA films shows decreased from 65 ̊ to range 42 47 ̊ after alkaline hydrolysis.

Ginsenoside nanoparticle: a new green drug delivery system

2016 ◽  
Vol 4 (3) ◽  
pp. 529-538 ◽  
Author(s):  
Lin Dai ◽  
Kefeng Liu ◽  
Chuanling Si ◽  
Luying Wang ◽  
Jing Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Ginsenoside Rb1 ◽  
Anticancer Effects ◽  
System P

Ginsenoside Rb1 is shown to self-assemble with anticancer drugs to form stable nanoparticles, which have greater anticancer effectsin vitroandin vivothan the free drugs.

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