Surface Engineered Poly(lactic acid) (PLA) Microspheres by Chemical Treatment for Drug Delivery System

2013 ◽  
Vol 594-595 ◽  
pp. 214-218 ◽  
Author(s):  
C.Y. Tham ◽  
Zuratul Ain Abdul Hamid ◽  
Z.A. Ahmad ◽  
H. Ismail
Keyword(s):  
Drug Delivery ◽  
Contact Angle ◽  
Lactic Acid ◽  
Drug Delivery System ◽  
Water Contact Angle ◽  
Delivery System ◽  
Alkaline Solution ◽  
Alkaline Hydrolysis ◽  
Poly Lactic Acid ◽  
Water Contact

Poly (lactic acid) (PLA) is well known for their biodegradability and bioresorbable properties and these properties made them suitable in drug delivery system as drug carriers. PLA is relatively hydrophobic and lack of cell-recognition group to interact with biologically active molecules which reduce the surface compatibility of microspheres. In this project, alkaline hydrolysis was used to induce hydrophilic functional group on the microspheres surface. Alkaline solution at 0.01M and 0.1M was used to modify microspheres surfaces. The engineered surfaces were evaluated using Scanning Electron Microscopy and Water Contact Angle. 0.1M alkaline solution hydrolyzed microspheres at higher extends as compared to 0.01M, where partial microspheres disintegrated and porous structure was revealed. The water contact angle of PLA films shows decreased from 65 ̊ to range 42 47 ̊ after alkaline hydrolysis.

Fabrication of Hydroxyapatite Microcapsules by Biomimetic Method

2007 ◽  
Vol 330-332 ◽  
pp. 1029-1032 ◽  
Author(s):  
Yasuhiro Tabe ◽  
Mitsuhiro Hibino ◽  
Takeshi Yao
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Body Fluid ◽  
Poly Lactic Acid ◽  
Biomimetic Method

Apatite nuclei were synthesized by raising pH of simulated body fluid (SBF). Poly (lactic acid) (PLA) microspheres were soaked in apatite nuclei suspension, and then apatite nuclei were attached to surfaces of the PLA microspheres. When these PLA microspheres were soaked in SBF, apatite nuclei on the PLA microspheres induced HAp. As a result, PLA microspheres coated with HAp were fabricated. The HAp-coated PLA microspheres were soaked in acetone. The PLA core was dissolved out, and then consequently hollow microcapsules constructed of HAp were fabricated. As HAp microcapsules have properties of bioaffinity and non-toxicity, they were expected to be applicable to an excellent carrier of drug delivery system.

scholarly journals Correction: In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 3623-3623
Author(s):  
Junyan Yao ◽  
Shijie Zhang ◽  
Wudan Li ◽  
Zhi Du ◽  
Yujie Li
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
System P

Correction for ‘In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system’ by Junyan Yao et al., RSC Adv., 2016, 6, 515–521.

scholarly journals SINTESIS POLI ASAM LAKTAT BERBOBOT MOLEKUL RENDAH MEMAKAI KATALIS STANNUM

2017 ◽  
Vol 1 (1) ◽  
pp. 94
Author(s):  
Ricson P. Hutagaol ◽  
Lany Nurhayati ◽  
Jessica Analy
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Lactic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Acid Catalyst ◽  
The Body ◽  
Polymerization Process ◽  
Poly Lactic Acid ◽  
Low Molecular Weight

Synthesis Of Poly Lactic Acid Catalyst To Use Low-molecular-weight Using Stannum Catalyst           Poly lactic acid is a polyester that can be produced using raw materials of renewable natural resources such as starch and cellulose. These polymers can be degraded by hydrolysis process in the body and excreted within a few months. This polymer is not toxic and has been widely used in medical field such as for implants and medium in drug delivery systems (Drug Delivery System, DDS). Low molecular weight polymers that accelerate the degradation and the increasing concentration of drug detachment, while polymers with high molecular weight have a lower solubility so degraded more slowly. Polymerization process is affected by the solvent used, reaction temperature, time of agitation and catalyst used. Stanum (Sn) is the best catalyst is used to obtain polymers at relatively low temperatures. Synthesis is done by mixing the lactic acid with xylene and Stanum as a catalyst. Variation Stanum catalyst used, ie 0%, 1.0%, 2.0%, 3.0%, and 4.0%. Reacted in a reactor at a temperature of 140 ° C for 14 hours. Added chloroform, filtered and added to cold methanol. The precipitate was filtered and washed with cold methanol. The rst deposits exposed in the air and then heated in an oven at 80 ° C. Based on the results of the study, obtained the concentration of 2% was an optimum concentration of Sn is used to produce 4.55 grams of poly lactic acid of 20 grams of lactic acid with a molecular weight of 23289.83g/mol and the residue Stanum at 175.174 ppm. Keywords : Poly lactic acid, polikondensasu, catalyst, sanum.  ABSTRAK          Poli asam laktat merupakan poliester yang dapat diproduksi menggunakan bahan baku sumber daya alam terbarukan seperti pati dan selulosa. Polimer ini dapat terdegradasi dengan proses hidrolisis dalam tubuh dan terekskresi dalam waktu beberapa bulan. Polimer ini tidak meracuni tubuh dan telah banyak digunakan dalam bidang kedokteran seperti untuk implan dan medium dalam sistem penyampaian obat (Drug Delivery System, DDS). Bobot molekul polimer yang rendah mempercepat degradasi dan naiknya konsentrasi lepasan obat, sedangkan polimer dengan bobot molekul tinggi memiliki kelarutan yang lebih rendah sehingga terdegradasi lebih lambat. Proses polimerisasi dipengaruhi oleh pelarut yang digunakan, suhu reaksi, waktu pengocokan dan katalis yang digunakan. Stanum (Sn) merupakan katalis yang paling baik digunakan untuk mendapatkan polimer pada suhu yang relatif rendah. Sintesis dilakukan dengan mencampur asam laktat dengan xilena dan stanum sebagai katalis. Dilakukan variasi katalis stanum yang digunakan, yaitu    0 % ; 1,0 % ; 2,0 % ; 3,0 % ; dan 4,0 %. Direaksikan dalam reaktor pada suhu  140 °C selama 14 jam. Ditambahkan kloroform, disaring dan ditambahkan metanol dingin. Endapan disaring dan dicuci dengan metanol dingin. Sisa endapan dianginkan di udara lalu dipanaskan dalam oven pada suhu 80 °C. Berdasarkan hasil penelitian, didapat konsentrasi 2% merupakan konsentrasi Sn yang paling optimum digunakan untuk menghasilkan 4,55 gram poli asam laktat dari 20 gram asam laktat dengan bobot molekul 23289,83 g/mol dan residu stanum sebesar 175,174 ppm.Kata kunci : Poli asam laktat, polikondensasu, katalis, stanum.

scholarly journals Recent advancement in wound healing dressing material

2019 ◽  
Vol 10 (3) ◽  
pp. 2572-2577 ◽  
Author(s):  
Awadhesh Kumar Pandey ◽  
Arun Kumar Dwivedi
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Lactic Acid ◽  
Drug Delivery System ◽  
Biodegradable Polymers ◽  
Delivery System ◽  
Mechanical Performance ◽  
Polymeric Materials ◽  
Wound Management ◽  
Poly Lactic Acid

Wounds have been occurring as long as the existence of life. Presently available advanced wound care products for dressing are beyond the reach of the majority Indian population, and they also do not completely fulfil the required benefits of therapeutic value. The dermal patch technology is the best-known and widely used approach for delivering drugs. It has been proven to be the fastest, easiest, safest and most economical way for drug delivery. The use of biodegradable polymers in wound management has been brought into prominence with new innovations in drug delivery system. Thus with a new dimension for the use of polymeric materials in or as wound healing, drug delivery devices involves incorporation of biodegradability into the drug delivery system. A number of degradable polymers are potentially useful for drug delivery including a variety of synthetic and natural substances such as Poly Lactic acid, Poly Crypolactone, Chitosen etc. Among all these Poly (lactic acid) (PLA) is the most readily biodegradable polymer in the surgical field. The biodegradable polymers have gained growing importance in the medical area, and these have been used in a wide number of applications in the human body, such as surgical sutures, controlled drug release systems, artificial skins, guides for nerves, veins and artificial arteries and orthopaedic devices. Biodegradable polymers have several physical and chemical characteristics, such as molecular mass average and distribution, glass transition and/or melting temperatures, monomer ratios and sequencing for copolymers. The knowledge of physicochemical characteristics of Poly Lactic acid polymers essential to understand its thermo-mechanical performance. In order to achieve appropriate wound healing, sustained release of the drug from the bio-degradable patch is necessary. So the assessment of the interaction between the drug and polymer is indispensable.

Surface Modification of Poly(lactic acid) (PLA) via Alkaline Hydrolysis Degradation

2014 ◽  
Vol 970 ◽  
pp. 324-327 ◽  
Author(s):  
Cho Yin Tham ◽  
Zuratul Ain Abdul Hamid ◽  
Zulkifli Ahmad ◽  
Hanafi Ismail
Keyword(s):  
Contact Angle ◽  
Lactic Acid ◽  
Surface Treatment ◽  
Alkaline Hydrolysis ◽  
Surface Hydrophobicity ◽  
Alkaline Treatment ◽  
Poly Lactic Acid ◽  
Surface Erosion ◽  
Water Contact ◽  
Surface Hydrophilicity

Surface hydrophobicity of poly (lactic acid) have raise the concerns of surface incompatibility of PLA to function as biomaterial. Thus, various approaches have been made to improve the surface hydrophilicity of PLA. In the present paper, PLA materials were surface modified by alkaline hydrolysis. The indication of the reduction in water contact angle value, from 65 ̊ to 50 ̊ and 15 ̊, in 0.01M and 1M alkaline concentration respectively, proven surface hydrophilicity of PLA film was improved. Further alkaline treatment after 24 hours shows not significant reduction in contact angle. Whereas, the erosion of film surfaces treated under 1M alkaline solution have been observed under polarized optical microscopy. Intrinsic viscosity measurement was also conducted to monitor the surface treatment process. As a whole, surface treatment was successful and sufficient when no further decreased in contact angle value, thus prevent extensive surface erosion.

The Role of Polymer Carrier and Process Parameters for Small Molecule Drug Delivery via Blended Electrospinning

Nano LIFE ◽  
2021 ◽  
Vol 11 (02) ◽  
pp. 2150001
Author(s):  
Yasaman Hamedani ◽  
Murugabaskar Balan ◽  
Soumitro Pal ◽  
Sankha Bhowmick
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fiber Diameter ◽  
The Body ◽  
Small Molecular Weight ◽  
Fibrous Scaffold ◽  
Water Contact ◽  
Polymer Carrier ◽  
Disease Specific

Delivery of therapeutic compounds to the diseased area in the body with minimized adverse effects is the underlying objective behind development of advanced drug delivery systems. Providing disease-specific release patterns is the ultimate goal of any drug delivery system. Electrospinning has been widely used for nanofiber fabrication. Having high aspect ratio and similarity to the extracellular matrix in the body make electrospun nanofibers a great candidate to be used as drug delivery implants. In this study, we report electrospinning to be a tunable technique capable of providing engineered, disease-specific drug release patterns. Using “one factor at a time” and “central composite design” techniques, we respectively demonstrate flow rate and applied voltage to be the two most significant parameters (with [Formula: see text]-values of 512.48 and 42.31) affecting the final fiber diameter, and capillary-to-collector distance as the least important one, by evaluating their influence, individually and combined, on the morphology of electrospun Poly (Lactide-co-Glycolide acid) nanofibers. Using the same two techniques, we also show that hydrophobicity of the polymeric fibrous scaffold, measured by water contact angle (WCA) with the [Formula: see text]-value of 376.44, is the main factor to consider when designing an electrospun fibrous drug delivery system for a specific disease, while fiber diameter can further modulate the release pattern of the drug from hydrophobic polymeric nanofibers. We finally support our hypothesis by comparing our findings with analysis of data derived from the literature. Taken together, our findings suggest electrospinning to be a tunable technique capable of providing various release patterns for any small molecular weight drug on the basis of the requirements of the diseases to be treated.

PLGA nanoparticle-based docetaxel/LY294002 drug delivery system enhances antitumor activities against gastric cancer

2019 ◽  
Vol 33 (10) ◽  
pp. 1394-1406 ◽  
Author(s):  
Juan Cai ◽  
Keyang Qian ◽  
Xueliang Zuo ◽  
Wuheng Yue ◽  
Yinzhu Bian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Delivery ◽  
Controlled Release ◽  
Mouse Model ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Poly Lactic Acid ◽  
Antitumor Effects

Docetaxel (TXT) is acknowledged as one of the most important chemotherapy agents for gastric cancer (GC). PI3K/AKT signaling is frequently activated in GC, and its inhibitor LY294002 exerts potent antitumor effects. However, the hydrophobicity of TXT and the poor solubility and low bioavailability of LY294002 limit their clinical application. To overcome these shortcomings, we developed poly(lactic acid/glycolic) (PLGA) nanoparticles loaded with TXT and LY294002. PLGA facilitated the accumulation of TXT and LY294002 at the tumor sites. The in vitro functional results showed that PLGA(TXT+LY294002) exhibited controlled-release and resulted in a markedly reduced proliferative capacity and an elevated apoptosis rate. An in vivo orthotopic GC mouse model and xenograft mouse model confirmed the anticancer superiority and tumor-targeting feature of PLGA(TXT+LY294002). Histological analysis indicated that PLGA(TXT+LY294002) was biocompatible and had no toxicity to major organs. Characterized by the combined slow release of TXT and LY294002, this novel PLGA-based TXT/LY294002 drug delivery system provides controlled release and tumor targeting and is safe, shedding light on the future of targeted therapy against GC.

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