ι-Carrageenan Tetrasaccharide from ι-Carrageenan Inhibits Islet β Cell Apoptosis Via the Upregulation of GLP-1 to Inhibit the Mitochondrial Apoptosis Pathway

2020 ◽  
Author(s):  
Yanqi Li ◽  
Yanchao Wang ◽  
Lei Zhang ◽  
Ziyi Yan ◽  
Jingjing Shen ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Mitochondrial Apoptosis ◽  
Β Cell ◽  
Apoptosis Pathway ◽  
Mitochondrial Apoptosis Pathway

scholarly journals Triptolide Induces Leydig Cell Apoptosis by Disrupting Mitochondrial Dynamics in Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Linyan Lv ◽  
Yajie Chang ◽  
Yanqing Li ◽  
Haicheng Chen ◽  
Jiahui Yao ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Cell Apoptosis ◽  
Mitochondrial Dynamics ◽  
Reproductive Toxicity ◽  
Mitochondrial Apoptosis ◽  
Mitochondrial Dynamic ◽  
Apoptosis Pathway ◽  
Mitochondrial Apoptosis Pathway

Triptolide is widely used in the clinical treatment of various diseases. Side effects, including reproductive toxicity to male patients, limit its application. However, no detailed mechanisms or potential intervention targets have been reported. In this study, we show that triptolide activated the mitochondrial apoptosis pathway in rat testicular Leydig cells and induced apoptosis both in vivo and in vitro, which may cause hypoleydigism and impair spermatogenesis. Mechanistically, triptolide-induced dynamin-related protein 1 (Drp1) overexpression, which interfered with mitochondrial dynamic stability to activate the mitochondrial apoptosis pathway. Mdivi-1, a selective Drp1 inhibitor, partially reversed the mitochondrial dynamic disturbance and rat testicular Leydig cell apoptosis induced by triptolide. Inhibiting Drp1 over-activation may be a new strategy for mitigating the reproductive toxicity of triptolide.

Selenium deficiency induces duodenal villi cell apoptosis via an oxidative stress-induced mitochondrial apoptosis pathway and an inflammatory signaling-induced death receptor pathway

Metallomics ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1390-1400 ◽  
Author(s):  
Jianfa Wang ◽  
Zhe Liu ◽  
Xianjing He ◽  
Shuai Lian ◽  
Jianbin Liang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Element ◽  
Cell Apoptosis ◽  
Death Receptor ◽  
Selenium Deficiency ◽  
Mitochondrial Apoptosis ◽  
Inflammatory Signaling ◽  
Apoptosis Pathway ◽  
Death Receptor Pathway ◽  
Mitochondrial Apoptosis Pathway

Selenium is an important nutritional trace element possessing antioxidant and anti-apoptotic properties in intestinal.

scholarly journals The effect of GSK-3β in arsenic-induced apoptosis of malignant tumor cells: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Xin Gao ◽  
Bin Deng ◽  
Shanshan Ran ◽  
Shugang Li
Keyword(s):  
Tumor Cell ◽  
Malignant Tumor ◽  
Cell Apoptosis ◽  
Caspase 3 ◽  
Meta Analysis ◽  
Mitochondrial Apoptosis ◽  
Apoptosis Pathway ◽  
Tumor Cell Apoptosis ◽  
Mitochondrial Apoptosis Pathway ◽  
Gsk 3Β

Abstract Purpose: Arsenic has been reported to induce apoptosis in malignant tumor cells, therefore, it may be regarded as a treatment for some cancers. The mitochondrial apoptosis pathway, mediated by GSK-3β, plays an important role in tumor cell apoptosis. Nonetheless, the regulation of GSK-3β by arsenic remains controversial. Materials and Methods: We included 19 articles, which conducts the role of GSK-3β in the process of arsenic-induced tumor cell apoptosis by the meta-analysis. Results: Compared with the control group, the expression of GSK-3β (SMD=-0.92,95% CI (-1.78,-0.06)), p-Akt (SMD=-5.46,95% CI (-8.67,-2.24)) were reduced in the arsenic intervention group. Meanwhile, the combined treatment of arsenic and Akt agonist can inhibit the expression of p-GSK-3β. Using the dose and time subgroup analysis, it was shown that the low-dose and sub-chronic arsenic exposure could inhibit the expression of p-Akt (P<0.05). In the subgroup analysis of GSK-3β sites, arsenic could inhibit p-Akt and GSK-3β (Ser9) (SMD =-0.95, 95% CI (-1.56,-0.33)). There was a dose-related effect seen between arsenic (≤8 μmol/L) and p-GSK-3β, and the expression of p-GSK-3β was gradually followed by the arsenic dose. When arsenic acted on GSK-3β (ser9), the expression of Mcl-1 and pro-caspase-3 were dropped, while the loss rate of mitochondrial membrane potential and cleaved-caspase-3 were increased significantly (P<0.05). Conclusion: This study revealed that arsenic could inhibit the expression of GSK-3β (Ser9) and then induce tumor cell apoptosis. It might be correlated with arsenic inhibiting p-Akt, down-regulating GSK-3β, and triggering the Mcl-1-mediated mitochondrial apoptosis pathway.

Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats

2021 ◽  
Vol 402 (2) ◽  
pp. 112574
Author(s):  
Si Ying Li ◽  
Chen Yi Wang ◽  
Jing Jing Zhao ◽  
Cai Yun Long ◽  
Yun Xia Xiao ◽  
...  
Keyword(s):  
Anorectal Malformations ◽  
Mitochondrial Apoptosis ◽  
Apoptosis Pathway ◽  
Mitochondrial Apoptosis Pathway

Purification and characterization of a cytotoxic neurotoxin-like protein from Naja haje haje venom that induces mitochondrial apoptosis pathway

2011 ◽  
Vol 85 (8) ◽  
pp. 941-952 ◽  
Author(s):  
Amr E. El Hakim ◽  
Amira M. Gamal-Eldeen ◽  
Yasser E. Shahein ◽  
Nahla M. Mansour ◽  
Ahmed F. Wahby ◽  
...  
Keyword(s):  
Mitochondrial Apoptosis ◽  
Purification And Characterization ◽  
Apoptosis Pathway ◽  
Mitochondrial Apoptosis Pathway ◽  
Naja Haje

3,3′,4,4′,5‐Pentachlorobiphenyl influences mitochondrial apoptosis pathway in granulosa cells

2019 ◽  
Vol 120 (9) ◽  
pp. 15337-15346 ◽  
Author(s):  
Tao Zhong ◽  
Jianmei Zhang ◽  
Xiaoying Han ◽  
Xiaoxiao Gongye ◽  
Tianqi Lyu ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Mitochondrial Apoptosis ◽  
Apoptosis Pathway ◽  
Mitochondrial Apoptosis Pathway
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