scholarly journals Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta

2018 ◽  
Vol 81 (12) ◽  
pp. 2750-2755 ◽  
Author(s):  
A. Jonathan Singh ◽  
Alexander P. Gorka ◽  
Heidi R. Bokesch ◽  
Antony Wamiru ◽  
Barry R. O’Keefe ◽  
...  
Keyword(s):  
Natural Product ◽  
Product Diversity ◽  
Naturally Occurring

scholarly journals New Pharmacological Opportunities for Betulinic Acid

Planta Medica ◽  
2017 ◽  
Vol 84 (01) ◽  
pp. 8-19 ◽  
Author(s):  
José Ríos ◽  
Salvador Máñez
Keyword(s):  
Metabolic Syndrome ◽  
Natural Product ◽  
Betulinic Acid ◽  
Therapeutic Potential ◽  
Present Review ◽  
Antitumor Effects ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Wide Range ◽  
Birch Trees

AbstractBetulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated from birch trees, but present in many other botanical sources. It is found in different plant organs, both as a free aglycon and as glycosyl derivatives. A wide range of pharmacological activities has been described for this triterpenoid, including antiviral and antitumor effects. In addition, several other interesting properties have been identified in the fields of immunity and metabolism, namely antidiabetic, antihyperlipidemic, and anti-inflammatory activities. Taken together, these latter three properties make betulinic acid a highly interesting prospect for treating metabolic syndrome. The present review focuses on the therapeutic potential of this agent, along with several of its semisynthetic derivatives, which could open new frontiers in the use of natural product-based medicines.

scholarly journals Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5938
Author(s):  
Jaehoon Sim ◽  
Eunbin Jang ◽  
Hyun Jin Kim ◽  
Hongjun Jeon
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Structural Features ◽  
Synthetic Approach ◽  
Synthetic Analog ◽  
Phase I Clinical Trials ◽  
Total Syntheses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Synthetic Approaches

Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synthetic analog of this natural product class, which is currently under Phase I clinical trials. Since its isolation in 2004 and the first total synthesis in 2007, a dozen total syntheses and synthetic approaches toward the pladienolide class have been reported to date. This review focuses on the eight completed total syntheses of naturally occurring pladienolides or their synthetic analogs, in addition to a synthetic approach to the main framework of the natural product.

Versuche zur Synthese natürlich vorkommender prenylierter Naphthalinderivate. Nachweis eines neuen Prenylnaphthochinon- derivates in Galium mollugo / Synthesis of Naturally Occurring Prenylated Naphthalene Derivates. Isolation of a New Prenylnaphthoquinone from Galium mollugo

1982 ◽  
Vol 37 (5-6) ◽  
pp. 354-362 ◽  
Author(s):  
Lutz Heide ◽  
Eckhard Leistner
Keyword(s):  
Natural Product ◽  
Root System ◽  
Spectroscopic Methods ◽  
Naphthalene Derivatives ◽  
Naturally Occurring

AbstractSeveral prenylated naphthalene derivatives were synthesized and characterized by spectroscopic methods. One of these compounds, 2-methoxycarbonyl-3-prenyl-1,4-naphthoquinone, was detected as a new natural product in the root system of Galium mollugo L. This new natural product is likely to be related to the biosynthesis of mollugin and anthraquinones.

Unlocking the Spatial Control of Secondary Metabolism Uncovers Hidden Natural Product Diversity in Nostoc punctiforme

2019 ◽  
Vol 14 (6) ◽  
pp. 1271-1279 ◽  
Author(s):  
Daniel Dehm ◽  
Julia Krumbholz ◽  
Martin Baunach ◽  
Vincent Wiebach ◽  
Katrin Hinrichs ◽  
...  
Keyword(s):  
Natural Product ◽  
Secondary Metabolism ◽  
Nostoc Punctiforme ◽  
Product Diversity ◽  
Spatial Control

scholarly journals Isolation and synthesis of cryptosanguinolentine (isocryptolepine), a naturally-occurring bioactive indoloquinoline alkaloid

RSC Advances ◽  
2020 ◽  
Vol 10 (32) ◽  
pp. 18978-19002
Author(s):  
Elida N. Thobokholt ◽  
Enrique L. Larghi ◽  
Andrea B. J. Bracca ◽  
Teodoro S. Kaufman
Keyword(s):  
Natural Product ◽  
Naturally Occurring

The isolation and properties of the heterocycle are detailed and the diversity of chemical approaches toward the natural product are systematically ordered and reviewed.

scholarly journals Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols

2016 ◽  
Vol 80 (3) ◽  
pp. 588-597 ◽  
Author(s):  
Max Crüsemann ◽  
Ellis C. O’Neill ◽  
Charles B. Larson ◽  
Alexey V. Melnik ◽  
Dimitrios J. Floros ◽  
...  
Keyword(s):  
Natural Product ◽  
Bacterial Strains ◽  
Product Diversity

Biodiversity and Natural Product Diversity

2003 ◽  
Vol 64 (6) ◽  
pp. 1171
Author(s):  
Monique S.J Simmonds
Keyword(s):  
Natural Product ◽  
Product Diversity

The Synthesis of (R)-2',3'-Dihydroxypropyl 5-Deoxy-5-Dimethylarsinyl-β-D-Riboside, a Naturally Occurring Arsenic-Containing Carbohydrate

1987 ◽  
Vol 40 (11) ◽  
pp. 1901 ◽  
Author(s):  
DP Mcadam ◽  
AMA Perera ◽  
RV Stick
Keyword(s):  
Natural Product ◽  
Hydroxy Group ◽  
Title Compound ◽  
Protecting Groups ◽  
Giant Clam ◽  
Free Hydroxy Group ◽  
Naturally Occurring ◽  
Step Procedure ◽  
Tridacna Maxima ◽  
Subsequent Chemical

The synthesis of the title compound, isolated from the brown kelp ( Ecklonia radiata ) or the giant clam (Tridacna maxima), is reported. Glycosidation of 1-O-acetyl-2,3,5-tri- O- benzoyl -β-D-ribose, either directly with (S)-1,2-di-O-benzylglycerol or via the derived orthoester with (S)-1,2-O-isopropylideneglycerol, led to two fully protected glycerol β-D- ribofuranosides. Subsequent chemical manipulations led to a common intermediate having a free hydroxy group at C5 of the D-ribose residue. Replacement of this hydroxy group by a chlorine atom allowed the introduction of the dimethylarsinyl group at C5 in a two-step procedure, and removal of protecting groups provided the natural product.

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