scholarly journals Isolation and synthesis of cryptosanguinolentine (isocryptolepine), a naturally-occurring bioactive indoloquinoline alkaloid

RSC Advances ◽  
2020 ◽  
Vol 10 (32) ◽  
pp. 18978-19002
Author(s):  
Elida N. Thobokholt ◽  
Enrique L. Larghi ◽  
Andrea B. J. Bracca ◽  
Teodoro S. Kaufman
Keyword(s):  
Natural Product ◽  
Naturally Occurring

The isolation and properties of the heterocycle are detailed and the diversity of chemical approaches toward the natural product are systematically ordered and reviewed.

scholarly journals New Pharmacological Opportunities for Betulinic Acid

Planta Medica ◽  
2017 ◽  
Vol 84 (01) ◽  
pp. 8-19 ◽  
Author(s):  
José Ríos ◽  
Salvador Máñez
Keyword(s):  
Metabolic Syndrome ◽  
Natural Product ◽  
Betulinic Acid ◽  
Therapeutic Potential ◽  
Present Review ◽  
Antitumor Effects ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Wide Range ◽  
Birch Trees

AbstractBetulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated from birch trees, but present in many other botanical sources. It is found in different plant organs, both as a free aglycon and as glycosyl derivatives. A wide range of pharmacological activities has been described for this triterpenoid, including antiviral and antitumor effects. In addition, several other interesting properties have been identified in the fields of immunity and metabolism, namely antidiabetic, antihyperlipidemic, and anti-inflammatory activities. Taken together, these latter three properties make betulinic acid a highly interesting prospect for treating metabolic syndrome. The present review focuses on the therapeutic potential of this agent, along with several of its semisynthetic derivatives, which could open new frontiers in the use of natural product-based medicines.

scholarly journals Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5938
Author(s):  
Jaehoon Sim ◽  
Eunbin Jang ◽  
Hyun Jin Kim ◽  
Hongjun Jeon
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Structural Features ◽  
Synthetic Approach ◽  
Synthetic Analog ◽  
Phase I Clinical Trials ◽  
Total Syntheses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Synthetic Approaches

Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synthetic analog of this natural product class, which is currently under Phase I clinical trials. Since its isolation in 2004 and the first total synthesis in 2007, a dozen total syntheses and synthetic approaches toward the pladienolide class have been reported to date. This review focuses on the eight completed total syntheses of naturally occurring pladienolides or their synthetic analogs, in addition to a synthetic approach to the main framework of the natural product.

Versuche zur Synthese natürlich vorkommender prenylierter Naphthalinderivate. Nachweis eines neuen Prenylnaphthochinon- derivates in Galium mollugo / Synthesis of Naturally Occurring Prenylated Naphthalene Derivates. Isolation of a New Prenylnaphthoquinone from Galium mollugo

1982 ◽  
Vol 37 (5-6) ◽  
pp. 354-362 ◽  
Author(s):  
Lutz Heide ◽  
Eckhard Leistner
Keyword(s):  
Natural Product ◽  
Root System ◽  
Spectroscopic Methods ◽  
Naphthalene Derivatives ◽  
Naturally Occurring

AbstractSeveral prenylated naphthalene derivatives were synthesized and characterized by spectroscopic methods. One of these compounds, 2-methoxycarbonyl-3-prenyl-1,4-naphthoquinone, was detected as a new natural product in the root system of Galium mollugo L. This new natural product is likely to be related to the biosynthesis of mollugin and anthraquinones.

scholarly journals Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta

2018 ◽  
Vol 81 (12) ◽  
pp. 2750-2755 ◽  
Author(s):  
A. Jonathan Singh ◽  
Alexander P. Gorka ◽  
Heidi R. Bokesch ◽  
Antony Wamiru ◽  
Barry R. O’Keefe ◽  
...  
Keyword(s):  
Natural Product ◽  
Product Diversity ◽  
Naturally Occurring

The Synthesis of (R)-2',3'-Dihydroxypropyl 5-Deoxy-5-Dimethylarsinyl-β-D-Riboside, a Naturally Occurring Arsenic-Containing Carbohydrate

1987 ◽  
Vol 40 (11) ◽  
pp. 1901 ◽  
Author(s):  
DP Mcadam ◽  
AMA Perera ◽  
RV Stick
Keyword(s):  
Natural Product ◽  
Hydroxy Group ◽  
Title Compound ◽  
Protecting Groups ◽  
Giant Clam ◽  
Free Hydroxy Group ◽  
Naturally Occurring ◽  
Step Procedure ◽  
Tridacna Maxima ◽  
Subsequent Chemical

The synthesis of the title compound, isolated from the brown kelp ( Ecklonia radiata ) or the giant clam (Tridacna maxima), is reported. Glycosidation of 1-O-acetyl-2,3,5-tri- O- benzoyl -β-D-ribose, either directly with (S)-1,2-di-O-benzylglycerol or via the derived orthoester with (S)-1,2-O-isopropylideneglycerol, led to two fully protected glycerol β-D- ribofuranosides. Subsequent chemical manipulations led to a common intermediate having a free hydroxy group at C5 of the D-ribose residue. Replacement of this hydroxy group by a chlorine atom allowed the introduction of the dimethylarsinyl group at C5 in a two-step procedure, and removal of protecting groups provided the natural product.

scholarly journals Quality of Tomato Slices Freshly Cut from Fruit Treated with Methyl Jasmonate

HortScience ◽  
2004 ◽  
Vol 39 (4) ◽  
pp. 817C-817
Author(s):  
Chien Wang*
Keyword(s):  
Shelf Life ◽  
Methyl Jasmonate ◽  
Natural Product ◽  
Vapor Concentration ◽  
The Third ◽  
Naturally Occurring ◽  
Previously Treated ◽  
Clear Plastic ◽  
Fresh Cut

The objective of this study was to determine if treatment with methyl jasmonate (MJ), a naturally occurring substance, would extend the shelf life of tomato slices, specifically when slices were cut from fruit previously treated with this natural product. Tomatoes were harvested at breaker stage. The fruit were divided into four lots. The first three lots were treated with MJ right after harvest at the breaker stage. Fruit from the first lot were sliced immediately after MJ treatment. Fruit from the second lot were placed at 20 °C and allowed to ripen to red stage before slicing. Fruit from the third lot were treated the same way as those in the second lot except they received an additional MJ treatment just before slicing. Fruit from the fourth lot were placed at 20 °C and allowed to ripen to red stage before MJ treatment and slicing. Each lot also included an untreated control. MJ treatments were carried out in 200-L airtight containers. MJ was spotted onto filter paper at final vapor concentration of 10-5 M. Fruit were cut with a meat slicer to obtain slices with 5-mm thickness. Slices were placed in 1-L clear plastic trays with lids and stored at 5 °C. Samples were transferred daily from 5 to 20 °C for evaluation. Fresh-cut tomatoes treated with MJ and sliced at breaker stage (lot 1) had less decay, better quality, and longer shelf life than the untreated slices. However, no differences were found between the control slices and treated slices at the red stage regardless the time of MJ treatment and whether or not additional MJ treatments were applied (lots 2, 3 & 4). The results indicate that the effectiveness of MJ in reducing decay and maintaining quality is affected by the stages of ripeness of tomatoes and the types of decay.

Synthesis and Antitumor Activity of Novel [1,2,4,5]-tetrazepino[6,7-b] indole Derivatives: Marine Natural Product Hyrtioreticuline C and D Analogues

2018 ◽  
Vol 19 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Zeinab A. Muhammad ◽  
Mohamed A.A. Radwan ◽  
Thoraya A. Farghaly ◽  
Hatem M. Gaber ◽  
Mahmuod M. Elaasser
Keyword(s):  
Natural Product ◽  
Carcinoma Cell ◽  
Biologically Active ◽  
Marine Natural Product ◽  
Basic Medium ◽  
Standard Drug ◽  
Reference Drug ◽  
Carcinoma Cell Lines ◽  
Naturally Occurring ◽  
Wide Range

Background: Several biologically active indole alkaloids have been isolated from marine organisms over the previous few years. Many scientsts interested in synthesis of the marine azepinoindole alkaloids due to their wide range of bioliogical activies. </P><P> Objective: We interested herein to synthesize a new series of some analogues of new naturally occurring azepinoindole alkaloids. </P><P> Method: A novel series of [1,2,4,5]tetrazepino[6,7-b]indoles, Marine natural product Hyrtioreticuline C and D analogues, were synthesized via the reaction of 3-hydrazonoindolin-2-one with hydrzaonoyl chlorides in basic medium. </P><P> Results: The spectral data of the products proved their structure. All new derivatives were tested against two carcinoma cell lines ((A-549 & HepG2)) in comparison with the well-known anticancer standard drug (cisplatin) and two derivatives from the tested compounds showed activity more potent than the reference drug. </P><P> Conclusion: We succeeded in synthesis of new antitumor active azepinoindole alkaloids.

Asymmetric total synthesis of naturally occurring spirocyclic tetranorsesquiterpenoid lanceolactone A

2018 ◽  
Vol 16 (27) ◽  
pp. 5027-5035 ◽  
Author(s):  
Ranjan Kumar Acharyya ◽  
Samik Nanda
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Asymmetric Total Synthesis ◽  
Cascade Cyclization ◽  
Naturally Occurring

Asymmetric total synthesis of naturally occurring γ-butenolide containing [4.4]spiro-tetrahydrofuran lanceolactone A has been reported in this present work. Bimetallic (“Pd–Cu”) cascade cyclization was the crucial reaction employed for the construction of the γ-butenolide framework of the natural product.

The synthesis of hydroxysmirnovine

2000 ◽  
Vol 78 (5) ◽  
pp. 542-545 ◽  
Author(s):  
Veejendra K Yadav ◽  
Philip Williams ◽  
Michael Benn
Keyword(s):  
Natural Product ◽  
Naturally Occurring

The synthesis of N-(4-acetamidobutyl)-N-((Z)-4-hydroxy-3-methyl-2-butenyl) guanidine confirmed this as the structure of the natural product hydroxysmirnovine.Key words: hydroxysmirnovine, synthesis, naturally occurring guanidines.

Two for One: Structure Revision of the Marine Sesterterpene Tetronic Acid Strobilinin to (8Z,13E,20Z)-Strobilinin and (8E,13Z,20Z)-Strobilinin

1994 ◽  
Vol 47 (5) ◽  
pp. 933 ◽  
Author(s):  
R Davis ◽  
RJ Capon
Keyword(s):  
Natural Product ◽  
Spectroscopic Analysis ◽  
Marine Natural Product ◽  
Geometric Isomers ◽  
Tetronic Acid ◽  
Naturally Occurring ◽  
Structure Revision ◽  
Single Compound ◽  
The Absolute ◽  
Absolute Stereochemistry

A reinvestigation of the known marine natural product strobilinin has revealed it not to be a single compound (2), but to consist of two naturally occurring geometric isomers, neither of which corresponds to the structure originally assigned. These isomers, (8E,13Z,20Z)- strobilinin (10) and (8Z,13E,20Z)-strobilinin (11), were resolved, characterized and identified as their respective acetate derivatives (6) and (7), and their structures assigned by spectroscopic analysis. It would appear that the absolute stereochemistry of the strobilinins is very likely opposite to that of co-occurring variabilin (1).

Sign in / Sign up

Export Citation Format

Share Document