Versuche zur Synthese natürlich vorkommender prenylierter Naphthalinderivate. Nachweis eines neuen Prenylnaphthochinon- derivates in Galium mollugo / Synthesis of Naturally Occurring Prenylated Naphthalene Derivates. Isolation of a New Prenylnaphthoquinone from Galium mollugo

1982 ◽  
Vol 37 (5-6) ◽  
pp. 354-362 ◽  
Author(s):  
Lutz Heide ◽  
Eckhard Leistner
Keyword(s):  
Natural Product ◽  
Root System ◽  
Spectroscopic Methods ◽  
Naphthalene Derivatives ◽  
Naturally Occurring

AbstractSeveral prenylated naphthalene derivatives were synthesized and characterized by spectroscopic methods. One of these compounds, 2-methoxycarbonyl-3-prenyl-1,4-naphthoquinone, was detected as a new natural product in the root system of Galium mollugo L. This new natural product is likely to be related to the biosynthesis of mollugin and anthraquinones.

scholarly journals New Pharmacological Opportunities for Betulinic Acid

Planta Medica ◽  
2017 ◽  
Vol 84 (01) ◽  
pp. 8-19 ◽  
Author(s):  
José Ríos ◽  
Salvador Máñez
Keyword(s):  
Metabolic Syndrome ◽  
Natural Product ◽  
Betulinic Acid ◽  
Therapeutic Potential ◽  
Present Review ◽  
Antitumor Effects ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Wide Range ◽  
Birch Trees

AbstractBetulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated from birch trees, but present in many other botanical sources. It is found in different plant organs, both as a free aglycon and as glycosyl derivatives. A wide range of pharmacological activities has been described for this triterpenoid, including antiviral and antitumor effects. In addition, several other interesting properties have been identified in the fields of immunity and metabolism, namely antidiabetic, antihyperlipidemic, and anti-inflammatory activities. Taken together, these latter three properties make betulinic acid a highly interesting prospect for treating metabolic syndrome. The present review focuses on the therapeutic potential of this agent, along with several of its semisynthetic derivatives, which could open new frontiers in the use of natural product-based medicines.

scholarly journals Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5938
Author(s):  
Jaehoon Sim ◽  
Eunbin Jang ◽  
Hyun Jin Kim ◽  
Hongjun Jeon
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Structural Features ◽  
Synthetic Approach ◽  
Synthetic Analog ◽  
Phase I Clinical Trials ◽  
Total Syntheses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Synthetic Approaches

Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synthetic analog of this natural product class, which is currently under Phase I clinical trials. Since its isolation in 2004 and the first total synthesis in 2007, a dozen total syntheses and synthetic approaches toward the pladienolide class have been reported to date. This review focuses on the eight completed total syntheses of naturally occurring pladienolides or their synthetic analogs, in addition to a synthetic approach to the main framework of the natural product.

scholarly journals Isolation and Preparation of ent-2,3-Secobeyer-15-en-2,3-dioic acid, 3-methyl ester- A Natural Product from Spirostachys africana

2007 ◽  
Vol 2 (7) ◽  
pp. 1934578X0700200
Author(s):  
Namboole Moses Munkombwe ◽  
Disah Dijogadifele ◽  
Ngonye Sabure
Keyword(s):  
Methyl Ester ◽  
Natural Product ◽  
Spectroscopic Methods ◽  
Dioic Acid

A new secobeyerenoic acid mono ester, ent-2,3-secobeyer-15-en-2,3-dioic acid, 3-methyl ester was isolated from the heartwood of Spirostachys africana and identified using spectroscopic methods. The mono ester was also prepared using two methods; by reacting the known diacid, ent-2,3-secobeyer-15-en-2,3-dioic acid with 1.5 mole equivalency of diazomethane, and methanolysis of ent-2,3-secobeyer-15-en-2,3-dioic anhydride.

Bromopyrrole Alkaloids from the Jamaican Sponge Didiscus Oxeata

2005 ◽  
Vol 2005 (7) ◽  
pp. 427-428 ◽  
Author(s):  
Jin-Feng Hu ◽  
Jiangnan Peng ◽  
Abul B. Kazi ◽  
Michelle Kelly ◽  
Mark T. Hamann
Keyword(s):  
Marine Sponges ◽  
Spectroscopic Methods ◽  
Biological Investigation ◽  
Naturally Occurring ◽  
Acetone Extracts ◽  
First Time

Three bromopyrrole alkaloids (1–3) were isolated from the acetone extracts of Didiscus oxeata during chemical and biological investigation of Caribbean and Indo-Pacific marine sponges. The structures were established by spectroscopic methods. Mukanadin D (3) was obtained for the first time as a naturally-occurring C11 bromopyrrole alkaloid.

scholarly journals New Sesquiterpene Pyridine Alkaloids from Hippocratea excelsa

2018 ◽  
Vol 13 (8) ◽  
pp. 1934578X1801300
Author(s):  
Megumi Furukawa ◽  
Masakatsu Furukawa ◽  
Mitsuko Makino ◽  
Taketo Uchiyama ◽  
Yasuo Fujimoto ◽  
...  
Keyword(s):  
Hexane Extract ◽  
Spectroscopic Methods ◽  
L1210 Cells ◽  
Naturally Occurring ◽  
New Compounds ◽  
Sesquiterpene Pyridine Alkaloids

In total, three sesquiterpene pyridine alkaloids, including two new compounds and a triterpene, were isolated from the n-hexane extract of the stem barks of Hippocratea excelsa. The structures of these compounds were elucidated by spectroscopic methods. Pristimerin, a naturally occurring triterpenoid, exhibited cytotoxicity against L1210 cells.

scholarly journals Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta

2018 ◽  
Vol 81 (12) ◽  
pp. 2750-2755 ◽  
Author(s):  
A. Jonathan Singh ◽  
Alexander P. Gorka ◽  
Heidi R. Bokesch ◽  
Antony Wamiru ◽  
Barry R. O’Keefe ◽  
...  
Keyword(s):  
Natural Product ◽  
Product Diversity ◽  
Naturally Occurring

scholarly journals Shushe Acids A-D from Ganoderma Applanatum

2017 ◽  
Vol 12 (3) ◽  
pp. 1934578X1701200
Author(s):  
Qi Luo ◽  
Yan-Jiao Zhang ◽  
Zhi-Qiang Shen ◽  
Peng Chen ◽  
Yong-Xian Cheng
Keyword(s):  
Succinic Acid ◽  
Natural Product ◽  
Gallic Acid ◽  
Spectroscopic Methods ◽  
Fruiting Bodies ◽  
Ganoderma Applanatum ◽  
Prevention And Treatment ◽  
New Compounds ◽  
Derivatives Of ◽  
Mcf 7

Ganoderma applanatum is a fungus used for the prevention and treatment of a variety of disorders in China. In the present study, four new compounds, named shushe acids A-D (1-4), were isolated from the fruiting bodies of this species. Their structures were identified on the basis of spectroscopic methods. Compounds 1-4 are all natural product hybrids composed of derivatives of gallic acid, glycerol and succinic acid. None of the four compounds showed activity against the MCF-7 cell line.

scholarly journals Isolation and synthesis of cryptosanguinolentine (isocryptolepine), a naturally-occurring bioactive indoloquinoline alkaloid

RSC Advances ◽  
2020 ◽  
Vol 10 (32) ◽  
pp. 18978-19002
Author(s):  
Elida N. Thobokholt ◽  
Enrique L. Larghi ◽  
Andrea B. J. Bracca ◽  
Teodoro S. Kaufman
Keyword(s):  
Natural Product ◽  
Naturally Occurring

The isolation and properties of the heterocycle are detailed and the diversity of chemical approaches toward the natural product are systematically ordered and reviewed.

The Synthesis of (R)-2',3'-Dihydroxypropyl 5-Deoxy-5-Dimethylarsinyl-β-D-Riboside, a Naturally Occurring Arsenic-Containing Carbohydrate

1987 ◽  
Vol 40 (11) ◽  
pp. 1901 ◽  
Author(s):  
DP Mcadam ◽  
AMA Perera ◽  
RV Stick
Keyword(s):  
Natural Product ◽  
Hydroxy Group ◽  
Title Compound ◽  
Protecting Groups ◽  
Giant Clam ◽  
Free Hydroxy Group ◽  
Naturally Occurring ◽  
Step Procedure ◽  
Tridacna Maxima ◽  
Subsequent Chemical

The synthesis of the title compound, isolated from the brown kelp ( Ecklonia radiata ) or the giant clam (Tridacna maxima), is reported. Glycosidation of 1-O-acetyl-2,3,5-tri- O- benzoyl -β-D-ribose, either directly with (S)-1,2-di-O-benzylglycerol or via the derived orthoester with (S)-1,2-O-isopropylideneglycerol, led to two fully protected glycerol β-D- ribofuranosides. Subsequent chemical manipulations led to a common intermediate having a free hydroxy group at C5 of the D-ribose residue. Replacement of this hydroxy group by a chlorine atom allowed the introduction of the dimethylarsinyl group at C5 in a two-step procedure, and removal of protecting groups provided the natural product.

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